Publications
Now showing items 2881-2900 of 5325 records
Impaired Cardiac Reserve and Abnormal Vascular Load Limit Exercise Capacity in Chronic Thromboembolic Disease.
JACC. CARDIOVASCULAR IMAGING - 01 Aug 2019
This study was a comprehensive evaluation of cardiopulmonary function in patients with chronic thromboembolic (pulmonary vascular) disease (CTED) during exercise.Exertional dyspnea is frequent following pulmonary embolism, but only a minority of patients eventually develops chronic thromboembolic pulmonary hypertension (CTEPH). Better understanding of the factors that limit exercise capacity in...
Persistent Impairment in Cardiopulmonary Fitness after Breast Cancer Chemotherapy.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 01 Aug 2019
Anthracycline chemotherapy (AC) is associated with acute reductions in cardiopulmonary fitness (V˙O2peak). We sought to determine whether changes in V˙O2peak and cardiac function persisted at 12 months post-AC completion, and whether changes in cardiac function explain the heightened long-term heart failure risk.Women with breast cancer scheduled for AC (n = 28) who participated in a nonrandomi...
Exome sequencing of Finnish isolates enhances rare-variant association power.
NATURE - 01 Aug 2019
Exome-sequencing studies have generally been underpowered to identify deleterious alleles with a large effect on complex traits as such alleles are mostly rare. Because the population of northern and eastern Finland has expanded considerably and in isolation following a series of bottlenecks, individuals of these populations have numerous deleterious alleles at a relatively high frequency. Here...
High-intensity interval training in chronic kidney disease: A randomized pilot study.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS - 01 Aug 2019
High-intensity interval training (HIIT) increases mitochondrial biogenesis and cardiorespiratory fitness in chronic disease populations, however has not been studied in people with chronic kidney disease (CKD). The aim of this study was to compare the feasibility, safety, and efficacy of HIIT with moderate-intensity continuous training (MICT) in people with CKD.Fourteen individuals with stage 3...
Lysophosphatidylcholine is a Major Component of Platelet Microvesicles Promoting Platelet Activation and Reporting Atherosclerotic Plaque Instability.
THROMBOSIS AND HAEMOSTASIS - 01 Aug 2019
Microvesicles (MVs) are small cell-derived vesicles, which are mainly released by activated cells. They are part of a communication network delivering biomolecules, for example, inflammatory molecules, via the blood circulation to remote cells in the body. Platelet-derived MVs are known to induce vascular inflammation. Research on the mediators and mechanisms of their inflammatory effects has a...
Cardiovascular effects of caffeinated beverages.
TRENDS IN CARDIOVASCULAR MEDICINE - 01 Aug 2019
Caffeine is the world's most popular 'drug', with tea and coffee a ubiquitous part of daily life. As a psychoactive stimulant, there are potential concerns regarding adverse cardiovascular squeal. Cardiovascular conditions, encompassing hypertension, coronary artery disease, rhythm disorders and heart failure affect billions of patients worldwide. We aim to provide a patient-centered comprehens...
Reply to letter by Frey et al. regarding the article: Reduction in mortality from implantable cardioverter-defibrillators in non-ischaemic cardiomyopathy patients is dependent on the presence of left ventricular scar.
EUROPEAN HEART JOURNAL - 30 Jul 2019
Sex-Based Mhrt Methylation Chromatinizes MeCP2 in the Heart.
ISCIENCE - 26 Jul 2019
In the heart, primary microRNA-208b (pri-miR-208b) and Myheart (Mhrt) are long non-coding RNAs (lncRNAs) encoded by the cardiac myosin heavy chain genes. Although preclinical studies have shown that lncRNAs regulate gene expression and are protective for pathological hypertrophy, the mechanism underlying sex-based differences remains poorly understood. In this study, we examined DNA- and RNA-me...
Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.
SCIENCE (NEW YORK, N.Y.) - 26 Jul 2019
Ceramides contribute to the lipotoxicity that underlies diabetes, hepatic steatosis, and heart disease. By genetically engineering mice, we deleted the enzyme dihydroceramide desaturase 1 (DES1), which normally inserts a conserved double bond into the backbone of ceramides and other predominant sphingolipids. Ablation of DES1 from whole animals or tissue-specific deletion in the liver and/or ad...
Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells.
PLOS PATHOGENS - 01 Jul 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors. Here we show that exosomes containing HIV-1 protein Nef (exNef) are rapidly taken up by macrophages releasing Nef into the cell interior. This caused down-regulation of ABCA1, reduction of cholesterol efflux and ...
