Publications
Now showing items 221-240 of 5702 records
The Development of Can Walk Can Run: A Walking and Running Program for People Living With and Beyond Cancer.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 11 Oct 2025
Finding new ways to support physical activity participation after cancer is an important challenge. This research aimed to develop a walking and running program that could support people living with and beyond cancer to participate in fun run-style events. Mixed methods research that followed guidance for developing complex interventions was conducted in 2 phases. Phase 1 included a review of p...
Diabetes mellitus and work participation.
NATURE REVIEWS. ENDOCRINOLOGY - 20 Oct 2025
Work participation is beneficial for health. Diabetes mellitus is highly prevalent among adults, and although it poses a substantial healthcare cost burden, the true burden might be greater than is currently appreciated through effects on work participation. This Review summarizes the evidence regarding the effect of diabetes mellitus on paid employment. Several studies report increased risks o...
Exome and Genome Sequencing Reveals Novel Variants for Severe Diabetic Retinopathy in Type 1 Diabetes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE - 01 Oct 2025
Diabetic retinopathy affects a substantial proportion of individuals with diabetes and, if not treated, may lead to acquired visual impairment or even blindness. An improved comprehension of the genetics of diabetic retinopathy (DR) is crucial in understanding the disease mechanisms. We aimed to identify rare and low-frequency variants predisposing to severe DR (SDR) in type 1 diabetes. Whole e...
Incidence of Type 2 Diabetes With Verapamil Compared With Other Calcium Channel Blockers.
DIABETES CARE - 30 Oct 2025
Evidence that the calcium channel blocker (CCB) verapamil slows type 1 diabetes progression suggests possible preventive benefits among people at risk of developing type 2 diabetes. We compared type 2 diabetes incidence between users of verapamil versus other CCBs in a population-based cohort. From a random sample of Australians in national subsidized health care databases, we identified 90,026...
Association of the Age at Type 2 Diabetes Onset With Diabetes Progression.
DIABETES CARE - 07 Nov 2025
To examine whether age at type 2 diabetes onset affects disease progression, assessed by changes in glycemic control and clinical biomarkers during follow-up. Participants in the Kerala Diabetes Prevention Program (K-DPP) and U.S. Diabetes Prevention Program (US-DPP) who developed type 2 diabetes during the trial were analyzed. Data on fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), trigl...
DNA Methylation Biomarkers Predict Offspring Metabolic Risk From Mothers With Hyperglycemia in Pregnancy.
DIABETES - 01 Sep 2025
Maternal hyperglycemia is linked to 19 cord blood DNA methylation biomarkers that predict offspring metabolic dysfunction. These methylation changes, associated with maternal glycemic status, improved the prediction of β-cell dysfunction at 7, 11, and 18 years of age compared with clinical factors alone. Validation in human β-cells and pancreatic ductal epithelial cells confirmed that hyperglyc...
MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY PLUS - 01 Sep 2025
The overproduction of reactive oxygen species (ROS) and mitochondrial dysregulation are regarded as key mechanisms in the progression of cardiac remodelling in cardiometabolic diseases including heart failure. Conventional treatments are often ineffective as they do not specifically target the underlying pathological mechanisms. Mitoquinone mesylate (MitoQ), a mitochondrial-targeted antioxidant...
Relationship between left ventricular wall stress and cardiac remodelling post-TAVR and MitraClip.
OPEN HEART - 31 Aug 2025
The relationship between left ventricular wall stress (LVWS) and cardiac remodelling post structural intervention has not previously been examined. We examined the relationship between LVWS and cardiac remodelling 6 months post transcatheter aortic valve replacement (TAVR) and MitraClip (MC). LVWS was calculated in 40 patients with severe aortic stenosis (AS) and 11 patients with severe mitral ...
Economic Evaluation of a Multicomponent mHealth Intervention for Stroke Management in Rural China: Cluster-Randomized Trial With 6-Year Follow-Up.
JMIR MHEALTH AND UHEALTH - 11 Sep 2025
To bridge the gap between clinical guidelines and suboptimal stroke management in rural settings, we conducted an implementation trial using evidence-based, mobile health-enabled strategies to empower primary care providers in rural China. The system-integrated and digital technology-enabled model of care (SINEMA) model was shown to significantly reduce blood pressure and mortality among people...
Global and Regional Prediabetes Prevalence: Updates for 2024 and Projections for 2050.
DIABETES CARE - 09 Sep 2025
Coenzyme Q10 and Cognition: A Review.
NUTRIENTS - 08 Sep 2025
<b>Background and Objective:</b> With an increase in the number of older citizens in most Western countries, cognitive decline is becoming an increasingly significant issue. Numerous age-related metabolic and physiological changes, such as increased inflammation and oxidative stress, decreased adenosine triphosphate (ATP) production, poorer cardiovascular function, and reduced cerebral blood fl...
