Publications
Now showing items 2641-2660 of 5325 records
Neutrophil-Derived S100A8/A9 Amplify Granulopoiesis Following Myocardial Infarction.
CIRCULATION - 16 Jan 2020
Myocardial infarction (MI) triggers myelopoiesis resulting in heightened production of neutrophils. However, the mechanisms that sustain their production and recruitment to the injured heart are unclear. Using a mouse model of the permanent ligation of the left anterior descending (LAD) artery and flow cytometry, we first characterized the temporal and spatial effects of MI on different myeloi...
Activity Accumulation and Cardiometabolic Risk in Youth: A Latent Profile Approach.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 01 Jul 2020
This cross-sectional study aimed to i) identify and characterize youth according to distinct physical activity (PA) and sedentary (SED) accumulation patterns, and ii) investigate associations of these derived patterns with cardiometabolic risk factors.ActiGraph accelerometer data from 7- to 13-yr-olds from two studies were pooled (n = 1219; 843 (69%) with valid accelerometry included in analysi...
Association between physical activity and risk of incident arrhythmias in 402 406 individuals: evidence from the UK Biobank cohort.
EUROPEAN HEART JOURNAL - 14 Apr 2020
Physical activity reduces cardiovascular disease burden and mortality, although its relationship with cardiac arrhythmias is less certain. The aim of this study was to assess the association between self-reported physical activity and atrial fibrillation (AF), ventricular arrhythmias and bradyarrhythmias, across the UK Biobank cohort.We included 402 406 individuals (52.5% female), aged 40-69 ye...
Computational saturation mutagenesis to predict structural consequences of systematic mutations in the beta subunit of RNA polymerase in .Mycobacterium leprae
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL - 01 Jan 2020
Rifampin resistance in leprosy may remain undetected due to the lack of rapid and effective diagnostic tools. A quick and reliable method is essential to determine the impacts of emerging detrimental mutations in the drug targets. The functional consequences of missense mutations in the β-subunit of RNA polymerase (RNAP) in () contribute to phenotypic resistance to rifampin in leprosy. Here, w...
An advanced mock circulation loop for in vitro cardiovascular device evaluation.
ARTIFICIAL ORGANS - 01 Jun 2020
Controlled and repeatable in vitro evaluation of cardiovascular devices using a mock circulation loop (MCL) is essential prior to in vivo or clinical trials. MCLs often consist of only a systemic circulation with no autoregulatory responses and limited validation. This study aimed to develop, and validate against human data, an advanced MCL with systemic, pulmonary, cerebral, and coronary circu...
Social and economic factors, maternal behaviours in pregnancy and neonatal adiposity in the PANDORA cohort.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Mar 2020
Australian Indigenous women experience high rates of social disadvantage and type 2 diabetes (T2D) in pregnancy, but it is not known how social factors and maternal behaviours impact neonatal adiposity in offspring of women with hyperglycaemia in pregnancy.Participants were Indigenous (n = 404) and Europid (n = 240) women with gestational diabetes mellitus (GDM) or T2D in pregnancy and their of...
Association of Indoor and Outdoor Air Pollution With Hand-Grip Strength Among Adults in Six Low- and Middle-Income Countries.
THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES - 20 Jan 2020
Air pollution has been associated with various health outcomes. Its effect on hand-grip strength, a measurement of the construct of muscle strength and health status, remains largely unknown.We used the survey data from 31,209 adults ≥ 50 years of age within Wave 1 of the Study on Global AGEing and Adult Health in six low- and middle-income countries. The outdoor concentration of fine particula...
The effect of parity on exercise physiology in women with heart failure with preserved ejection fraction.
ESC HEART FAILURE - 01 Feb 2020
Women are overrepresented amongst patients with heart failure with preserved ejection fraction (HFpEF); however, the underpinning mechanism for this asymmetric distribution is unclear. Pregnancy represents a potential gender-specific risk factor for HFpEF. It leads to significant physiological adaption, and increasing parity has been associated with some cardiovascular risk. We sought to examin...
MicroRNA-126 protects against vascular injury by promoting homing and maintaining stemness of late outgrowth endothelial progenitor cells.
STEM CELL RESEARCH & THERAPY - 21 Jan 2020
Endothelial progenitor cells (EPCs) contribute to reendothelialization and neovascularization and protect against vascular injury and ischemia of various organs. We have previously shown downregulation of microRNA (miR)-126 in EPCs from diabetic patients, which contributes to dysfunction of EPCs including impaired migratory ability. The aims of the present study were to examine (1) in vitro the...
Identifying Increases in Activity of the Human RVLM Through MSNA-Coupled fMRI.
