Publications
Now showing items 2101-2120 of 5325 records
CSM-AB: graph-based antibody-antigen binding affinity prediction and docking scoring function.
BIOINFORMATICS (OXFORD, ENGLAND) - 04 Nov 2021
Understanding antibody-antigen interactions is key to improving their binding affinities and specificities. While experimental approaches are fundamental for developing new therapeutics, computational methods can provide quick assessment of binding landscapes, guiding experimental design. Despite this, little effort has been devoted to accurately predicting the binding affinity between antibodi...
Short- and Long-Term Outcomes After Transcatheter Aortic Valve Implantation in Public and Private Hospital Settings: A Propensity-Matched Analysis.
HEART, LUNG & CIRCULATION - 01 Dec 2021
To compare short- and long-term outcomes after transcatheter aortic valve implantation (TAVI) in the public and private hospital setting.Propensity-matched, retrospective analysis of a prospective registry.Patients with severe aortic stenosis who underwent TAVI at a tertiary public hospital (n=507) and an experienced private hospital (n=436).The primary endpoint was all-cause mortality.Patients...
Risk Prediction Using Polygenic Risk Scores for Prevention of Stroke and Other Cardiovascular Diseases.
01 Aug 2021
Early prediction of risk of cardiovascular disease (CVD), including stroke, is a cornerstone of disease prevention. Clinical risk scores have been widely used for predicting CVD risk from known risk factors. Most CVDs have a substantial genetic component, which also has been confirmed for stroke in recent gene discovery efforts. However, the role of genetics in prediction of risk of CVD, includ...
Role of the sympathetic nervous system in cardiometabolic control: implications for targeted multiorgan neuromodulation approaches.
JOURNAL OF HYPERTENSION - 01 Aug 2021
Sympathetic overdrive plays a key role in the perturbation of cardiometabolic homeostasis. Diet-induced and exercise-induced weight loss remains a key strategy to combat metabolic disorders, but is often difficult to achieve. Current pharmacological approaches result in variable responses in different patient cohorts and long-term efficacy may be limited by medication intolerance and nonadheren...
Perturbed BMP signaling and denervation promote muscle wasting in cancer cachexia.
04 Aug 2021
Most patients with advanced solid cancers exhibit features of cachexia, a debilitating syndrome characterized by progressive loss of skeletal muscle mass and strength. Because the underlying mechanisms of this multifactorial syndrome are incompletely defined, effective therapeutics have yet to be developed. Here, we show that diminished bone morphogenetic protein (BMP) signaling is observed ear...
Cardiac cellularity is dependent upon biological sex and is regulated by gonadal hormones.
CARDIOVASCULAR RESEARCH - 29 Aug 2021
Sex differences have been consistently identified in cardiac physiology and incidence of cardiac disease. However, the underlying biological causes for the differences remain unclear. We sought to characterize the cardiac non-myocyte cellular landscape in female and male hearts to determine whether cellular proportion of the heart is sex-dependent and whether endocrine factors modulate the card...
Declining mortality in older people with type 2 diabetes masks rising excess risks at younger ages: a population-based study of all-cause and cause-specific mortality over 13 years.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 30 Aug 2021
Excess mortality in people with vs without type 2 diabetes (T2DM) has fallen, but it is unclear whether men/women at all ages have benefited and which causes of death have driven these trends.All-cause and cause-specific mortality rates and excess mortality [by mortality rate ratios (MRRs) relative to the non-diabetic general population] were examined in 1 268 018 Australians with T2DM register...
Aberrations in circulating ceramide levels are associated with poor clinical outcomes across localised and metastatic prostate cancer.
PROSTATE CANCER AND PROSTATIC DISEASES - 01 Sep 2021
Dysregulated lipid metabolism is associated with more aggressive pathology and poorer prognosis in prostate cancer (PC). The primary aim of the study is to assess the relationship between the plasma lipidome and clinical outcomes in localised and metastatic PC. The secondary aim is to validate a prognostic circulating 3-lipid signature specific to metastatic castration-resistant PC (mCRPC).Comp...
Cardiovascular Screening of Elite Athletes by Sporting Organizations in Australia: A Survey of Chief Medical Officers.
CLINICAL JOURNAL OF SPORT MEDICINE : OFFICIAL JOURNAL OF THE CANADIAN ACADEMY OF SPORT MEDICINE - 01 Sep 2021
To compare cardiovascular screening policies of Australian elite sporting organizations.Online survey.Elite/professional sports in Australia.Chief medical officers (CMOs) of elite/professional sports in Australia, including rugby union and league, cricket, tennis, Australian football, and cycling.Survey questions about each sport's cardiac screening policy: which screening components were inclu...
Lipin 1 modulates mRNA splicing during fasting adaptation in liver.
JCI INSIGHT - 08 Sep 2021
Lipin 1 regulates cellular lipid homeostasis through roles in glycerolipid synthesis (through phosphatidic acid phosphatase activity) and transcriptional coactivation. Lipin 1-deficient individuals exhibit episodic disease symptoms that are triggered by metabolic stress, such as stress caused by prolonged fasting. We sought to identify critical lipin 1 activities during fasting. We determined t...
