Publications
Now showing items 2801-2820 of 5325 records
Objectively measured access to recreational destinations and leisure-time physical activity: Associations and demographic moderators in a six-country study.
HEALTH & PLACE - 07 Sep 2019
Within the growing body of research linking neighbourhood environmental attributes with physical activity, associations between recreational destinations and non-walking leisure-time physical activity (LTPA) are rarely studied, and to date, not across multiple cities. We examined six potential associations of objectively-measured access to private recreational facilities (e.g., fitness centres,...
The Baker Biobank: Understanding Cardiovascular Outcomes.
HEART, LUNG & CIRCULATION - 01 Jul 2020
Cardiovascular diseases (CVDs) and diabetes are two of the most important public health problems. Outcomes for patients with these disorders vary considerably, likely due to the added influence of a range of interacting clinical, metabolic, environmental, lifestyle, genetic and psychosocial risk factors associated with these diseases. The Baker Biobank study was designed to characterise these f...
New Molecules for Treating Resistant Hypertension: a Clinical Perspective.
CURRENT HYPERTENSION REPORTS - 10 Sep 2019
To review the findings of trials evaluating pharmacological treatment approaches for hypertension in general, and resistant hypertension (RH) in particular, and propose future research and clinical directions.RH is defined as blood pressure (BP) that remains above target levels despite adherence to at least three antihypertensive medications, including a diuretic. Thus far, clinical trials of p...
Trends in incidence of total or type 2 diabetes: systematic review.
BMJ (CLINICAL RESEARCH ED.) - 11 Sep 2019
To assess what proportions of studies reported increasing, stable, or declining trends in the incidence of diagnosed diabetes.Systematic review of studies reporting trends of diabetes incidence in adults from 1980 to 2017 according to PRISMA guidelines.Medline, Embase, CINAHL, and reference lists of relevant publications.Studies of open population based cohorts, diabetes registries, and adminis...
Brief recommendations for participation in leisure time or competitive sports in athletes-patients with coronary artery disease: Summary of a Position Statement from the Sports Cardiology Section of the European Association of Preventive Cardiology (EAPC).
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 01 May 2020
This paper presents a brief summary of the recommendations from the Sports Cardiology section of the European Association of Preventive Cardiology (EAPC) on sports-participation in patients with coronary artery disease, coronary artery anomalies or spontaneous dissection of the coronary arteries, all entities being associated with myocardial ischaemia. Given the wealth of evidence supporting th...
Sarcopenia: A Time for Action. An SCWD Position Paper.
JOURNAL OF CACHEXIA, SARCOPENIA AND MUSCLE - 15 Sep 2019
The term sarcopenia was introduced in 1988. The original definition was a "muscle loss" of the appendicular muscle mass in the older people as measured by dual energy x-ray absorptiometry (DXA). In 2010, the definition was altered to be low muscle mass together with low muscle function and this was agreed upon as reported in a number of consensus papers. The Society of Sarcopenia, Cachexia and ...
In Vitro Human Implantation Model Reveals a Role for Endometrial Extracellular Vesicles in Embryo Implantation: Reprogramming the Cellular and Secreted Proteome Landscapes for Bidirectional Fetal-Maternal Communication.
PROTEOMICS - 17 Sep 2019
Embryo implantation into maternal endometrium is critical for initiation and establishment of pregnancy, requiring developmental synchrony between endometrium and blastocyst. However, factors regulating human endometrial-embryo crosstalk and facilitate implantation remain largely unknown. Extracellular vesicles (EVs) are emerging as important mediators of this process. Here, we used a trophecto...
Complex interaction of obesity, intentional weight loss and heart failure: a systematic review and meta-analysis.
HEART (BRITISH CARDIAC SOCIETY) - 01 Jan 2020
The aim of the meta-analysis was to determine the association of obesity and heart failure (HF) and the cardiac impact of intentional weight loss following bariatric surgery on cardiac structure and myocardial function in obese subjects.MEDLINE, Embase and Web of Science were searched up to 3 April 2018. Studies reporting association and prognostic impact of obesity in HF and the impact of inte...
Studying the Response of Aortic Endothelial Cells under Pulsatile Flow Using a Compact Microfluidic System.
ANALYTICAL CHEMISTRY - 17 Sep 2019
We describe a piezoelectric pumping system for studying the mechanobiology of human aortic endothelial cells (HAECs) under pulsatile flow in microfluidic structures. The system takes advantage of commercially available components, including pumps, flow sensors, and microfluidic channels, which can be easily integrated, programmed, and operated by cellular biologists. Proof-of-concept experiment...
Differences in regional grey matter volume of the brain are related to mean blood pressure and muscle sympathetic nerve activity in normotensive humans.