FRONTIERS IN NEUROSCIENCE - 01 Jan 2019
We initially developed concurrent recording of muscle sympathetic nerve activity (MSNA) and functional magnetic resonance imaging (fMRI) of the brain to functionally identify the human homolog of the rostral ventrolateral medulla (RVLM). Here we summarize the cortical and subcortical connections to the RVLM, as identified using MSNA-coupled fMRI.MSNA was recorded via tungsten microelectrodes in...
Primary Health Care for Aboriginal Australian Women in Remote Communities after a Pregnancy with Hyperglycaemia.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 22 Jan 2020
Hyperglycaemia in pregnancy contributes to adverse outcomes for women and their children. The postpartum period is an opportune time to support women to reduce cardiometabolic and diabetes risk in subsequent pregnancies.To identify strengths and gaps in current care for Aboriginal women after a pregnancy complicated by hyperglycaemia.A retrospective review of the 12 month postpartum care provid...
Joint Associations of Leisure Screen Time and Physical Activity with Academic Performance in a Sample of Japanese Children.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH - 24 Jan 2020
Studies have shown the potential effects of sedentary behavior and physical activity on not only physical and mental health but also academic performance in children. Nevertheless, studies have only focused on either sedentary behavior or physical activity. Examining the joint effects of both behaviors on academic performance provides detailed insights into the patterns of these behaviors in re...
Seasonal variation in blood pressure: Evidence, consensus and recommendations for clinical practice. Consensus statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability.
JOURNAL OF HYPERTENSION - 01 Jul 2020
: Blood pressure (BP) exhibits seasonal variation with lower levels at higher environmental temperatures and higher at lower temperatures. This is a global phenomenon affecting both sexes, all age groups, normotensive individuals, and hypertensive patients. In treated hypertensive patients it may result in excessive BP decline in summer, or rise in winter, possibly deserving treatment modificat...
Metabolic Profiles Help Discriminate Mild Cognitive Impairment from Dementia Stage in Alzheimer's Disease.
JOURNAL OF ALZHEIMER'S DISEASE : JAD - 28 Jan 2020
Accurate differentiation between neurodegenerative diseases is developing quickly and has reached an effective level in disease recognition. However, there has been less focus on effectively distinguishing the prodromal state from later dementia stages due to a lack of suitable biomarkers. We utilized the Disease State Index (DSI) machine learning classifier to see how well quantified metabolom...
A 12-month lifestyle intervention does not improve cardiac autonomic function in patients with chronic kidney disease.
AUTONOMIC NEUROSCIENCE : BASIC & CLINICAL - 01 Mar 2020
Patients with chronic kidney disease (CKD) are at a high risk of future autonomic dysfunction and cardiovascular disease. The aim of this study was to examine the effects of a 12-month lifestyle intervention (LI) involving regular aerobic exercise on cardiac autonomic function in CKD patients.Pooled exploratory analysis.113 eligible patients with stage 3-4 CKD (eGFR 25-60 ml/min/1.75m) particip...
A novel small molecule compound VCP979 improves ventricular remodeling in murine models of myocardial ischemia/reperfusion injury.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE - 01 Feb 2020
Persistent ventricular remodeling following myocardial ischemia/reperfusion (MI/R) injury results in functional decompensation and eventual progression to heart failure. VCP979, a novel small‑molecule compound developed in‑house, possesses anti‑inflammatory and anti‑fibrotic activities. In the present study, no significant pathological effect was observed following the administration of VCP979 ...
Reduced Exercise Capacity in Diabetes Mellitus Is Not Associated with Impaired Deformation or Twist.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Apr 2020
Exercise capacity is frequently reduced in people with diabetes mellitus (DM) and may be due to subclinical cardiac dysfunction. Speckle-tracking echocardiography is now widely available; however, the clinical utility and significance of left ventricular (LV) strain and twist parameters remain uncertain. We hypothesized that LV strain and twist would be reduced in DM subjects during exercise.Ad...
Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis.
NATURE COMMUNICATIONS - 30 Jan 2020
Physical activity has been associated with lower risks of breast and colorectal cancer in epidemiological studies; however, it is unknown if these associations are causal or confounded. In two-sample Mendelian randomisation analyses, using summary genetic data from the UK Biobank and GWA consortia, we found that a one standard deviation increment in average acceleration was associated with lowe...
Delineating a role for the mitochondrial permeability transition pore in diabetic kidney disease by targeting cyclophilin D.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 31 Jan 2020
Mitochondrial stress has been widely observed in diabetic kidney disease (DKD). Cyclophilin D (CypD) is a functional component of the mitochondrial permeability transition pore (mPTP) which allows the exchange of ions and solutes between the mitochondrial matrix to induce mitochondrial swelling and activation of cell death pathways. CypD has been successfully targeted in other disease contexts ...
Trends in diabetes incidence worldwide: Are the findings real?
MATURITAS - 01 Jul 2020
