Publications
Now showing items 1761-1780 of 5702 records
Hybrid Closed Loop Using a Do-It-Yourself Artificial Pancreas System in Adults With Type 1 Diabetes.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY - 14 Feb 2023
There is increasing use of open-source artificial pancreas systems (APS) in the management of Type 1 diabetes. Our aim was to assess the safety and efficacy of the automated insulin delivery system AndroidAPS (AAPS), compared with stand-alone pump therapy in people with type 1 diabetes. The primary outcome was the difference in the percentage of time in range (TIR, 70-180 mg/dL). Secondary aims...
Top 10 International Priorities for Physical Fitness Research and Surveillance Among Children and Adolescents: A Twin-Panel Delphi Study.
SPORTS MEDICINE (AUCKLAND, N.Z.) - 01 Feb 2023
The measurement of physical fitness has a history that dates back nearly 200 years. Recently, there has been an increase in international research and surveillance on physical fitness creating a need for setting international priorities that could help guide future efforts.This study aimed to produce a list of the top 10 international priorities for research and surveillance on physical fitness...
Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH.
ISCIENCE - 20 Jan 2023
Sucrose, the primary circulating sugar in plants, contains equal amounts of fructose and glucose. The latter is the predominant circulating sugar in animals and thus the primary fuel source for various tissue and cell types in the body. Chronic excessive energy intake has, however, emerged as a major driver of obesity and associated pathologies including nonalcoholic fatty liver diseases (NAFLD...
embryoTox: Using Graph-Based Signatures to Predict the Teratogenicity of Small Molecules.
JOURNAL OF CHEMICAL INFORMATION AND MODELING - 23 Jan 2023
Teratogenic drugs can lead to extreme fetal malformation and consequently critically influence the fetus's health, yet the teratogenic risks associated with most approved drugs are unknown. Here, we propose a novel predictive tool, embryoTox, which utilizes a graph-based signature representation of the chemical structure of a small molecule to predict and classify molecules likely to be safe du...
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial.
EUROPEAN HEART JOURNAL. ACUTE CARDIOVASCULAR CARE - 27 Jan 2023
Opioid analgesia has been shown to interfere with the bioavailability of oral P2Y12 inhibitors prompting the search for safe and effective non-opioid analgesics to treat ischaemic chest pain.The lidocAine Versus Opioids In MyocarDial infarction trial was a prospective, Phase II, prehospital, open-label, non-inferiority, randomized controlled trial enrolling patients with suspected STEACS with m...
Impact of prehospital opioid dose on angiographic and clinical outcomes in acute coronary syndromes.
01 Feb 2023
An adverse interaction whereby opioids impair and delay the gastrointestinal absorption of oral P2Y inhibitors has been established, however the clinical significance of this in acute coronary syndrome (ACS) is uncertain. We sought to characterise the relationship between prehospital opioid dose and clinical outcomes in patients with ACS.12Patients given opioid treatment by emergency medical se...
Disease specific determinants of cardiopulmonary fitness in systemic sclerosis.
01 Feb 2023
We aimed to quantify the burden of exercise intolerance in systemic sclerosis (SSc) and explore the disease features that contribute to impaired exercise capacity (measured as peak oxygen uptake, peak VO) to provide novel mechanistic insights into the causes of physical disability in SSc.2Thirty-three SSc patients with no history of cardiac disease and no active myositis underwent cardiac and s...
Studying the Synergistic Effect of Substrate Stiffness and Cyclic Stretch Level on Endothelial Cells Using an Elastomeric Cell Culture Chamber.
ACS APPLIED MATERIALS & INTERFACES - 01 Feb 2023
Endothelial cells lining blood vessels are continuously exposed to biophysical cues that regulate their function in health and disease. As we age, blood vessels lose their elasticity and become stiffer. Vessel stiffness alters the mechanical forces that endothelial cells experience. Despite ample evidence on the contribution of endothelial cells to vessel stiffness, less is known about how vess...
COVID-19 thromboembolism is reduced in ambulatory, but not hospitalized patients, following COVID-19 vaccination Short title: COVID-19 thromboembolism.
HAEMATOLOGICA - 26 Jan 2023
Not available.
Regulation of mineralocorticoid receptor activation by circadian protein TIMELESS.
01 Jan 2023
The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that regulates cardiorenal physiology and disease. Ligand-dependent MR transactivation involves a conformational change in the MR and recruitment of coregulatory proteins to form a unique DNA-binding complex at the hormone response element in target gene promoters. Differences in the recruitment of coregulatory prote...
