Publications
Now showing items 3361-3380 of 5385 records
Nucleocytoplasmic shuttling: The ins and outs of quantitative imaging.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY & PHYSIOLOGY - 01 Oct 2018
Nucleocytoplasmic protein shuttling is integral to the transmission of signals between the nucleus and the cytoplasm. The nuclear/cytoplasmic distribution of proteins of interest can be determined via fluorescence microscopy, following labelling of the target protein with fluorophore-conjugated antibodies (immunofluorescence) or by tagging the target protein with an autofluorescent protein, suc...
Correlates of Climate Variability and Dengue Fever in Two Metropolitan Cities in Bangladesh.
CUREUS - 01 Oct 2018
Dengue fever is a major public health concern in Bangladesh with increased incidence during monsoon. We aimed to assess the correlation of temperature, humidity, and rainfall on dengue fever in two dengue endemic cities in Bangladesh. It was a time series analysis of climate factors and dengue occurrence data in Dhaka and Chittagong cities from 1 January 2000 to 31 December 2009. Daily mean tem...
Does the subtype of acute coronary syndrome treated by percutaneous coronary intervention predict long-term clinical outcomes?
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES - 01 Oct 2018
The prognosis of patients undergoing percutaneous coronary intervention (PCI) for different subtypes of acute coronary syndromes (ACS) remains unclear. We compared short- and long-term mortality in patients undergoing PCI for unstable angina (UA), non-ST-elevation myocardial infarction (NSTEMI), and ST-elevation myocardial infarction (STEMI).This was a retrospective cohort study of 13 184 patie...
Impact of body mass index on mortality and hospitalisation of patients with atrial fibrillation.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING : JOURNAL OF THE WORKING GROUP ON CARDIOVASCULAR NURSING OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 01 Oct 2018
Atrial fibrillation represents a substantial clinical and public health issue. The definitive impact of body mass index on prognosis of patients with chronic (persistent or permanent) atrial fibrillation remains undetermined.The purpose of this study was to investigate the association of body mass index with health outcomes (mortality and re-hospitalisation) of patients with chronic atrial fibr...
Random-amplitude sinusoidal linear acceleration causes greater vestibular modulation of skin sympathetic nerve activity than constant-amplitude acceleration.
EXPERIMENTAL BRAIN RESEARCH - 01 Oct 2018
We tested the hypothesis that random variations in the magnitude of sinusoidal linear acceleration cause greater modulation of skin sympathetic nerve activity (SSNA), but not muscle sympathetic nerve activity (MSNA), than sinusoidal stimuli of the same frequency but constant amplitude. Subjects (n = 22) were seated in a sealed room mounted on a linear motor that could deliver peak sinusoidal ac...
Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: a meta-analysis of randomised clinical trials.
HEART (BRITISH CARDIAC SOCIETY) - 01 Oct 2018
Although oxygen therapy has been used for over a century in the management of patients with suspected acute myocardial infarction (AMI), recent studies have raised concerns around the efficacy and safety of supplemental oxygen in normoxaemic patients.To synthesise the evidence from randomised controlled trials (RCTs) that investigated the effects of supplemental oxygen therapy compared with roo...
Association with right atrial strain with right atrial pressure: an invasive validation study.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 01 Oct 2018
Echocardiographic assessment of right atrial pressure (RAP) from inferior vena cava (RAP) dimension may underestimate catheter-derived (RAP). As right atrial (RA) deformation, measured by speckle tracking, is preload-dependent, we hypothesized that RA strain may improve estimation of RAP. Right atrial strain components [RA reservoir function (ƐR), peak RA contraction (ƐCT) and RA conduit functi...
Turning a blind eye: HTLV-1-associated uveitis in Indigenous adults from Central Australia.
INTERNATIONAL OPHTHALMOLOGY - 01 Oct 2018
We describe the first two cases of HTLV-1 associated uveitis to be associated with HTLV-1c subtype infection.Case report.Uveitis was demonstrated in two Indigenous Australian men, both of whom had high HTLV-1c proviral loads in peripheral blood. Visual outcomes were poor in each case.Clinicians should be aware of HTLV-1c infection as a cause of uveitis in Australia, and HTLV-1 serology should b...
MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines.
JOURNAL OF LIPID RESEARCH - 01 Oct 2018
Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the plasma lipidome also occur in conditions that are not directly linked to lipid metabolism; therefore, plasma l...
Mitochondrial dysfunction-related lipid changes occur in nonalcoholic fatty liver disease progression.
JOURNAL OF LIPID RESEARCH - 01 Oct 2018
Nonalcoholic fatty liver disease (NAFLD) comprises fat-accumulating conditions within hepatocytes that can cause severe liver damage and metabolic comorbidities. Studies suggest that mitochondrial dysfunction contributes to its development and progression and that the hepatic lipidome changes extensively in obesity and in NAFLD. To gain insight into the relationship between lipid metabolism and...
