Publications
Now showing items 2581-2600 of 5702 records
Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice.
METABOLITES - 06 May 2021
Plasmalogens or alkenylphospholipids are a sub-class of glycerophospholipids with numerous biological functions and are thought to have protective effects against metabolic disease. Dietary supplementation with alkylglycerols (AKGs) has been shown to increase endogenous plasmalogen levels, however effective modulation of different molecular plasmalogen species has not yet been demonstrated. In ...
Taxonomic signatures of cause-specific mortality risk in human gut microbiome.
NATURE COMMUNICATIONS - 11 May 2021
The collection of fecal material and developments in sequencing technologies have enabled standardised and non-invasive gut microbiome profiling. Microbiome composition from several large cohorts have been cross-sectionally linked to various lifestyle factors and diseases. In spite of these advances, prospective associations between microbiome composition and health have remained uncharacterise...
Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial.
JMIR RESEARCH PROTOCOLS - 13 May 2021
Many older adults spend the majority of their waking hours sitting, which increases their risk of chronic diseases. Given the challenges that many older adults face when engaging in moderate-to-vigorous physical activity, understanding the health benefits of decreasing sitting time and increasing the number of sit-to-stand transitions is needed to address this growing public health concern.The ...
Loss of the long non-coding RNA OIP5-AS1 exacerbates heart failure in a sex-specific manner.
ISCIENCE - 25 Jun 2021
Long non-coding RNAs (lncRNAs) have been demonstrated to influence numerous biological processes, being strongly implicated in the maintenance and physiological function of various tissues including the heart. The lncRNA OIP5-AS1 (/C) has been studied in several settings; however its role in cardiac pathologies remains mostly uncharacterized. Using a series of and methods, we demonstrate that...
Circulating Soluble ACE2 and Upstream microRNA Expressions in Serum of Type 2 Diabetes Mellitus Patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 17 May 2021
The global coronavirus disease 2019 (COVID-19) pandemic was associated with multiple organ failure and comorbidities, such as type 2 diabetes mellitus (T2DM). Risk factors, such as age, gender, and obesity, were associated with COVID-19 infection. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is known to use several host receptors for viral entry, such as angiotensin-converting e...
Sedentary time in a nationally representative sample of adults in Japan: Prevalence and sociodemographic correlates.
PREVENTIVE MEDICINE REPORTS - 01 Sep 2021
Sedentary behaviour is associated with risks of detrimental health outcomes. It is crucial to understand how much time people spend in sedentary behaviour and what factors affect too much sedentary time for effective intervention. However, few studies examined the prevalence and the correlates of sedentary behaviour in Japan. Therefore, we assessed total sedentary time and its sociodemographic ...
Renal ACE2 (Angiotensin-Converting Enzyme 2) Expression Is Modulated by Dietary Fiber Intake, Gut Microbiota, and Their Metabolites.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2021
Prospective Screening for Primary Aldosteronism in Patients With Suspected Obstructive Sleep Apnea.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2021
[Figure: see text].
Role of Microparticles in Cardiovascular Disease: Implications for Endothelial Dysfunction, Thrombosis, and Inflammation.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2021
[Figure: see text].
Reducing occupational sitting time in adults with type 2 diabetes: Qualitative experiences of an office-adapted mHealth intervention.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 01 Jun 2021
Understanding barriers and facilitators for limiting occupational sitting and what impact it has on health on those with type 2 diabetes is essential for future trials and intervention development in primary healthcare settings. This study aimed to explore the feasibility and acceptability of an intervention using mobile health (mHealth) technology, together with counselling by a diabetes speci...
Sex-Specific Associations between Blood Pressure and Risk of Atrial Fibrillation Subtypes in the Tromsø Study.
JOURNAL OF CLINICAL MEDICINE - 05 Apr 2021
The aim of this study was to explore sex-specific associations between systolic blood pressure (SBP), hypertension, and the risk of incident atrial fibrillation (AF) subtypes, including paroxysmal, persistent, and permanent AF, in a general population. A total of 13,137 women and 11,667 men who participated in the fourth survey of the Tromsø Study (1994-1995) were followed up for incident AF un...
