Publications
Now showing items 2021-2040 of 5325 records
pdCSM-cancer: Using Graph-Based Signatures to Identify Small Molecules with Anticancer Properties.
JOURNAL OF CHEMICAL INFORMATION AND MODELING - 26 Jul 2021
The development of new, effective, and safe drugs to treat cancer remains a challenging and time-consuming task due to limited hit rates, restraining subsequent development efforts. Despite the impressive progress of quantitative structure-activity relationship and machine learning-based models that have been developed to predict molecule pharmacodynamics and bioactivity, they have had mixed su...
Platelets, coagulation, and the vascular wall: the quest to better understand and smarten up our therapeutic targeting of this triad in primary and secondary prevention of cardiovascular events.
CARDIOVASCULAR RESEARCH - 27 Jul 2021
Machine learning powered tools for automated analysis of muscle sympathetic nerve activity recordings.
PHYSIOLOGICAL REPORTS - 01 Aug 2021
Automated analysis and quantification of physiological signals in clinical practice and medical research can reduce manual labor, increase efficiency, and provide more objective, reproducible results. To build a novel platform for the analysis of muscle sympathetic nerve activity (MSNA), we employed state-of-the-art data processing and machine learning applications. Data processing methods for ...
T-Cell Expression and Release of Kidney Injury Molecule-1 in Response to Glucose Variations Initiates Kidney Injury in Early Diabetes.
DIABETES - 01 Aug 2021
Half of the mortality in diabetes is seen in individuals <50 years of age and commonly predicted by the early onset of diabetic kidney disease (DKD). In type 1 diabetes, increased urinary albumin-to-creatinine ratio (uACR) during adolescence defines this risk, but the pathological factors responsible remain unknown. We postulated that early in diabetes, glucose variations contribute to kidney i...
Associations of healthy food choices with gut microbiota profiles.
02 Aug 2021
Diet has a major influence on the human gut microbiota, which has been linked to health and disease. However, epidemiological studies on associations of a healthy diet with the microbiota utilizing a whole-diet approach are still scant.To assess associations between healthy food choices and human gut microbiota composition, and to determine the strength of association with functional potential....
CRP Enhances the Innate Killing Mechanisms Phagocytosis and ROS Formation in a Conformation and Complement-Dependent Manner.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2021
Phagocytosis and the formation of reactive oxygen species (ROS) in phagocytic leukocytes are an effective killing mechanism of the innate host defense. These cellular processes of innate immunity function in a complex interplay with humoral factors. C-reactive protein (CRP) in its activated, monomeric isoform (mCRP) has been shown to activate immune cells the classical complement pathway. We i...
Healthy Breastfeeding Infants Consume Different Quantities of Milk Fat Globule Membrane Lipids.
NUTRIENTS - 25 Aug 2021
The human milk fat globule membrane (MFGM) contains important lipids for growing infants. Anthropometric measurements, milk samples, and infant milk intake were collected in a cohort of eleven healthy mother-infant dyads during exclusive breastfeeding from birth to six months. One hundred and sixty-six MFGM lipids were analysed using liquid chromatography-mass spectrometry, and the infant intak...
TSMDA: Target and symptom-based computational model for miRNA-disease-association prediction.
MOLECULAR THERAPY. NUCLEIC ACIDS - 03 Dec 2021
The emergence of high-throughput sequencing techniques has revealed a primary role of microRNAs (miRNAs) in a wide range of diseases, including cancers and neurodegenerative disorders. Understanding novel relationships between miRNAs and diseases can potentially unveil complex pathogenesis mechanisms, leading to effective diagnosis and treatment. The investigation of novel miRNA-disease associa...
Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.
01 Sep 2021
Follicular helper T (T) cells are a specialized subset of CD4 T cells that essentially support germinal center responses where high-affinity and long-lived humoral immunity is generated. The regulation of T cell survival remains unclear. Here we report that T cells show intensified lipid peroxidation and altered mitochondrial morphology, resembling the features of ferroptosis, a form of program...
Screening rates for diabetic retinopathy among Aboriginal and Torres Strait Islander women with hyperglycaemia in pregnancy: The PANDORA cohort study.
