Publications
Now showing items 2721-2740 of 5702 records
Fructose stimulated de novo lipogenesis is promoted by inflammation.
NATURE METABOLISM - 01 Oct 2020
Benign hepatosteatosis, affected by lipid uptake, de novo lipogenesis and fatty acid (FA) oxidation, progresses to non-alcoholic steatohepatitis (NASH) on stress and inflammation. A key macronutrient proposed to increase hepatosteatosis and NASH risk is fructose. Excessive intake of fructose causes intestinal-barrier deterioration and endotoxaemia. However, how fructose triggers these alteratio...
Reducing hepatic PKD activity lowers circulating VLDL cholesterol.
THE JOURNAL OF ENDOCRINOLOGY - 01 Sep 2020
Protein kinase D (PKD) is emerging as an important kinase regulating energy balance and glucose metabolism; however, whether hepatic PKD activity can be targeted to regulate these processes is currently unclear. In this study, hepatic PKD activity was reduced using adeno-associated virus vectors to express a dominant-negative (DN) version of PKD1, which impairs the action of all three PKD isofo...
Matrix-Induced Autologous Chondrocyte Implantation (MACI) Grafting for Osteochondral Lesions of the Talus.
FOOT & ANKLE INTERNATIONAL - 01 Sep 2020
Matrix-induced autologous chondrocyte implantation (MACI) is an established treatment method for larger joints and has shown promising results in the ankle as well. We present a series of patients after ankle MACI with long-term follow-up of clinical and radiological outcomes.We present the follow-up of 15 patients who underwent MACI grafting from August 2003 to February 2006. The mean follow-u...
Endocrine aspects of ACE2 regulation: RAAS, steroid hormones and SARS-CoV-2.
THE JOURNAL OF ENDOCRINOLOGY - 01 Nov 2020
Coronavirus disease (COVID-19) is caused by a new strain of coronavirus, the severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2. At the time of writing, SARS-CoV-2 has infected over 5 million people worldwide. A key step in understanding the pathobiology of the SARS-CoV-2 was the identification of -converting enzyme 2 (ACE2) as the receptor for SARS-CoV-2 to gain entry into host cell...
scClassify: sample size estimation and multiscale classification of cells using single and multiple reference.
MOLECULAR SYSTEMS BIOLOGY - 01 Jun 2020
Automated cell type identification is a key computational challenge in single-cell RNA-sequencing (scRNA-seq) data. To capitalise on the large collection of well-annotated scRNA-seq datasets, we developed scClassify, a multiscale classification framework based on ensemble learning and cell type hierarchies constructed from single or multiple annotated datasets as references. scClassify enables ...
Post-infarct left ventricular thrombosis is mechanistically related to ventricular wall rupture.
MEDICAL HYPOTHESES - 01 Nov 2020
Left ventricular thrombus (LVT) after acute myocardial infarction (AMI) remains to be a common complication bearing adverse prognostic implication. Majority of LVT occurs within the first week after AMI. Over decades, the regional stasis of blood flow is regarded as the main reason for LVT formation. Here we hypothesize that LVT developed within the first week after AMI is the consequence of an...
The impact of diabetes on the productivity and economy of Bangladesh.
BMJ GLOBAL HEALTH - 01 Jun 2020
To estimate the impact of type 2 diabetes in terms of mortality, years of life lost (YLL) and productivity-adjusted life years (PALY) lost in Bangladesh.A life table model was constructed to estimate the productivity of the Bangladeshi population of current working age (20-59 years) with diabetes. Follow-up to 60 years (retirement age) was simulated. The life table analysis was then repeated as...
Haemodynamic Effect of Left Atrial and Left Ventricular Cannulation with a Rapid Speed Modulated Rotary Blood Pump During Rest and Exercise: Investigation in a Numerical Cardiorespiratory Model.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY - 01 Aug 2020
The left atrium and left ventricle are the primary inflow cannulation sites for heart failure patients supported by rotary blood pumps (RBPs). Haemodynamic differences exist between inflow cannulation sites and have been well characterized at rest, yet the effect during exercise with the same centrifugal RBP has not been previously well established. The purpose of this study was to investigate ...
Genetic Variants of the Gene Are Associated with Risk of Metabolic Syndrome in the Emirati Population.PLCXD3
GENES - 18 Jun 2020
Phosphatidylinositol-specific phospholipase C X domain 3 has been shown to influence pancreatic β-cell function by disrupting insulin signaling. Herein, we investigated two genetic variants in the gene in relation to type 2 diabetes (T2D) or metabolic syndrome (MetS) in the Emirati population. In total, 556 adult Emirati individuals (306 T2D and 256 controls) were genotyped for two variants ...
