Publications
Now showing items 1881-1900 of 5325 records
Pathophysiology and therapeutic relevance of PI3K(p110α) protein in atrial fibrillation: A non-interventional molecular therapy strategy.
PHARMACOLOGICAL RESEARCH - 01 Mar 2021
Genetically modified animal studies have revealed specific expression patterns and unequivocal roles of class I PI3K isoenzymes. PI3K(p110α), a catalytic subunit of class I PI3Ks is ubiquitously expressed and is well characterised in the cardiovascular system. Given that genetic inhibition of PI3K(p110α) causes lethal phenotype embryonically, the catalytic subunit is critically important in hou...
Improving reporting standards for polygenic scores in risk prediction studies.
NATURE - 01 Mar 2021
Polygenic risk scores (PRSs), which often aggregate results from genome-wide association studies, can bridge the gap between initial discovery efforts and clinical applications for the estimation of disease risk using genetics. However, there is notable heterogeneity in the application and reporting of these risk scores, which hinders the translation of PRSs into clinical care. Here, in a colla...
Interrupting Prolonged Sitting and Endothelial Function in Polycystic Ovary Syndrome.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE - 01 Mar 2021
In healthy adults, the impairment of vascular function associated with prolonged sitting can be mitigated with intermittent brief bouts of activity. It is unknown whether these benefits extend to women with polycystic ovary syndrome (PCOS), in whom vascular function is typically impaired and sitting time is high. We examined the acute effect of regularly interrupting sitting time with brief sim...
Marshalling the Tools for Successful Endocardial Atrial Ablation.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Mar 2021
Can the Past Re-Shape the Future?: New Insights Into PVC-Mediated Cardiomyopathy From the CHF-STAT Trial and the Retelling of a Familiar Story.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Mar 2021
Cardiac Imaging for Coronary Heart Disease Risk Stratification in Chronic Kidney Disease.
JACC. CARDIOVASCULAR IMAGING - 01 Mar 2021
Chronic kidney disease (CKD), defined as dysfunction of the glomerular filtration apparatus, is an independent risk factor for the development of coronary artery disease (CAD). Patients with CKD are at a substantially higher risk of cardiovascular mortality compared with the age- and sex-adjusted general population with normal kidney function. The risk of CAD and mortality in patients with CKD ...
Projecting the Transmitral Mean Gradient in Degenerative Mitral Stenosis for Heart Rate and Stroke Volume.
JACC. CARDIOVASCULAR IMAGING - 01 Mar 2021
The intersect of genetics, environment, and microbiota in asthma-perspectives and challenges.
THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY - 01 Mar 2021
In asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition...
RE: Blockade of apoptosis signal-regulating kinase 1 ameliorates cardiac dysfunction in cardiorenal syndrome via enhancing angiogenesis.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 01 Mar 2021
Gaps in the Care of Familial Hypercholesterolaemia in Australia: First Report From the National Registry.
HEART, LUNG & CIRCULATION - 01 Mar 2021
Familial hypercholesterolaemia (FH) is under-diagnosed and under-treated worldwide, including Australia. National registries play a key role in identifying patients with FH, understanding gaps in care and advancing the science of FH to improve care for these patients.The FH Australasia Network has established a national web-based registry to raise awareness of the condition, facilitate service ...
Can post-mortem coronary artery calcium scores aid diagnosis in young sudden death?
FORENSIC SCIENCE, MEDICINE, AND PATHOLOGY - 01 Mar 2021
This study sought to explore the feasibility and utility of post-mortem coronary artery calcium (CAC) scoring in identifying patients with ischemic heart disease as cause of sudden death. 100 deceased patients aged 18-50 years underwent post-mortem examination in the setting of sudden death. At post-mortem, fifty cases were determined to have ischemic heart disease, and fifty had death attribut...
