Publications
Now showing items 3341-3360 of 5385 records
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.
THE NEW ENGLAND JOURNAL OF MEDICINE - 18 Oct 2018
Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.From 2010 through 2014, we enrolled community-dwelling men and women in Australia and the United States who were 70 years of age or older (or ≥65 years of age among b...
Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
THE NEW ENGLAND JOURNAL OF MEDICINE - 18 Oct 2018
Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear.From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanic...
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.
THE NEW ENGLAND JOURNAL OF MEDICINE - 18 Oct 2018
In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo.From 2...
Response by Howden and Levine to Letters Regarding Article, "Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications for Heart Failure Prevention".
CIRCULATION - 16 Oct 2018
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 16 Oct 2018
Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited genomic scope and limited sample sizes.This study sought to construct a genomic risk score for CAD and to estimate its potential as a screening t...
Advanced Imaging to Phenotype Patients With a Systemic Right Ventricle.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 16 Oct 2018
Background Reduced ventricular function and decreased exercise capacity are widespread in adults with complete transposition of the great arteries after atrial switch ( TGA -Mustard/Senning) and congenitally corrected TGA (cc TGA ). Advanced imaging techniques may help to better phenotype these patients and evaluate exercise cardiac response. Methods and Results Thirty-three adults with a syste...
Relation of Alcohol Consumption to Risk of Heart Failure in Patients Aged 65 to 84 Years With Hypertension.
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Oct 2018
Although a high level of alcohol consumption is associated with cardiomyopathy, the benefit or risk of moderate alcohol consumption on incident heart failure (HF) is unknown. This study examined the association between alcohol consumption and risk for HF in older adults with hypertension. The study analyzed data from a cohort of 6,083 participants aged 65 to 84 years at baseline (1995 to 2001) ...
Trajectories of childhood immune development and respiratory health relevant to asthma and allergy.
ELIFE - 15 Oct 2018
Events in early life contribute to subsequent risk of asthma; however, the causes and trajectories of childhood wheeze are heterogeneous and do not always result in asthma. Similarly, not all atopic individuals develop wheeze, and vice versa. The reasons for these differences are unclear. Using unsupervised model-based cluster analysis, we identified latent clusters within a prospective birth c...
Circulating metabolic biomarkers of renal function in diabetic and non-diabetic populations.
SCIENTIFIC REPORTS - 15 Oct 2018
Using targeted NMR spectroscopy of 227 fasting serum metabolic traits, we searched for novel metabolic signatures of renal function in 926 type 2 diabetics (T2D) and 4838 non-diabetic individuals from four independent cohorts. We furthermore investigated longitudinal changes of metabolic measures and renal function and associations with other T2D microvascular complications. 142 traits correlat...
Baseline and on-statin treatment lipoprotein(a) levels for prediction of cardiovascular events: individual patient-data meta-analysis of statin outcome trials.
LANCET (LONDON, ENGLAND) - 13 Oct 2018
Elevated lipoprotein(a) is a genetic risk factor for cardiovascular disease in general population studies. However, its contribution to risk for cardiovascular events in patients with established cardiovascular disease or on statin therapy is uncertain.Patient-level data from seven randomised, placebo-controlled, statin outcomes trials were collated and harmonised to calculate hazard ratios (HR...
What strategies do desk-based workers choose to reduce sitting time and how well do they work? Findings from a cluster randomised controlled trial.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 12 Oct 2018
Large amounts of sitting at work have been identified as an emerging occupational health risk, and findings from intervention trials have been reported. However, few such reports have examined participant-selected strategies and their relationships with behaviour change.The Stand Up Victoria cluster-randomised controlled trial was a workplace-delivered intervention comprising organisational, en...
Relative Importance of Baseline and Longitudinal Evaluation in the Follow-Up of Vasodilator Therapy in Pulmonary Arterial Hypertension.
JACC. CARDIOVASCULAR IMAGING - 12 Oct 2018
The aim of this study was to evaluate the relative value of baseline and follow-up echocardiographic assessment of pulmonary artery systolic pressure (PASP) and right ventricular (RV) function in assessing response to vasodilator therapy in pulmonary arterial hypertension (PAH).Routine follow-up of PASP and RV function is widely obtained in patients undergoing treatment for PAH, but the value o...
Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial.
BMJ (CLINICAL RESEARCH ED.) - 10 Oct 2018
To evaluate the impact of a multicomponent intervention (Stand More AT (SMArT) Work) designed to reduce sitting time on short (three months), medium (six months), and longer term (12 months) changes in occupational, daily, and prolonged sitting, standing, and physical activity, and physical, psychological, and work related health.Cluster two arm randomised controlled trial.National Health Servi...
What are the determinants of a concerned vision of the future when living with type 2 diabetes? Results from the E3N-AfterDiab study.
CHRONIC ILLNESS - 03 Oct 2018
Objectives Identification of characteristics associated with a negative experience with type 2 diabetes may help to develop novel intervention to improve the outlook of people with the disease. Our aim was to identify determinants of a self-reported concerned vision about the future when living with type 2 diabetes. Methods In 2630 women with type 2 diabetes from the E3N-AfterDiab study, we use...
Missing Heritability of Hypertension and Our Microbiome.
CIRCULATION - 02 Oct 2018
Improving health care accessibility for older adults with frailty: the role of Geographical Information Systems.
AGING CLINICAL AND EXPERIMENTAL RESEARCH - 01 Oct 2018
The National Echocardiography Database Australia (NEDA): Rationale and methodology.
AMERICAN HEART JOURNAL - 01 Oct 2018
The National Echocardiography Database Australia (NEDA) is a new echocardiography database collecting digital measurements on both a retrospective and prospective basis. To date, echocardiographic data from 435,133 individuals (aged 61.6 ± 17.9 years) with linkage to 59,725 all-cause deaths during a median of 40 months follow-up have been collected. These data will inform a number of initial an...
Effect of Dietary Factors on Cardiac Rhythm.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Oct 2018
The interaction between arrhythmias and certain lifestyle factors such as obesity and alcohol consumption is well-established. There is significant public and professional interest in the role of various diets, vitamins, and minerals in cardiovascular health. However, many widely held beliefs are not supported by the literature. There is limited evidence for routine magnesium and omega-3 poly-u...
The Real-World Cost-Effectiveness of Coronary Artery Bypass Surgery Versus Stenting in High-Risk Patients: Propensity Score-Matched Analysis of a Single-Centre Experience.
APPLIED HEALTH ECONOMICS AND HEALTH POLICY - 01 Oct 2018
There are limited economic evaluations comparing coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI) for multi-vessel coronary artery disease (MVCAD) in contemporary, routine clinical practice.The aim was to perform a cost-effectiveness analysis comparing CABG and PCI in patients with MVCAD, from the perspective of the Australian public hospital payer, using obse...
What matters in Cardiovascular Research? Scientific discovery driving clinical delivery.
CARDIOVASCULAR RESEARCH - 01 Oct 2018
