Publications
Now showing items 2261-2280 of 5325 records
Deletion of Orphan G Protein-Coupled Receptor GPR37L1 in Mice Alters Cardiovascular Homeostasis in a Sex-Specific Manner.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2020
GPR37L1 is a family A orphan G protein-coupled receptor (GPCR) with a putative role in blood pressure regulation and cardioprotection. In mice, genetic ablation of causes sex-dependent effects; female mice lacking (GPR37L1) have a modest but significant elevation in blood pressure, while male GPR37L1 mice are more susceptible to cardiovascular dysfunction following angiotensin II-induced hype...
A Stress Syndrome Prototype Reflects Type 3 Diabetes and Ischemic Stroke Risk: The SABPA Study.
BIOLOGY - 18 Feb 2021
Type 3 diabetes (T3D) accurately reflects that dementia, e.g., Alzheimer's disease, represents insulin resistance and neurodegeneration in the brain. Similar retinal microvascular changes were observed in Alzheimer's and chronic stressed individuals. Hence, we aimed to show that chronic stress relates to T3D dementia signs and retinopathy, ultimately comprising a Stress syndrome prototype refle...
Prospective relationships of adolescents' screen-based sedentary behaviour with depressive symptoms: the Millennium Cohort Study.
PSYCHOLOGICAL MEDICINE - 19 Feb 2021
Frequent use of screen-based devices could be a modifiable risk factor for adolescent depression, but findings have been inconsistent and mostly from cross-sectional studies. We examined prospective associations of video gaming, social media, and internet use with depressive symptoms in adolescents.A total of 11 341 adolescents from the Millennium Cohort Study, a representative, UK population-b...
Recent advances in bioanalytical methods to measure proteome stability in cells.
THE ANALYST - 26 Feb 2021
Proteome stability constitutes an essential aspect of protein homeostasis (proteostasis). Proteostasis networks maintain proteins and their interactors in a defined conformation for their activity, localisation, and function. However, endogenous or exogenous stressors can perturb proteostasis integrity and deplete folding capacity, generating destabilized folding intermediates and deleterious a...
Correction: Recent advances in bioanalytical methods to measure proteome stability in cells.
THE ANALYST - 11 Mar 2021
Correction for 'Recent advances in bioanalytical methods to measure proteome stability in cells' by Shouxiang Zhang et al., Analyst, 2021, DOI: 10.1039/d0an01547d.
Trends in the incidence of diagnosed diabetes: a multicountry analysis of aggregate data from 22 million diagnoses in high-income and middle-income settings.
THE LANCET. DIABETES & ENDOCRINOLOGY - 01 Apr 2021
Diabetes prevalence is increasing in most places in the world, but prevalence is affected by both risk of developing diabetes and survival of those with diabetes. Diabetes incidence is a better metric to understand the trends in population risk of diabetes. Using a multicountry analysis, we aimed to ascertain whether the incidence of clinically diagnosed diabetes has changed over time.In this m...
Apoptosis signal-regulating kinase 1 inhibition reverses deleterious indoxyl sulfate-mediated endothelial effects.
LIFE SCIENCES - 01 May 2021
Indoxyl sulfate (IS), a protein-bound uremic toxin, is implicated in endothelial dysfunction, which contributes to adverse cardiovascular events in chronic kidney disease. Apoptosis signal regulating kinase 1 (ASK1) is a reactive oxygen species-driven kinase involved in IS-mediated adverse effects. This study assessed the therapeutic potential of ASK1 inhibition in alleviating endothelial effec...
Translational Potential of Non-coding RNAs for Cardiovascular Disease.
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY - 14 Apr 2020
Heart failure is the end result of a variety of cardiovascular disease states. Heart failure remains a challenge to treat, and the incidence continues to rise with an aging population, and increasing rates of diabetes and obesity. Non-coding RNAs, once considered as "junk DNA", have emerged as powerful transcriptional regulators and potential therapeutic targets for the treatment of heart failu...
Understanding the Role of Extracellular Vesicles in Multiple Myeloma
HEMATOLOGIC MALIGNANCIES - 01 Jul 2020
Understanding the Role of Extracellular Vesicles in Multiple Myeloma
Prematurity negatively impacts therapeutic effect of human amnion epithelial cells in experimental bronchopulmonary dysplasia
CYTOTHERAPY - 01 May 2020
Extracellular vesicles derived from human amniotic epithelial cells (hAEC-EVs) have been previously shown to be beneficial in a preclinical model of bronchopulmonary dysplasia (BPD) when obtained from full-term, healthy pregnancies. In this study, we compare their therapeutic potential against preterm, complicated pregnancies.
