Publications
Now showing items 281-300 of 4875 records
Coffee drinking then and now: research continues to better understand this ubiquitous beverage.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 01 Dec 2023
Neuro-HIV-New insights into pathogenesis and emerging therapeutic targets.
FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY - 01 Dec 2023
HIV-associated neurocognitive disorders (HAND) is a term describing a complex set of cognitive impairments accompanying HIV infection. Successful antiretroviral therapy (ART) reduces the most severe forms of HAND, but milder forms affect over 50% of people living with HIV (PLWH). Pathogenesis of HAND in the ART era remains unknown. A variety of pathogenic factors, such as persistent HIV replica...
Class IIa HDACs inhibit cell death pathways and protect muscle integrity in response to lipotoxicity.
CELL DEATH & DISEASE - 01 Dec 2023
Lipotoxicity, the accumulation of lipids in non-adipose tissues, alters the metabolic transcriptome and mitochondrial metabolism in skeletal muscle. The mechanisms involved remain poorly understood. Here we show that lipotoxicity increased histone deacetylase 4 (HDAC4) and histone deacetylase 5 (HDAC5), which reduced the expression of metabolic genes and oxidative metabolism in skeletal muscle,...
Childhood Non-HDL Cholesterol and LDL Cholesterol and Adult Atherosclerotic Cardiovascular Events.
CIRCULATION - 28 Nov 2023
Although low-density lipoprotein cholesterol (LDL-C) remains the primary cholesterol target in clinical practice in children and adults, non-high-density lipoprotein cholesterol (non-HDL-C) has been suggested as a more accurate measure of atherosclerotic cardiovascular disease (ASCVD) risk. We examined the associations of childhood non-HDL-C and LDL-C levels with adult ASCVD events and determin...
Should we continue to subsidise therapeutics with uncertain efficacy? Health economic implications for icosapent ethyl.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 30 Nov 2023
New perspective on the mechanisms of cardiac fibrosis.
SCIENCE BULLETIN - 30 Nov 2023
Inter-software and inter-scan variability in measurement of epicardial adipose tissue: a three-way comparison of a research-specific, a freeware and a coronary application software platform.
01 Dec 2023
Epicardial adipose tissue (EAT) is a proposed marker of cardiovascular risk; however, clinical application may be limited by variability in post-processing software platforms. We assessed inter-vendor agreement of EAT volume (EATv) and attenuation on both contrast-enhanced (CE) and non-contrast CT (NCT) using a standard coronary CT reporting software (Vitrea), an EAT research-specific software ...
Maternal diet quality and associations with plasma lipid profiles and pregnancy-related cardiometabolic health.
EUROPEAN JOURNAL OF NUTRITION - 01 Dec 2023
To assess the relationship of early pregnancy maternal diet quality (DQ) with maternal plasma lipids and indicators of cardiometabolic health, including blood pressure (BP), gestational diabetes mellitus (GDM) and gestational weight gain (GWG).Women (n = 215) aged 18-40 years with singleton pregnancies were recruited at 10-20 weeks gestation. Diet quality was assessed by the Dietary Guideline I...
Assessing atrial myopathy with cardiac magnetic resonance imaging in embolic stroke of undetermined source.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 15 Oct 2023
Left atrial myopathy has been implicated in atrial fibrillation (AF)-related stroke and embolic stroke of undetermined source (ESUS).To use advanced cardiac magnetic resonance (CMR) imaging techniques, including left atrial (LA) strain and 4D flow CMR, to identify atrial myopathy in patients with ESUS.20 patients with ESUS and no AF or other cause for stroke, and 20 age and sex-matched controls...
Coronary Artery Disease Risk Prediction in Patients With Severe Aortic Stenosis: Development and Validation of the Aortic Stenosis-Coronary Artery Disease (AS-CAD) Score.
THE AMERICAN JOURNAL OF CARDIOLOGY - 15 Oct 2023
Patients at a low risk of coronary artery disease (CAD) could be triaged to noninvasive coronary computed tomography angiogram instead of invasive coronary angiography, reducing health care costs and patient morbidity. Therefore, we aimed to develop a CAD risk prediction score to identify those who underwent transcatheter aortic valve implantation (TAVI) at a low risk of CAD. We enrolled 1,782 ...