Rescue PCI in the management of STEMI: Contemporary results from the Melbourne Interventional Group registry.
INTERNATIONAL JOURNAL OF CARDIOLOGY. HEART & VASCULATURE - 01 Apr 2021
Fibrinolysis is an important reperfusion strategy in the management of ST-elevation myocardial infarction (STEMI) when timely access to primary percutaneous coronary intervention (PPCI) is unavailable. Rescue PCI is generally thought to have worse outcomes than PPCI in STEMI. We aimed to determine short- and long-term outcomes of patients with rescue PCI versus PPCI for treatment of STEMI.Patie...
Device Therapy of Hypertension.
CIRCULATION RESEARCH - 02 Apr 2021
In the past decade, efforts to improve blood pressure control have looked beyond conventional approaches of lifestyle modification and drug therapy to embrace interventional therapies. Based upon animal and human studies clearly demonstrating a key role for the sympathetic nervous system in the etiology of hypertension, the newer technologies that have emerged are predominantly aimed at neuromo...
Left atrial, pulmonary vein, and left atrial appendage anatomy in Indigenous individuals: Implications for atrial fibrillation.
INTERNATIONAL JOURNAL OF CARDIOLOGY. HEART & VASCULATURE - 01 Jun 2021
Indigenous Australians experience a greater burden of AF. Whether this is in-part due to differences in arrhythmogenic structures that appear to contribute to AF differences amongst other ethnicities is not known.We studied forty individuals matched for ethnicity and other AF risk factors. Computed tomography imaging was used to characterise left atrial (LA), pulmonary vein (PV), and left atria...
Myelodysplasia Syndrome, Clonal Hematopoiesis and Cardiovascular Disease.
CANCERS - 19 Apr 2021
The development of myelodysplasia syndromes (MDS) is multiphasic and can be driven by a plethora of genetic mutations and/or abnormalities. MDS is characterized by a hematopoietic differentiation block, evidenced by increased immature hematopoietic cells, termed blast cells and decreased mature circulating leukocytes in at least one lineage (i.e., cytopenia). Clonal hematopoiesis of indetermina...
Apoptotic Ablation of Platelets Reduces Atherosclerosis in Mice With Diabetes.
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Mar 2021
People with diabetes are at a significantly higher risk of cardiovascular disease, in part, due to accelerated atherosclerosis. Diabetic subjects have increased number of platelets that are activated, more reactive, and respond suboptimally to antiplatelet therapies. We hypothesized that reducing platelet numbers by inducing their premature apoptotic death would decrease atherosclerosis. Approa...
Catheter Ablation Versus Medication in Atrial Fibrillation and Systolic Dysfunction: Late Outcomes of CAMERA-MRI Study.
JACC. CLINICAL ELECTROPHYSIOLOGY - 14 Dec 2020
This study sought to determine the long-term outcomes of restoring sinus rhythm with catheter ablation (CA).The CAMERA-MRI (Catheter Ablation Versus Medical Rate Control in Atrial Fibrillation and Heart Failure-An MRI-Guided Multicenter Randomized Controlled Trial) study demonstrated that restoration of sinus rhythm with CA significantly improved left ventricular ejection fraction (LVEF) compar...
Association Between Depressive Symptoms and Incident Cardiovascular Diseases.
JAMA - 15 Dec 2020
It is uncertain whether depressive symptoms are independently associated with subsequent risk of cardiovascular diseases (CVDs).To characterize the association between depressive symptoms and CVD incidence across the spectrum of lower mood.A pooled analysis of individual-participant data from the Emerging Risk Factors Collaboration (ERFC; 162 036 participants; 21 cohorts; baseline surveys, 1960...
Which Blood Pressure Measurement Best Predicts Cardiovascular Outcomes?
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 22 Dec 2020
Reassuring News for Athletes With Atrial Fibrillation, But Perhaps Not All Athletes.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Oct 2020
