Publications
Now showing items 121-140 of 5325 records
Assessing the predicted impact of single amino acid substitutions in MAPK proteins for CAGI6 challenges.
HUMAN GENETICS - 20 Feb 2025
New thermodynamic and functional studies have been recently conducted to evaluate the impact of amino acid substitutions on the Mitogen Activated Protein Kinases 1 and 3 (MAPK1/3). The Critical Assessment of Genome Interpretation (CAGI) data provider, at Sapienza University of Rome, measured the unfolding free energy and the enzymatic activity of a set of variants (MAPK challenge dataset). Ther...
High-Intensity Interval Training for Individuals With Isolated Impaired Fasting Glucose: Protocol for a Proof-of-Concept Randomized Controlled Trial.
20 Feb 2025
Standard lifestyle interventions have shown limited efficacy in preventing type 2 diabetes among individuals with isolated impaired fasting glucose (i-IFG). Hence, tailored intervention approaches are necessary for this high-risk group. This study aims to (1) assess the feasibility of conducting a high-intensity interval training (HIIT) study and the intervention acceptability among individuals...
Effects of year Long Aerobic Exercise on Left Atrial Size in Patients with Left Ventricular Hypertrophy.
THE AMERICAN JOURNAL OF CARDIOLOGY - 20 Feb 2025
Habitual aerobic exercise is associated with left atrial (LA) enlargement which may increase risk of atrial fibrillation. Patients with LVH and increased LV stiffness may be more predisposed to LA remodeling due to higher LA pressures during exercise. We tested the hypothesis 1 year of aerobic exercise training would increase LA size to a greater extent in patients with LVH than controls. Adult...
Protocolised Management of Acute Myocardial Infarction Complicated by Cardiogenic Shock in Australia-Initial Experience From a Hub-and-Spoke Model.
CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS : OFFICIAL JOURNAL OF THE SOCIETY FOR CARDIAC ANGIOGRAPHY & INTERVENTIONS - 21 Feb 2025
Acute myocardial infarction complicated by cardiogenic shock (AMICS) confers short-term mortality of 40%-50%. Protocolised network management of AMICS patients as part of a hub-and-spoke model supported by upstream mechanical circulatory support (MCS) is gaining traction globally to treat AMICS. We conducted a prospective multicenter study in Melbourne, Australia describing our 5-year experienc...
Prospective relationships between left ventricular mass, brachial and central blood pressures in participants from the UK Biobank.
JOURNAL OF HYPERTENSION - 24 Jan 2025
Central SBP purports to aid hypertension management. This concept is founded on cross-sectional studies; however, findings are mixed and few report longitudinal relationships between changes in blood pressure (BP) and outcomes. This study aimed to determine associations of changes in brachial BP and central BP with changes in left ventricular mass index (LVMi), as an important hypertension-rela...
The impact of technology-use of hypothermic machine perfusion: the next standard of care for controlled donation after circulatory death allograft preservation?
ANNALS OF CARDIOTHORACIC SURGERY - 26 Jan 2025
Using the Staircase Approach to increase movement: a systematic search and review to inform a novel sedentary behaviour intervention for older adults.
HEALTH PROMOTION AND CHRONIC DISEASE PREVENTION IN CANADA : RESEARCH, POLICY AND PRACTICE - 01 Feb 2025
Traditional approaches to supporting older adults in adopting and maintaining an active lifestyle have largely failed. The previously proposed "Staircase Approach" offers a new foundation for developing interventions and public health strategies; this approach includes Step 1 (changing sedentary behaviour) and Steps 2 to 4 (incorporating more physical activity of increasing levels of intensity)...
The Sociocebo, Socioebo, Or Socebo Effect.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Feb 2025
The impact of the surrounding social ecosystem on the wellbeing of an individual is well known. Based on this concept in the brief article we propose a novel term called the socebo effect, which may be defined as the positive impact that occurs secondary to a change in the psychological factors associated with disease, the physician, the person-physician interaction, and/or the public and its h...
Socionutrition: The science of socionutrients.
JPMA. THE JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION - 01 Feb 2025
Nutrients are substances used by an organism to survive, grow and reproduce. "Social used in relation to" companionship and society. In this opinion piece, we propose and propound a novel concept, Socionutrition, and discuss the science of socionutrients, socionutrient triggers and modifiers, as well as socionutrient abuse. We discuss these parameters in relation to health and explore their rel...
