Publications
Now showing items 181-200 of 5582 records
Health Care Cost Burden of Atrial Fibrillation Presentations to Emergency Departments.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jun 2025
Pulsed Field Ablation for Atrial Fibrillation in Hypertrophic Cardiomyopathy: The Plot Thickens.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jun 2025
Turning Back Time: Regression to Paroxysmal or No AF From Persistent AF With Cryoablation.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jun 2025
Identification and Validation of Novel Lipids Linked to Bone Mineral Density Change and Fracture Risk.
CALCIFIED TISSUE INTERNATIONAL - 25 Jun 2025
To identify and validate lipid metabolites associated with bone mineral density (BMD) change and fracture risk through integrated Mendelian randomization (MR) and observational analyses. Two-sample MR analysis was first performed to uncover potential causal relationships between 32 lipid classes and 576 lipid species and BMD and fractures. Identified signatures were subsequently validated in an...
Management of metabolic dysfunction-associated steatotic liver disease (MASLD)-An expert consensus statement from Indian diabetologists' perspective.
DIABETES, OBESITY & METABOLISM - 02 Jun 2025
In India, the increasing prevalence of diabetes and obesity poses a significant threat towards a surge in the incidence of metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease (NAFLD). Concomitant with the evolving guidelines, there is a need to direct and spread awareness among practicing diabetologists to identify and screen hig...
Mechanical unloading is accompanied by reverse metabolic remodelling in the failing heart: Identification of a novel citraconate-mediated pathway.
EUROPEAN JOURNAL OF HEART FAILURE - 04 Jun 2025
Although functional recovery of the failing heart with left ventricular assist device (LVAD) unloading can occur, the underpinning mechanism is unclear. We aimed to characterize the effect of myocardial biochemical effect of LVAD support in vivo and in vitro. We performed targeted metabolomics and lipidomics on transcardiac (arterial and coronary sinus) blood samples collected from healthy volu...
Cardiometabolic determinants of aortic and carotid intima-media thickness in adolescence.
ATHEROSCLEROSIS - 21 May 2025
Comprehensive longitudinal data in healthy populations on cardiometabolic determinants of arterial intima-media thickness (IMT), especially aortic IMT, in adolescence are lacking. We aimed to examine in detail how cardiometabolic risk factors associate with aortic and carotid intima-media thickness (IMT) in adolescence. Participants (n = 522) were healthy individuals from Special Turku Coronary...
Global type 1 diabetes prevalence, incidence, and mortality estimates 2025: Results from the International diabetes Federation Atlas, 11th Edition, and the T1D Index Version 3.0.
DIABETES RESEARCH AND CLINICAL PRACTICE - 22 May 2025
Globally, symptomatic type 1 diabetes (T1D) prevalence varies markedly. The International Diabetes Federation 11thEdition Atlas/T1D Index Version 3.0 estimated 2025 numbers for 202 countries/territories ("countries"), and projected to2040. The T1D Index model, a Markov model with sub-models for incidence-over-time, adult incidence, and mortality-over-time, was updated with recent population-bas...
Differentiating Physical Activity Frequency and Density-Commentary on: "Optimal Frequency of Interrupting Prolonged Sitting for Cardiometabolic Health: A Systematic Review and Meta-Analysis of Randomized Crossover Trials".
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS - 01 Jun 2025
Visceral adipose tissue demonstrates a stronger association with venous thromboembolism than body mass index.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS : JTH - 27 May 2025
Increased body mass index (BMI) is associated with an increased risk of venous thrombosis. However, recent data has highlighted that visceral adipose tissue (VAT) volume may be a better marker of cardiometabolic risk. To investigate the relationship between VAT volume and VTE risk and explore whether increased VAT volumes is associated with VTE risk. We performed a cross-sectional study utilisi...
Associations of context-specific sitting time with depressive symptoms in middle-aged and older adults with and without abnormal glucose metabolism.
