Publications
Now showing items 2341-2360 of 5702 records
The effect of posture on maximal oxygen uptake in active healthy individuals.
01 May 2021
Semi-supine and supine cardiopulmonary exercise testing (CPET) with concurrent cardiac imaging has emerged as a valuable tool for evaluating patients with cardiovascular disease. Yet, it is unclear how posture effects CPET measures. We aimed to discern the effect of posture on maximal oxygen uptake (VOmax) and its determinants using three clinically relevant cycle ergometers.2In random order, 1...
Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model.
CLINICAL RESEARCH IN CARDIOLOGY : OFFICIAL JOURNAL OF THE GERMAN CARDIAC SOCIETY - 01 May 2021
Cardiovascular and metabolic regulation is governed by neurohumoral signalling in relevant organs such as kidney, liver, pancreas, duodenum, adipose tissue, and skeletal muscle. Combined targeting of relevant neural outflows may provide a unique therapeutic opportunity for cardiometabolic disease.We aimed to investigate the feasibility, safety, and performance of a novel device-based approach f...
Fruit and vegetable intake is inversely associated with perceived stress across the adult lifespan.
CLINICAL NUTRITION (EDINBURGH, SCOTLAND) - 01 May 2021
Poor nutritional habits are linked to higher perceived stress, but the relationship between fruit and vegetable (FV) intake and stress is uncertain. The primary aim of this cross-sectional study was to explore the relationship between FV intake and perceived stress in a population-based cohort of men and women aged ≥25 years from the Australian Diabetes, Obesity and Lifestyle (AusDiab) Study. A...
Adverse impact of chronic kidney disease on clinical outcomes following percutaneous coronary intervention.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS - 01 May 2021
We aimed to assess the impact of the severity of chronic kidney disease (CKD) with long-term clinical outcomes in patients undergoing percutaneous coronary intervention (PCI).We analyzed data on consecutive patients undergoing PCI enrolled in the Victorian Cardiac Outcomes Registry (VCOR) from January 2014 to December 2018. Patients were stratified into tertiles of renal function; estimated glo...
Gut microbiome, prebiotics, intestinal permeability and diabetes complications.
BEST PRACTICE & RESEARCH. CLINICAL ENDOCRINOLOGY & METABOLISM - 01 May 2021
Diabetes is a metabolic condition. The composition of the gut microbiota is altered in diabetes with reduced levels of short chain fatty acids (SCFA) producers, notably butyrate. Butyrate is associated with a number of beneficial effects including promoting the integrity of the gastrointestinal barrier. Diabetes may lead to an increase in the permeability of the gut barrier, which is thought to...
Green Algorithms: Quantifying the Carbon Footprint of Computation.
01 Jun 2021
Climate change is profoundly affecting nearly all aspects of life on earth, including human societies, economies, and health. Various human activities are responsible for significant greenhouse gas (GHG) emissions, including data centers and other sources of large-scale computation. Although many important scientific milestones are achieved thanks to the development of high-performance computin...
Older Adults' Daily Step Counts and Time in Sedentary Behavior and Different Intensities of Physical Activity.
JOURNAL OF EPIDEMIOLOGY - 05 May 2021
Daily step count is the simplest measure of physical activity. However, little is known about how daily step count related to time spent in different intensities of physical activity (PA) and sedentary behavior (SB).These cross-sectional data were derived from 450 older Japanese adults (56.7% men; mean age, 74.3 years) who were randomly selected from three communities and responded a survey. Da...
The impact of coronary heart disease prevention on work productivity: a 10-year analysis.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 08 May 2021
To determine the impact of preventing new (incident) cases of coronary heart disease (CHD) on years of life and productivity, using the novel measure 'productivity-adjusted life year' (PALY), over the next 10 years.A dynamic life table model was constructed for the total Australian working-age population (15-69 years) over 10 years (2020-2029), separated by CHD status. Productivity estimates we...
Response to Sanchis-Gomar et al. 'Atrial fibrillation in athletes and non-athletes: evidence of different causative mechanisms'.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 10 May 2021
Associations of Total Legume, Pulse, and Soy Consumption with Incident Type 2 Diabetes: Federated Meta-Analysis of 27 Studies from Diverse World Regions.
11 May 2021
The consumption of legumes is promoted as part of a healthy diet in many countries but associations of total and types of legume consumption with type 2 diabetes (T2D) are not well established. Analyses across diverse populations are lacking despite the availability of unpublished legume consumption data in prospective cohort studies.To examine the prospective associations of total and types of...
Dietary Nitrate Intake Is Positively Associated with Muscle Function in Men and Women Independent of Physical Activity Levels.