Development of Extracellular Vesicle Therapeutics: Challenges, Considerations, and Opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY - 01 Jan 2021
Extracellular vesicles (EVs) hold great promise as therapeutic modalities due to their endogenous characteristics, however, further bioengineering refinement is required to address clinical and commercial limitations. Clinical applications of EV-based therapeutics are being trialed in immunomodulation, tissue regeneration and recovery, and as delivery vectors for combination therapies. Native/b...
The known knowns and known unknowns of vaccine-induced thrombotic thrombocytopaenia.
CARDIOVASCULAR RESEARCH - 28 Sep 2021
The proteomes of endometrial stromal cell-derived extracellular vesicles following a decidualizing stimulus define the cells' potential for decidualization success.
MOLECULAR HUMAN REPRODUCTION - 29 Sep 2021
Adequate endometrial stromal cell (ESC) decidualization is vital for endometrial health. Given the importance of extracellular vesicles (EVs) in intercellular communication, we investigated how their protein landscape is reprogrammed and dysregulated during decidual response. Small EVs (sEVs) from human ESC-conditioned media at Day-2 and -14 following decidual stimuli were grouped as well- (WD)...
Genomic risk prediction of coronary artery disease in women with breast cancer: a prospective cohort study.
BREAST CANCER RESEARCH : BCR - 30 Sep 2021
Advancements in cancer therapeutics have resulted in increases in cancer-related survival; however, there is a growing clinical dilemma. The current balancing of survival benefits and future cardiotoxic harms of oncotherapies has resulted in an increased burden of cardiovascular disease in breast cancer survivors. Risk stratification may help address this clinical dilemma. This study is the fir...
Novel Relationship Between Plasmalogen Lipid Signatures and Carnosine in Humans.
MOLECULAR NUTRITION & FOOD RESEARCH - 01 Oct 2021
Carnosine is a naturally occurring dipeptide abundant in the skeletal and cardiac muscle and brain, which has been shown to improve glucose metabolism and cardiovascular risk. This study showed that carnosine supplementation had positive changes on plasma lipidome. Here, this study aimed to establish the relationship of muscle carnosine and serum carnosinase-1 with cardiometabolic risk factors ...
Associations of neighborhood built and social environments with frailty among mid-to-older aged Australian adults.
GERIATRICS & GERONTOLOGY INTERNATIONAL - 01 Oct 2021
Neighborhood environmental attributes are associated with physical activity and health status. We examined cross-sectional associations of built and social environmental attributes with frailty among community-dwelling mid-to-older aged adults in Australia.Data from 3419 adults aged 50-74 years living in 200 neighborhoods in Brisbane, Australia, were used. Frailty status was assessed by a frail...
Temporal Trends in Patient Risk Profile and Clinical Outcomes Following Percutaneous Coronary Intervention.
CARDIOVASCULAR REVASCULARIZATION MEDICINE : INCLUDING MOLECULAR INTERVENTIONS - 01 Oct 2021
Patient selection and procedural characteristics continue to evolve in percutaneous coronary intervention (PCI). Australian data on long-term trends and outcomes are limited. This study aimed to identify long-term temporal trends in patient characteristics and outcomes in a large Australian PCI cohort.We analysed data from 41,146 PCI procedures included in the multi-centre Melbourne Interventio...
Relationship between Circulating Lipids and Cytokines in Metastatic Castration-Resistant Prostate Cancer.
CANCERS - 01 Oct 2021
Circulating lipids or cytokines are associated with prognosis in metastatic castration-resistant prostate cancer (mCRPC). This study aimed to understand the interactions between lipid metabolism and immune response in mCRPC by investigating the relationship between the plasma lipidome and cytokines. Plasma samples from two independent cohorts of men with mCRPC ( = 146, 139) having life-prolongi...
Pulmonary Disease Is Associated With Human T-Cell Leukemia Virus Type 1c Infection: A Cross-sectional Survey in Remote Aboriginal Communities.
CLINICAL INFECTIOUS DISEASES : AN OFFICIAL PUBLICATION OF THE INFECTIOUS DISEASES SOCIETY OF AMERICA - 05 Oct 2021
The human T-cell leukemia virus type 1 (HTLV-1) subtype c is endemic to central Australia. We report the first large-scale, community-based, health survey of HTLV-1 and its disease associations in this setting.Aboriginal community residents aged >2 years in 7 remote communities were invited to do a health survey that included a questionnaire, spirometry, and clinical examination by a physician ...
Gestational diabetes is associated with postpartum hemorrhage in Indigenous Australian women in the PANDORA study: A prospective cohort.
INTERNATIONAL JOURNAL OF GYNAECOLOGY AND OBSTETRICS: THE OFFICIAL ORGAN OF THE INTERNATIONAL FEDERATION OF GYNAECOLOGY AND OBSTETRICS - 01 Nov 2021
To assess associations of hyperglycemia in pregnancy with the risk of postpartum hemorrhage (PPH) in a prospective cohort of Indigenous and non-Indigenous women, compared with normoglycemia.Data were from 1102 (48% Indigenous) women of the Pregnancy And Neonatal Diabetes Outcomes in Remote Australia (PANDORA) Study. Age-adjusted associations of gestational diabetes mellitus (GDM) or pre-existin...