Diurnal patterns of objectively measured sedentary time and interruptions to sedentary time are associated with glycaemic indices in type 2 diabetes.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 01 Nov 2020
To investigate diurnal patterns of sedentary time and interruptions to sedentary time and their associations with achievement of pre-meal glucose, post-meal glucose, bedtime glucose and the dawn phenomenon targets and with duration of hypoglycaemia, euglycaemia, hyperglycaemia and above target range.Intensive longitudinal study.In 37 adults with type 2 diabetes, the FreeStyle Libre and activPAL...
Interplay between Clonal Hematopoiesis of Indeterminate Potential and Metabolism.
TRENDS IN ENDOCRINOLOGY AND METABOLISM: TEM - 01 Jul 2020
Clonal hematopoiesis of indeterminate potential (CHIP), defined as a clone of hematopoietic cells consisting of a single acquired mutation during a lifetime, has recently been discovered to be a major risk factor for atherosclerotic cardiovascular disease (CVD). As such, this phenomenon has sparked interest into the role that these single mutations may play in CVD. Atherosclerotic CVD is a comp...
New urban mobility: a catalyst to enhance population health.
PERSPECTIVES IN PUBLIC HEALTH - 01 Jul 2020
Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial.
THE LANCET. NEUROLOGY - 01 Jul 2020
Diabetes is an independent risk factor for cognitive impairment. We aimed to investigate the association between the glucagon-like peptide-1 (GLP-1) receptor agonist dulaglutide and cognitive impairment as an exploratory analysis within the Researching Cardiovascular Events With a Weekly Incretin in Diabetes (REWIND) trial.REWIND is a randomised, double-blind placebo-controlled trial at 371 sit...
Luminal microbiota related to Crohn's disease recurrence after surgery.
GUT MICROBES - 01 Nov 2020
Microbial factors are likely to be involved in the recurrence of Crohn's disease (CD) after bowel resection. We investigated the luminal microbiota before and longitudinally after surgery, in relation to disease recurrence, using 16S metagenomic techniques.In the prospective Post-Operative Crohn's Endoscopic Recurrence (POCER) study, fecal samples were obtained before surgery and 6, 12, and 18 ...
Low Vitamin D Serum Level Is Associated with HDL-C Dyslipidemia and Increased Serum Thrombomodulin Levels of Insulin-Resistant Individuals.
DIABETES, METABOLIC SYNDROME AND OBESITY : TARGETS AND THERAPY - 01 Jan 2020
Insulin-resistant individuals are known to have dyslipidemia and are predicted to be at high risk of cardiovascular events. Vitamin D deficiency was shown to be associated with dyslipidemia; however, the type of dyslipidemia associated with vitamin D deficiency in insulin-resistant individuals is not determined. Furthermore, there is evidence linking insulin resistance with low-grade inflammati...
Coronavirus disease 2019 (COVID-19): angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers and cardiovascular disease.
THE MEDICAL JOURNAL OF AUSTRALIA - 01 Jun 2020
Treatment Options for Poor Responders to Bariatric Surgery.
CURRENT OBESITY REPORTS - 01 Sep 2020
This review aims to evaluate the latest evidence on the treatment options for perceived poor responders to bariatric surgery and provide practitioners with a guide on when to consider revisional surgery and when to consider alternatives.The use of adjuvant pharmacotherapy has been increasingly described in the literature as an adjunct to primary bariatric surgery, in order to attain more weight...
Pulmonary vein atrial tachycardia: do we really need to isolate or freeze?
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY : AN INTERNATIONAL JOURNAL OF ARRHYTHMIAS AND PACING - 01 Nov 2020
Microstructural changes in the trigeminal nerve of patients with episodic migraine assessed using magnetic resonance imaging.
THE JOURNAL OF HEADACHE AND PAIN - 29 May 2020
There is histological evidence of microstructural changes in the zygomaticotemporal branch of the trigeminal nerve in migraineurs. This raises the possibility that altered trigeminal nerve properties contribute to migraine pathophysiology. Whilst it is not possible to explore the anatomy of small trigeminal nerve branches it is possible to explore the anatomy of the trigeminal root entry zone u...
Regional brain responses associated with using imagination to evoke and satiate thirst.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA - 16 Jun 2020
In response to dehydration, humans experience thirst. This subjective state is fundamental to survival as it motivates drinking, which subsequently corrects the fluid deficit. To elicit thirst, previous studies have manipulated blood chemistry to produce a physiological thirst stimulus. In the present study, we investigated whether a physiological stimulus is indeed required for thirst to be ex...
