Publications
Now showing items 3301-3320 of 5702 records
Cardiovascular disease management in people with diabetes outside North America and Western Europe in 2006 and 2015.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 01 Jul 2019
Optimal treatment of cardiovascular disease is essential to decrease mortality among people with diabetes, but information is limited on how actual treatment relates to guidelines. We analysed changes in therapeutic approaches to anti-hypertensive and lipid-lowering medications in people with Type 2 diabetes from 2006 and 2015.Summary data from clinical services in seven countries outside North...
The impact of diabetes on productivity in China.
DIABETOLOGIA - 01 Jul 2019
Diabetes increases the risk of premature death and reduces work productivity. We estimated the impact of diabetes in China in terms of mortality, years of life lost, and productivity-adjusted life years (PALYs) lost in the Chinese population.Life table modelling was used with simulated follow-up of those with diabetes in the Chinese population of working age (20-49 years in women and 20-59 year...
Sedentary Behavior, Physical Activity, and All-Cause Mortality: Dose-Response and Intensity Weighted Time-Use Meta-analysis.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION - 01 Jul 2019
Previous studies have placed those with excessive sedentary behavior at increased risk of all-cause mortality. There is evidence of interdependency of sedentary behavior with physical activity, and its elucidation will have implications for guidelines and practice. This study investigated if sedentary behavior-related mortality risk can be offset by moderate- to vigorous-intensity physical acti...
Sildenafil enhances central hemodynamic responses to exercise, but not V̇o, in people with diabetes mellitus.2peak
JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) - 01 Jul 2019
Exercise capacity is frequently reduced in people with diabetes mellitus (DM), and the contribution of pulmonary microvascular dysfunction remains undefined. We hypothesized that pulmonary microvascular disease, measured by a novel exercise echocardiography technique termed pulmonary transit of agitated contrast (PTAC), would be greater in subjects with DM and that the use of pulmonary vasodila...
A Metabolic Screen in Adolescents Reveals an Association Between Circulating Citrate and Cortical Bone Mineral Density.
JOURNAL OF BONE AND MINERAL RESEARCH : THE OFFICIAL JOURNAL OF THE AMERICAN SOCIETY FOR BONE AND MINERAL RESEARCH - 01 Jul 2019
Observations that insulin and adiponectin levels are related to cortical bone size in adolescents, independently of body composition, suggest factors related to fat metabolism directly influence skeletal development. To explore this question, we examined associations between a metabolic screen focusing on fat metabolism, and peripheral quantitative computed tomography (pQCT) measures of the mid...
Risk Prediction in Heart Failure: Untranslatable or Lost in Translation?
JOURNAL OF CARDIAC FAILURE - 01 Jul 2019
Moderate morning rise in blood pressure has lowest risk of stroke but only in women.
JOURNAL OF HYPERTENSION - 01 Jul 2019
The morning period which is recognized as the highest risk for cardiovascular events is associated with a surge in blood pressure (BP). However, it is unclear what aspect of this rise is important.To determine whether the rate of rise (RoR), the magnitude (day night difference) or the product [BP power (BPPower)] is associated with increased cardiovascular risk.We developed a logistic equation ...
Left Ventricular Dyssynchrony: Prognostic Marker or Disease Mechanism?
JACC. CARDIOVASCULAR IMAGING - 01 Jul 2019
Rethinking good cholesterol: a clinicians' guide to understanding HDL.
THE LANCET. DIABETES & ENDOCRINOLOGY - 01 Jul 2019
Low HDL cholesterol dyslipidaemia affects about half of people with type 2 diabetes and represents a major independent risk factor for atherosclerotic cardiovascular disease. The "good cholesterol" label was coined decades ago on the basis of a presumed causal role of HDL cholesterol in atherosclerotic cardiovascular disease. However, this view has been challenged by the negative results of sev...
The effect of frequency of activity interruptions in prolonged sitting on postprandial glucose metabolism: A randomized crossover trial.
METABOLISM: CLINICAL AND EXPERIMENTAL - 01 Jul 2019
The primary objective was to test the hypothesis that increased frequency of interruptions in prolonged sitting reduces postprandial glycemia independent of energy intake and expenditure.Healthy, sedentary, centrally obese men (n = 14; age*, 28.2 (23.4; 38.3) years; BMI, 31.9 ± 6.7 kg/m; VOmax*, 39.5 (38.8; 40.9) ml/min/kg; HbA1c, 5.3 ± 0.4% (34.1 ± 4.2 mmol/mol); mean ± SD (*median (25th; 75th...