11 May 2021
Nitrate supplements can improve vascular and muscle function. Whether higher habitual dietary nitrate is associated with better muscle function remains underexplored.The aim was to examine whether habitual dietary nitrate intake is associated with better muscle function in a prospective cohort of men and women, and whether the relation was dependent on levels of physical activity.The sample (n ...
Understanding the influence of left ventricular assist device inflow cannula alignment and the risk of intraventricular thrombosis.
BIOMEDICAL ENGINEERING ONLINE - 11 May 2021
Adverse neurological events associated with left ventricular assist devices (LVADs) have been suspected to be related to thrombosis. This study aimed to understand the risks of thrombosis with variations in the implanted device orientation. A severely dilated pulsatile patient-specific left ventricle, modelled with computational fluid dynamics, was utilised to identify the risk of thrombosis fo...
Non-linear optical imaging of atherosclerotic plaques in the context of SIV and HIV infection prominently detects crystalline cholesterol esters.
PLOS ONE - 01 Jan 2021
Chronic HIV infection may exacerbate atherosclerotic vascular disease, which at advanced stages presents as necrotic plaques rich in crystalline cholesterol. Such lesions can catastrophically rupture precipitating myocardial infarct and stroke, now important causes of mortality in those living with HIV. However, in this population little is known about plaque structure relative to crystalline c...
Genome wide association study of response to interval and continuous exercise training: the Predict-HIIT study.
JOURNAL OF BIOMEDICAL SCIENCE - 13 May 2021
Low cardiorespiratory fitness (V̇O) is highly associated with chronic disease and mortality from all causes. Whilst exercise training is recommended in health guidelines to improve V̇O, there is considerable inter-individual variability in the V̇O response to the same dose of exercise. Understanding how genetic factors contribute to V̇O training response may improve personalisation of exercise ...
Yap regulates skeletal muscle fatty acid oxidation and adiposity in metabolic disease.
NATURE COMMUNICATIONS - 17 May 2021
Obesity is a major risk factor underlying the development of metabolic disease and a growing public health concern globally. Strategies to promote skeletal muscle metabolism can be effective to limit the progression of metabolic disease. Here, we demonstrate that the levels of the Hippo pathway transcriptional co-activator YAP are decreased in muscle biopsies from obese, insulin-resistant human...
Acute Exposure to Diesel Exhaust Increases Muscle Sympathetic Nerve Activity in Humans.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 18 May 2021
Background Diesel exhaust (DE) emissions are a major contributor to ambient air pollution and are strongly associated with cardiovascular morbidity and mortality. Exposure to traffic-related particulate matter is linked with acute adverse cardiovascular events; however, the mechanisms are not fully understood. We examined the role of the autonomic nervous system during exposure to DE that has p...
May Measurement Month 2019: an analysis of blood pressure screening results from Australia.
EUROPEAN HEART JOURNAL SUPPLEMENTS : JOURNAL OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 01 May 2021
May Measurement Month (MMM) is an annual global blood pressure (BP) screening campaign aimed at obtaining standardized BP measurements and other relevant health information from members of the community to increase awareness of elevated BP and the associated risks. Adults (≥18 years) were recruited through opportunistic sampling across the various Australian states during May 2019. Three BP rea...
Distinguishing between PTEN clinical phenotypes through mutation analysis.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL - 01 Jan 2021
Phosphate and tensin homolog on chromosome ten (PTEN) germline mutations are associated with an overarching condition known as PTEN hamartoma tumor syndrome. Clinical phenotypes associated with this syndrome range from macrocephaly and autism spectrum disorder to Cowden syndrome, which manifests as multiple noncancerous tumor-like growths (hamartomas), and an increased predisposition to certain...
The Impact of Simvastatin on Lipidomic Markers of Cardiovascular Risk in Human Liver Cells Is Secondary to the Modulation of Intracellular Cholesterol.
METABOLITES - 25 May 2021
Statins are the first-line lipid-lowering therapy for reducing cardiovascular disease (CVD) risk. A plasma lipid ratio of two phospholipids, PI(36:2) and PC(18:0_20:4), was previously identified to explain 58% of the relative CVD risk reduction associated with pravastatin, independent of a change in low-density lipoprotein-cholesterol. This ratio may be a potential biomarker for the treatment e...
Oxygen Pathway Limitations in Patients With Chronic Thromboembolic Pulmonary Hypertension.
CIRCULATION - 25 May 2021
Exertional intolerance is a limiting and often crippling symptom in patients with chronic thromboembolic pulmonary hypertension (CTEPH). Traditionally the pathogenesis has been attributed to central factors, including ventilation/perfusion mismatch, increased pulmonary vascular resistance, and right heart dysfunction and uncoupling. Pulmonary endarterectomy and balloon pulmonary angioplasty pro...
