Publications
Now showing items 2921-2940 of 5325 records
Adeno-Associated Virus Gene Therapy: Translational Progress and Future Prospects in the Treatment of Heart Failure.
HEART, LUNG & CIRCULATION - 01 Nov 2018
Despite advances in treatment over the past decade, heart failure remains a significant public health burden and a leading cause of death in the developed world. Gene therapy provides a promising approach for preventing and reversing cardiac abnormalities, however, clinical application has shown limited success to date. A substantial effort is being invested into the development of recombinant ...
Sitting Less and Moving More: Implications for Hypertension.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Nov 2018
Body Silhouette Trajectories Across the Lifespan and Vascular Aging.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Nov 2018
Vascular aging is a major contributor to cardiovascular disease and can be quantified by higher carotid stiffness, intima-media thickness and diameter, and hypertension. Weight gain across the lifetime may be an important, modifiable determinant of vascular aging. We therefore aimed to assess lifetime body silhouette trajectories (a marker of weight change across the lifespan) in relation to va...
Perceived stress is inversely related to ideal cardiovascular health: The Paris Prospective Study III.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 01 Nov 2018
What Do Workers Do to Reduce Their Sitting Time? The Relationships of Strategy Use and Workplace Support With Desk-Based Workers' Behavior Changes in a Workplace-Delivered Sitting-Reduction and Activity-Promoting Intervention.
JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE - 01 Nov 2018
To explore workers' sitting-reduction and activity-promoting strategy use following an intervention targeting these changes, and whether strategy use and perceived workplace support impacted on 3-month sitting and activity outcomes.This secondary analysis in desk-based workers (n = 83) utilized data collected on questionnaire-derived strategy use and workplace support, and activPAL3-derived sit...
Use of Atrial Strain to Predict Atrial Fibrillation After Cerebral Ischemia.
JACC. CARDIOVASCULAR IMAGING - 01 Nov 2018
This study sought to identify whether atrial strain could be used as an imaging biomarker to predict atrial fibrillation (AF).AF is found in up to 30% of cryptogenic cerebrovascular accidents (CVAs), which themselves account for 30% to 40% of ischemic CVA.This observational study evaluated all patients who had an echocardiogram (transthoracic echocardiogram [TTE]) following presentation with cr...
Regular Alcohol Consumption Is Associated With Impaired Atrial Mechanical Function in the Atrial Fibrillation Population: A Cross-Sectional MRI-Based Study.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Nov 2018
This study sought to determine the impact of regular alcohol consumption on left atrial (LA) mechanical and reservoir function.Earlier studies suggest that regular alcohol intake is associated with increased atrial fibrillation (AF) and LA dilatation.This study prospectively enrolled 160 patients with paroxysmal or persistent AF to undergo 3-T cardiac magnetic resonance (CMR) imaging in sinus r...
Fetal growth restriction shortens cardiac telomere length, but this is attenuated by exercise in early life.
PHYSIOLOGICAL GENOMICS - 01 Nov 2018
Fetal and postnatal growth restriction cause a predisposition to cardiovascular disease (CVD) in adulthood. Telomeres are repetitive DNA-protein structures that protect chromosome ends, and the loss of these repeats (a reduction in telomere length) is associated with CVD. As exercise preserves telomere length and cardiovascular health, the aim of this study was to determine the effects of growt...
Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts - CORRIGENDUM.
PSYCHOLOGICAL MEDICINE - 01 Nov 2018
Cognition, psychosis risk and metabolic measures in two adolescent birth cohorts.
PSYCHOLOGICAL MEDICINE - 01 Nov 2018
Psychoses, especially schizophrenia, are often preceded by cognitive deficits and psychosis risk states. Altered metabolic profiles have been found in schizophrenia. However, the associations between metabolic profiles and poorer cognitive performance and psychosis risk in the population remain to be determined.Detailed molecular profiles were measured for up to 8976 individuals from two genera...
The Macrophage in Cardiac Homeostasis and Disease: JACC Macrophage in CVD Series (Part 4).
