Publications
Now showing items 1841-1860 of 5325 records
Evolution of Myocardial Dysfunction in Asymptomatic Patients at Risk of Heart Failure.
JACC. CARDIOVASCULAR IMAGING - 01 Feb 2021
The determinants of changes in systolic and diastolic parameters in patients age >65 years, at risk of heart failure (HF), and with and without asymptomatic type 2 diabetes mellitus (T2DM) was assessed by echocardiography. The association between metformin and myocardial function was also assessed.The increasing prevalence of T2DM will likely further fuel the epidemic of HF. Understanding the d...
Reallocating sedentary time with total physical activity and physical activity bouts in children: Associations with cardiometabolic biomarkers.
JOURNAL OF SPORTS SCIENCES - 01 Feb 2021
This cross-sectional study examined theoretical effects of reallocating sedentary time (SED) with total physical activity, and physical activity bouts of varying intensities, on children's cardiometabolic biomarkers. Baseline data from the Transform-Us! trial (Melbourne, Australia) was used. Participant data were included if accelerometer and blood biomarker data were complete (n = 169; 8.7 [0....
Excellent suppression of physiological myocardial FDG activity in patients with cardiac sarcoidosis.
JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY - 01 Feb 2021
Suppression of physiological myocardial FDG activity is vital in patients undergoing PET/CT for assessment of known or suspected cardiac sarcoidosis. This study aims to evaluate the efficacy of physiological myocardial FDG suppression following a protocol change to a 24-h high fat very low carbohydrate (HFVLC) diet and prolonged fast.A retrospective review of patients undergoing FDG PET/CT for ...
Nocturnal hypertension: a common phenotype in a tertiary clinical setting associated with increased arterial stiffness and central blood pressure.
JOURNAL OF HYPERTENSION - 01 Feb 2021
Although the detrimental effect of increased mean blood pressure (BP) is well established, the role of the dynamic and circadian features of BP is less well defined but may be similarly important. In this prospective analysis of hypertensive patients from a tertiary hospital hypertension clinic, we investigated whether the presence of night-time systolic hypertension is associated with more pro...
Identifying new cellular mechanisms of mineralocorticoid receptor activation in the heart.
JOURNAL OF HUMAN HYPERTENSION - 01 Feb 2021
Recent studies have expanded our understanding of the actions of the mineralocorticoid receptor (MR) to a diverse array of tissue types that differ substantially from the epithelial cells of the renal nephron. In these cell types the role of the MR has been largely, but not exclusively, defined in terms of pathogenic signalling pathways leading to tissue injury and remodelling. Macrophages and ...
Diet-related gut microbial metabolites and sensing in hypertension.
JOURNAL OF HUMAN HYPERTENSION - 01 Feb 2021
Advances in sequencing technology have increased our understanding of the composition of the gut microbiota and their contribution to health and disease states, including in cardiovascular diseases such as hypertension. The gut microbiota is heavily influenced by diet and produce metabolites such as short-chain fatty acids (SCFAs) and trimethylamine-N-oxide (TMAO) from various food sources. SCF...
CPAP increases physical activity in obstructive sleep apnea with cardiovascular disease.
JOURNAL OF CLINICAL SLEEP MEDICINE : JCSM : OFFICIAL PUBLICATION OF THE AMERICAN ACADEMY OF SLEEP MEDICINE - 01 Feb 2021
Uncertainty exists over whether continuous positive airway pressure (CPAP) treatment improves moderate to vigorous physical activity levels in those with obstructive sleep apnea. We aimed to determine effects of CPAP on moderate to vigorous physical activity among participants with co-occurring cardiovascular disease and obstructive sleep apnea.The Sleep Apnea cardioVascular Endpoints (SAVE) tr...
Microvascular changes at different stages of chronic kidney disease.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 01 Feb 2021
Patients with progressing chronic kidney disease (CKD) are more likely to experience cardio- and cerebrovascular events than progressing to end-stage renal disease. The authors explored whether retinal microvascular calibers differed with the degree of renal impairment and between the standard and extended optic disk and may serve as a simple additional tool for risk stratification in this high...
Reducing intracranial pressure by reducing central venous pressure: assessment of potential countermeasures to spaceflight-associated neuro-ocular syndrome.
JOURNAL OF APPLIED PHYSIOLOGY (BETHESDA, MD. : 1985) - 01 Feb 2021
Spaceflight-associated neuro-ocular syndrome (SANS) involves unilateral or bilateral optic disc edema, widening of the optic nerve sheath, and posterior globe flattening. Owing to posterior globe flattening, it is hypothesized that microgravity causes a disproportionate change in intracranial pressure (ICP) relative to intraocular pressure. Countermeasures capable of reducing ICP include thigh ...
Feasibility, Reproducibility, and Clinical Implications of the Novel Fully Automated Assessment for Global Longitudinal Strain.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 01 Feb 2021
Despite evidence of its usefulness, measurement of global longitudinal strain (GLS) has not been widely accepted as a clinical routine, because it requires proficiency and is time consuming. Automated assessment of GLS may be the solution for this situation. The aim of this study was to investigate the feasibility, reproducibility, and predictive value of automated strain analysis compared with...
