Publications
Now showing items 3281-3300 of 5385 records
Association of Volumetric Epicardial Adipose Tissue Quantification and Cardiac Structure and Function.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 04 Dec 2018
Background Epicardial adipose tissue ( EAT ) is in immediate apposition to the underlying myocardium and, therefore, has the potential to influence myocardial systolic and diastolic function or myocardial geometry, through paracrine or compressive mechanical effects. We aimed to review the association between volumetric EAT and markers of myocardial function and geometry. Methods and Results Pu...
Plasma lipid species at type 1 diabetes onset predict residual beta-cell function after 6 months.
METABOLOMICS : OFFICIAL JOURNAL OF THE METABOLOMIC SOCIETY - 04 Dec 2018
The identification of metabolomic dysregulation appears promising for the prediction of type 1 diabetes and may also reveal metabolic pathways leading to beta-cell destruction. Recent studies indicate that regulation of multiple phospholipids precede the presence of autoantigens in the development of type 1 diabetes.We hypothesize that lipid biomarkers in plasma from children with recent onset ...
Breaking up sitting time after stroke - How much less sitting is needed to improve blood pressure after stroke (BUST-BP-Dose): Protocol for a dose-finding study.
CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS - 01 Mar 2019
Excessive sitting is detrimentally associated with cardiovascular disease and all-cause mortality. Frequent breaks in prolonged sitting can improve cardiometabolic responses in non-stroke populations. However, this has not been established in stroke survivors. This study will determine the most effective dose of activity breaks that (i) produce clinically meaningful improvements in mean systoli...
Identification of service improvement opportunities in an Australian community transition care program.
AGING CLINICAL AND EXPERIMENTAL RESEARCH - 01 Dec 2018
Transition care programs (TCPs) are designed to optimise functional recovery and independence in older adults post-hospitalisation. These programs are under high demand, and understanding inefficiencies in patient flow are a key step towards service improvement.To identify service improvement opportunities in an Australian community TCP service.An in-depth retrospective study of 113 community T...
Flash glucose monitoring-using technology to improve outcomes for patients with diabetes.
THE AUSTRALIAN JOURNAL OF RURAL HEALTH - 01 Dec 2018
Impact of an integrated diabetes service involving specialist outreach and primary health care on risk factors for micro- and macrovascular diabetes complications in remote Indigenous communities in Australia.
THE AUSTRALIAN JOURNAL OF RURAL HEALTH - 01 Dec 2018
To determine the impact of an integrated diabetes service involving specialist outreach and primary health care teams on risk factors for micro- and macrovascular diabetes complications in three remote Indigenous Australian communities over a 12-month period.Quantitative, retrospective evaluation.Primary health care clinics in remote Indigenous communities in Australia.One-hundred-and-twenty-fo...
Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis.
DIABETES - 01 Dec 2018
Increasing evidence points to the fact that defects in the resolution of inflammatory pathways predisposes individuals to the development of chronic inflammatory diseases, including diabetic complications such as accelerated atherosclerosis. The resolution of inflammation is dynamically regulated by the production of endogenous modulators of inflammation, including lipoxin A4 (LXA). Here, we ex...
An Automated Grading System for Detection of Vision-Threatening Referable Diabetic Retinopathy on the Basis of Color Fundus Photographs.
DIABETES CARE - 01 Dec 2018
The goal of this study was to describe the development and validation of an artificial intelligence-based, deep learning algorithm (DLA) for the detection of referable diabetic retinopathy (DR).A DLA using a convolutional neural network was developed for automated detection of vision-threatening referable DR (preproliferative DR or worse, diabetic macular edema, or both). The DLA was tested by ...
Exercise training in heart failure: a long way to go yet.
EUROPEAN JOURNAL OF HEART FAILURE - 01 Dec 2018
Serelaxin attenuates renal inflammation and fibrosis in a mouse model of dilated cardiomyopathy.
EXPERIMENTAL PHYSIOLOGY - 01 Dec 2018
What is the central question of this study? The aim was to determine the renoprotective effects of serelaxin in the setting of chronic heart failure. What are the main findings and its importance? Our data indicate that serelaxin can reduce renal fibrosis and inflammation in experimental heart failure. Currently, there are no effective treatments to rescue renal function in heart failure patien...
