Publications
Now showing items 181-200 of 5702 records
Redefining Osteoporosis: A Global Call for Equity, Evidence, and Access- Perspectives from Asia and Africa.
ENDOCRINE PRACTICE : OFFICIAL JOURNAL OF THE AMERICAN COLLEGE OF ENDOCRINOLOGY AND THE AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS - 30 Jan 2026
Activator protein-1 (AP-1) inhibition prevents endothelial to mesenchymal transition in diabetes-associated atherosclerosis: a translational study.
CARDIOVASCULAR DIABETOLOGY - 29 Jan 2026
Endothelial to mesenchymal transition (EndMT), the transformation of endothelial cells into a mesenchymal-like state, is regulated by various factors, including transcription factors such as activator protein 1 (AP-1). While recent studies have confirmed the role of EndMT in atherosclerosis, the involvement of AP-1 in EndMT, particularly in the context of human diabetes, remains unclear. This s...
Global, Regional, and National Estimates of Undiagnosed Diabetes in Adults: Findings From the 2025 IDF Diabetes Atlas.
DIABETES CARE - 28 Jan 2026
Undiagnosed diabetes leads to delayed treatment and increased risk of complications, exacerbating global disease burdens. In this study, we estimated the prevalence and absolute numbers of individuals with undiagnosed diabetes globally and across regions and quantified gaps in national diabetes detection efforts. We systematically compiled estimates of biomarker-based diabetes prevalence and se...
Statin initiation among cancer survivors with asymptomatic coronary atherosclerosis.
CARDIO-ONCOLOGY (LONDON, ENGLAND) - 19 Jan 2026
Multi-omic analysis of human PHACTR1 signaling networks.
COMMUNICATIONS BIOLOGY - 19 Jan 2026
Genetic studies have linked PHACTR1 to a range of vascular diseases, underscoring its pivotal role in vascular biology. However, the full spectrum of PHACTR1-mediated signaling pathways remains largely unexplored. To bridge this gap, we employ a multi-omics pipeline combining pairwise differential expression analysis, multi-omics pathway integration, and feature-level correlation analyses acros...
A Context-Adapted Diabetes Prevention Program (Small Steps for Big Changes) in Australia: Protocol for a Hybrid Implementation-Effectiveness Study.
19 Jan 2026
With type 2 diabetes rates escalating worldwide, including in Australia, effective, acceptable, sustainable, and scalable diabetes prevention programs are needed. Small Steps for Big Changes (SSBC) is a Canadian-developed, community-delivered diet and exercise counseling intervention for individuals at risk of type 2 diabetes. The 3- to 6-week intervention can be delivered by trained non-health...
Ketone Profiles in Community-Dwelling Adults with Type 1 Diabetes Using Continuous Ketone Monitoring.
DIABETES TECHNOLOGY & THERAPEUTICS - 12 Feb 2026
We aimed to assess continuous ketone monitor (CKM) profiles in community-dwelling adults with type 1 diabetes. Two-weeks CKM (Abbott, Alameda, CA) run-in data (PARTNER study: ACTRN12624000448549) were analyzed by groups <0.6, 0.6-0.9, and ≥1.0 mmol/L defined as at least one reading in the highest ketone range. Results are median interquartile range (IQR). Sixty-four participants (age 49.8 [40.2...
Glycemic Outcomes During Outpatient Use of Automated Insulin Delivery Without Meal Announcement in Adults with Type 1 Diabetes: Results from the CLOSE IT Randomized Controlled Trial.
DIABETES TECHNOLOGY & THERAPEUTICS - 12 Feb 2026
Current automated insulin delivery (AID) systems recommend manual insulin delivery prior to meals (hybrid closed-loop [HCL]). Data are needed on the efficacy of an AID system without meal announcement. In this randomized, open-label, parallel-arm trial, we established participants with type 1 diabetes aged 18-70 years on an open-source AID system, with meal announcement, during a 12-week run-in...
Structural and functional modifications of neuronal lipid rafts: implications for HIV-associated neurological disorders.
JOURNAL OF NEUROINFLAMMATION - 11 Feb 2026
The association between smoking and diabetic neuropathy: a systematic review and meta-analysis.
24 Dec 2025
The study aimed to systematically review the evidence on the association between smoking and the risk of diabetic neuropathy, with a particular emphasis on the risk of peripheral neuropathy among individuals with diabetes mellitus. MEDLINE, EMBASE, SCOPUS, and CENTRAL databases were searched for studies published before August 2024. Cross-sectional, case-control, and cohort studies that assesse...
