Publications
Now showing items 3141-3160 of 5325 records
Relaxin as a Therapeutic Target for the Cardiovascular Complications of Diabetes.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2018
Cardiovascular complications are the major cause of mortality in patients with diabetes. This is closely associated with both macrovascular and microvascular complications of diabetes, which lead to organ injuries in diabetic patients. Previous studies have consistently demonstrated the beneficial effects of relaxin treatment for protection of the vasculature, with evidence of antioxidant and a...
The Right Ventricle: From Bench to Bedside.
BIOMED RESEARCH INTERNATIONAL - 01 Jan 2001
Association of ambient particulate matter with heart failure incidence and all-cause readmissions in Tasmania: an observational study.
BMJ OPEN - 10 May 2018
We sought to investigate the relationship between air quality and heart failure (HF) incidence and rehospitalisation to elucidate whether there is a threshold in this relationship and whether this relationship differs for HF incidence and rehospitalisation.This retrospective observational study was performed in an Australian state-wide setting, where air pollution is mainly associated with wood...
Cdc42 - A tryst between host cholesterol metabolism and infection.
SMALL GTPASES - 04 May 2018
Emerging evidence points to an important connection between pathogenesis of intracellular infections and host cholesterol metabolism. In our study we demonstrated that human cytomegalovirus exploits host small GTPase Cdc42 to hijack cellular cholesterol efflux pathway. It appears that the virus uses host machinery to stimulate cholesterol efflux by modifying lipid rafts and altering properties ...
The Effect of ACTN3 Gene Doping on Skeletal Muscle Performance.
AMERICAN JOURNAL OF HUMAN GENETICS - 03 May 2018
Loss of expression of ACTN3, due to homozygosity of the common null polymorphism (p.Arg577X), is underrepresented in elite sprint/power athletes and has been associated with reduced muscle mass and strength in humans and mice. To investigate ACTN3 gene dosage in performance and whether expression could enhance muscle force, we performed meta-analysis and expression studies. Our general meta-ana...
Rationale and design of a trial to personalize risk assessment in familial coronary artery disease.
AMERICAN HEART JOURNAL - 01 May 2018
The lifetime risk of coronary artery disease (CAD) is doubled in people with a family history of premature disease, yet this risk is not captured in most 5- or 10-year risk assessment algorithms. Coronary artery calcium scoring (CCS) is a marker of subclinical CAD risk, which has been shown in observational studies to provide prognostic information that is incremental to clinical assessment; is...
Follicular B Cells Promote Atherosclerosis via T Cell-Mediated Differentiation Into Plasma Cells and Secreting Pathogenic Immunoglobulin G.
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 May 2018
B cells promote or protect development of atherosclerosis. In this study, we examined the role of MHCII (major histocompatibility II), CD40 (cluster of differentiation 40), and Blimp-1 (B-lymphocyte-induced maturation protein) expression by follicular B (FO B) cells in development of atherosclerosis together with the effects of IgG purified from atherosclerotic mice.Using mixed chimeric mice w...
Infective dermatitis associated with human T-lymphotropic virus type 1 infection in Adelaide, South Australia.
THE AUSTRALASIAN JOURNAL OF DERMATOLOGY - 01 May 2018
Evidence that TLR4 Is Not a Receptor for Saturated Fatty Acids but Mediates Lipid-Induced Inflammation by Reprogramming Macrophage Metabolism.
CELL METABOLISM - 01 May 2018
Chronic inflammation is a hallmark of obesity and is linked to the development of numerous diseases. The activation of toll-like receptor 4 (TLR4) by long-chain saturated fatty acids (lcSFAs) is an important process in understanding how obesity initiates inflammation. While experimental evidence supports an important role for TLR4 in obesity-induced inflammation in vivo, via a mechanism thought...
Selective vs. Global Renal Denervation: a Case for Less Is More.
CURRENT HYPERTENSION REPORTS - 01 May 2018
Review the renal nerve anatomy and physiology basics and explore the concept of global vs. selective renal denervation (RDN) to uncover some of the fundamental limitations of non-targeted renal nerve ablation and the potential superiority of selective RDN.Recent trials testing the efficacy of RDN showed mixed results. Initial investigations targeted global RDN as a therapeutic goal. The repeat ...