JOURNAL OF HYPERTENSION - 01 Feb 2020
The brainstem plays a critically important role in the beat-to-beat control of blood pressure, as well as setting mean blood pressure (MBP). We recently showed that regional cerebral blood flow to specific brainstem nuclei is inversely related to resting MBP in healthy normotensive individuals. Here we tested the hypothesis that grey matter volume in these same nuclei, and areas above the brain...
Low Serum High-Density Lipoprotein Cholesterol Levels Associate with the C9orf72 Repeat Expansion in Frontotemporal Lobar Degeneration Patients.
JOURNAL OF ALZHEIMER'S DISEASE : JAD - 19 Sep 2019
Decreased levels of serum high-density lipoprotein (HDL) cholesterol have previously been linked to systemic inflammation and neurodegenerative diseases, such as Alzheimer's disease. Here, we aimed to analyze the lipoprotein profile and inflammatory indicators, the high-sensitivity C-reactive peptide (hs-CRP) and glycoprotein acetyls (GlycA), in sporadic and C9orf72 repeat expansion-associated ...
Globally elevating the AGE clearance receptor, OST48, does not protect against the development of diabetic kidney disease, despite improving insulin secretion.
SCIENTIFIC REPORTS - 20 Sep 2019
The accumulation of advanced glycation end products (AGEs) have been implicated in the development and progression of diabetic kidney disease (DKD). There has been interest in investigating the potential of AGE clearance receptors, such as oligosaccharyltransferase-48 kDa subunit (OST48) to prevent the detrimental effects of excess AGE accumulation seen in the diabetic kidney. Here the objectiv...
Acid-Sensing Ion Channels Blockade Attenuates Pressor and Sympathetic Responses to Skeletal Muscle Metaboreflex Activation in Humans.
JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) - 23 Sep 2019
In animals, the blockade of acid-sensing ion channels (ASICs), cation pore-forming membrane proteins located in the free nerve endings of group IV afferent fibres, attenuates increases in arterial pressure (AP) and sympathetic nerve activity (SNA) during muscle contraction. Therefore, ASICs play a role in mediating the metabolic component (skeletal muscle metaboreflex) of the exercise pressor r...
Treatment of type 2 diabetes with the designer cytokine IC7Fc.
NATURE - 01 Oct 2019
The gp130 receptor cytokines IL-6 and CNTF improve metabolic homeostasis but have limited therapeutic use for the treatment of type 2 diabetes. Accordingly, we engineered the gp130 ligand IC7Fc, in which one gp130-binding site is removed from IL-6 and replaced with the LIF-receptor-binding site from CNTF, fused with the Fc domain of immunoglobulin G, creating a cytokine with CNTF-like, but IL-6...
Pharmacological treatment initiation for type 2 diabetes in Australia: are the guidelines being followed?
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 01 Aug 2020
To determine the patterns and predictors of pharmacological treatment initiation for type 2 diabetes and whether treatment initiation is consistent with Australian clinical practice guidelines that recommend metformin monotherapy.Individuals aged 40-99 years initiating a non-insulin type 2 diabetes medication between July 2013 and February 2018 were identified from a 10% random national sample ...
Chronic kidney disease and valvular heart disease: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.
KIDNEY INTERNATIONAL - 01 Oct 2019
Chronic kidney disease (CKD) is a major risk factor for valvular heart disease (VHD). Mitral annular and aortic valve calcifications are highly prevalent in CKD patients and commonly lead to valvular stenosis and regurgitation, as well as complications including conduction system abnormalities and endocarditis. VHD, especially mitral regurgitation and aortic stenosis, is associated with signifi...
Diuretics and skin cancer: should a common prescription come with advice to avoid sun exposure?
JOURNAL OF HYPERTENSION - 01 Oct 2019
Autocrine IFN-I inhibits isocitrate dehydrogenase in the TCA cycle of LPS-stimulated macrophages.
THE JOURNAL OF CLINICAL INVESTIGATION - 01 Oct 2019
Macrophage activation in response to LPS is coupled to profound metabolic changes, typified by accumulation of the TCA cycle intermediates citrate, itaconate, and succinate. We have identified that endogenous type I IFN controls the cellular citrate/α-ketoglutarate ratio and inhibits expression and activity of isocitrate dehydrogenase (IDH); and, via 13C-labeling studies, demonstrated that auto...
Paroxysmal Hypertension Associated With Presyncope.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Oct 2019
Usefulness of myocardial work measurement in the assessment of left ventricular systolic reserve response to spironolactone in heart failure with preserved ejection fraction.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 01 Oct 2019
Improvement in left ventricular (LV) systolic reserve, including exertional increase in global longitudinal strain (GLS), may contribute to the clinical benefit from therapeutic interventions in heart failure with preserved ejection fraction (HFpEF). However, GLS is an afterload-dependent parameter, and its measurements may not adequately reflect myocardial contractility recruitment with exerci...