CLINICAL & EXPERIMENTAL OPHTHALMOLOGY - 01 Sep 2021
Genome-Wide Association Study Identifies a Functional Variant Associated With HDL-C (High-Density Lipoprotein Cholesterol) Levels and Premature Coronary Artery Disease.SIDT2
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Sep 2021
Low HDL-C (high-density lipoprotein cholesterol) is the most frequent dyslipidemia in Mexicans, but few studies have examined the underlying genetic basis. Our purpose was to identify genetic variants associated with HDL-C levels and cardiovascular risk in the Mexican population.A genome-wide association studies for HDL-C levels in 2335 Mexicans, identified four loci associated with genome-wide...
Sugar sweetened beverages and increasing prevalence of type 2 diabetes in the Indigenous community of Australia.
NUTRITION, METABOLISM, AND CARDIOVASCULAR DISEASES : NMCD - 22 Sep 2021
The aim of this viewpoint was to discuss a profound health gap in type 2 diabetes that exists between Indigenous and non-Indigenous Australians.In Australia, type 2 diabetes is ranked as the fastest growing chronic condition, with the rates of type 2 diabetes higher among Indigenous than non-Indigenous Australians. Improvements to diet could aid in reducing overweight and obesity in the Indigen...
Associations Between Fruit Intake and Risk of Diabetes in the AusDiab Cohort.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 27 Sep 2021
Fruit, but not fruit juice, intake is inversely associated with type 2 diabetes mellitus (T2DM). However, questions remain about the mechanisms by which fruits may confer protection.The aims of this work were to examine associations between intake of fruit types and 1) measures of glucose tolerance and insulin sensitivity and 2) diabetes at follow-up.Among participants of the Australian Diabete...
Totally Occluded Culprit Coronary Artery in Patients with Non-ST-Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Oct 2021
The short- and long-term implications of identifying totally occluded culprit coronary arteries (TOCCA) in patients presenting with non-ST-elevation myocardial infarction (NSTEMI) have not been well studied. This study compares clinical characteristics, short- and long-term outcomes of patients with NSTEMI identified with TOCCA to that of patients with non-TOCCA undergoing percutaneous coronary...
Factors Associated With Hypertension Awareness, Treatment, and Control Among Adults in Kerala, India.
FRONTIERS IN PUBLIC HEALTH - 01 Jan 2021
Hypertension, the most significant risk factor for cardiovascular disease, is an increasing contributor to global health burden, particularly in low- and middle-income countries (LMICs) such as India. While the rates of hypertension awareness, treatment, and control in India have been reported in several studies, the factors associated with these rates are less well-understood. Existing studies...
Editorial: Translational Approaches for Targeting Cardiovascular Complications of Diabetes.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2021
ASHA-Led Community-Based Groups to Support Control of Hypertension in Rural India Are Feasible and Potentially Scalable.
FRONTIERS IN MEDICINE - 01 Jan 2021
To improve the control of hypertension in low- and middle-income countries, we trialed a community-based group program co-designed with local policy makers to fit within the framework of India's health system. Trained accredited social health activists (ASHAs), delivered the program, in three economically and developmentally diverse settings in rural India. We evaluated the program's implementa...
The role of β adrenergic receptor on infection development after ischaemic stroke.2
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH - 01 Dec 2021
Mechanisms underlying post-stroke immune impairments and subsequent development of fatal lung infection have been suggested to involve multiple pathways, including hyperactivation of the sympathetic nervous system (SNS), which results in the excessive release of catecholamines and activation of β-adrenergic receptors (βARs). Indeed, previous reports from experimental studies demonstrated that p...
Author Correction: Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.
01 Dec 2021
Ultrasonic particles: An approach for targeted gene delivery.
ADVANCED DRUG DELIVERY REVIEWS - 01 Dec 2021
Gene therapy has been widely investigated for the treatment of genetic, acquired, and infectious diseases. Pioneering work utilized viral vectors; however, these are suspected of causing serious adverse events, resulting in the termination of several clinical trials. Non-viral vectors, such as lipid nanoparticles, have attracted significant interest, mainly due to their successful use in vaccin...