RAGE Deletion Confers Renoprotection by Reducing Responsiveness to Transforming Growth Factor-β and Increasing Resistance to Apoptosis.
DIABETES - 01 May 2018
Signaling via the receptor of advanced glycation end products (RAGE)-though complex and not fully elucidated in the setting of diabetes-is considered a key injurious pathway in the development of diabetic nephropathy (DN). We report here that RAGE deletion resulted in increased expression of fibrotic markers (collagen I and IV, fibronectin) and the inflammatory marker MCP-1 in primary mouse mes...
The Productivity Burden of Diabetes at a Population Level.
DIABETES CARE - 01 May 2018
Recent studies suggest that diabetes may impact work productivity. In the current study, we sought to estimate the lifetime and population impact of diabetes on productivity using the novel measure of "productivity-adjusted life years" (PALYs).Using age-specific mortality rates and a productivity index attributable to diabetes (akin to the quality of life index, but which adjusts for reduction ...
Impact of age at diagnosis and duration of type 2 diabetes on mortality in Australia 1997-2011.
DIABETOLOGIA - 01 May 2018
Current evidence suggests that type 2 diabetes may have a greater impact on those with earlier diagnosis (longer duration of disease), but data are limited. We examined the effect of age at diagnosis of type 2 diabetes on the risk of all-cause and cause-specific mortality over 15 years.The data of 743,709 Australians with type 2 diabetes who were registered on the National Diabetes Services Sch...
Y-chromosome lineage determines cardiovascular organ T-cell infiltration in the stroke-prone spontaneously hypertensive rat.
FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY - 01 May 2018
The essential role of the Y chromosome in male sex determination has largely overshadowed the possibility that it may exert other biologic roles. Here, we show that Y-chromosome lineage is a strong determinant of perivascular and renal T-cell infiltration in the stroke-prone spontaneously hypertensive rat, which, in turn, may influence vascular function and blood pressure (BP). We also show, fo...
Defining Hypertension - A Storm Across the Pacific.
HEART, LUNG & CIRCULATION - 01 May 2018
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study.
HUMAN MOLECULAR GENETICS - 01 May 2018
Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino acid levels, we performed single variant and gene-based tests of association between nine serum amino acids (alanine, glutamine, glycine, histidine, isoleuci...
Understanding patients and spouses experiences of patient education following a cardiac event and eliciting attitudes and preferences towards incorporating cardiopulmonary resuscitation training: A qualitative study.
JOURNAL OF ADVANCED NURSING - 01 May 2018
The aim of this study was to gain a comprehensive perspective about the experience of patient and spousal education following an acute cardiac event. The second objective was to elicit an understanding of patient and spousal attitudes, preferences and intentions towards future cardiopulmonary resuscitation training.Patients with cardiovascular disease require comprehensive patient and family ed...
Lipoxins Regulate the Early Growth Response-1 Network and Reverse Diabetic Kidney Disease.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : JASN - 01 May 2018
The failure of spontaneous resolution underlies chronic inflammatory conditions, including microvascular complications of diabetes such as diabetic kidney disease. The identification of endogenously generated molecules that promote the physiologic resolution of inflammation suggests that these bioactions may have therapeutic potential in the context of chronic inflammation. Lipoxins (LXs) are l...
May measurement month 2017-a concerted global effort to raise awareness of elevated blood pressure.
JOURNAL OF HUMAN HYPERTENSION - 01 May 2018
Visit-to-visit (long-term) and ambulatory (short-term) blood pressure variability to predict mortality in an elderly hypertensive population.
JOURNAL OF HYPERTENSION - 01 May 2018
To explore the association of different types of blood pressure (BP) variability measures estimated from either short-term ambulatory reading-to-reading or long-term clinic visit-to-visit BP records with long-term survival in an elderly treated hypertensive population.A subset of patients (n = 508) aged at least 65-years was studied from the Second Australian National Blood Pressure study. We e...
