Publications
Now showing items 2661-2680 of 5702 records
Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.
NATURE METABOLISM - 01 Oct 2020
Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to ob...
Incidence and Predictors of Unplanned Hospital Readmission after Percutaneous Coronary Intervention.
JOURNAL OF CLINICAL MEDICINE - 10 Oct 2020
Unplanned readmissions to hospital after percutaneous coronary intervention (PCI) pose a significant burden to the healthcare system and are potentially preventable. In this study, we sought to determine the incidence of, and risk factors for, unplanned hospital readmissions within 30 days following PCI. We prospectively collected data on 28,488 patients undergoing PCI between 2013 and 2019, wh...
Dimethyl Fumarate and Its Esters: A Drug with Broad Clinical Utility?
PHARMACEUTICALS (BASEL, SWITZERLAND) - 13 Oct 2020
Fumaric acid esters (FAEs) are small molecules with anti-oxidative, anti-inflammatory and immune-modulating effects. Dimethyl fumarate (DMF) is the best characterised FAE and is approved and registered for the treatment of psoriasis and Relapsing-Remitting Multiple Sclerosis (RRMS). Psoriasis and RRMS share an immune-mediated aetiology, driven by severe inflammation and oxidative stress. DMF, a...
Seventeen-Year Associations between Diet Quality Defined by the Health Star Rating and Mortality in Australians: The Australian Diabetes, Obesity and Lifestyle Study (AusDiab).
CURRENT DEVELOPMENTS IN NUTRITION - 01 Nov 2020
The Health Star Rating (HSR) is the government-endorsed front-of-pack labeling system in Australia and New Zealand.We aimed to examine prospective associations of a dietary index (DI) based on the HSR, as an indicator of overall diet quality, with all-cause and cardiovascular disease (CVD) mortality.We utilized data from the national population-based Australian Diabetes, Obesity and Lifestyle S...
Dog ownership and adults' objectively-assessed sedentary behaviour and physical activity.
SCIENTIFIC REPORTS - 15 Oct 2020
Evidence suggests a positive effect of dog ownership on physical activity. However, most previous studies used self-reported physical activity measures. Additionally, it is unknown whether owning a dog is associated with adults' sedentary behaviour, an emerging health risk factor. In this study, physical activity and sedentary behaviour were objectively collected between 2013 and 2015 from 693 ...
A Multicenter Study of Neutrophil-to-Lymphocyte Ratio in Primary Aldosteronism.
JOURNAL OF THE ENDOCRINE SOCIETY - 01 Dec 2020
Hypertensive patients with primary aldosteronism (PA) have a higher risk of cardiovascular complications than those with blood pressure-matched essential hypertension. The excess cardiovascular consequences of PA can be attributed to the proinflammatory effect of excessive aldosterone and mineralocorticoid receptor activation in a range of peripheral tissues and cell types. The neutrophil-to-ly...
Manipulation of the gut microbiota by the use of prebiotic fibre does not override a genetic predisposition to heart failure.
SCIENTIFIC REPORTS - 21 Oct 2020
Increasing evidence supports a role for the gut microbiota in the development of cardiovascular diseases such as hypertension and its progression to heart failure (HF). Dietary fibre has emerged as a modulator of the gut microbiota, resulting in the release of gut metabolites called short-chain fatty acids (SCFAs), such as acetate. We have shown previously that fibre or acetate can protect agai...
Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches.
SCIENTIFIC REPORTS - 22 Oct 2020
Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene rpoB. Previously we have highlighted that these mutations reduce protein affinities within the RNA polymerase complex, subsequently reducing nucleic acid affinity. Here, we have used these insights to develop a co...
ThermoMutDB: a thermodynamic database for missense mutations.
NUCLEIC ACIDS RESEARCH - 08 Jan 2021
Proteins are intricate, dynamic structures, and small changes in their amino acid sequences can lead to large effects on their folding, stability and dynamics. To facilitate the further development and evaluation of methods to predict these changes, we have developed ThermoMutDB, a manually curated database containing >14,669 experimental data of thermodynamic parameters for wild type and mutan...
Downregulation of by Cholic Acid and Chenodeoxycholic Acid in Double Knockout Mice: Differential Cardiovascular Outcome.Cyp7a1
FRONTIERS IN ENDOCRINOLOGY - 01 Jan 2020
Sterol 27-hydroxylase (CYP27A1) is a key enzyme in bile acids (BAs) biosynthesis and a regulator of cholesterol metabolism. double knockout (DKO) mice fed with western diet (WD) are protected from atherosclerosis up-regulation of hepatic and . Since feeding BAs ameliorates metabolic changes in KO mice, we tested BAs feeding on the development of atherosclerosis in DKO mice. DKO mice were fe...