Factors influencing patient decision delay in activation of emergency medical services for suspected ST-elevation myocardial infarction.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING : JOURNAL OF THE WORKING GROUP ON CARDIOVASCULAR NURSING OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 01 Mar 2021
The purpose of this study was to identify factors associated with time delay to emergency medical services for patients with suspected ST-elevation myocardial infarction.This observational study involved 1994 suspected ST-elevation myocardial infarction patients presenting to the emergency medical services in Melbourne, Australia, between October 2011-January 2014. Factors associated with delay...
Alarmin-activated B cells accelerate murine atherosclerosis after myocardial infarction via plasma cell-immunoglobulin-dependent mechanisms.
EUROPEAN HEART JOURNAL - 01 Mar 2021
Myocardial infarction (MI) accelerates atherosclerosis and greatly increases the risk of recurrent cardiovascular events for many years, in particular, strokes and MIs. Because B cell-derived autoantibodies produced in response to MI also persist for years, we investigated the role of B cells in adaptive immune responses to MI.We used an apolipoprotein-E-deficient (ApoE-/-) mouse model of MI-ac...
Productivity Benefits of Preventing Type 2 Diabetes in Australia: A 10-Year Analysis.
DIABETES CARE - 01 Mar 2021
Diabetes imposes a heavy burden on both health and productivity. In this study, we sought to estimate the potential productivity gains associated with the prevention of type 2 diabetes over the next 10 years in Australia.Dynamic life table models were constructed to estimate years of life lived and productivity-adjusted life-years (PALYs) lived by Australians aged 20-69 years over the period fr...
Specific NLRP3 Inhibition Protects Against Diabetes-Associated Atherosclerosis.
DIABETES - 01 Mar 2021
Low-grade persistent inflammation is a feature of diabetes-driven vascular complications, in particular activation of the Nod-like receptor family pyrin domain containing 3 (NLRP3) inflammasome to trigger the maturation and release of the inflammatory cytokine interleukin-1β (IL-1β). We investigated whether inhibiting the NLRP3 inflammasome, through the use of the specific small-molecule NLRP3 ...
Comparison of ambulatory blood pressure between patients with primary aldosteronism and other forms of hypertension.
CLINICAL ENDOCRINOLOGY - 01 Mar 2021
Primary aldosteronism (PA) is a potentially curable cause of hypertension associated with worse cardiovascular prognosis than blood pressure-matched essential hypertension (EH). Effective targeted treatment for PA is available with the greatest benefit seen if treatment is started early, prior to the development of end-organ damage. However, PA is currently substantially under-diagnosed. The st...
Case of Mistaken Identity: Cobalt Cardiomyopathy Versus Amyloidosis on Cardiac MRI.
CIRCULATION. CARDIOVASCULAR IMAGING - 01 Mar 2021
Role of Mineralocorticoid and Angiotensin Type 1 Receptors in the Paraventricular Nucleus in Angiotensin-Induced Hypertension.
FRONTIERS IN PHYSIOLOGY - 01 Jan 2021
The hypothalamic paraventricular nucleus (PVN) is an important site where an interaction between circulating angiotensin (Ang) and mineralocorticoid receptor (MR) activity may modify sympathetic nerve activity (SNA) to influence long-term elevation of blood pressure. We examined in conscious Ang II-treated rabbits, the effects on blood pressure and tonic and reflex renal SNA (RSNA) of microinje...
The Preventable Productivity Burden of Kidney Disease in Australia.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : JASN - 09 Mar 2021
Kidney disease is associated with impaired work productivity. However, the collective effect of missed work days, reduced output at work, and early withdrawal from the workforce is rarely considered in health-economic evaluations.To determine the effect on work productivity of preventing incident cases of kidney disease, using the novel measure "productivity-adjusted life year" (PALY), we const...
DAMPening Mortality in COVID-19: Therapeutic Insights From Basic Cardiometabolic Studies on S100A8/A9.
CIRCULATION - 09 Mar 2021
