Publications
Now showing items 3301-3320 of 5385 records
Patient-Related Determinants of Glycaemic Control in People with Type 2 Diabetes in the Gulf Cooperation Council Countries: A Systematic Review.
JOURNAL OF DIABETES RESEARCH - 01 Jan 2018
The aim of this systematic review is to assess patient-related factors affecting glycaemic control among people with type 2 diabetes in the Arabian Gulf Council countries. MEDLINE, Embase, PsycINFO, CINAHL, and Cochrane CENTRAL databases were searched from their date of inception to May 2016. Two researchers independently identified eligible studies and assessed the risk of bias. A total of 13 ...
Oxidative Stress and NLRP3-Inflammasome Activity as Significant Drivers of Diabetic Cardiovascular Complications: Therapeutic Implications.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2018
It is now increasingly appreciated that inflammation is not limited to the control of pathogens by the host, but rather that sterile inflammation which occurs in the absence of viral or bacterial pathogens, accompanies numerous disease states, none more so than the complications that arise as a result of hyperglycaemia. Individuals with type 1 or type 2 diabetes mellitus (T1D, T2D) are at incre...
Lipids, Lipoproteins, and Metabolites and Risk of Myocardial Infarction and Stroke.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 13 Feb 2018
Blood lipids are established risk factors for myocardial infarction (MI), but uncertainty persists about the relevance of lipids, lipoprotein particles, and circulating metabolites for MI and stroke subtypes.This study sought to investigate the associations of plasma metabolic markers with risks of incident MI, ischemic stroke (IS), and intracerebral hemorrhage (ICH).In a nested case-control st...
Gene delivery of medium chain acyl-coenzyme A dehydrogenase induces physiological cardiac hypertrophy and protects against pathological remodelling.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 14 Feb 2018
We previously showed that medium chain acyl-coenzyme A dehydrogenase (MCAD, key regulator of fatty acid oxidation) is positively modulated in the heart by the cardioprotective kinase, phosphoinositide 3-kinase (PI3K(p110α)). Disturbances in cardiac metabolism are a feature of heart failure (HF) patients and targeting metabolic defects is considered a potential therapeutic approach. The specific...
Correspondence: Reply to 'Compound 17b and formyl peptide receptor biased agonism in relation to cardioprotective effects in ischaemia-reperfusion injury'.
NATURE COMMUNICATIONS - 07 Feb 2018
Mild cognitive impairment impacts health outcomes of patients with atrial fibrillation undergoing a disease management intervention.
OPEN HEART - 01 Jan 2018
Mild cognitive impairment (MCI) is prevalent in atrial fibrillation (AF) and has the potential to contribute to poor outcomes. We investigated the influence of MCI on survival and rehospitalisation in patients with chronic forms of AF undergoing a home-based, AF-specific disease management intervention (home-based intervention (HBI)) or standard management (SM).The Montreal Cognitive Assessment...
Metabolic characterization of menopause: cross-sectional and longitudinal evidence.
BMC MEDICINE - 06 Feb 2018
Women who experience menopause are at higher cardiometabolic risk and often display adverse changes in metabolic biomarkers compared with pre-menopausal women. It remains elusive whether the changes in cardiometabolic biomarkers during the menopausal transition are due to ovarian aging or chronological aging. Well-conducted longitudinal studies are required to determine this. The aim of this st...
A ligand-specific blockade of the integrin Mac-1 selectively targets pathologic inflammation while maintaining protective host-defense.
NATURE COMMUNICATIONS - 06 Feb 2018
Integrin-based therapeutics have garnered considerable interest in the medical treatment of inflammation. Integrins mediate the fast recruitment of monocytes and neutrophils to the site of inflammation, but are also required for host defense, limiting their therapeutic use. Here, we report a novel monoclonal antibody, anti-M7, that specifically blocks the interaction of the integrin Mac-1 with ...
Validation of Predictive Score of 30-Day Hospital Readmission or Death in Patients With Heart Failure.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Feb 2018
Existing prediction algorithms for the identification of patients with heart failure (HF) at high risk of readmission or death after hospital discharge are only modestly effective. We sought to validate a recently developed predictive model of 30-day readmission or death in HF using an Australia-wide sample of patients. This study used data from 1,046 patients with HF at teaching hospitals in 5...
