Publications
Now showing items 2581-2600 of 5325 records
Joint international consensus statement for ending stigma of obesity.
NATURE MEDICINE - 01 Apr 2020
People with obesity commonly face a pervasive, resilient form of social stigma. They are often subject to discrimination in the workplace as well as in educational and healthcare settings. Research indicates that weight stigma can cause physical and psychological harm, and that affected individuals are less likely to receive adequate care. For these reasons, weight stigma damages health, underm...
Intravascular Follistatin gene delivery improves glycemic control in a mouse model of type 2 diabetes.
FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY - 01 Apr 2020
Type 2 diabetes (T2D) manifests from inadequate glucose control due to insulin resistance, hypoinsulinemia, and deteriorating pancreatic β-cell function. The pro-inflammatory factor Activin has been implicated as a positive correlate of severity in T2D patients, and as a negative regulator of glucose uptake by skeletal muscle, and of pancreatic β-cell phenotype in mice. Accordingly, we sought t...
Effect of Salt Supplementation on Sympathetic Activity and Endothelial Function in Salt-Sensitive Type 2 Diabetes.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 01 Apr 2020
Lower sodium intake is paradoxically associated with higher mortality in type 2 diabetes (T2D).To determine whether sympathetic nervous system (SNS) activation and endothelial dysfunction contribute to these observations, we examined the effect of salt supplementation on these systems in people with T2D with habitual low sodium. We hypothesized that salt supplementation would lower SNS activity...
May Measurement Month 2018: a pragmatic global screening campaign to raise awareness of blood pressure by the International Society of Hypertension.
EUROPEAN HEART JOURNAL - 01 Jul 2019
Raised blood pressure (BP) is the biggest contributor to mortality and disease burden worldwide and fewer than half of those with hypertension are aware of it. May Measurement Month (MMM) is a global campaign set up in 2017, to raise awareness of high BP and as a pragmatic solution to a lack of formal screening worldwide. The 2018 campaign was expanded, aiming to include more participants and c...
CODE RED: Overturning Australia’s cholesterol complacency.
BAKER HEART AND DIABETES INSTITUTE - 01 Feb 2020
Baker Heart and Diabetes Institute, Melbourne, Australia
Principles of Hormone / Behavior Relations
23 Jan 2018
Elsevier Academic Press
Principles of Hormone/Behavior Relations, Second Edition, provides an introduction to the underlying principles of endocrine regulation of behavior, a newly emerging area of research within neurobiology and endocrinology. It addresses the properties of hormone/behavior relations, including the influence of family background, timing issues, neuroanatomical features, cellu...
Off-target drug effects on platelet function: Protecting an Achilles heel of drug development
CURRENT OPINION IN TOXICOLOGY - 01 Oct 2019
The development of new drugs is often limited or even halted by their side effects on platelet number or function. This review introduces the signalling pathways and the role of various platelet receptors, such as GPIIb/IIIa, GPIb-IX-V, GPVI and P-selectin. The large scope of platelet function tests are described, including aggregometry, flow cytometry, VerifyNow, adhesion and in vivo thrombosi...
A Self‐Assembled Fluorescent Nanoprobe for Imaging and Therapy of Cardiac Ischemia/Reperfusion Injury
ADVANCED THERAPEUTICS - 29 Jan 2019
There is a strong medical need for precision imaging of ischemic tissue and even more so for delivery of drugs specifically to the ischemic tissue at risk of functional damage. To date, no targeting epitopes or mechanisms have been established in ischemia/reperfusion injury that allow specific molecular targeting for either diagnosis or therapy, a deficiency that contributes to myocardial infar...
Characterising an Alternative Murine Model of Diabetic Cardiomyopathy.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2019
The increasing burden of heart failure globally can be partly attributed to the increased prevalence of diabetes, and the subsequent development of a distinct form of heart failure known as diabetic cardiomyopathy. Despite this, effective treatment options have remained elusive, due partly to the lack of an experimental model that adequately mimics human disease. In the current study, we combin...
Hematopoiesis is regulated by cholesterol efflux pathways and lipid rafts: connections with cardiovascular diseases.
JOURNAL OF LIPID RESEARCH - 01 May 2020
Lipid rafts are highly ordered regions of the plasma membrane that are enriched in cholesterol and sphingolipids and play important roles in many cells. In hematopoietic stem and progenitor cells (HSPCs), lipid rafts house receptors critical for normal hematopoiesis. Lipid rafts also can bind and sequester kinases that induce negative feedback pathways to limit proliferative cytokine receptor c...