Combining structure and genomics to understand antimicrobial resistance.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL - 01 Jan 2020
Antimicrobials against bacterial, viral and parasitic pathogens have transformed human and animal health. Nevertheless, their widespread use (and misuse) has led to the emergence of antimicrobial resistance (AMR) which poses a potentially catastrophic threat to public health and animal husbandry. There are several routes, both intrinsic and acquired, by which AMR can develop. One major route is...
Interventional Approaches for Loin Pain Hematuria Syndrome and Kidney-Related Pain Syndromes.
CURRENT HYPERTENSION REPORTS - 31 Oct 2020
Loin pain hematuria syndrome (LPHS) frequently presents with severe chronic pain that poses a clinical challenge. Current treatment approaches are mostly empirical and include a wide range of therapeutic strategies such as physical therapy, local and systemic analgesia, interventional and surgical approaches usually flanked by psycho-behavioral therapy, and other strategies. LPHS often impacts ...
Transcatheter Aortic Valve Implantation, Atrial Fibrillation, and Bleeding: A Surprisingly Fatal Attraction.
THROMBOSIS AND HAEMOSTASIS - 01 Nov 2020
Physiological principles of Starling-like control of rotary ventricular assist devices.
EXPERT REVIEW OF MEDICAL DEVICES - 01 Nov 2020
: This review explores the Starling-like physiological control method (SLC) for rotary ventricular assist devices (VADs) for severe heart failure. The SLC, based on mathematical models of the circulation, has two functions modeling each ventricle. The first function controls the output of the VAD to the arterial pool according to Starling's law, while the second function accounts for how the bl...
Efficacy of an Online Physical Activity Intervention Coordinated With Routine Clinical Care: Protocol for a Pilot Randomized Controlled Trial.
JMIR RESEARCH PROTOCOLS - 03 Nov 2020
Most adults are not achieving recommended levels of physical activity (150 minutes/week, moderate-to-vigorous intensity). Inadequate activity levels are associated with numerous poor health outcomes, and clinical recommendations endorse physical activity in the front-line treatment of obesity, diabetes, dyslipidemia, and hypertension. A framework for physical activity prescription and referral ...
TMEPAI/PMEPA1 Is a Positive Regulator of Skeletal Muscle Mass.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2020
Inhibition of myostatin- and activin-mediated SMAD2/3 signaling using ligand traps, such as soluble receptors, ligand-targeting propeptides and antibodies, or follistatin can increase skeletal muscle mass in healthy mice and ameliorate wasting in models of cancer cachexia and muscular dystrophy. However, clinical translation of these extracellular approaches targeting myostatin and activin has ...
Inhibition of interleukin-1β signalling promotes atherosclerotic lesion remodelling in mice with inflammatory arthritis.
CLINICAL & TRANSLATIONAL IMMUNOLOGY - 01 Jan 2020
Rheumatoid arthritis (RA), an inflammatory joint disorder, independently increases the risk of cardiovascular disease (CVD). IL-1β contributes to both RA and CVD. We hypothesised that inhibiting IL-1 signalling with the IL-1R antagonist, anakinra, would dampen inflammation and promote resolution of atherosclerosis in arthritic mice.Low-density lipoprotein receptor (Ldlr)-deficient mice were fed...
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer's disease.
NATURE COMMUNICATIONS - 10 Nov 2020
Changes to lipid metabolism are tightly associated with the onset and pathology of Alzheimer's disease (AD). Lipids are complex molecules comprising many isomeric and isobaric species, necessitating detailed analysis to enable interpretation of biological significance. Our expanded targeted lipidomics platform (569 species across 32 classes) allows for detailed lipid separation and characterisa...
Combined Assessment of Functional and Metabolic Performance of Human Donor Hearts: Possible Application in Donation After Circulatory Death.
TRANSPLANTATION - 01 Jul 2021
Donation after circulatory death (DCD) represents an increasing source of organs. However, evaluating the suitability of DCD hearts for transplantation represents a challenge. Contractile function is the ultimate determinant of recovery. We developed a novel technique in an ex vivo rig for the measurement of contractility using intraventricular balloons. We compared this technique with the meas...
HARP: a database of structural impacts of systematic missense mutations in drug targets of .Mycobacterium leprae
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL - 01 Jan 2020
Computational Saturation Mutagenesis is an approach that employs systematic mutagenesis of each amino acid residue in the protein to all other amino acid types, and predicts changes in thermodynamic stability and affinity to the other subunits/protein counterparts, ligands and nucleic acid molecules. The data thus generated are useful in understanding the functional consequences of mutations i...
