Publications
Now showing items 2781-2800 of 5325 records
Diabetes care in remote Australia: the antenatal, postpartum and inter-pregnancy period.
BMC PREGNANCY AND CHILDBIRTH - 28 Oct 2019
Aboriginal and Torres Strait Islander women experience high rates of diabetes in pregnancy (DIP), contributing to health risks for mother and infant, and the intergenerational cycle of diabetes. By enhancing diabetes management during pregnancy, postpartum and the interval between pregnancies, the DIP Partnership aims to improve health outcomes and reduce risks early in the life-course. We desc...
dendPoint: a web resource for dendrimer pharmacokinetics investigation and prediction.
SCIENTIFIC REPORTS - 29 Oct 2019
Nanomedicine development currently suffers from a lack of efficient tools to predict pharmacokinetic behavior without relying upon testing in large numbers of animals, impacting success rates and development costs. This work presents dendPoint, the first in silico model to predict the intravenous pharmacokinetics of dendrimers, a commonly explored drug vector, based on physicochemical propertie...
Understanding and Influencing Occupational Sedentary Behavior: A Mixed-Methods Approach in a Multiethnic Asian Population.
HEALTH EDUCATION & BEHAVIOR : THE OFFICIAL PUBLICATION OF THE SOCIETY FOR PUBLIC HEALTH EDUCATION - 01 Jun 2020
We aim to assess sedentary behavior (SB) and its determinants, as well as potential strategies to reduce SB among employees in a tertiary hospital in Singapore, using a mixed-methods approach grounded in the socioecological framework. All employees with email and security guards of a tertiary hospital in Singapore were invited to complete a questionnaire that captured sociodemographics and self...
Impaired l-arginine-nitric oxide pathway contributes to the pathogenesis of resistant hypertension.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 30 Oct 2019
The precise mechanisms underlying resistant hypertension remain elusive. Reduced nitric oxide (NO) bioavailability is frequently documented in chronic kidney disease, obesity, diabetes and advanced age, all of which are risk factors for resistant hypertension. Sympathetic overactivity and chronic activation of the renin-angiotensin system are salient features of resistant hypertension. Interest...
Multivariate Genome-wide Association Analysis of a Cytokine Network Reveals Variants with Widespread Immune, Haematological, and Cardiometabolic Pleiotropy.
AMERICAN JOURNAL OF HUMAN GENETICS - 05 Dec 2019
Cytokines are essential regulatory components of the immune system, and their aberrant levels have been linked to many disease states. Despite increasing evidence that cytokines operate in concert, many of the physiological interactions between cytokines, and the shared genetic architecture that underlies them, remain unknown. Here, we aimed to identify and characterize genetic variants with pl...
Inpatient diabetes care requires adequate support, not just HbA screening.1c
THE MEDICAL JOURNAL OF AUSTRALIA - 31 Oct 2019
Extracellular HtrA2 Induces Apoptosis in Human Umbilical Vein Endothelial Cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 31 Oct 2019
The serine protease high-temperature-required protein A2 (HtrA2) has been identified as a key intracellular molecule promoting apoptosis in cells during ischemia reperfusion (IR) injury. IR injury in ST-segment elevation myocardial infarction (STEMI) contributes to overall myocardial damage. HtrA2 has further been shown to be significantly increased in the serum of patients with STEMI. In the p...
Platelets as Central Actors in Thrombosis-Reprising an Old Role and Defining a New Character.
SEMINARS IN THROMBOSIS AND HEMOSTASIS - 01 Nov 2019
Platelets have long been considered simple anucleate cells that rapidly adhere and aggregate at sites of vascular injury. However, recent in vivo experimental data have shed new light on the platelet response to vascular injury. These data have unexpectedly revealed that platelet thrombus formation is a highly dynamic process and yields a platelet thrombus with a distinct hierarchical structure...
Preoperative biomarker evaluation for the prediction of cardiovascular events after major vascular surgery.
JOURNAL OF VASCULAR SURGERY - 01 Nov 2019
The cause of perioperative myocardial infarction (PMI) is postulated to involve hemodynamic stress or coronary plaque destabilization. We aimed to evaluate perioperative factors in patients with peripheral artery disease (PAD) undergoing major vascular surgery to determine the likely mechanisms and predictors of PMI.This was a prospective cohort study of 133 patients undergoing major vascular s...
Changes in skin blood flow, respiration and blood pressure in participants reporting motion sickness during sinusoidal galvanic vestibular stimulation.
EXPERIMENTAL PHYSIOLOGY - 01 Nov 2019
What is the central question of the study? We have previously shown that sinusoidal galvanic vestibular stimulation induces greater modulation of skin sympathetic nerve activity, but not muscle sympathetic nerve activity, in participants who report nausea during simulated motion, but the effects on skin blood flow and blood pressure are unknown. What is the main finding and its importance? Duri...