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance.
AGING AND DISEASE - 25 Dec 2025
The decline in ovarian endocrine function represents a pivotal event in female aging, initiating systemic biological deterioration well before the end of reproductive capacity. We propose that Hormone Replacement Therapy (HRT) may constitute an early stage geroprotective intervention with mechanistic relevance across the 12 hallmarks of aging. Despite extensive clinical use, HRT remains underut...
Emotional Management In Chronic Disease.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2025
Persons living with chronic disease present with a wide array of emotions. These range from affable and accepting, action- oriented attitude, to anxious, afraid or apathic, adynamic acceptance of disease. Yet others may be argumentative and angry, or openly aggressive and antisocial. Increasingly, primary care practitioners also encounter 'pseudo academic' or hyperaware' patients, who base thei...
Impactful behavioural therapy (IBT) in obesity care.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Dec 2025
Intensive behavioural therapy is said to be the first line treatment of obesity. The choice of the adjective 'intensive', however, is open to debate. The term 'impactful behavioural therapy' seems more appropriate for the management of persons living with obesity. This refers to a sustained supportive psychosocial intervention, embedded in routine care, designed to modify existing behaviours, a...
High-salt diet induces immune-independent re-differentiation, metabolic shut down and cell cycle arrest of melanoma.
CELL DEATH & DISEASE - 20 Dec 2025
High salt diet (HSD) is known to reduce cancer growth in some tumor models, which has been attributed to tissue accumulation of sodium that enhances local anti-tumor immunity. Here, we show that a HSD inhibits melanoma growth independent of sodium accumulation and immune cells in skin and lung. Melanoma cells from mice on a HSD upregulated the metabolic inhibitor Tuberous sclerosis complex 2 (T...
Immune and metabolic signatures characterise constipation-driven endophenotypes in Parkinson's disease.
NPJ PARKINSON'S DISEASE - 20 Dec 2025
Parkinson's disease (PD) is a progressive neurodegenerative disorder defined by motor impairments. However, people with PD (PwPD) experience a defined spectrum of non-motor symptoms, with gastrointestinal dysfunction the most common and earliest-presenting. Evidence suggests that PD pathology may originate in the gut, where microbial dysbiosis and immune dysregulation contribute to neuroinflamm...
PM2.5 promotes non-small cell lung cancer tumorigenesis by miR-21-5p targeting <i>PDE4DIP</i> accumulated.
TRANSLATIONAL CANCER RESEARCH - 30 Nov 2025
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide. Fine particulate matter (PM2.5) is associated with increased risk of lung cancer. microRNAs (miRNAs) play an important role in a variety of cancers, including NSCLC. In NSCLC, existing literature has revealed upregulation of miR-21-5p. Nonetheless, the molecular mechanism of miR-21-5p in NSCLC develop...
Diabetes in adolescents without obesity in India: An underrecognized phenotype.
WORLD JOURNAL OF CLINICAL PEDIATRICS - 09 Dec 2025
Adolescent type 2 diabetes mellitus (T2DM) is on the rise in India and is commonly attributed to co-existence of overweight and obesity in adolescents. In this line, a study by Maheshwari <i>et al</i> titled 'Prevalence of obesity, determinants, and its association with hyperglycaemia among community dwelling older adolescents in India' concluded that overweight, obesity, socioeconomic factors ...
Soluble RAGE further stratifies risk of coronary artery and end-stage kidney disease in high-risk individuals with type 1 diabetes and treatment-resistant hypertension.
CARDIOVASCULAR DIABETOLOGY - 12 Dec 2025
Soluble receptor for advanced glycation end-products (sRAGE) modulates RAGE-mediated inflammation and oxidative stress. We investigated if sRAGE stratifies cardiovascular and kidney disease risk in individuals with type 1 diabetes and baseline treatment-resistant hypertension (TRH). This study included 1262 adults with type 1 diabetes from the FinnDiane study who were on antihypertensive therap...
Midlife and the menopause transition in type 2 diabetes mellitus prevention.
NATURE REVIEWS. ENDOCRINOLOGY - 01 Dec 2025
Sleep and physical activity trade-offs and dementia risk: a prospective cohort study in UK Biobank participants.
BMC MEDICINE - 03 Dec 2025
Engaging in regular physical activity and obtaining recommended amounts of sleep are touted as strategies to promote healthy brain aging. However, as each day is only 24 h long, changing time spent in one activity must come at the expense or gain of another, making it necessary to understand how the whole 24-h activity composition is associated with dementia risk. We investigated the effect of ...
