Publications
Now showing items 3221-3240 of 5702 records
Venoarterial extracorporeal membrane oxygenation: A systematic review of selection criteria, outcome measures and definitions of complications.
JOURNAL OF CRITICAL CARE - 01 Oct 2019
The purpose of this study was to systematically investigate the reporting of selection criteria and outcome measures, and to examine definitions of complications used in venoarterial extracorporeal membrane oxygenation studies (V-A ECMO).Medline, EMBASE and the Cochrane central register were searched for V-A ECMO studies from January 2005 to July 2017. Studies with ≤99 patients or without patie...
Higher human T-cell leukaemia virus type 1 (HTLV-1) proviral load is associated with end-stage kidney disease in Indigenous Australians: Results of a case-control study in central Australia.
JOURNAL OF MEDICAL VIROLOGY - 01 Oct 2019
Case series suggest that human T-cell leukaemia virus type 1 (HTLV-1) is associated with kidney disease; however, little is known about the impact of proviral load (PVL). The present study was commenced to determine whether higher HTLV-1 PVL is associated with end stage kidney disease (ESKD) in Indigenous Australians. A case-control study was conducted in Alice Springs Hospital (ASH), 1 July 20...
Cognitive Function of Elderly Persons in Japanese Neighborhoods: The Role of Street Layout.
AMERICAN JOURNAL OF ALZHEIMER'S DISEASE AND OTHER DEMENTIAS - 01 Sep 2019
The aims of this study were to examine (a) associations of two metric and space syntax measures of street layout with the cognitive function of Japanese older adults and (b) the extent to which objectively assessed physical activity mediated such associations.Cross-sectional data from 277 older adults who lived in Japan were used. Street layout attributes were objectively calculated for each pa...
Future of Echocardiography in Australia.
HEART, LUNG & CIRCULATION - 01 Sep 2019
Within trial cost-utility analysis of disease management program for patients hospitalized with atrial fibrillation: results from the SAFETY trial.
JOURNAL OF MEDICAL ECONOMICS - 01 Sep 2019
The potential impact of disease management to optimize quality of care, health outcomes, and total healthcare costs across a range of cardiac disease states is unknown. A trial-based cost-utility analysis was conducted alongside a randomized controlled trial of 335 patients with chronic, non-valvular AF (without heart failure; the SAFETY Trial) discharged to home from three tertiary referral h...
Differential plasma postprandial lipidomic responses to krill oil and fish oil supplementations in women: A randomized crossover study.
NUTRITION (BURBANK, LOS ANGELES COUNTY, CALIF.) - 01 Sep 2019
There is no convincing evidence that krill oil (KO) consumption results in a higher incorporation of long chain ω-3 polyunsaturated fatty acids into blood lipid fractions than fish oil (FO). This study examined the postprandial plasma lipidomic responses to KO supplementation compared with FO supplementation in healthy women.Ten women (aged 18-45 y) consumed a high-fat (15 g of olive oil) break...
A metabolic profile of all-cause mortality risk identified in an observational study of 44,168 individuals.
NATURE COMMUNICATIONS - 20 Aug 2019
Predicting longer-term mortality risk requires collection of clinical data, which is often cumbersome. Therefore, we use a well-standardized metabolomics platform to identify metabolic predictors of long-term mortality in the circulation of 44,168 individuals (age at baseline 18-109), of whom 5512 died during follow-up. We apply a stepwise (forward-backward) procedure based on meta-analysis res...
Development and validation of a ceramide- and phospholipid-based cardiovascular risk estimation score for coronary artery disease patients.
EUROPEAN HEART JOURNAL - 14 Jan 2020
Distinct ceramide lipids have been shown to predict the risk for cardiovascular disease (CVD) events, especially cardiovascular death. As phospholipids have also been linked with CVD risk, we investigated whether the combination of ceramides with phosphatidylcholines (PCs) would be synergistic in the prediction of CVD events in patients with atherosclerotic coronary heart disease in three indep...
Association of Reduced Apical Untwisting With Incident HF in Asymptomatic Patients With HF Risk Factors.
JACC. CARDIOVASCULAR IMAGING - 01 Jan 2020
This study investigated the prognostic utility of left ventricular (LV) untwisting (UT) in the elderly patients at risk of heart failure (HF).LV UT mechanics represent a unique combination of LV filling linking ventricular relaxation and suction. The value of this parameter in the prediction of outcomes in patients at risk of HF is unclear.A group of 465 asymptomatic subjects ≥65 years of age w...
Asymptomatic Left Ventricular Diastolic Dysfunction: Predicting Progression to Symptomatic Heart Failure.
JACC. CARDIOVASCULAR IMAGING - 01 Jan 2020
Asymptomatic left ventricular diastolic dysfunction (ALVDD) (diastolic abnormalities and normal ejection fraction in the absence of symptoms) is associated with incident heart failure (HF) and decreased survival. Abnormalities of diastolic function might therefore be included in the definition of stage B HF, which denotes individuals at risk for the development of HF. Imaging techniques, especi...