Renal denervation for treating congenital long QT syndrome: shortening the QT interval or modulating sympathetic tone?
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 01 Nov 2019
SYMPATHETIC BAROREFLEX SENSITIVITY IS INVERSELY RELATED TO VASCULAR TRANSDUCTION IN MALES BUT NOT FEMALES.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Nov 2019
Sympathetic baroreflex sensitivity (BRS) is a measure of how effectively the baroreflex buffers beat-to-beat changes in blood pressure through the modulation of muscle sympathetic nerve activity (MSNA). However, current methods of assessment do not take into account the transduction of sympathetic nerve activity at the level of the vasculature, which is known to vary between individuals. In thi...
Association of Body Mass Index and Extreme Obesity With Long-Term Outcomes Following Percutaneous Coronary Intervention.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 05 Nov 2019
Background Previous studies have reported a protective effect of obesity compared with normal body mass index (BMI) in patients undergoing percutaneous coronary intervention (PCI). However, it is unclear whether this effect extends to the extremely obese. In this large multicenter registry-based study, we sought to examine the relationship between BMI and long-term clinical outcomes following P...
Site-Specific Glycation and Chemo-enzymatic Antibody Sortagging for the Retargeting of rAAV6 to Inflamed Endothelium.
MOLECULAR THERAPY. METHODS & CLINICAL DEVELOPMENT - 13 Sep 2019
Gene therapy holds great potential for conditions such as cardiovascular disease, including atherosclerosis and also vascular cancers, yet available vectors such as the adeno-associated virus (rAAV) transduce the vasculature poorly. To enable retargeting, a single-chain antibody (scFv) that binds to the vascular cell-adhesion molecule (VCAM-1) overexpressed at areas of endothelial inflammation ...
Interrupting Sitting Time with Simple Resistance Activities Lowers Postprandial Insulinemia in Adults with Overweight or Obesity.
OBESITY (SILVER SPRING, MD.) - 01 Sep 2019
This study aimed to examine the effects on postprandial glucose and insulin responses of interrupting sitting time with brief bouts of simple resistance activities (SRAs) in adults with overweight or obesity.Participants (n = 19) were recruited for a randomized crossover trial involving the following two 6-hour conditions: (1) uninterrupted sitting or (2) sitting with 3-minute bouts of SRAs (ha...
A Single-Center Experience of the Optimal Initial Immunosuppressive Strategy for Preventing Early Acute Cellular Rejection in Orthotopic Heart Transplantation Associated With Renal Dysfunction.
PROGRESS IN TRANSPLANTATION (ALISO VIEJO, CALIF.) - 01 Dec 2019
Renal dysfunction is a common complication following heart transplantation that may be worsened by the early initiation of calcineurin inhibitors. Antithymocyte globulin (ATG) or basiliximab has been used to delay or avoid calcineurin inhibitors. The most effective strategy for preventing early acute cellular rejection in this context is uncertain.We retrospectively reviewed all heart transplan...
Non-invasive blood pressure monitoring underestimates hypertensive response to exercise in suspected heart failure with preserved ejection fraction.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 01 Dec 2020
Relaxin reduces endothelium-derived vasoconstriction in hypertension: Revealing new therapeutic insights.
BRITISH JOURNAL OF PHARMACOLOGY - 01 Jan 2020
Endothelium-derived vasoconstriction is a hallmark of vascular dysfunction in hypertension. In some cases, an overproduction of endothelium-derived prostacyclin (PGI ) can cause contraction rather than relaxation. Relaxin is well known for its vasoprotective actions, but the possibility that this peptide could also reverse endothelium-derived vasoconstriction has never been investigated. We tes...
Adherence, Persistence, and Switching Among People Prescribed Sodium Glucose Co-transporter 2 Inhibitors: A Nationwide Retrospective Cohort Study.
ADVANCES IN THERAPY - 03 Sep 2019
Non-adherence and non-persistence to diabetes medications are associated with worse clinical outcomes. In this study, we aimed to characterise the 1-year switching, adherence, and persistence patterns among people with diabetes aged 18 years and older prescribed sodium-glucose co-transporter 2 inhibitors (SGLT2is) in Australia.Using data from Australia's national Pharmaceutical Benefits Scheme ...
Glycolysis Is Required for LPS-Induced Activation and Adhesion of Human CD14CD16 Monocytes.+
FRONTIERS IN IMMUNOLOGY - 01 Jan 2019
Monocytes in humans consist of 3 subsets; CD14CD16 (classical), CD14CD16 (intermediate) and CD14CD16 (non-classical), which exhibit distinct and heterogeneous responses to activation. During acute inflammation CD14CD16 monocytes are significantly elevated and migrate to the sites of injury via the adhesion cascade. The field of immunometabolism has begun to elucidate the importance of the engag...
