Publications
Now showing items 181-200 of 5325 records
Genome-wide characterization of 54 urinary metabolites reveals molecular impact of kidney function.
NATURE COMMUNICATIONS - 02 Jan 2025
Dissecting the genetic mechanisms underlying urinary metabolite concentrations can provide molecular insights into kidney function and open possibilities for causal assessment of urinary metabolites with risk factors and disease outcomes. Proton nuclear magnetic resonance metabolomics provides a high-throughput means for urinary metabolite profiling, as widely applied for blood biomarker studie...
Single-pulse transcranial magnetic stimulation of the dorsolateral prefrontal cortex does not directly affect muscle sympathetic nerve activity in humans.
CEREBRAL CORTEX (NEW YORK, N.Y. : 1991) - 03 Dec 2024
Transcranial magnetic stimulation (TMS) is applied both in research settings and clinically, notably in treating depression through the dorsolateral prefrontal cortex (dlPFC). We have recently shown that transcranial alternating current stimulation of the dlPFC partially entrains muscle sympathetic nerve activity (MSNA) to the stimulus. We, therefore, aimed to further explore the sympathetic pr...
Computed Tomography Coronary Angiography Is Feasible and Reliable for Proximal Coronary Segment Interpretation in Patients with Elevated Body Mass Index.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE - 11 Dec 2024
Computed tomography coronary angiography (CTCA) is under-utilised in detecting coronary artery disease (CAD) in obese patients due to concerns about non-evaluable testing. We hypothesise that these concerns are predominantly related to smaller and branch coronary vessels, and CTCA remains adequate for proximal segment stenosis interpretation, which has significant clinical implications. This re...
Advancing type 1 diabetes therapy: autologous islet transplant breakthrough.
SIGNAL TRANSDUCTION AND TARGETED THERAPY - 23 Dec 2024
Assessing the predicted impact of single amino acid substitutions in calmodulin for CAGI6 challenges.
HUMAN GENETICS - 23 Dec 2024
Recent thermodynamic and functional studies have been conducted to evaluate the impact of amino acid substitutions on Calmodulin (CaM). The Critical Assessment of Genome Interpretation (CAGI) data provider at University of Verona (Italy) measured the melting temperature (T<sub>m</sub>) and the percentage of unfolding (%unfold) of a set of CaM variants (CaM challenge dataset). Thermodynamic meas...
Predicting Type 2 Diabetes and Testosterone Effects in high-risk Australian men: Development and external validation of a 2 year risk model.
25 Dec 2024
We have shown that men aged 50 years+ at high risk of type 2 diabetes treated with testosterone together with a lifestyle program reduced the risk of type 2 diabetes at two years by 40% compared to a lifestyle program alone. To develop a personalized approach to treatment, we aimed to explore a prognostic model for incident type 2 diabetes at two years and investigate biomarkers predictive of t...
IUPHAR Themed Review: The Gut Microbiome in Schizophrenia.
PHARMACOLOGICAL RESEARCH - 26 Dec 2024
Gut microbial dysbiosis or altered gut microbial consortium, in schizophrenia suggests a pathogenic role through the gut-brain axis, influencing neuroinflammatory and neurotransmitter pathways critical to psychotic, affective, and cognitive symptoms. Paradoxically, conventional psychotropic interventions may exacerbate this dysbiosis, with antipsychotics, particularly olanzapine, demonstrating ...
Blood methylation biomarkers are associated with diabetic kidney disease progression in type 1 diabetes.
MEDRXIV : THE PREPRINT SERVER FOR HEALTH SCIENCES - 29 Nov 2024
DNA methylation differences are associated with kidney function and diabetic kidney disease (DKD), but prospective studies are scarce. Therefore, we aimed to study DNA methylation in a prospective setting in the Finnish Diabetic Nephropathy Study type 1 diabetes (T1D) cohort. We analysed baseline blood sample-derived DNA methylation (Illumina's EPIC array) of 403 individuals with normal albumin...
Cost-effectiveness of oral immunotherapy for egg allergy according to age of therapy commencement.
THE JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. IN PRACTICE - 13 Dec 2024
Egg oral immunotherapy can induce desensitization or remission of egg allergy in children. To determine the cost-effectiveness of OIT for raw egg allergy in school-aged children compared to egg avoidance, and the most cost-effective age at which to commence treatment. A decision-analytic Markov model estimated the health and cost outcomes of 1000 children aged four years with egg allergy, compa...
Personalized Profiling of Lipoprotein and Lipid Metabolism Based on 1018 Measures from Combined Quantitative NMR and LC-MS/MS Platforms.
ANALYTICAL CHEMISTRY - 16 Dec 2024
Applications of advanced omics methodologies are increasingly popular in biomedicine. However, large-scale studies aiming at clinical translation are typically siloed to single technologies. Here, we present the first comprehensive large-scale population data combining 209 lipoprotein measures from a quantitative NMR spectroscopy platform and 809 lipid classes and species from a quantitative LC...
Circadian disruption and its impact on the cardiovascular system.
