Publications
Now showing items 1561-1580 of 5325 records
Individualized Beta-Blocker Treatment for High Blood Pressure Dictated by Medical Comorbidities: Indications Beyond the 2018 European Society of Cardiology/European Society of Hypertension Guidelines.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jun 2022
Several hypertension guidelines have removed beta-blockers from their previous position as first-choice drugs for the treatment of hypertension. However, this downgrading may not be justified by available evidence because beta-blockers lower blood pressure as effectively as other major antihypertensive drugs and have solid documentation in preventing cardiovascular complications. Suspected inco...
Environmental determinants of human milk composition in relation to health outcomes.
ACTA PAEDIATRICA (OSLO, NORWAY : 1992) - 01 Jun 2022
Humans are exposed to environmental factors at every stage of life including infancy. The aim of this mini-review was to present a narrative of environmental factors influencing human milk composition. Current literature shows lactation is a dynamic process and is responsive to multiple environmental challenges including geographical location, lifestyle, persistent pollutants and maternal facto...
Feasibility of semi-recumbent bicycle exercise Doppler echocardiography for the evaluation of the right heart and pulmonary circulation unit in different clinical conditions: the RIGHT heart international NETwork (RIGHT-NET)
THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING - 01 Jul 2021
Exercise Doppler echocardiography (EDE) is a well-validated tool in ischemic and valvular heart diseases. However, its use in the assessment of the right heart and pulmonary circulation unit (RH-PCU) is limited. The aim of this study is to assess the semi-recumbent bicycle EDE feasibility for the evaluation of RH-PCU in a large multi-center population, from healthy individuals and elite athlete...
Strain-Guided Management of Potentially Cardiotoxic Cancer Therapy.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 02 Feb 2021
In patients at risk of cancer therapy-related cardiac dysfunction (CTRCD), initiation of cardioprotective therapy (CPT) is constrained by the low sensitivity of ejection fraction (EF) for minor changes in left ventricular (LV) function. Global longitudinal strain (GLS) is a robust and sensitive marker of LV dysfunction, but existing observational data have been insufficient to support a routine...
Effect of a 3-Year Lifestyle Intervention in Patients with Chronic Kidney Disease: A Randomized Clinical Trial.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : JASN - 01 Feb 2022
Supervised lifestyle interventions have the potential to significantly improve physical activity and fitness in patients with CKD.To assess the efficacy of a lifestyle intervention in patients with CKD to improve cardiorespiratory fitness and exercise capacity over 36 months, we conducted a randomized clinical trial, enrolling 160 patients with stage 3-4 CKD, with 81 randomized to usual care an...
Sex differences in prehospital analgesia in patients presenting with acute coronary syndromes and their association with clinical outcomes.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS - 01 Mar 2022
This study examined if sex differences in prehospital pain scores, opioid administration, and clinical outcomes exist in acute coronary syndrome (ACS) patients.Sex differences persist in ACS presentation, management, and outcomes. The impact of sex differences on prehospital pain management of ACS with opioids is unknown.Patients presenting with ACS via ambulance (2014-2018) that underwent perc...
The Carbon Footprint of Bioinformatics.
MOLECULAR BIOLOGY AND EVOLUTION - 02 Mar 2022
Bioinformatic research relies on large-scale computational infrastructures which have a nonzero carbon footprint but so far, no study has quantified the environmental costs of bioinformatic tools and commonly run analyses. In this work, we estimate the carbon footprint of bioinformatics (in kilograms of CO2 equivalent units, kgCO2e) using the freely available Green Algorithms calculator (www.gr...
Chewing the fat on platelet CXCR7.
BLOOD - 17 Mar 2022
Telemedicine to Timor-Leste: implementing an international cardiac telehealth service during population dislocation, floods and COVID-19.
INTERNAL MEDICINE JOURNAL - 23 Mar 2022
The East Timor Hearts Fund (ETHF) has provided cardiac services in Timor-Leste since 2010, conducting three clinics yearly. With international border closures due to the COVID-19 pandemic, development of collaborative telehealth services was required.Scoping discussions identified major challenges (structural, patient-related and medical system-related). At two pilot clinics, patient history, i...
Identification of novel lipid biomarkers in xmrk- and Myc-induced models of hepatocellular carcinoma in zebrafish.
CANCER & METABOLISM - 04 Apr 2022
Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and is accompanied by complex dysregulation of lipids. Increasing evidence suggests that particular lipid species are associated with HCC progression. Here, we aimed to identify lipid biomarkers of HCC associated with the induction of two oncogenes, xmrk, a zebrafish homolog of the human epidermal growth factor receptor (EGF...
Pericoronary Adipose Tissue: Another Arrow in the Quiver of CT Coronary Angiography.