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 30 Oct 2018
Macrophages are integral components of cardiac tissue and exert profound effects on the healthy and diseased heart. Paradigm shifting studies using advanced molecular techniques have revealed significant complexity within these macrophage populations that reside in the heart. In this final of a 4-part review series covering the macrophage in cardiovascular disease, the authors review the origin...
Objectively-Assessed Patterns and Reported Domains of Sedentary Behavior Among Japanese Older Adults.
JOURNAL OF EPIDEMIOLOGY - 27 Oct 2018
Prolonged periods of sitting time can be adversely associated with older adults' well-being and functional capacities. Understanding patterns and contexts of sedentary behaviors (SB) can inform approaches to prevention. This study examined Japanese older adults' objectively-assessed patterns and reported domains of SB and their interrelationships.Participants (n = 297; aged 65-84 years) of this...
Effect of Central Sympathoinhibition With Moxonidine on Sympathetic Nervous Activity in Polycystic Ovary Syndrome-A Randomized Controlled Trial.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2018
Sympathetic nervous system (SNS) activity is increased in polycystic ovary syndrome (PCOS). Moxonidine is a centrally acting sympatholytic drug with known beneficial effects on hypertension, insulin sensitivity, dyslipidemia and inflammation. In this double-blind placebo controlled randomized clinical trial we examined the effect of moxonidine on modulating sympathetic activity and downstream m...
Distinct contributions of hyperglycemia and high-fat feeding in metabolic syndrome-induced neuroinflammation.
JOURNAL OF NEUROINFLAMMATION - 22 Oct 2018
High-fat feeding and hyperglycemia, key risk factors for the development of metabolic syndrome (MetS), are emerging to associate with increased risk of developing dementia and cognitive decline. Despite this, clinical and experimental studies have yet to elucidate the specific contributions of either high-fat feeding or hyperglycemia to potential neuroinflammatory components. In this study, we ...
Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly.
THE NEW ENGLAND JOURNAL OF MEDICINE - 18 Oct 2018
Aspirin is a well-established therapy for the secondary prevention of cardiovascular events. However, its role in the primary prevention of cardiovascular disease is unclear, especially in older persons, who have an increased risk.From 2010 through 2014, we enrolled community-dwelling men and women in Australia and the United States who were 70 years of age or older (or ≥65 years of age among b...
Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
THE NEW ENGLAND JOURNAL OF MEDICINE - 18 Oct 2018
Information on the use of aspirin to increase healthy independent life span in older persons is limited. Whether 5 years of daily low-dose aspirin therapy would extend disability-free life in healthy seniors is unclear.From 2010 through 2014, we enrolled community-dwelling persons in Australia and the United States who were 70 years of age or older (or ≥65 years of age among blacks and Hispanic...
Effect of Aspirin on All-Cause Mortality in the Healthy Elderly.
THE NEW ENGLAND JOURNAL OF MEDICINE - 18 Oct 2018
In the primary analysis of the Aspirin in Reducing Events in the Elderly (ASPREE) trial, now published in the Journal, we report that the daily use of aspirin did not provide a benefit with regard to the primary end point of disability-free survival among older adults. A numerically higher rate of the secondary end point of death from any cause was observed with aspirin than with placebo.From 2...
Response by Howden and Levine to Letters Regarding Article, "Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications for Heart Failure Prevention".
CIRCULATION - 16 Oct 2018
Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 16 Oct 2018
Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited genomic scope and limited sample sizes.This study sought to construct a genomic risk score for CAD and to estimate its potential as a screening t...
Advanced Imaging to Phenotype Patients With a Systemic Right Ventricle.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 16 Oct 2018
Background Reduced ventricular function and decreased exercise capacity are widespread in adults with complete transposition of the great arteries after atrial switch ( TGA -Mustard/Senning) and congenitally corrected TGA (cc TGA ). Advanced imaging techniques may help to better phenotype these patients and evaluate exercise cardiac response. Methods and Results Thirty-three adults with a syste...