The Australia and New Zealand Cardio-Oncology Registry: evaluation of chemotherapy-related cardiotoxicity in a national cohort of paediatric cancer patients.
INTERNAL MEDICINE JOURNAL - 01 Feb 2021
Cancer therapy related cardiac dysfunction (CTRCD) is an area of increasing focus, particularly during the survivorship period, for paediatric, adolescent and adult cancer survivors. With the advent of immunotherapy and targeted therapy, there is a new set of mechanisms from which paediatric and young adult patients with cancer may suffer cardiovascular injury. Furthermore, cardiovascular disea...
Impact of disease stage on the performance of strain markers in the prediction of atrial fibrillation.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 01 Feb 2021
Assessing atrial fibrillation (AF) risk may be useful in primary prevention (PP; people with risk factors) and secondary prevention (SP; eg. embolic stroke of unknown source). We sought whether disease stage influenced the prediction of AF by echocardiography.We compared a PP cohort (351 community-based participants ≥65 years with ≥1 risk factor for AF) and a SP cohort (453 patients after trans...
Practical Guidance for Food Consumption to Prevent Cardiovascular Disease.
HEART, LUNG & CIRCULATION - 01 Feb 2021
This dietary guidance, informed by best contemporary evidence, aims to assist medical practitioners and allied health professionals in advising patients for the primary and secondary prevention of cardiovascular disease (CVD). While differing in some details from other current guidelines, the core messages accord with those published in 2019 by the American College of Cardiology/American Heart ...
The role of systolic-diastolic coupling in distinguishing impaired diastolic recoil in healthy aging and heart failure with preserved ejection fraction.
ECHOCARDIOGRAPHY (MOUNT KISCO, N.Y.) - 01 Feb 2021
Age-related changes to left ventricular (LV) early diastolic recoil confound the diagnostic value of e' velocity in heart failure with preserved ejection fraction (HFpEF). Systolic-diastolic coupling quantifies passive left ventricular elastic recoil and may be superior to e' in differentiating abnormal diastolic recoil in HFpEF from healthy aging. This study aims to determine the effect of hea...
The association of socioeconomic disadvantage and remoteness with receipt of type 2 diabetes medications in Australia: a nationwide registry study.
DIABETOLOGIA - 01 Feb 2021
In recent years, several new medications for the treatment of type 2 diabetes have been released and some evidence indicates sociodemographic disparity in their utilisation. We sought to investigate sociodemographic disparities in receipt of diabetes medications across Australia.This study included 1,203,317 people with type 2 diabetes registered on the Australian National Diabetes Services Sch...
Impact of age at type 2 diabetes mellitus diagnosis on mortality and vascular complications: systematic review and meta-analyses.
DIABETOLOGIA - 01 Feb 2021
Few studies examine the association between age at diagnosis and subsequent complications from type 2 diabetes. This paper aims to summarise the risk of mortality, macrovascular complications and microvascular complications associated with age at diagnosis of type 2 diabetes.Data were sourced from MEDLINE and All EBM (Evidence Based Medicine) databases from inception to July 2018. Observational...
Can patterns of medication use explain the increasing incidence of end stage kidney disease among people with diabetes in Australia?
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Feb 2021
Recently, an increase in the incidence of end-stage kidney disease (ESKD) among people with type 2 diabetes (T2D) aged < 50 years and ≥ 80 years has been observed in Australia. We examined whether patterns of medication use are likely to explain these trends.Among National Diabetes Services Scheme registrants, we determined the annual prevalence of dispensed glucose-lowering (GL), blood-pressur...
The International Diabetes Federation's guide for diabetes epidemiological studies.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Feb 2021
Sedentary Behavior and Diabetes Risk Among Women Over the Age of 65 Years: The OPACH Study.
DIABETES CARE - 01 Feb 2021
To evaluate whether sedentary time (ST) and/or sedentary behavior patterns are related to incident diabetes in the U.S.'s oldest age-groups.Women without physician-diagnosed diabetes ( = 4,839, mean ± SD age = 79 ± 7 years) wore accelerometers for ≥4 days and were followed up to 6 years for self-reported newly diagnosed diabetes requiring treatment with medications. Hazard ratios (HRs) for inci...
Recording and quantifying sympathetic outflow to muscle and skin in humans: methods, caveats and challenges.
CLINICAL AUTONOMIC RESEARCH : OFFICIAL JOURNAL OF THE CLINICAL AUTONOMIC RESEARCH SOCIETY - 01 Feb 2021
The development of microneurography, in which the electrical activity of axons can be recorded via an intrafascicular microelectrode inserted through the skin into a peripheral nerve in awake human participants, has contributed a great deal to our understanding of sensorimotor control and the control of sympathetic outflow to muscle and skin. This review summarises the different approaches to r...