Domestication of Campylobacter jejuni NCTC 11168.
MICROBIAL GENOMICS - 01 Jul 2019
Reference and type strains of well-known bacteria have been a cornerstone of microbiology research for decades. The sharing of well-characterized isolates among laboratories has run in parallel with research efforts and enhanced the reproducibility of experiments, leading to a wealth of knowledge about trait variation in different species and the underlying genetics. Campylobacter jejuni strain...
Sleep influences on cardio-metabolic health in Indigenous populations.
SLEEP MEDICINE - 01 Jul 2019
Indigenous populations continue to be among the world's most marginalized population groups. Studies in Indigenous populations from high income countries (including the United States, Canada, Australia, and New Zealand) indicate increased risk of sleep disorders compared to non-Indigenous populations. Poor sleep, whether it be short sleep duration or fragmented sleep, is a well-established risk...
Optimal cut-points of visceral adipose tissue areas for cardiometabolic risk factors in a Chinese population: a cross-sectional study.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 30 Jun 2019
To determine the optimal cut-points of visceral adipose tissue (VAT) areas at different anatomic levels to discriminate participants with cardiometabolic risk factors in a Chinese middle-aged population.A total of 1744 individuals who underwent regular health checks in Nanjing BENQ Medical Center from January 2013 to December 2016 were included in this cross-sectional study. VAT areas were meas...
Respiratory syncytial virus co-opts host mitochondrial function to favour infectious virus production.
ELIFE - 27 Jun 2019
Although respiratory syncytial virus (RSV) is responsible for more human deaths each year than influenza, its pathogenic mechanisms are poorly understood. Here high-resolution quantitative imaging, bioenergetics measurements and mitochondrial membrane potential- and redox-sensitive dyes are used to define RSV's impact on host mitochondria for the first time, delineating RSV-induced microtubule/...
Taking the pulse of Timor-Leste's cardiac needs: a ten-year descriptive time-trend analysis.
INTERNAL MEDICINE JOURNAL - 25 Jun 2019
Timor-Leste is one of the poorest countries in the world. The East Timor Hearts Fund (ETHF) is a charitable organization involving Australian cardiologists providing outreach screening and access to cardiac interventions.The ETHF database was sectioned into two-year intervals (2009/10, 2011/12, 2013/14, 2015/16, 2017/18). Demographics and clinical outcomes of patients were compared, with subgro...
Renal Denervation for Treating Hypertension: Current Scientific and Clinical Evidence.
JACC. CARDIOVASCULAR INTERVENTIONS - 24 Jun 2019
Initial studies of catheter-based renal denervation (RDN) for uncontrolled HTN using radiofrequency ablation in the main renal arteries showed that RDN was effective in lowering office blood pressure (BP). However, the first randomized sham-controlled trial, SYMPLICITY-HTN-3, did not show significantly lower office or 24-h ambulatory systolic BP compared with sham treatment. Subsequent studies ...
Rare variant significantly alters de novo ceramide synthesis pathway.DEGS1
JOURNAL OF LIPID RESEARCH - 21 Jun 2019
The ceramide synthesis pathway is essential to human biology and health but genetic influences remain unexplored. The core function of this pathway is the generation of biologically active ceramide from its precursor, dihydroceramide. Dihydroceramides have diverse, often protective, biological roles; conversely, increased ceramide levels are biomarkers of complex disease. To explore the geneti...
Relaxin mitigates microvascular damage and inflammation following cardiac ischemia-reperfusion.
BASIC RESEARCH IN CARDIOLOGY - 19 Jun 2019
Microvascular obstruction (MVO) and leakage (MVL) forms a pivotal part of microvascular damage following cardiac ischemia-reperfusion (IR). We tested the effect of relaxin therapy on MVO and MVL in mice following cardiac IR injury including severity of MVO and MVL, opening capillaries, infarct size, regional inflammation, cardiac function and remodelling, and permeability of cultured endothelia...
Renal Denervation Update From the International Sympathetic Nervous System Summit: JACC State-of-the-Art Review.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 18 Jun 2019
Three recent renal denervation studies in both drug-naïve and drug-treated hypertensive patients demonstrated a significant reduction of ambulatory blood pressure compared with respective sham control groups. Improved trial design, selection of relevant patient cohorts, and optimized interventional procedures have likely contributed to these positive findings. However, substantial variability i...
Gene Regulatory Networks to Explain Coronary Artery Disease Heritability.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 18 Jun 2019
