Publications
Now showing items 1721-1740 of 5702 records
Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors vs. Dipeptidyl Peptidase-4 Inhibitors in Frail People With Diabetes Who Were Recently Hospitalized.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2022
Sodium-glucose cotransporter-2 inhibitors (SGLT-2Is) reduce heart failure (HF) hospitalizations and major adverse cardiovascular events (MACE) in general type 2 diabetes populations. The objective of this study was to determine whether SGLT-2Is vs. dipeptidyl peptidase-4 inhibitors (DPP-4Is) are associated with reductions in MACE, HF hospitalizations and mortality in frail people with type 2 di...
Exploring Systemic Inflammation in the Relationships Between Poor Sleep Health or Shift-Work and Blood Pressure Across BMI, Sex and Age Groups
JOURNAL OF THE ENDOCRINE SOCIETY - 01 Nov 2022
Circadian challenges such as social and travel jetlag, poor sleep health or undertaking shift-work is becoming increasingly linked to incidences of cardiovascular disease, metabolic syndrome and hypertension due to the impact of circadian disruption. Currently, studies that address how such challenges can become specific risk factors for the development of hypertension show inconsistent finding...
CD14 inhibition mitigates left ventricular damage and dysfunction following myocardial infarction
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY - 31 Dec 2022
CD14 mediates immunological responses to damage-associated message patterns (DAMPs) released from damaged cells during acute myocardial infarction. The cardiac impact of CD14 inhibition following myocardial ischemia-reperfusion (MIR) remains undefined. This investigation rigorously assessed both early MIR-associated injury and subsequent cardiac damage and dysfunction following selective antibo...
Noninvasive Identification of Carditis in Acute Rheumatic Fever.
JACC. CARDIOVASCULAR IMAGING - 01 Apr 2022
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MicroRNA-132 may be associated with blood pressure and liver steatosis-preliminary observations in obese individuals.
JOURNAL OF HUMAN HYPERTENSION - 01 Oct 2022
Recent findings in experimental models have shown that the microRNA miR-132 (mir-132) is an important regulator of liver homeostasis and lipid metabolism. We aimed to assess miR-132 expression in liver and fat tissues of obese individuals and examine its association with blood pressure (BP) and hepatic steatosis. We examined obese individuals undergoing bariatric surgery for weight loss (n = 19...
Type-2 Diabetes and the Clinical Importance of Exaggerated Exercise Blood Pressure.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Oct 2022
Exaggerated exercise blood pressure (EEBP) during clinical exercise testing is associated with poor blood pressure (BP) control and cardiovascular disease (CVD). Type-2 diabetes (T2DM) is thought to be associated with increased prevalence of EEBP, but this has never been definitively determined and was the aim of this study.Clinical exercise test records were analyzed from 13 268 people (aged 5...
An Aspirin a Day….
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Oct 2022
Removing unwanted variation from large-scale RNA sequencing data with PRPS.
NATURE BIOTECHNOLOGY - 01 Jan 2023
Accurate identification and effective removal of unwanted variation is essential to derive meaningful biological results from RNA sequencing (RNA-seq) data, especially when the data come from large and complex studies. Using RNA-seq data from The Cancer Genome Atlas (TCGA), we examined several sources of unwanted variation and demonstrate here how these can significantly compromise various down...
Tissue-Mimicking Materials for Ultrasound-Guided Needle Intervention Phantoms: A Comprehensive Review.
ULTRASOUND IN MEDICINE & BIOLOGY - 01 Jan 2023
Ultrasound-guided needle interventions are common procedures in medicine, and tissue-mimicking phantoms are widely used for simulation training to bridge the gap between theory and clinical practice in a controlled environment. This review assesses tissue-mimicking materials from 24 studies as candidates for a high-fidelity ultrasound phantom, including methods for evaluating relevant acoustic ...
Treatment of haematuria with factor concentrate in people with haemophilia is associated with low rates of complications.
