Publications
Now showing items 261-280 of 4599 records
The T1D Index: Implications of Initial Results, Data Limitations, and Future Development.
CURRENT DIABETES REPORTS - 01 Oct 2023
Current global information on incidence, prevalence, and mortality of type 1 diabetes (T1D) is limited, particularly in low- and middle-income countries. To address this gap in evidence, JDRF, Life for a Child, International Society for Pediatric and Adolescent Diabetes, and International Diabetes Federation have developed the T1D Index, which uses a Markov mathematical model, and machine learn...
Clinimetrics: Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-Fatigue).
JOURNAL OF PHYSIOTHERAPY - 01 Oct 2023
A two-point strategy to clarify prognosis in >80 year olds experiencing out of hospital cardiac arrest.
RESUSCITATION - 01 Oct 2023
The global population is aging, with the number of ≥80-year-olds projected to triple over the next 30 years. Rates of out-of-hospital cardiac arrest (OHCA) are also increasing within this age group.The Victorian Ambulance Cardiac Arrest Registry was utilised to identify OHCAs in patients aged ≥80 years between 2002-2021. Predictors of survival to discharge were defined and a prognostic score de...
Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality.
THE NEW ENGLAND JOURNAL OF MEDICINE - 05 Oct 2023
Five modifiable risk factors are associated with cardiovascular disease and death from any cause. Studies using individual-level data to evaluate the regional and sex-specific prevalence of the risk factors and their effect on these outcomes are lacking.We pooled and harmonized individual-level data from 112 cohort studies conducted in 34 countries and 8 geographic regions participating in the ...
Effect of High-Intensity Power Training on Cognitive Function in Older Adults With Type 2 Diabetes: Secondary Outcomes of the GREAT2DO Study.
THE JOURNALS OF GERONTOLOGY. SERIES A, BIOLOGICAL SCIENCES AND MEDICAL SCIENCES - 06 Oct 2022
We sought to determine the effects of 12 months of power training on cognition, and whether improvements in body composition, muscle strength, and/or aerobic capacity (VO2peak) were associated with improvements in cognition in older adults with type 2 diabetes (T2D). Participants with T2D were randomized to power training or low-intensity sham exercise control condition, 3 days per week for 12 ...
A plasma protein signature associated with cognitive function in men without severe cognitive impairment.
01 Sep 2023
A minimally invasive blood-based assessment of cognitive function could be a promising screening strategy to identify high-risk groups for the incidence of Alzheimer's disease.The study included 448 cognitively unimpaired men (mean age 64.1 years) drawn from the Geelong Osteoporosis Study. A targeted mass spectrometry-based proteomic assay was performed to measure the abundance levels of 269 pl...
Measurement of stress-induced sympathetic nervous activity using multi-wavelength PPG.
ROYAL SOCIETY OPEN SCIENCE - 01 Aug 2023
The onset of stress triggers sympathetic arousal (SA), which causes detectable changes to physiological parameters such as heart rate, blood pressure, dilation of the pupils and sweat release. The objective quantification of SA has tremendous potential to prevent and manage psychological disorders. Photoplethysmography (PPG), a non-invasive method to measure skin blood flow changes, has been us...
Editorial: Novel biomarkers and extracellular vesicles in endocrine hypertension and related disorders.
FRONTIERS IN ENDOCRINOLOGY - 01 Jan 2023
Vitamin D supplementation for improving bone density in vitamin D-deficient children and adolescents: systematic review and individual participant data meta-analysis of randomized controlled trials.
01 Sep 2023
Vitamin D supplements are widely used for improving bone health in children and adolescents, but their effects in vitamin D-deficient children are unclear.This study aimed to examine whether the effect of vitamin D supplementation on bone mineral density (BMD) in children and adolescents differs by baseline vitamin D status and estimate the effect in vitamin D-deficient individuals.This is a sy...
Increased intracellular miR-142 in adults with Type 1 diabetes.
JOURNAL OF DIABETES AND ITS COMPLICATIONS - 25 Aug 2023
microRNAs (miRs), including miR-142, modulate gene expression and processes implicated in vascular damage and may serve as therapeutic targets and agents, including in Type 1 diabetes (T1D). The project aimed to assess whether miR-142 levels differ between people with and without T1D, and to analyse miR-142 associations with cardiovascular (CVD) risk factors. Intracellular miRs were isolated fr...
Physical Activity Assessed by Wrist and Thigh Worn Accelerometry and Associations with Cardiometabolic Health.