Mechanical Wave Speeds in Healthy and Pathologic Hearts: Depends on Where and When You Look.
JACC. CARDIOVASCULAR IMAGING - 05 Oct 2023
Hospital admissions among people with diabetes: a systematic review.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 09 Oct 2023
To describe the reasons for hospital admission among people with diabetes.We searched Emcare, Embase, Medline, and Google Scholar databases for population-based studies describing the causes of hospitalisation among people with diabetes. We included articles published in English from 1980 to 2022. For each study, we determined the most frequent reasons for admission. Studies were assessed for q...
Rapid and in-depth proteomic profiling of small extracellular vesicles for ultralow samples.
PROTEOMICS - 03 Oct 2023
The integration of robust single-pot, solid-phase-enhanced sample preparation with powerful liquid chromatography-tandem mass spectrometry (LC-MS/MS) is routinely used to define the extracellular vesicle (EV) proteome landscape and underlying biology. However, EV proteome studies are often limited by sample availability, requiring upscaling cell cultures or larger volumes of biofluids to genera...
The challenge of risk stratification in hypertrophic cardiomyopathy: Clinical, genetic and imaging insights from a quaternary referral centre.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 04 Oct 2023
Hypertrophic cardiomyopathy (HCM) is the commonest genetic cardiomyopathy and may result in sudden cardiac death (SCD). Clinical risk stratification scores are utilised to estimate SCD risk and determine potential utility of a primary prevention implantable cardioverter defibrillator (ICD).Patients with a confirmed diagnosis of HCM from a quaternary HCM service were defined according to clinica...
Mentally-passive sedentary behavior and incident depression: Mediation by inflammatory markers.
JOURNAL OF AFFECTIVE DISORDERS - 15 Oct 2023
Sedentary behavior (SB; time spent sitting, as distinct from lack of exercise or physical activity) is associated with depression, yet little is known about the relationship between different types of SB (e.g., mentally-passive versus mentally-active) with depression and potential biological mediators of these associations.We used cohort data from the 1958 National Child Development Study (n = ...
Phenotyping patients with aortic stenosis using cluster analysis to determine mortality and suitability for transcatheter aortic valve replacement
EUROPEAN HEART JOURNAL - 03 Oct 2023
Current classification of aortic stenosis (AS) is based on guideline-recommended echocardiographic criteria. Heterogeneity of patients with AS is increasingly recognised. Clinical and demographic factors in addition to echocardiographic parameters can determine those who may derive the greatest benefit from transcatheter aortic valvular replacement (TAVR) and influence patient outcomes.
Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk.
NATURE GENETICS - 01 Nov 2023
The analysis of longitudinal data from electronic health records (EHRs) has the potential to improve clinical diagnoses and enable personalized medicine, motivating efforts to identify disease subtypes from patient comorbidity information. Here we introduce an age-dependent topic modeling (ATM) method that provides a low-rank representation of longitudinal records of hundreds of distinct diseas...
Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 26 Sep 2023
Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery disease (CAD). However, a substantial number of individuals develop coronary atherosclerosis despite no SMuRFs. SMuRFless patients presenting with myocardial infarction have been observed to have an unexpected higher early mortality compa...
Prevalence of illicit drug use in young patients with sudden cardiac death.
HEART RHYTHM - 01 Oct 2023
Illicit drug use may accelerate coronary disease and cardiac hypertrophy or stimulate arrhythmias. Rates of illicit drug use in young patients with sudden cardiac death (SCD) are uncertain.The purpose of this study was to identify rates of illicit drug use in young patients with SCD.A prospective statewide registry identified out-of-hospital patients with cardiac arrest aged 18-50 years from Ap...
New-onset atrial fibrillation prediction: the HARMS2-AF risk score.
EUROPEAN HEART JOURNAL - 21 Sep 2023
Lifestyle risk factors are a modifiable target in atrial fibrillation (AF) management. The relative contribution of individual lifestyle risk factors to AF development has not been described. Development and validation of an AF lifestyle risk score to identify individuals at risk of AF in the general population are the aims of the study.The UK Biobank (UKB) and Framingham Heart Study (FHS) are ...
