Publications
Now showing items 121-140 of 5595 records
Relationship between left ventricular wall stress and cardiac remodelling post-TAVR and MitraClip.
OPEN HEART - 31 Aug 2025
The relationship between left ventricular wall stress (LVWS) and cardiac remodelling post structural intervention has not previously been examined. We examined the relationship between LVWS and cardiac remodelling 6 months post transcatheter aortic valve replacement (TAVR) and MitraClip (MC). LVWS was calculated in 40 patients with severe aortic stenosis (AS) and 11 patients with severe mitral ...
Economic Evaluation of a Multicomponent mHealth Intervention for Stroke Management in Rural China: Cluster-Randomized Trial With 6-Year Follow-Up.
JMIR MHEALTH AND UHEALTH - 11 Sep 2025
To bridge the gap between clinical guidelines and suboptimal stroke management in rural settings, we conducted an implementation trial using evidence-based, mobile health-enabled strategies to empower primary care providers in rural China. The system-integrated and digital technology-enabled model of care (SINEMA) model was shown to significantly reduce blood pressure and mortality among people...
Global and Regional Prediabetes Prevalence: Updates for 2024 and Projections for 2050.
DIABETES CARE - 09 Sep 2025
Coenzyme Q10 and Cognition: A Review.
NUTRIENTS - 08 Sep 2025
<b>Background and Objective:</b> With an increase in the number of older citizens in most Western countries, cognitive decline is becoming an increasingly significant issue. Numerous age-related metabolic and physiological changes, such as increased inflammation and oxidative stress, decreased adenosine triphosphate (ATP) production, poorer cardiovascular function, and reduced cerebral blood fl...
Performance and Perceptual Responses to Cluster Sets in Pneumatic-Resistance Exercises: Impact of Exercise Selection, Sex, and Strength.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE - 08 Sep 2025
This study examined the effects of cluster sets (CS) versus traditional sets (TRAD) on performance and perceptual responses during pneumatic chest press (CP) and leg press (LP). Exercise-specific differences and the influence of sex and strength were also explored. Forty-seven recreationally resistance-trained young adults (23 male and 24 female) performed CP and LP at 70% 1-repetition maximum ...
Engagement With Conversational Agent-Enabled Interventions in Cardiometabolic Disease Self-Management: Systematic Review.
JMIR MHEALTH AND UHEALTH - 18 Sep 2025
Well-designed conversational agents can improve health care capacity to meet the dynamic and complex needs of people self-managing cardiometabolic diseases (CMD). However, a lack of empirical evidence on conversational agent-enabled intervention design features and their impact on engagement make it challenging to comprehensively evaluate effectiveness. This review synthesizes evidence on conve...
Decreased Endogenous Nitric Oxide Production in Patients with Acute Decompensated Heart Failure with Preserved Ejection Fraction.
JOURNAL OF CLINICAL MEDICINE - 22 Aug 2025
<b>Background:</b> Heart failure with a preserved ejection fraction (HFpEF) accounts for approximately 50% of patients with heart failure. Endothelial dysfunction has been documented in HFpEF, and impaired nitric oxide (NO) production may be a contributing factor in patients decompensating from chronic to acute HFpEF. Plasma nitrite (NO<sub>2</sub><sup>-</sup>), but not plasma nitrate (NO<sub>3...
Socio-economic position and the prevalence of ten chronic diseases in Australia, 2021: a whole of population census data analysis.
THE MEDICAL JOURNAL OF AUSTRALIA - 19 Aug 2025
To investigate differences in the prevalence of specific chronic diseases in Australia by selected measures of socio-economic position, and by age group and sex, using representative national census population data. Cross-sectional, whole of population study; analysis of 2021 Australian census data. People aged 40 years or older for whom 2021 Australian census health status and socio-economic p...
<i>ACTN3</i> genotype influences androgen response in developing murine skeletal muscle.
SCIENCE ADVANCES - 29 Aug 2025
Androgens act through androgen receptor (AR) to maintain muscle mass. Evidence suggests that this pathway is influenced by "the gene for speed," <i>ACTN3</i> (α-actinin-3). Given that one in five people lack α-actinin-3, it is possible that they may respond to androgens differently. Here, we show that α-actinin-3 deficiency decreases AR in muscles of mice and humans (in males and females) and t...
An eyecare foundation model for clinical assistance: a randomized controlled trial.
NATURE MEDICINE - 28 Aug 2025
In the context of an increasing need for clinical assessments of foundation models, we developed EyeFM, a multimodal vision-language eyecare copilot, and conducted a multifaceted evaluation, including retrospective validations, multicountry efficacy validation as a clinical copilot and a double-masked randomized controlled trial (RCT). EyeFM was pretrained on 14.5 million ocular images from fiv...
International Variation in Case Fatality After Major Coronary or Cerebrovascular Events in Individuals With Type 2 Diabetes: Evidence From ADVANCE, TECOS, and EXSCEL.