Long-term and recent trends in hypertension awareness, treatment, and control in 12 high-income countries: an analysis of 123 nationally representative surveys.
LANCET (LONDON, ENGLAND) - 24 Aug 2019
Antihypertensive medicines are effective in reducing adverse cardiovascular events. Our aim was to compare hypertension awareness, treatment, and control, and how they have changed over time, in high-income countries.We used data from people aged 40-79 years who participated in 123 national health examination surveys from 1976 to 2017 in 12 high-income countries: Australia, Canada, Finland, Ger...
Rising rural body-mass index is the main driver of the global obesity epidemic in adults.
NATURE - 01 May 2019
Body-mass index (BMI) has increased steadily in most countries in parallel with a rise in the proportion of the population who live in cities. This has led to a widely reported view that urbanization is one of the most important drivers of the global rise in obesity. Here we use 2,009 population-based studies, with measurements of height and weight in more than 112 million adults, to report nat...
National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: a pooled analysis of 458 population-based studies in Asian and Western countries.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 01 Feb 2020
Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries.We pooled 458 population-based studies with 82.1 million participant...
World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions.
THE LANCET. GLOBAL HEALTH - 01 Oct 2019
To help adapt cardiovascular disease risk prediction approaches to low-income and middle-income countries, WHO has convened an effort to develop, evaluate, and illustrate revised risk models. Here, we report the derivation, validation, and illustration of the revised WHO cardiovascular disease risk prediction charts that have been adapted to the circumstances of 21 global regions.In this model ...
Burden of macro- and micro-vascular complications of type 2 diabetes in Bangladesh.
DIABETES & METABOLIC SYNDROME - 01 Jan 2001
The aim was to estimate the burden of macro- and micro-vascular complications on hospitalisation and healthcare cost among people with type 2 diabetes mellitus in Bangladesh.A cross-sectional study was carried out in 2017. A total of 1253 patients were recruited from six hospitals. Information related to cost and complications of type 2 diabetes were collected. Multiple logistic and non-paramet...
Glycaemic Control for People with Type 2 Diabetes Mellitus in Bangladesh - An urgent need for optimization of management plan.
SCIENTIFIC REPORTS - 15 Jul 2019
The objective of this study was to identify the determinants of glycaemic control among people with type 2 diabetes mellitus in Bangladesh. A cross-sectional study was carried out during March to September 2017, and 1253 adult patients with type 2 diabetes mellitus were recruited from six hospitals. Data were collected from patients via face-to-face interview, and their medical records were rev...
Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9 edition.th
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Nov 2019
To provide global estimates of diabetes prevalence for 2019 and projections for 2030 and 2045.A total of 255 high-quality data sources, published between 1990 and 2018 and representing 138 countries were identified. For countries without high quality in-country data, estimates were extrapolated from similar countries matched by economy, ethnicity, geography and language. Logistic regression was...
Comparing different definitions of prediabetes with subsequent risk of diabetes: an individual participant data meta-analysis involving 76 513 individuals and 8208 cases of incident diabetes.
BMJ OPEN DIABETES RESEARCH & CARE - 01 Jan 2019
There are currently five widely used definition of prediabetes. We compared the ability of these to predict 5-year conversion to diabetes and investigated whether there were other cut-points identifying risk of progression to diabetes that may be more useful.We conducted an individual participant meta-analysis using longitudinal data included in the Obesity, Diabetes and Cardiovascular Disease ...
Living liveable? RESIDE's evaluation of the "Liveable Neighborhoods" planning policy on the health supportive behaviors and wellbeing of residents in Perth, Western Australia.
SSM - POPULATION HEALTH - 01 Apr 2020
The RESIDential Environments (RESIDE) project is a unique longitudinal natural experiment designed to evaluate the health impacts of the "Liveable Neighbourhoods" planning policy, which was introduced by the Western Australian government to create more walkable suburbs.To summarize the RESIDE evidence of the impact of the planning policy on a range of health-supportive behaviours and wellbeing ...
The application of artificial intelligence (AI) techniques to identify frailty within a residential aged care administrative data set.
INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS - 01 Apr 2020
Research has shown that frailty, a geriatric syndrome associated with an increased risk of negative outcomes for older people, is highly prevalent among residents of residential aged care facilities (also called long term care facilities or nursing homes). However, progress on effective identification of frailty within residential care remains at an early stage, necessitating the development of...