The cost of diabetes and obesity in Australia.
JOURNAL OF MEDICAL ECONOMICS - 01 Oct 2018
To assess and compare the direct healthcare and non-healthcare costs and government subsidies by body weight and diabetes status.The Australian Diabetes, Obesity and Lifestyle study collected health service utilization and health-related expenditure data at the 2011-2012 follow-up surveys. Costing data were available for 4,409 participants. Unit costs for 2016-2017 were used where available or ...
Diagnosis of Nonischemic Stage B Heart Failure in Type 2 Diabetes Mellitus: Optimal Parameters for Prediction of Heart Failure.
JACC. CARDIOVASCULAR IMAGING - 01 Oct 2018
This study sought to identify whether impaired global longitudinal strain (GLS), diastolic dysfunction (DD), or left atrial enlargement (LAE) should be added to stage B heart failure (SBHF) criteria in asymptomatic patients with type 2 diabetes mellitus.SBHF is a precursor to clinical heart failure (HF), and its recognition justifies initiation of cardioprotective therapy. However, original def...
One-Year Safety and Clinical Outcomes of a Transcatheter Interatrial Shunt Device for the Treatment of Heart Failure With Preserved Ejection Fraction in the Reduce Elevated Left Atrial Pressure in Patients With Heart Failure (REDUCE LAP-HF I) Trial: A Randomized Clinical Trial.
JAMA CARDIOLOGY - 01 Oct 2018
In patients with heart failure (HF) and left ventricular ejection fraction (LVEF) equal to or greater than 40%, a transcatheter interatrial shunt device (IASD; Corvia Medical) reduces exercise pulmonary capillary wedge pressure (PCWP) and is safe compared with sham control treatment at 1 month of follow-up. The longer-term safety and patency of the IASD has not yet been demonstrated in the sett...
Renal denervation: one step backwards, three steps forward.
NATURE REVIEWS. NEPHROLOGY - 01 Oct 2018
Selection of Bypass vs Sleeve for the Management of Type-2 Diabetes in Severely Obese: Could Ethnicity Play a Role?
OBESITY SURGERY - 01 Oct 2018
Prospective data was evaluated to see whether bariatric procedure type made any difference to diabetes remission.One hundred eighty-six consecutive patients of Indian ethnicity (M:F 89:97) with type 2 diabetes mellitus (T2DM) and HbA1c > 6.5 were assessed before and at 1 year following surgery. Age, BMI, C-peptide and duration of diabetes (ABCD - described by WJ Lee), insulin use, baseline HbA1...
Associations of neighborhood environmental attributes with adults' objectively-assessed sedentary time: IPEN adult multi-country study.
PREVENTIVE MEDICINE - 01 Oct 2018
Neighborhood environmental attributes have been found to be associated with residents' time spent walking and in physical activity, in studies from single countries and in multiple-country investigations. There are, however, mixed findings on such environmental relationships with sedentary (sitting) time, which primarily have used evidence derived from single-country investigations with self-re...
Challenges Facing Parents in Academia.
CIRCULATION RESEARCH - 28 Sep 2018
Imaging and Management of Heart Failure and Preserved Ejection Fraction.
CURRENT TREATMENT OPTIONS IN CARDIOVASCULAR MEDICINE - 27 Sep 2018
The prevalence of heart failure with preserved ejection fraction (HFpEF) is rising and in some places, it is already the most prevalent form of heart failure. The usual treatments of HF do not improve mortality or outcomes in HFpEF, suggesting a distinct pathophysiology that remains poorly characterized. The neutrality of clinical trial results is also attributable to the heterogeneity of patie...
Cross-sectional associations of sedentary behaviour and physical activity on depression in Japanese older adults: an isotemporal substitution approach.
BMJ OPEN - 25 Sep 2018
Reducing sedentary behaviour (SB) and increasing physical activity (PA) have been shown to be associated with decreased depression. However, there are yet few studies examining the potential benefits on older adults' depression, when SB is replaced with PA. This study aimed to examine the associations of objectively assessed SB, light-intensity PA (LPA) and moderate-to-vigorous PA (MVPA) with d...
Generation of MicroRNA-34 Sponges and Tough Decoys for the Heart: Developments and Challenges.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2018
Heart failure (HF) is a debilitating and deadly chronic disease, with almost 50% of patients with HF dying within 5 years of diagnosis. With limited effective therapies to treat or cure HF, new therapies are greatly needed. microRNAs (miRNAs) are small non-coding RNA molecules that are powerful regulators of gene expression and play a key role in almost every biological process. Disruptions in ...
