Publications
Now showing items 3241-3260 of 5325 records
Understanding the Role of Obesity Trajectories in the Development of Left Ventricular Dysfunction: Another Step on the Path to Heart Failure Screening?
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Dec 2018
Fine tuning renal denervation.
JOURNAL OF HYPERTENSION - 01 Dec 2018
Impaired sensorimotor control of the hand in congenital absence of functional muscle spindles.
JOURNAL OF NEUROPHYSIOLOGY - 01 Dec 2018
Patients with hereditary sensory and autonomic neuropathy type III (HSAN III) exhibit marked ataxia, including gait disturbances. We recently showed that functional muscle spindle afferents in the leg, recorded via intraneural microelectrodes inserted into the peroneal nerve, are absent in HSAN III, although large-diameter cutaneous afferents are intact. Moreover, there is a tight correlation b...
Association of Abnormal Left Ventricular Functional Reserve With Outcome in Heart Failure With Preserved Ejection Fraction.
JACC. CARDIOVASCULAR IMAGING - 01 Dec 2018
This study sought to determine the prognostic value of abnormal diastolic and systolic responses to exercise (on the basis of exertional E/e' and global longitudinal strain rate [GSR]) in a well-characterized population of patients with heart failure with preserved ejection fraction (HFpEF).Impaired cardiovascular functional reserve is believed to contribute to adverse outcomes in HFpEF. Howeve...
Electrocardiographic Features Differentiating Arrhythmogenic Right Ventricular Cardiomyopathy From an Athlete's Heart.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Dec 2018
This study sought to compare electrocardiogram (ECG) variants in athletic and arrhythmogenic right ventricular cardiomyopathy (ARVC) cohorts matched for the confounders of age, sex, and ethnicity.Anterior T-wave inversion (TWI) is a common electrocardiographic finding in both athletes and patients with ARVC, and is a frequent conundrum in the setting of pre-participation screening. J-point elev...
Optimizing Catheter Contact and Improving Outcomes of Atrial Fibrillation Ablation: Jet Ventilation Avoids the Turbulence.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Dec 2018
Disentangling the genetic overlap between cholesterol and suicide risk.
NEUROPSYCHOPHARMACOLOGY : OFFICIAL PUBLICATION OF THE AMERICAN COLLEGE OF NEUROPSYCHOPHARMACOLOGY - 01 Dec 2018
Suicide is major public health concern; one million individuals worldwide die by suicide each year of which there are many more attempts. Thus, it is imperative that robust and reliable indicators, or biomarkers, of suicide risk be identified so that individuals at risk can be identified and provided appropriate interventions as quickly as possible. Previous work has revealed a relationship bet...
Endothelial function and dysfunction: Impact of metformin.
PHARMACOLOGY & THERAPEUTICS - 01 Dec 2018
Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and metabolic diseases. Current evidence suggests that the anti-diabetic drug metformin improves insulin resistance and protects against endothelial dysfunction in the vasculature. Hereby, we provide a ti...
Brown adipose tissue and lipid metabolism: New strategies for identification of activators and biomarkers with clinical potential.
PHARMACOLOGY & THERAPEUTICS - 01 Dec 2018
Development of therapeutic agents directed towards increasing brown adipose tissue (BAT) energy expenditure to combat obesity and its comorbidities is currently an area of intense research. Both preclinical and clinical studies have suggested a potentially significant role for BAT in regulating whole body energy expenditure as well as glucose and lipid metabolism. Lipids, particularly long chai...
Blood pressure reactivity at onset of mental stress determines sympathetic vascular response in young adults.
PHYSIOLOGICAL REPORTS - 01 Dec 2018
We have previously shown in young males that the rate of rise in blood pressure (BP) at the onset of mental stress determines whether or not muscle sympathetic nerve activity (MSNA) has a role in driving the pressor response. The aim of this study was to investigate these interactions in young females. BP and MSNA were recorded continuously in 19 females and 21 males during 2-min mental stresso...
Characterising risk of in-hospital mortality following cardiac arrest using machine learning: A retrospective international registry study.
PLOS MEDICINE - 01 Nov 2018
Resuscitated cardiac arrest is associated with high mortality; however, the ability to estimate risk of adverse outcomes using existing illness severity scores is limited. Using in-hospital data available within the first 24 hours of admission, we aimed to develop more accurate models of risk prediction using both logistic regression (LR) and machine learning (ML) techniques, with a combination...