A Retrospective Evaluation of Risk of Peripartum Cardiac Dysfunction in Survivors of Childhood, Adolescent and Young Adult Malignancies.
CANCERS - 24 Jul 2019
Long-term survivors of childhood, adolescent and young adult (AYA) malignancies with past exposure to potentially cardiotoxic treatments are at risk of peripartum cardiac dysfunction. Incidence and risk factors for peripartum cardiac dysfunction and maternal cardiac outcomes in this population were investigated. Eligible long-term survivors were aged <30 years at cancer diagnosis, with ≥1 pregn...
Muscle specific kinase protects dystrophic mdx mouse muscles from eccentric contraction-induced loss of force-producing capacity.
THE JOURNAL OF PHYSIOLOGY - 24 Jul 2019
Adeno-associated viral vector was used to elevate the expression of muscle specific kinase (MuSK) and rapsyn (a cytoplasmic MuSK effector protein) in the tibialis anterior muscle of wild-type and dystrophic (mdx) mice. In mdx mice, enhanced expression of either MuSK or rapsyn ameliorated the acute loss of muscle force associated with strain injury. Increases in sarcolemmal immunolabelling for u...
Novel Role for the AnxA1-Fpr2/ALX Signaling Axis as a Key Regulator of Platelet Function to Promote Resolution of Inflammation.
CIRCULATION - 23 Jul 2019
Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory responses is essential to restore homeostasis. Platelets play a crucial part in the integration of thrombosis and inflammation. Their role as participants in the resolution of thromboinflammation is underappreciated; therefore we used...
Activin A-induced cachectic wasting is attenuated by systemic delivery of its cognate propeptide in male mice.
ENDOCRINOLOGY - 19 Jul 2019
In cancer, elevated activin levels promote cachectic wasting of muscle, irrespective of tumour progression. In excess, activins A and B utilise the myostatin signalling pathway in muscle, triggering a decrease in protein synthesis and an increase in protein degradation, which ultimately leads to atrophy. Recently, we demonstrated that local delivery of engineered activin and myostatin propeptid...
Author's reply: Caffeinated beverages and cardiovascular disease.
TRENDS IN CARDIOVASCULAR MEDICINE - 19 Jul 2019
The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause mortality in type 2 diabetes: the ADVANCE-ON study.
DIABETOLOGIA - 13 Jul 2019
Some studies have reported that annual change in eGFR (eGFR slope) is associated with the future risk of end-stage kidney disease, cardiovascular disease and death in general or chronic kidney disease cohorts. However, the benefits of using eGFR slopes for prediction of major clinical outcomes in diabetes are unclear.We used data from the Action in Diabetes and Vascular Disease: Preterax and Di...
Changes in plasma lipids predict pravastatin efficacy in secondary prevention.
JCI INSIGHT - 11 Jul 2019
BACKGROUNDStatins have pleiotropic effects on lipid metabolism. The relationship between these effects and future cardiovascular events is unknown. We characterized the changes in lipids upon pravastatin treatment and defined the relationship with risk reduction for future cardiovascular events.METHODSPlasma lipids (n = 342) were measured in baseline and 1-year follow-up samples from a Long-Ter...
Prediabetes: lifestyle, pharmacotherapy or regulation?
THERAPEUTIC ADVANCES IN ENDOCRINOLOGY AND METABOLISM - 01 Jan 2019
The rapidly rising number of people with diabetes worldwide has led to multiple attempts to identify effective means of preventing type 2 diabetes. Lifestyle interventions have shown impressive efficacy in multiple clinical trials of people with impaired glucose tolerance, but, as currently formulated, appear to have very little impact on impaired fasting glucose. Attempts to roll out lifestyle...
Associations of neighborhood walkability with intensity- and bout-specific physical activity and sedentary behavior of older adults in Japan.
GERIATRICS & GERONTOLOGY INTERNATIONAL - 09 Jul 2019
We examined the relationships of objectively-measured walkability with accelerometer-measured activity patterns including bout-specific moderate-to-vigorous physical activity (MVPA), light-intensity physical activity (LPA) and sedentary behavior in older Japanese adults.This cross-sectional study included 450 men and women (mean age 74 years) who were randomly selected from a resident registry ...
Prime time viewing of the ischemic heart: New technologies allow imaging and flow assessment of the microvasculature in the beating heart.
CARDIOVASCULAR RESEARCH - 04 Jul 2019