TRENDS IN ENDOCRINOLOGY AND METABOLISM: TEM - 19 Dec 2024
Circadian rhythms are highly conserved biorhythms of ~24 h that govern many fundamental biological processes, including cardiovascular (CV) homeostasis. Disrupting the timing of cellular oscillators promotes cellular stress, and induction of pathogenic pathways underpins the pathogenesis of many CV diseases (CVDs). Thus, shift work, late eating, sleep disturbances, and other disruptors can resu...
Hippo pathway activation causes multiple lipid derangements in a murine model of cardiomyopathy.
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS - 19 Dec 2024
Metabolic reprogramming occurs in cardiomyopathy and heart failure contributing to progression of the disease. Activation of cardiac Hippo pathway signaling has been implicated in mediating mitochondrial dysfunction and metabolic reprogramming in cardiomyopathy, albeit influence of Hippo pathway on lipid profile is unclear. Using a dual-omics approach, we determined alterations of cardiac lipid...
Faecal metaproteomics analysis reveals a high cardiovascular risk profile across healthy individuals and heart failure patients.
GUT MICROBES - 01 Dec 2025
The gut microbiota is a crucial link between diet and cardiovascular disease (CVD). Using fecal metaproteomics, a method that concurrently captures human gut and microbiome proteins, we determined the crosstalk between gut microbiome, diet, gut health, and CVD. Traditional CVD risk factors (age, BMI, sex, blood pressure) explained < 10% of the proteome variance. However, unsupervised human prot...
Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear-encoded noncoding RNAs.
FASEB JOURNAL : OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY - 15 Dec 2024
Mitochondria are central to cellular function, particularly in metabolically active tissues such as skeletal muscle. Nuclear-encoded RNAs typically localize within the nucleus and cytosol but a small population may also translocate to subcellular compartments such as mitochondria. We aimed to investigate the nuclear-encoded RNAs that localize within the mitochondria of skeletal muscle cells and...
International norms for adult handgrip strength: A systematic review of data on 2.4 million adults aged 20 to 100+ years from 69 countries and regions.
JOURNAL OF SPORT AND HEALTH SCIENCE - 22 Nov 2024
Muscular strength is a powerful marker of current health status and robust predictor of age-related disease and disability. Handgrip strength (HGS) using isometric dynamometry is a convenient, feasible, and widely used method of assessing muscular strength among people of all ages. While adult HGS norms have been published for many countries, no study has yet synthesized available data to produ...
First-in-human experience of high-energy ElectroPulse pulsed field ablation: Acute results for pulmonary veins and posterior wall isolation.
HEART RHYTHM - 07 Nov 2024
Different iterations of catheter and energy delivery system configurations are evolving for pulsed field ablation (PFA); however, some have used large and complex catheters, required large sheaths, and had a recognized risk of hemolysis. The purpose of this study was to evaluate the acute safety and efficacy of a custom designed 8F variable loop multielectrode mapping and PFA catheter with cont...
Acute oral digoxin in healthy adults hastens fatigue and increases plasma K<sup>+</sup> during intense exercise, despite preserved skeletal muscle Na<sup>+</sup>,K<sup>+</sup>-ATPase.
THE JOURNAL OF PHYSIOLOGY - 23 Nov 2024
We investigated acute effects of the Na<sup>+</sup>,K<sup>+</sup>-ATPase (NKA) inhibitor, digoxin, on muscle NKA content and isoforms, arterial plasma [K<sup>+</sup>] ([K<sup>+</sup>]<sub>a</sub>) and fatigue with intense exercise. In a randomised, crossover, double-blind design, 10 healthy adults ingested 0.50 mg digoxin (DIG) or placebo (CON) 60 min before cycling for 1 min at 60% then at 95...
The impact of ethnicity and its definition on diabetes prevalence: A national Australian whole-of-population study.
DIABETES RESEARCH AND CLINICAL PRACTICE - 20 Nov 2024
We assessed the extent to which using large geographic regions to group ethnicities (ancestries or countries-of-birth) masked intra-regional variation in diabetes risk. We performed a cross-sectional analysis of the 2021 Australian National Census, which included self-reported health data. Ethnicity-specific diabetes prevalence was age/sex-standardised to a reference population of all census re...
The road to renal denervation for hypertension and beyond (HF): two decades of failed, succeeded, and to be determined.
HEART FAILURE REVIEWS - 07 Nov 2024
Activation of the sympathetic nervous system has been attributed to the development of hypertension. Two established approaches for treating hypertension are pharmacotherapy and lifestyle changes. With an improved understanding of renal nerve anatomy and physiology, renal denervation has been proposed as an alternative treatment for hypertension. Specifically, it has been shown that the interru...
Light Walking Patterns and Postprandial Cardiometabolic Responses in Young Obese Adults: A Randomized Crossover Study.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 11 Nov 2024
Recent studies suggest that light-intensity physical activity may enhance cardiometabolic health and reduce mortality risk in adults. However, more information is required to understand the patterns of light-intensity physical activity and postprandial cardiometabolic health. This study examined the effects of different light-intensity walking patterns on postprandial cardiometabolic responses ...