Mental health-related emergency department presentations and hospital admissions in a cohort of urban Aboriginal children and adolescents in New South Wales, Australia: findings from SEARCH.
BMJ OPEN - 28 Nov 2018
The aim of the current study is to quantify mental health-related emergency department (ED) presentations and hospitalisations, and associated child and family characteristics, in children recruited through four Aboriginal Community Controlled Health Organisations.Four Aboriginal Community Controlled Health Services that deliver primary care. All services were located in urban or large regional...
Metabolomic Consequences of Genetic Inhibition of PCSK9 Compared With Statin Treatment
CIRCULATION - 27 Nov 2018
Both statins and proprotein convertase subtilisin/
kexin type 9 (PCSK9) inhibitors lower blood low-density lipoprotein cholesterol levels to reduce risk of cardiovascular events. To assess potential differences between metabolic effects of these 2 lipid-lowering therapies, we performed detailed lipid and metabolite profiling of a large randomized statin trial and compared the results with the e...
Associations of context-specific sitting time with markers of cardiometabolic risk in Australian adults.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 20 Nov 2018
High volumes of sitting time are associated with an elevated risk of type 2 diabetes and cardiovascular disease, and with adverse cardiometabolic risk profiles. However, previous studies have predominately evaluated only total sitting or television (TV) viewing time, limiting inferences about the specific cardiometabolic health impacts of sitting accumulated in different contexts. We examined a...
Jeopardized Myocardium Defined by Late Gadolinium Enhancement Magnetic Resonance Imaging Predicts Survival in Patients With Ischemic Cardiomyopathy: Impact of Revascularization.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 20 Nov 2018
Background The prognostic impact of jeopardized myocardium ( JM ) in patients with advanced ischemic cardiomyopathy ( ICM ) is unclear. We hypothesized that JM is an independent predictor of mortality in patients with advanced ICM . Methods and Results Patients with ICM who underwent cardiac magnetic resonance imaging between January 2002 and January 2013 were included in our study. JM was iden...
A novel synthetic small molecule DMFO targets Nrf2 in modulating proinflammatory/antioxidant mediators to ameliorate inflammation.
FREE RADICAL RESEARCH - 13 Nov 2018
Inflammation is a protective immune response against invading pathogens, however, dysregulated inflammation is detrimental. As the complex inflammatory response involves multiple mediators, including the involvement of reactive oxygen species, concomitantly targeting proinflammatory and antioxidant check-points may be a more rational strategy. We report the synthesis and anti-inflammatory/antio...
Inhibition of Adenosine Monophosphate-Activated Protein Kinase-3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance.
HEPATOLOGY COMMUNICATIONS - 01 Jan 2019
Adenosine monophosphate-activated protein kinase (AMPK) regulates multiple signaling pathways involved in glucose and lipid metabolism in response to changes in hormonal and nutrient status. Cell culture studies have shown that AMPK phosphorylation and inhibition of the rate-limiting enzyme in the mevalonate pathway 3-hydroxy-3-methylglutaryl (HMG) coenzyme A (CoA) reductase (HMGCR) at serine-8...
Population-Based Gut Microbiome Associations With Hypertension.
CIRCULATION RESEARCH - 09 Nov 2018
Ejection Fraction Pros and Cons: JACC State-of-the-Art Review.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 06 Nov 2018
Ejection fraction (EF) reflects both cardiac function and remodeling, and is widely recognized as a valuable diagnostic and prognostic tool. Its use in a variety of settings, ranging from heart failure and myocardial infarction to valvular heart disease, has made it a cornerstone of modern cardiology, pervading guidelines and practice. However, the development of the test was in another era, wi...
Association of Change in Cardiovascular Risk Factors With Incident Cardiovascular Events.
JAMA - 06 Nov 2018
There is consistent evidence of the association between ideal cardiovascular health and lower incident cardiovascular disease (CVD); however, most studies used a single measure of cardiovascular health.To examine how cardiovascular health changes over time and whether these changes are associated with incident CVD.Prospective cohort study in a UK general community (Whitehall II), with examinati...