JACC. CARDIOVASCULAR IMAGING - 01 May 2022
Effects of chronotropic incompetence on exercise capacity in people with heart failure versus age-matched controls.
HEART FAILURE REVIEWS - 01 May 2022
Chronotropic incompetence (CI) is an inability to adequately raise heart rate during physiological stress. We established CI prevalence and exercise capacity in heart failure versus healthy age-matched controls. We conducted a systematic search (1966-July 1, 2020) and meta-analysis of studies reporting peak VO in people with heart failure with reduced (HFrEF) and preserved (HFpEF) left ventricu...
Physical activity and glioma: a case-control study with follow-up for survival.
01 May 2022
High-grade disease accounts for ~ 70% of all glioma, and has a high mortality rate. Few modifiable exposures are known to be related to glioma risk or mortality.We examined associations between lifetime physical activity and physical activity at different ages (15-18 years, 19-29 years, 30-39 years, last 10 years) with the risk of glioma diagnosis, using data from a hospital-based family case-c...
Trend in Blood Pressure Control Post Antihypertensive Drug Initiation in the U.S.
AMERICAN JOURNAL OF PREVENTIVE MEDICINE - 01 May 2022
The aim of this study is to evaluate the temporal trends in systolic blood pressure control over 18 months after blood pressure‒lowering drug initiation in the U.S.From U.S. nationally representative electronic health records, 1,036,775 adults initiating and continuing blood pressure‒lowering drugs for ≥18 months during 2006-2018 were identified (January 2021). Prevalence trends of cardiovascul...
Avoiding the re-do sternotomy: treatment of an ascending aortic pseudoaneurysm using a percutaneous Amplatzer PFO closure device.
VASCULAR - 03 May 2022
Ascending aortic pseudoaneurysms are a common phenomenon requiring surgical intervention but can pose high surgical risks in medically complex patients. We report a novel approach to percutaneous closure of ascending aortic pseudoaneurysms using an Amplatzer PFO closure device.We present the case of a 65-year-old male with haemoptysis on a background of multiple cardiac surgeries and chronic ki...
Physical activity and sedentary behaviour over adulthood in relation to all-cause and cause-specific mortality: a systematic review of analytic strategies and study findings.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY - 09 May 2022
Questions remain about the effect on mortality of physical activity and sedentary behaviour over time. We summarized the evidence from studies that assessed exposure from multiple time points and critiqued the analytic approaches used.A search was performed on MEDLINE, Embase, Emcare, Scopus and Web of Science up to January 2021 for studies of repeatedly assessed physical activity or sedentary ...
Hemodynamics of small arterial return cannulae for venoarterial extracorporeal membrane oxygenation.
ARTIFICIAL ORGANS - 01 Jun 2022
Venoarterial extracorporeal membrane oxygenation (ECMO) provides mechanical support for critically ill patients with cardiogenic shock. Typically, the size of the arterial return cannula is chosen to maximize flow. However, smaller arterial cannulae may reduce cannula-related complications and be easier to insert. This in vitro study quantified the hemodynamic effect of different arterial retur...
Impaired postprandial skeletal muscle vascular responses to a mixed meal challenge in normoglycaemic people with a parent with type 2 diabetes.
DIABETOLOGIA - 01 Jan 2022
Microvascular blood flow (MBF) increases in skeletal muscle postprandially to aid in glucose delivery and uptake in muscle. This vascular action is impaired in individuals who are obese or have type 2 diabetes. Whether MBF is impaired in normoglycaemic people at risk of type 2 diabetes is unknown. We aimed to determine whether apparently healthy people at risk of type 2 diabetes display impaire...
Dairy Foods: Is Its Cardiovascular Risk Profile Changing?
CURRENT ATHEROSCLEROSIS REPORTS - 01 Jan 2022
The majority of international guidelines for cardiovascular disease (CVD) prevention recommend moderate intake of low fat or fat-free products, and limiting full fat dairy food because of its high saturated fatty acid content. Recent equivocal observational studies and greater understanding of the complex nature of dairy foods has led to reappraisal for some types of dairy foods.Current guideli...
Nurse co-ordinated health and lifestyle modification for reducing multiple cardio-metabolic risk factors in regional adults: outcomes from the MODERN randomized controlled trial.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING : JOURNAL OF THE WORKING GROUP ON CARDIOVASCULAR NURSING OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 11 Jan 2022
Nurse-led health and lifestyle modification programmes can prevent cardio-metabolic diseases and be advantageous where health disparities exist.To assess the effectiveness of a nurse-driven health and lifestyle modification programme in improving cardio-metabolic risk parameters for higher-risk regional residing adults.We conducted an open, parallel-group randomized controlled trial in two site...