DIABETES CARE - 28 Aug 2025
To examine differences in case-fatality incidence among individuals with type 2 diabetes after major coronary or cerebrovascular events by geographic region and country income level. We studied ADVANCE, TECOS, and EXSCEL participants who experienced within-trial major coronary (fatal or nonfatal myocardial infarction or sudden cardiac death) or cerebrovascular (fatal or nonfatal stroke) events....
Alterations in ether lipid metabolism in obesity revealed by systems genomics of multi-omics datasets.
PLOS BIOLOGY - 01 Aug 2025
Ratios between two metabolites are sensitive indicators of metabolic changes. Lipidomic profiling studies have revealed that plasma ether lipids, a class of glycero- and glycerophospho-lipids with reported health benefits, are negatively associated with obesity. Here, we utilized lipid ratios as surrogate markers of lipid metabolism to explore the processes underlying the inverse relationship b...
Clinical and cardiovascular magnetic resonance factors associated with elevated neutrophil-to-lymphocyte ratio in patients with heart failure: an analysis of a single-centre, prospective registry.
BMJ OPEN - 27 Aug 2025
The neutrophil-to-lymphocyte ratio (NLR) is defined as the ratio of neutrophils to lymphocytes measured in the full blood count. It has been studied across a range of conditions including cancer, sepsis and stroke. It has been proven that in patients with heart failure (HF) with reduced ejection fraction (HF-rEF), an elevated NLR reflects a higher risk of adverse outcomes. The aim of this study...
Mapping cerebral blood flow in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and orthostatic intolerance: insights from a systematic review.
26 Aug 2025
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a complex and debilitating condition with a large proportion of patients that experience orthostatic intolerance (OI). This systematic review aimed to assess whether cerebral blood flow (CBF) is reduced in ME/CFS and OI, and whether the presence of both conditions leads to an additional decline in CBF. PubMed (from 1943), MEDLINE (f...
Sedentary Behavior and Health Consequences: A Systematic Scoping Review of Prospective and Longitudinal Studies in Japan.
JOURNAL OF EPIDEMIOLOGY - 16 Aug 2025
This scoping review summarizes and evaluates evidence from Japan on prospective relationships of sedentary behavior (too much sitting as distinct from too little physical activity) with health outcomes, forming the basis for Japan's new sedentary behavior guidelines. It also identified evidence gaps and provided recommendations for future public health guidelines. A systematic search was conduc...
Heme oxygenase-1 polymorphisms associate with ischemic cardiac complications and all-cause mortality in type 1 diabetes.
CARDIOVASCULAR DIABETOLOGY - 18 Aug 2025
Heme oxygenase 1 (HO-1), encoded by the HMOX1 gene is a highly inducible enzyme with multiple cardiovascular protective properties. Polymorphisms of the HMOX1 gene, especially a guanine-thymine dinucleotide repeat polymorphism (GTn), affects its transcriptional activity and is associated with cardiovascular complications in the general population. We studied the association of HMOX1 polymorphis...
Co-design of a digital health lifestyle intervention for adults with metabolic dysfunction-associated steatotic liver disease.
JOURNAL OF TELEMEDICINE AND TELECARE - 19 Aug 2025
IntroductionBehavioural changes targeting diet and physical activity to achieve weight loss are considered the cornerstones of metabolic dysfunction-associated steatotic liver disease (MASLD) management. Digital health interventions effectively address barriers in accessing such lifestyle interventions particularly for persons in remote and regional communities that have high rates of MASLD and...
In silico prediction of optimal multifactorial intervention in chronic kidney disease.
21 Aug 2025
Chronic kidney disease (CKD) contributes to global morbidity and mortality. Early, targeted intervention can help mitigate its impact. CK273 is a urinary peptide classifier previously validated in a prospective clinical trial for the early detection of nephropathy. We hypothesized that drug-induced molecular changes in the urinary peptidome could be predicted in silico and guide selecting inter...
Free-Living Muscle Activity in Type 2 Diabetes Across Whole-of-Day Sitting, Standing, and Walking.
14 Aug 2025
In adults with type 2 diabetes, we used thigh-worn accelerometers and electromyographic (EMG) shorts to investigate muscle activity in a free-living environment. Quadriceps, hamstring, and gluteal muscle EMG was normalized individually to that during isometric maximal voluntary contraction (%EMGMVC). Devices were worn concurrently by 18 participants (11 female) for an average of 3.2 days. Media...
2025 ADS/ANZCA/GESA/NACOS clinical practice recommendations on the peri-procedural use of GLP-1/GIP receptor agonists.
ANAESTHESIA AND INTENSIVE CARE - 14 Aug 2025
Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used for the treatment of type 2 diabetes and/or obesity. The physiological actions of endogenous GLP-1, and synthetic GLP-1RAs include inhibition of gastric emptying. This has peri-procedural implications due to the potential increased risk of retained gastric contents which may result in pulmonary aspiration. There is a need for ...