Australian Trends in Procedural Characteristics and Outcomes in Patients Undergoing Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Feb 2018
Over the last decade, systems of care for ST-elevation myocardial infarction (STEMI) have evolved to try to improve outcomes and timely access to percutaneous coronary intervention (PCI). There have also been advances in PCI techniques and adjunctive pharmacotherapies. In this study, we sought to determine temporal changes in practices and clinical outcomes of PCI in patients with STEMI. We pro...
Weight Loss and Exercise Alter the High-Density Lipoprotein Lipidome and Improve High-Density Lipoprotein Functionality in Metabolic Syndrome.
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Feb 2018
High-density lipoprotein (HDL) lipid composition and function may better reflect cardiovascular risk than HDL cholesterol concentration. This study characterized the relationships between HDL composition, metabolism, and function in metabolic syndrome (MetS) patients and how changes in composition after weight loss (WL) and exercise treatments are related to function.Plasma samples from MetS pa...
Blood pressure monitoring: theory and practice. European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability Teaching Course Proceedings.
BLOOD PRESSURE MONITORING - 01 Feb 2018
The European Society of Hypertension (ESH) Working Group on Blood Pressure (BP) Monitoring and Cardiovascular Variability organized a Teaching Course on 'Blood Pressure Monitoring: Theory and Practice' during the 2017 ESH Meeting in Milan, Italy. This course performed by 11 international BP monitoring experts covered key topics of BP monitoring, including office BP measurement, ambulatory BP mo...
Associations of occupational standing with musculoskeletal symptoms: a systematic review with meta-analysis.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Feb 2018
Given the high exposure to occupational standing in specific occupations, and recent initiatives to encourage intermittent standing among white-collar workers, a better understanding of the potential health consequences of occupational standing is required. We aimed to review and quantify the epidemiological evidence on associations of occupational standing with musculoskeletal symptoms.A syste...
Mind the Gap: Mismatches Between Clinicians and Patients in Heart Failure Medication Management.
CARDIOVASCULAR DRUGS AND THERAPY - 01 Feb 2018
Previous studies on the 'treatment gap' in patients with heart failure (HF) have focused either on prescribing or patients' adherence to prescribed treatment. This study sought to determine whether or not recent initiatives to close the gap have also minimised any mismatches between physicians' expectation of their patients' medications, medications in the patients' possession and their actual ...
The burden and nature of malnutrition among patients in regional hospital settings: A cross-sectional survey.
CLINICAL NUTRITION ESPEN - 01 Feb 2018
Indigenous people experience a higher burden of nutrition-related conditions and are more likely to experience food insecurity compared to non-Indigenous people. Consequently, they remain at increased risk of malnutrition; particularly when residing in regional or remote areas. This study aims to compare and characterise the burden and nature of malnutrition among a representative cohort of Ind...
Atrial deformation in athletes with AF: chronic adverse remodelling or transient mechanical stunning?
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 01 Feb 2018
Incorporating cardiopulmonary resuscitation training into a cardiac rehabilitation programme: A feasibility study.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING : JOURNAL OF THE WORKING GROUP ON CARDIOVASCULAR NURSING OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 01 Feb 2018
Patients with a cardiac history are at future risk of cardiac events, including out-of-hospital cardiac arrest. Targeting cardiopulmonary resuscitation (CPR) training to family members of cardiac patients has long been advocated, but is an area in need of contemporary research evidence. An environment yet to be investigated for targeted training is cardiac rehabilitation.To evaluate the feasibi...
High-density lipoprotein and cardiac glucose metabolism: Implications for management of acute coronary syndromes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 01 Feb 2018
Absence of rotational activity detected using 2-dimensional phase mapping in the corresponding 3-dimensional phase maps in human persistent atrial fibrillation.
HEART RHYTHM - 01 Feb 2018
Current phase mapping systems for atrial fibrillation create 2-dimensional (2D) maps. This process may affect the accurate detection of rotors. We developed a 3-dimensional (3D) phase mapping technique that uses the 3D locations of basket electrodes to project phase onto patient-specific left atrial 3D surface anatomy.We sought to determine whether rotors detected in 2D phase maps were present ...
Acute Kidney Injury: It's not just the 'big' burns.
INJURY - 01 Feb 2018
Acute Kidney Injury (AKI) complicates the management of at least 25% of patients with severe burns and is associated with long term complications. Most research focuses on the patients with more severe burns, and whether the same factors are associated with the development of AKI in patients with burns between 10 and 19% total body surface area (TBSA) is unknown. The aims of this study were to ...