Australian employee perceptions of an organizational-level intervention to reduce sitting.
HEALTH PROMOTION INTERNATIONAL - 01 Dec 2018
Stand Up Lendlease-a cluster-randomized trial targeting reductions in sitting time in Australian office workers (n = 153, 18 manager-led teams, 1 organization)-effectively reduced sitting time during work hours and across the day after 12 months. The trial included two arms: organizational-support strategies (e.g. manager support, emails) with or without an activity tracker. The current study a...
Pioneering Australia's First Atrial Fibrillation Guidelines.
HEART, LUNG & CIRCULATION - 01 Dec 2018
The ventricular residence time distribution derived from 4D flow particle tracing: a novel marker of myocardial dysfunction.
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 01 Dec 2018
4D flow cardiac magnetic resonance (CMR) imaging allows visualisation of blood flow in the cardiac chambers and great vessels. Post processing of the flow data allows determination of the residence time distribution (RTD), a novel means of assessing ventricular function, potentially providing additional information beyond ejection fraction. We evaluated the RTD measurement of efficiency of left...
The future burden of lung cancer attributable to current modifiable behaviours: a pooled study of seven Australian cohorts.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 01 Dec 2018
Knowledge of preventable disease and differences in disease burden can inform public health action to improve health and health equity. We quantified the future lung cancer burden preventable by behavioural modifications across Australia.We pooled seven Australian cohort studies (n = 367 058) and linked them to national registries to identify lung cancers and deaths. We estimated population att...
Breaking up sitting time after stroke (BUST-stroke).
INTERNATIONAL JOURNAL OF STROKE : OFFICIAL JOURNAL OF THE INTERNATIONAL STROKE SOCIETY - 01 Dec 2018
People with stroke sit for long periods each day, which may compromise blood glucose control and increase risk of recurrent stroke. Studies in other populations have found regular activity breaks have a significant immediate (within-day) positive effect on glucose metabolism. We examined the effects of breaking up uninterrupted sitting with frequent, short bouts of light-intensity physical acti...
Frequent, short bouts of light-intensity exercises while standing decreases systolic blood pressure: Breaking Up Sitting Time after Stroke (BUST-Stroke) trial.
INTERNATIONAL JOURNAL OF STROKE : OFFICIAL JOURNAL OF THE INTERNATIONAL STROKE SOCIETY - 01 Dec 2018
Stroke survivors sit for long periods each day. Uninterrupted sitting is associated with increased risk of cardiovascular disease. Breaking up uninterrupted sitting with frequent, short bouts of light-intensity physical activity has an immediate positive effect on blood pressure and plasma clotting factors in healthy, overweight, and type 2 diabetic populations.We examined the effect of frequen...
Passive and mentally-active sedentary behaviors and incident major depressive disorder: A 13-year cohort study.
JOURNAL OF AFFECTIVE DISORDERS - 01 Dec 2018
Regular physical activity reduces the risk of depression onset and is an effective treatment for mood disorders. Recent studies have reported that sedentary behavior (SB) increases the risk of depression in adults, but relationships of different types of SBs with depression have not been examined systematically. We explored longitudinal relationships of passive (e.g. watching TV) and mentally-a...
Understanding the Role of Obesity Trajectories in the Development of Left Ventricular Dysfunction: Another Step on the Path to Heart Failure Screening?
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Dec 2018
Fine tuning renal denervation.
JOURNAL OF HYPERTENSION - 01 Dec 2018
Impaired sensorimotor control of the hand in congenital absence of functional muscle spindles.
JOURNAL OF NEUROPHYSIOLOGY - 01 Dec 2018
Patients with hereditary sensory and autonomic neuropathy type III (HSAN III) exhibit marked ataxia, including gait disturbances. We recently showed that functional muscle spindle afferents in the leg, recorded via intraneural microelectrodes inserted into the peroneal nerve, are absent in HSAN III, although large-diameter cutaneous afferents are intact. Moreover, there is a tight correlation b...