Emergency medical service delays in ST-elevation myocardial infarction: a meta-analysis.
HEART (BRITISH CARDIAC SOCIETY) - 01 Mar 2020
To evaluate emergency medical services (EMS) delays and their impact on time to treatment and mortality in patients with ST-elevation myocardial infarction (STEMI).We collected data on EMS time intervals from published studies across five electronic databases. The primary EMS interval was the time in minutes between first medical contact and arrival at hospital door (FMC-to-door time). Secondar...
Effect of the novel histamine H receptor antagonist SENS-111 on spontaneous nystagmus in a rat model of acute unilateral vestibular loss.4
BRITISH JOURNAL OF PHARMACOLOGY - 01 Feb 2020
Histamine H receptors are expressed in the peripheral vestibular system, and their selective inhibition improves vertigo symptoms in rats with unilateral vestibular lesions. The effects of SENS-111, a selective oral H receptor antagonist with high affinity to both animal and human receptors, on vertigo symptoms was evaluated in a translational in vivo model of unilateral vestibular loss.4Pharma...
Early Gastrointestinal Complications From Ventricular Assist Devices is Increased by Non-Pulsatile Flow.
HEART, LUNG & CIRCULATION - 01 Feb 2020
Measurements of organ flow and perfusion during cardiopulmonary bypass suggest that perfusion of the splanchnic bed can be impaired by non-pulsatile flow. We postulated that non-pulsatile flow from centrifugal ventricular assist devices might also compromise splanchnic blood flow and cause bowel ischaemia especially in the period of circulatory instability early post-implant. The aim of the pre...
Feasibility and impact of sit-stand workstations with and without exercise in office workers at risk of low back pain: A pilot comparative effectiveness trial.
APPLIED ERGONOMICS - 01 Apr 2019
The aim of this study was to compare the feasibility and impact of sit-stand workstations plus advice, with or without exercise, on back pain and sitting time in office workers at risk of low back pain (LBP). Eligible participants (n = 29/169; 17% overall) were randomized to receive a sit-stand workstation and advice with (n = 16) or without (n = 13) progressive resistance exercise training for...
Improving skin integration around long-term percutaneous devices using fibrous scaffolds in a reconstructed human skin equivalent model.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH. PART B, APPLIED BIOMATERIALS - 01 Apr 2020
The interface between synthetic percutaneous devices and skin is a common area for bacterial infection, which may ultimately result in failure of the device. Better integration of percutaneous devices with skin may help reduce infection rates due to the creation of a dermal seal. However, the mismatch in material and chemical properties of devices and skin presents a challenge for closing the d...
Adiposity and estrogen receptor-positive, postmenopausal breast cancer risk: Quantification of the mediating effects of fasting insulin and free estradiol.
INTERNATIONAL JOURNAL OF CANCER - 15 Mar 2020
Adiposity increases estrogen receptor (ER)-positive postmenopausal breast cancer risk. While mechanisms underlying this relationship are uncertain, dysregulated sex-steroid hormone production and insulin signaling are likely pathways. Our aim was to quantify mediating effects of fasting insulin and free estradiol in the adiposity and ER-positive postmenopausal breast cancer association. We used...
Lipidomic Profiling of Murine Macrophages Treated with Fatty Acids of Varying Chain Length and Saturation Status.
METABOLITES - 23 Apr 2018
Macrophages are abundant within adipose tissue depots where they are exposed to fatty acids, leading to lipid accumulation. Herein, we have determined the effects of various fatty acids on the macrophage lipidome. Using targeted mass-spectrometry, we were able to detect 641 individual lipid species in primary murine macrophages treated with a variety of saturated fatty acids and an un-saturated...
Mapping human pluripotent stem cell-endothelial cell differentiation using scRNA-seq: a step towards therapeutic angiogenesis.
EUROPEAN HEART JOURNAL - 01 Mar 2020
Development and Use of Prediction Models for Classification of Cardiovascular Risk of Remote Indigenous Australians.
HEART, LUNG & CIRCULATION - 01 Mar 2020
Cardiovascular disease (CVD) is the leading cause of death for Indigenous Australians. There is widespread belief that current tools have deficiencies for assessing CVD risk in this high-risk population. We sought to develop a 5-year CVD risk score using a wide range of known risk factors to further improve CVD risk prediction in this population.We used clinical and demographic information on I...
Driving with cardiac devices in Australia. Does a review of recent evidence prompt a change in guidelines?
INTERNAL MEDICINE JOURNAL - 01 Mar 2020
Australian Driving Guidelines for patients with pacemakers and implanted cardioverter defibrillators are in line with many around the world, with some minor differences. Some aspects of these guidelines lack contemporary evidence in key decision-making areas and make broad recommendations regarding groups with heterogeneous populations. In addition, more recent studies suggest lower rates of ad...