SENSORS (BASEL, SWITZERLAND) - 23 Aug 2023
Physical activity is increasingly being captured by accelerometers worn on different body locations. The aim of this study was to examine the associations between physical activity volume (average acceleration), intensity (intensity gradient) and cardiometabolic health when assessed by a thigh-worn and wrist-worn accelerometer. A sample of 659 office workers wore an Axivity AX3 on the non-domin...
Socioeconomic status and diabetes technology use in youth with type 1 diabetes: a comparison of two funding models.
FRONTIERS IN ENDOCRINOLOGY - 01 Jan 2023
Technology use, including continuous glucose monitoring (CGM) and insulin pump therapy, is associated with improved outcomes in youth with type 1 diabetes (T1D). In 2017 CGM was universally funded for youth with T1D in Australia. In contrast, pump access is primarily accessed through private health insurance, self-funding or philanthropy. The study aim was to investigate the use of diabetes tec...
Defining the lipid profiles of human milk, infant formula, and animal milk: implications for infant feeding.
FRONTIERS IN NUTRITION - 01 Jan 2023
Breastfed infants have lower disease risk compared to formula-fed infants, however, the mechanisms behind this protection are unknown. Human milk has a complex lipidome which may have many critical roles in health and disease risk. However, human milk lipidomics is challenging, and research is still required to fully understand the lipidome and to interpret and translate findings. This study ai...
Mapping the cellular and molecular landscape of cardiac non-myocytes in murine diabetic cardiomyopathy.
ISCIENCE - 20 Oct 2023
Diabetes is associated with a significantly elevated risk of heart failure. However, despite extensive efforts to characterize the phenotype of the diabetic heart, the molecular and cellular protagonists that underpin cardiac pathological remodeling in diabetes remain unclear, with a notable paucity of data regarding the impact of diabetes on non-myocytes within the heart. Here we aimed to defi...
A pilot genome-wide association study meta-analysis of gastroparesis.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL - 08 Sep 2023
Gastroparesis (GP) is characterized by delayed gastric emptying in the absence of mechanical obstruction.Genetic predisposition may play a role; however, investigation at the genome-wide level has not been performed.We carried out a genome-wide association study (GWAS) meta-analysis on (i) 478 GP patients from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Cl...
Cardiotoxicity of anti-cancer drugs: cellular mechanisms and clinical implications.
FRONTIERS IN CARDIOVASCULAR MEDICINE - 01 Jan 2023
Cardio-oncology is an emerging field that seeks to enhance quality of life and longevity of cancer survivors. It is pertinent for clinicians to understand the cellular mechanisms of prescribed therapies, as this contributes to robust understanding of complex treatments and off-target effects, improved communication with patients, and guides long term care with the goal to minimise or prevent ca...
Community-developed checklists for publishing images and image analyses.
NATURE METHODS - 14 Sep 2023
Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However, for scientists wishing to publish obtained images and image-analysis results, there are currently no unified guidelines for best practices. Consequently, microscopy images and image data in publications may be...
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
SCIENCE ADVANCES - 15 Sep 2023
The incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor. There are no approved treatments to treat NASH. Here, we first used single-nucleus RNA sequencing to characterize a mouse model that mimics human NASH-driven HCC, the mouse fed a high-fat diet. Activation of endoplasmic ...
Aldosterone and renin concentrations and blood pressure in young Indigenous and non-Indigenous adults in the Northern Territory: a cross-sectional study.
THE MEDICAL JOURNAL OF AUSTRALIA - 18 Sep 2023
To evaluate aldosterone and renin levels and aldosterone-to-renin ratios (ARRs) in young Indigenous and non-Indigenous adults in the Northern Territory, and their association with blood pressure levels.Cross-sectional study; single time point sub-study of two prospective birth cohort studies.Participants in the Aboriginal Birth Cohort (ABC) - born to Indigenous mothers at the Royal Darwin Hospi...
Prevalence of atrial septal defects and patent foramen ovale in a cohort of sudden cardiac death patients undergoing autopsy.
JOURNAL OF CARDIOLOGY - 19 Sep 2023
Patent foramen ovale (PFO) and atrial septal defects (ASD) have been described in up to 30 % of subjects in autopsy series but contemporary data are scarce. It is important to confirm the prevalence of ASD/PFO in the general population given the potential associated stroke risk and the increasing availability of intervention via PFO closure.A state-wide prospective out-of-hospital cardiac arres...