Immune Checkpoint Inhibitor Myocarditis and Cellular Rejection in Orthotopic Heart Transplant Recipients.
JACC. CARDIOONCOLOGY - 01 Dec 2022
Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases.
FRONTIERS IN NUTRITION - 01 Jan 2022
We aimed to evaluate the association between leisure-time physical activity (PA) and mortality risk in adults with major chronic diseases. A total of 170,579 adults with major chronic diseases aged 30-84 years from the U.S. National Health Interview Surveys (1997-2014) with linkage to the National Death Index (NDI) through December 31, 2015 were included in this study. During a median follow-up...
A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein.
EMBO MOLECULAR MEDICINE - 11 Jan 2023
C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert, pentameric CRP (pCRP) structure to a pentameric CRP intermediate (pCRP*) and ultimately to the monomeric CRP (mCRP) form, both exhibiting highly ...
No fear: Willingness of smartphone activated first responders to assist with cardiac arrest during the COVID-19 pandemic.
RESUSCITATION PLUS - 01 Mar 2023
To understand the fear and willingness to respond of smartphone activated first responders during the COVID-19 pandemic.We invited smartphone activated first responders registered with the GoodSAM application in Victoria, Australia to take part in an online survey in November 2020. We assessed willingness to respond to an alert and provide CPR during the pandemic and administered the Fear of CO...
Ammonium chloride administration prevents training-induced improvements in mitochondrial respiratory function in the soleus muscle of male rats.
AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY - 28 Nov 2022
Exercise training can increase both mitochondrial content and mitochondrial respiration. Despite its popularity, high-intensity exercise can be accompanied by mild acidosis (also present in certain pathological states), which may limit exercise-induced adaptations to skeletal muscle mitochondria. The aim of this study was to determine if administration of ammonium chloride (0.05 g/kg) to Wistar...
Molecular and pro-inflammatory aspects of COVID-19: The impact on cardiometabolic health.
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR BASIS OF DISEASE - 01 Dec 2022
Obesity, type 2 diabetes (T2DM), hypertension (HTN), and Cardiovascular Disease (CVD) often cluster together as "Cardiometabolic Disease" (CMD). Just under 50% of patients with CMD increased the risk of morbidity and mortality right from the beginning of the COVID-19 pandemic as it has been reported in most countries affected by the SARS-CoV2 virus. One of the pathophysiological hallmarks of CO...
Extracellular vesicles carrying HIV-1 Nef induce long-term hyperreactivity of myeloid cells.
CELL REPORTS - 22 Nov 2022
A possible explanation for chronic inflammation in HIV-infected individuals treated with anti-retroviral therapy is hyperreactivity of myeloid cells due to a phenomenon called "trained immunity." Here, we demonstrate that human monocyte-derived macrophages originating from monocytes initially treated with extracellular vesicles containing HIV-1 protein Nef (exNef), but differentiating in the ab...
Prevalence and trend of smokeless tobacco use and its associated factors among adolescents aged 12-16 years in 138 countries/territories, 1999-2019.
BMC MEDICINE - 25 Nov 2022
Smokeless tobacco use is popular in some regions worldwide, but it receives less attention compared to cigarette smoking. We aimed to estimate the recent prevalence of, and trends in, smokeless tobacco use and to examine its associated factors among adolescents aged 12-16 years in 138 countries/territories (hereafter "countries") from 1999 to 2019.Data from the Global Youth Tobacco Survey condu...
Television-viewing time and bodily pain in Australian adults with and without type 2 diabetes: 12-year prospective relationships.
BMC PUBLIC HEALTH - 29 Nov 2022
Bodily pain is a common presentation in several chronic diseases, yet the influence of sedentary behaviour, common in ageing adults, is unclear. Television-viewing (TV) time is a ubiquitous leisure-time sedentary behaviour, with a potential contribution to the development of bodily pain. We examined bodily pain trajectories and the longitudinal relationships of TV time with the bodily pain seve...
Cardiovascular magnetic resonance imaging characteristics in patients with methamphetamine-associated cardiomyopathy.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIOVASCULAR MAGNETIC RESONANCE - 01 Dec 2022
Methamphetamine-associated cardiomyopathy (MA-CMP) is an increasingly recognised aetiology of cardiomyopathy. Cardiovascular magnetic resonance (CMR) is a specialised cardiac imaging modality commonly used in assessment of cardiomyopathy. We aimed to identify specific CMR features associated with MA-CMP.A retrospective cohort study of CMR scans was performed in a single centre between January 2...