HAEMOPHILIA : THE OFFICIAL JOURNAL OF THE WORLD FEDERATION OF HEMOPHILIA - 01 Jan 2023
"The Times They Are A-Changin'" at Diabetes Care.
DIABETES CARE - 01 Jan 2023
Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction.
THERANOSTICS - 01 Jan 2023
Chemotherapy is a common clinical strategy for cancer treatment. However, the accompanied cardiomyopathy renders cancer patients under risk of another life-threatening condition. Whereas Hippo pathway is known to play key roles in both cancerogenesis and heart disease, it remains unclear whether Hippo pathway activation mediates chemotherapy-induced cardiomyopathy. In human breast cancer cells...
Improving the rate of inferior vena cava filter retrieval through multidisciplinary engagement.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS - 01 Jan 2023
The placement of retrievable inferior vena cava (IVC) filters occurs commonly, but retrieval rates remain low. Consequently, there is an unmet clinical need to ensure appropriate follow-up and retrieval of these devices.To determine the association between an IVC filter surveillance team with filter retrievals or a documented filter plan, time to retrieval, and incidence of filter complications...
CSM-Toxin: A Web-Server for Predicting Protein Toxicity.
PHARMACEUTICS - 28 Jan 2023
Biologics are one of the most rapidly expanding classes of therapeutics, but can be associated with a range of toxic properties. In small-molecule drug development, early identification of potential toxicity led to a significant reduction in clinical trial failures, however we currently lack robust qualitative rules or predictive tools for peptide- and protein-based biologics. To address this, ...
Age as a predictor of clinical outcomes and determinant of therapeutic measures for emergency medical services treated cardiogenic shock.
JOURNAL OF GERIATRIC CARDIOLOGY : JGC - 28 Jan 2023
The impact of age on outcomes in cardiogenic shock (CS) is poorly described in the pre-hospital setting. We assessed the impact of age on outcomes of patients treated by emergency medical services (EMS).This population-based cohort study included consecutive adult patients with CS transported to hospital by EMS. Successfully linked patients were stratified into tertiles by age (18-63, 64-77, an...
Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants.
SCIENTIFIC DATA - 31 Jan 2023
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and ratios of 249 circulating metabolites, lipids, and lipoprotein sub-fractions. Here we identify and characterise additional sources of unwanted technical variation influenci...
Do neighbourhood traffic-related air pollution and socio-economic status moderate the associations of the neighbourhood physical environment with cognitive function? Findings from the AusDiab study.
THE SCIENCE OF THE TOTAL ENVIRONMENT - 01 Feb 2023
Characteristics of the neighbourhood environment, including the built and natural environment, area-level socio-economic status (SES) and air pollution, have been linked to cognitive health. However, most studies have focused on single neighbourhood characteristics and have not considered the extent to which the effects of environmental factors may interact. We examined the associations of meas...
COVID-19-Associated Myocardial Injury: Solving a Mystery Inside an Enigma.
JACC. BASIC TO TRANSLATIONAL SCIENCE - 01 Feb 2023
Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE mice.-/-
BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE - 01 Feb 2023
Methylglyoxal (MGO) is a reactive glucose metabolite linked to diabetic cardiovascular disease (CVD). MGO levels surge during intermittent hyperglycemia. We hypothesize that these MGO spikes contribute to atherosclerosis, and that pyridoxamine as a MGO quencher prevents this injury. To study this, we intravenously injected normoglycemic 8-week old male C57Bl6 ApoE mice with normal saline (NS, n...
Lipids regulated by exercise and phosphoinositide 3-kinase: potential role as biomarkers and therapeutic targets for cardiovascular disease
CURRENT OPINION IN PHYSIOLOGY - 20 Jan 2023
Lipids are organic biomolecules that provide structural support to cells, but are also important for energy storage and signaling. Lipid profiling has emerged as a new technology with the potential of identifying new biomarkers and therapeutic targets. The lipid composition of cardiomyocyte membranes is altered during the process of cardiac remodeling, including exercise-induced heart enlargeme...
