Publications
Now showing items 1701-1720 of 5702 records
Evaluating hierarchical machine learning approaches to classify biological databases.
BRIEFINGS IN BIOINFORMATICS - 18 Jul 2022
The rate of biological data generation has increased dramatically in recent years, which has driven the importance of databases as a resource to guide innovation and the generation of biological insights. Given the complexity and scale of these databases, automatic data classification is often required. Biological data sets are often hierarchical in nature, with varying degrees of complexity, i...
A solution NMR view of lipidic cubic phases: Structure, dynamics, and beyond
BIOCHIMICA ET BIOPHYSICA ACTA. ADVANCES - 01 Jan 2022
Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a range of time scales, the screening of drug candidates with site specificity, and for the quantitation of molecular translational diffusion. Lyotropic lipidic cubic phases...
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
CELL STEM CELL - 01 Aug 2019
Tumors are composed of phenotypically heterogeneous cancer cells that often resemble various differentiation states of their lineage of origin. Within this hierarchy, it is thought that an immature subpopulation of tumor-propagating cancer stem cells (CSCs) differentiates into non-tumorigenic progeny, providing a rationale for therapeutic strategies that specifically eradicate CSCs or induce th...
Defining cardiac fibrosis complexity and regulation towards therapeutic development
CLINICAL AND TRANSLATIONAL DISCOVERY - 01 Jan 2023
Abstract Cardiac fibrosis is insidious, accelerating cardiovascular diseases, heart failure, and death. With a notable lack of effective therapies, advances in both understanding and targeted treatment of fibrosis are urgently needed. Remodelling of the extracellular matrix alters the biomechanical and biochemical cardiac structure and function, disrupting cell-matrix interactions and exacerbat...
Device-measured physical activity, adiposity and mortality: a harmonised meta-analysis of eight prospective cohort studies.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Jul 2022
The joint associations of total and intensity-specific physical activity with obesity in relation to all-cause mortality risk are unclear.We included 34 492 adults (72% women, median age 62.1 years, 2034 deaths during follow-up) in a harmonised meta-analysis of eight population-based prospective cohort studies with mean follow-up ranging from 6.0 to 14.5 years. Standard body mass index categori...
A Comprehensive Approach to Managing Methamphetamine-Associated Cardiomyopathy.
01 Jul 2022
Methamphetamines are illicit drugs of the amphetamine-type stimulant class that have been increasing in popularity, availability, and purity in recent decades. As a result, rates of methamphetamine-associated cardiomyopathy (MAC) are rising globally. MAC is associated with high rates of sudden cardiac arrest, late presentation, and poor outcomes. This review discusses the medical management of ...
Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases.
PHARMACOLOGY & THERAPEUTICS - 01 Jul 2022
C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been recognized almost exclusively as a marker of inflammation and predictor of cardiovascular risk. However, accumulating evidence indicates that CRP is also a direct pathogenic pro-inflammatory mediator in atherosclerosis and cardiovascular diseases. The 'CRP system' consists of at least two protein conformations wi...
Tackling an unmet need in sports cardiology: understanding exercise-induced cardiac remodelling and its clinical consequences.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Jul 2022
Treatment gaps, 1-year readmission and mortality following myocardial infarction by diabetes status, sex and socioeconomic disadvantage.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH - 01 Jul 2022
We evaluated variation in treatment for, and outcomes following, myocardial infarction (MI) by diabetes status, sex and socioeconomic disadvantage.We included all people aged ≥30 years who were discharged alive from hospital following MI between 1 July 2012 and 30 June 2017 in Victoria, Australia (n=43 272). We assessed receipt of inpatient procedures and discharge dispensing of cardioprotectiv...
Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis.
MOLECULAR METABOLISM - 01 Jul 2022
Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development. Previously, it has been shown that HMG-CoA-Reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway, can be phosphorylated and inactivated by the metabolic stress sensor AMP-activated protein kinase (AMPK). However, the physiological signifi...