DIABETES RESEARCH AND CLINICAL PRACTICE - 15 May 2025
The relationship between sitting time and depressive symptoms may be influenced by contextual factors, including the sitting domain, type, and cognitive activity. Research on these dynamics among people with abnormal glucose metabolism (AGM) is limited. We examined associations between contextual sitting time and depressive symptoms in adults with and without AGM (IFG, IGT, T2D). Data were obta...
The Cold Spark: A Novel Synergistic Paradigm With Pulsed Field Cryoablation.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 21 May 2025
Rare pathogenic variants in G-protein-coupled receptor genes involved in gut-to-host communication are associated with cardiovascular disease risk.
CARDIOVASCULAR RESEARCH - 22 May 2025
Outcomes of Septal Myectomy Associated With Surgical Volume.
HEART, LUNG & CIRCULATION - 22 May 2025
Previous studies have reported an inverse relationship between hospital septal myectomy (SM) volume and outcomes, without assessments of surgeon volume and SM outcomes. This Australia and New Zealand-based study sought to appraise the relationships between hospital volume, surgeon volume, and SM outcomes. Data were collected from the Australian and New Zealand Society of Cardiac and Thoracic Su...
Shear-Dependent Platelet Aggregation by ChAdOx1 nCoV-19 Vaccine: A Novel Biophysical Mechanism for Arterial Thrombosis.
BLOOD - 13 May 2025
Rare thrombotic events associated with ChAdOx1 nCoV-19 (ChAdOx1) vaccination have raised concerns; however, the underlying mechanisms remain elusive. Here we report a novel biophysical mechanism by which ChAdOx1 directly interacts with platelets under arterial shear conditions, potentially contributing to post-vaccination arterial thrombosis. Using microfluidic post assays, we demonstrate that ...
Lipidomic Profiling of a Preclinical Model of Streptozotocin-Induced Diabetic Cardiomyopathy Reveals Potential Plasma Biomarkers.
HEART, LUNG & CIRCULATION - 13 May 2025
Cross-talk between microbiota-gut-brain axis and blood pressure regulation.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 08 May 2025
Hypertension, or high blood pressure (BP), is a widespread condition affecting one in three adults globally. Despite the availability of treatment options, 50% of hypertensive patients in countries such as Australia fail to achieve adequate BP control, often due to a lack of response to current therapies. Diet plays a crucial role in BP regulation. A high-fibre diet reduces BP through the gut m...
Multiparity induces persistent myocardial structural, functional and transcriptomic remodelling in mice.
SCIENTIFIC REPORTS - 07 Jul 2025
Pregnancy poses unique hemodynamic and metabolic demands on the heart. Recent data suggests that a history of multiple pregnancies may be associated with a late-term increased risk of heart failure with preserved ejection fraction (HFpEF), however, the mechanistic basis is unknown. We postulated that the repetitive biological and hemodynamic impact of multiple pregnancies could cause persistent...
Annexin-A1 deficiency uncovers female-specific pathways in blood pressure control and cardiovascular remodeling in mice.
COMMUNICATIONS BIOLOGY - 06 Jul 2025
Cardiovascular disease exhibits distinct sex-based differences, yet the mechanisms underlying these differences remain under-explored. The pro-resolving mediator annexin-A1 (ANXA1) is a pivotal regulator in inflammation resolution and tissue homeostasis, including within the cardiovascular system. However, the sex-specific differences in ANXA1 in blood pressure regulation have not been investig...
Variation and prognostic potential of the gut antibiotic resistome in the FINRISK 2002 cohort.
NATURE COMMUNICATIONS - 01 Jul 2025
The spread of antibiotic-resistant bacteria has severely reduced the efficacy of antibiotics and now contributes to 1 million deaths annually. The gut microbiome is a major reservoir of antibiotic resistance in humans, yet the extent to which gut antibiotic resistance gene load varies within human populations and the drivers that contribute most to this variation remain unclear. Here, we demons...