Relationship of Degree of Systolic Dysfunction to Variations in Exercise Capacity and Hemodynamic Status in HFpEF.
JACC. CARDIOVASCULAR IMAGING - 01 Feb 2020
Multimorbidity and multiple causes of death in heart failure
JOURNAL OF PUBLIC HEALTH - 18 Feb 2020
Patients with heart failure (HF) usually have multiple comorbid conditions that interact with HF, either leading to its development, aggravating its progression or reducing the effectiveness of treatment. Although the prevalence of HF comorbidities has been studied, more evidence is needed on the strength of their independent association with HF and HF mortality.
Aortic Thickness: A Forgotten Paradigm in Risk Stratification of Aortic Disease.
AORTA (STAMFORD, CONN.) - 01 Oct 2020
This study aimed at risk-stratifying aortic dilatation using aortic wall thickness (AWT) and comparing methods of AWT assessment. Demographic, epidemiological, and perioperative data on 72 consecutive aortic surgeries (age = 62 years[standard deviation (SD) = 12] years) performed by a single surgeon were collected from hospital database. Aortic thickness was measured on computed tomography scan...
Editorial: Inflammation in Cardiovascular Diseases: Role of the Endothelium and Emerging Therapeutics.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2020
Non-Alcoholic Steatohepatitis: A Review of Its Mechanism, Models and Medical Treatments.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2020
Non-alcoholic steatohepatitis (NASH) develops from non-alcoholic fatty liver disease (NAFLD). Currently, around 25% of the population is estimated to have NAFLD, and 25% of NAFLD patients are estimated to have NASH. NASH is typically characterized by liver steatosis inflammation, and fibrosis driven by metabolic disruptions such as obesity, diabetes, and dyslipidemia. NASH patients with signifi...
Human Cytomegalovirus-Encoded microRNAs Can Be Found in Saliva Samples from Renal Transplant Recipients.
NON-CODING RNA - 18 Dec 2020
Human cytomegalovirus (HCMV) infections are common following renal transplantation and may have long-lasting effects. HCMV can be measured directly by viral DNA or indirectly via host immune responses. HCMV-encoded microRNA (miRNA) may alter the pathobiology of HCMV infections and contribute to the progression of HCMV disease. HCMV-encoded miRNAs can be detected in blood but have not been sough...
Origins and diversity of macrophages in health and disease.
CLINICAL & TRANSLATIONAL IMMUNOLOGY - 01 Jan 2020
Macrophages are the first immune cells in the developing embryo and have a central role in organ development, homeostasis, immunity and repair. Over the last century, our understanding of these cells has evolved from being thought of as simple phagocytic cells to master regulators involved in governing a myriad of cellular processes. A better appreciation of macrophage biology has been matched ...
Less Nocturnal Hypoglycemia but Equivalent Time in Range Among Adults with Type 1 Diabetes Using Insulin Pumps Versus Multiple Daily Injections.
DIABETES TECHNOLOGY & THERAPEUTICS - 01 Jun 2021
This prerandomization analysis from the Australian HCL-Adult trial (registration number: ACTRN12617000520336) compared masked continuous glucose monitoring (CGM) metrics among adults using insulin pumps versus multiple daily injections (MDIs), who were all self-monitoring blood glucose (SMBG). Adults with type 1 diabetes, using an insulin pump or MDIs without real-time CGM (and entering a tria...
Acute glycaemic management before, during and after exercise for cardiac rehabilitation participants with diabetes mellitus: a joint statement of the British and Canadian Associations of Cardiovascular Prevention and Rehabilitation, the International Council for Cardiovascular Prevention and Rehabilitation and the British Association of Sport and Exercise Sciences.
BRITISH JOURNAL OF SPORTS MEDICINE - 23 Dec 2020
Type 1 (T1) and type 2 (T2) diabetes mellitus (DM) are significant precursors and comorbidities to cardiovascular disease and prevalence of both types is still rising globally. Currently,~25% of participants (and rising) attending cardiac rehabilitation in Europe, North America and Australia have been reported to have DM (>90% have T2DM). While there is some debate over whether improving glycae...
Unveiling six potent and highly selective antileishmanial agents via the open source compound collection 'Pathogen Box' against antimony-sensitive and -resistant Leishmania braziliensis.
BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE - 01 Jan 2021
Despite all efforts to provide new chemical entities to tackle leishmaniases, we are still dependent on a the limited drug arsenal, together with drawbacks like toxicity and drug-resistant parasites. Collaborative drug discovery emerged as an option to speed up the way to find alternative antileishmanial agents. This is the case of Medicines for Malaria Ventures - MMV, that promotes an open sou...