Global Impact of Different Blood Pressure Thresholds in 4 021 690 Participants of the May Measurement Month Initiative.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jul 2022
Influential guidelines currently define hypertension at different thresholds of blood pressure (BP). The global May Measurement Month initiative provides a unique opportunity to estimate the potential consequences of universal lowering of BP thresholds on the prevalence of hypertension based on a large, real-world, patient-level data set.The average of the second and third of 3 attended BP read...
Impact of device length on electrogram sensing in miniaturized insertable cardiac monitors.
JOURNAL OF ELECTROCARDIOLOGY - 01 Jan 2022
Little data exists on electrogram sensing in current generation of miniaturized insertable cardiac monitors (ICMs).To compare the sensing capability of ICM with different vector length: Medtronic Reveal LINQ (~40 mm) vs. Biotronik Biomonitor III (BM-III, ~70 mm).De-identified remote monitoring transmissions from n = 40 patients with BM-III were compared with n = 80 gender and body mass index (B...
Return to exercise post-COVID-19 infection: A pragmatic approach in mid-2022.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 01 Jul 2022
Glucagon-like peptide-1 receptor agonist (GLP1-RA) therapy in type 2 diabetes.
AUSTRALIAN JOURNAL OF GENERAL PRACTICE - 01 Jul 2022
Type 2 diabetes (T2D) is a national health priority. Its rising prevalence is accompanied by a high burden of diabetes-related complications, many of which are preventable. Numerous glucose-lowering medications have been developed in recent years with growing evidence relating to their efficacy and safety. These advances have increased the complexity of prescribing decisions in T2D.This review ...
Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies.
PROGRESS IN LIPID RESEARCH - 01 Jul 2022
Large 'omics studies are of particular interest to population and clinical research as they allow elucidation of biological pathways that are often out of reach of other methodologies. Typically, these information rich datasets are produced from multiple coordinated profiling studies that may include lipidomics, metabolomics, proteomics or other strategies to generate high dimensional data. In ...
Differences in Accelerometer-Measured Physical Activity and Sedentary Behavior Between Middle-Aged Men and Women in Japan: A Compositional Data Analysis.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 01 Jul 2022
Differences in accelerometer-measured sedentary behavior and different physical activity (PA) intensities between men and women have been poorly described. The authors examined gender differences in time-use activity composition and total volume of PA.A cross-sectional mail survey was conducted from 2013 to 2015 with a randomized sample of 6000 middle-aged (40-64 y) community-dwelling Japanese ...
The Role of Human Milk Lipids and Lipid Metabolites in Protecting the Infant against Non-Communicable Disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 06 Jul 2022
Non-communicable diseases continue to increase globally and have their origins early in life. Early life obesity tracks from childhood to adulthood, is associated with obesity, inflammation, and metabolic dysfunction, and predicts non-communicable disease risk in later life. There is mounting evidence that these factors are more prevalent in infants who are formula-fed compared to those who are...
Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis.
SCIENTIFIC REPORTS - 07 Jul 2022
Atherosclerosis and its complications are major causes of cardiovascular morbidity and death. Apart from risk factors such as hypercholesterolemia and inflammation, the causal molecular mechanisms are unknown. One proposed causal mechanism involves elevated levels of reactive oxygen species (ROS). Indeed, early expression of the ROS forming NADPH oxidase type 5 (Nox5) in vascular endothelial ce...
Intervention effects on children's movement behaviour accumulation as a result of the Transform-Us! school- and home-based cluster randomised controlled trial.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 07 Jul 2022
It is unknown if and how children's movement behaviour accumulation patterns change as a result of physical activity and/or sedentary behaviour interventions. It is important to establish the effectiveness of interventions targeting changes in such accumulation patterns. This study aimed to investigate the effect of the Transform-Us! school- and home-based intervention program on children's mov...
Trained Immunity and HIV Infection.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2022
Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for many years. Recently, underlying mechanisms of this phenomenon have started to come to light. It was found that the key cells responsible for heterologous protection are innate immune cells such as natural killer cells (NKs), dendritic cell...