Performance and Perceptual Responses to Cluster Sets in Pneumatic-Resistance Exercises: Impact of Exercise Selection, Sex, and Strength.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE - 08 Sep 2025
This study examined the effects of cluster sets (CS) versus traditional sets (TRAD) on performance and perceptual responses during pneumatic chest press (CP) and leg press (LP). Exercise-specific differences and the influence of sex and strength were also explored. Forty-seven recreationally resistance-trained young adults (23 male and 24 female) performed CP and LP at 70% 1-repetition maximum ...
Engagement With Conversational Agent-Enabled Interventions in Cardiometabolic Disease Self-Management: Systematic Review.
JMIR MHEALTH AND UHEALTH - 18 Sep 2025
Well-designed conversational agents can improve health care capacity to meet the dynamic and complex needs of people self-managing cardiometabolic diseases (CMD). However, a lack of empirical evidence on conversational agent-enabled intervention design features and their impact on engagement make it challenging to comprehensively evaluate effectiveness. This review synthesizes evidence on conve...
Decreased Endogenous Nitric Oxide Production in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction.
JOURNAL OF CLINICAL MEDICINE - 22 Aug 2025
<b>Background:</b> Heart failure with a preserved ejection fraction (HFpEF) accounts for approximately 50% of patients with heart failure. Endothelial dysfunction has been documented in HFpEF, and impaired nitric oxide (NO) production may be a contributing factor in patients decompensating from chronic to acute HFpEF. Plasma nitrite (NO<sub>2</sub><sup>-</sup>), but not plasma nitrate (NO<sub>3...
Socio-economic position and the prevalence of ten chronic diseases in Australia, 2021: a whole of population census data analysis.
THE MEDICAL JOURNAL OF AUSTRALIA - 19 Aug 2025
To investigate differences in the prevalence of specific chronic diseases in Australia by selected measures of socio-economic position, and by age group and sex, using representative national census population data. Cross-sectional, whole of population study; analysis of 2021 Australian census data. People aged 40 years or older for whom 2021 Australian census health status and socio-economic p...
<i>ACTN3</i> genotype influences androgen response in developing murine skeletal muscle.
SCIENCE ADVANCES - 29 Aug 2025
Androgens act through androgen receptor (AR) to maintain muscle mass. Evidence suggests that this pathway is influenced by "the gene for speed," <i>ACTN3</i> (α-actinin-3). Given that one in five people lack α-actinin-3, it is possible that they may respond to androgens differently. Here, we show that α-actinin-3 deficiency decreases AR in muscles of mice and humans (in males and females) and t...
An eyecare foundation model for clinical assistance: a randomized controlled trial.
NATURE MEDICINE - 28 Aug 2025
In the context of an increasing need for clinical assessments of foundation models, we developed EyeFM, a multimodal vision-language eyecare copilot, and conducted a multifaceted evaluation, including retrospective validations, multicountry efficacy validation as a clinical copilot and a double-masked randomized controlled trial (RCT). EyeFM was pretrained on 14.5 million ocular images from fiv...
International Variation in Case Fatality After Major Coronary or Cerebrovascular Events in Individuals With Type 2 Diabetes: Evidence From ADVANCE, TECOS, and EXSCEL.
DIABETES CARE - 28 Aug 2025
To examine differences in case-fatality incidence among individuals with type 2 diabetes after major coronary or cerebrovascular events by geographic region and country income level. We studied ADVANCE, TECOS, and EXSCEL participants who experienced within-trial major coronary (fatal or nonfatal myocardial infarction or sudden cardiac death) or cerebrovascular (fatal or nonfatal stroke) events....
Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets.
PLOS BIOLOGY - 01 Aug 2025
Ratios between two metabolites are sensitive indicators of metabolic changes. Lipidomic profiling studies have revealed that plasma ether lipids, a class of glycero- and glycerophospho-lipids with reported health benefits, are negatively associated with obesity. Here, we utilized lipid ratios as surrogate markers of lipid metabolism to explore the processes underlying the inverse relationship b...
Clinical and cardiovascular magnetic resonance factors associated with elevated neutrophil-to-lymphocyte ratio in patients with heart failure: an analysis of a single-centre, prospective registry.
BMJ OPEN - 27 Aug 2025
The neutrophil-to-lymphocyte ratio (NLR) is defined as the ratio of neutrophils to lymphocytes measured in the full blood count. It has been studied across a range of conditions including cancer, sepsis and stroke. It has been proven that in patients with heart failure (HF) with reduced ejection fraction (HF-rEF), an elevated NLR reflects a higher risk of adverse outcomes. The aim of this study...