Testosterone Treatment and Sexual Function in Men: Secondary Analysis of the T4DM (Testosterone for Diabetes) Trial.
THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM - 10 Feb 2025
The combined effects of testosterone treatment and lifestyle intervention on sexual function in men at high risk of type 2 diabetes are unclear. To assess the effect of testosterone treatment with a lifestyle intervention in men aged 50-74 years at high risk of, or newly diagnosed with, type 2 diabetes (OGTT). A secondary analysis of the Testosterone for the Prevention of Type 2 Diabetes (T4DM)...
Understanding the Association Between Home Broadband Connection and Well-Being Among Middle-Aged and Older Adults in China: Nationally Representative Panel Data Study.
JOURNAL OF MEDICAL INTERNET RESEARCH - 10 Feb 2025
Access to digital technology is among the major social determinants of health, and digital divide impacts health inequality. Yet, the impact of digital connectivity on the well-being and psychosocial outcomes in adults has not been fully studied. The aim of this study was to investigate the association of home broadband connection with health and well-being of middle-aged adults and adults olde...
Genomic data sharing: you don't know what you've got (till it's gone).
NATURE REVIEWS. GENETICS - 12 Feb 2025
Estimating cancer incidence attributable to physical inactivity in the United States.
CANCER - 15 Feb 2025
Previous estimates of the number of cancers attributable to physical inactivity in the United States have typically focused on only three malignancies (colon, endometrial, and postmenopausal breast cancer). Contemporary epidemiologic evidence suggests that physical inactivity could contribute to up to 15 types of cancer, and a dose-response effect has been demonstrated for 13 of these. This stu...
Breaking barriers: Smart vaccine platforms for cancer immunomodulation.
CANCER COMMUNICATIONS (LONDON, ENGLAND) - 03 Feb 2025
Despite significant advancements in cancer treatment, current therapies often fail to completely eradicate malignant cells. This shortfall underscores the urgent need to explore alternative approaches such as cancer vaccines. Leveraging the immune system's natural ability to target and kill cancer cells holds great therapeutic potential. However, the development of cancer vaccines is hindered b...
Location of Left Ventricular Outflow Tract Measurements for Stroke Volume Estimation With Echocardiography.
HEART, LUNG & CIRCULATION - 03 Feb 2025
The location of the left ventricular outflow tract (LVOT) for measurement of Doppler LVOT stroke volume (SV) remains contentious. Current guidelines recommend LVOT measures at or within 5 mm to 10 mm of the aortic annulus. We aimed to determine the Doppler LVOT SV location that most closely agreed with gold standard cardiac magnetic resonance imaging (CMR). This was a retrospective, single-cent...
Ezetimibe Eligibility and Prescribing in Patients With Acute Coronary Syndrome.
HEART, LUNG & CIRCULATION - 03 Feb 2025
Ezetimibe is a safe and effective medication for achieving secondary prevention low-density lipoprotein-cholesterol (LDL-C) targets after acute coronary syndrome (ACS). We sought to examine ezetimibe prescribing after ACS and the effects of expanding the Australian Pharmaceutical Benefits Scheme eligibility criteria. A retrospective analysis was performed for the rates and factors of ezetimibe ...
Screening for coronary artery disease among cancer survivors: rationale and design of the REDEEM-CAD study.
CARDIO-ONCOLOGY (LONDON, ENGLAND) - 04 Feb 2025
Cancer survivors are reported to be at a heightened risk of coronary artery disease (CAD) due to shared risk factors, potentially cardiotoxic cancer treatments and premature aging in survivors. Early identification of those who are at greater risk, followed by protective treatment, can prevent CAD progression. However, to date there was a relative paucity of prospective data to optimally guide ...
Clinical utility and implementation of polygenic risk scores for predicting cardiovascular disease.
EUROPEAN HEART JOURNAL - 05 Feb 2025
Genome-wide association studies have revealed hundreds of genetic variants associated with cardiovascular diseases (CVD). Polygenic risk scores (PRS) can capture this information in a single metric and hold promise for use in CVD risk prediction. Importantly, PRS information can reflect the causally mediated risk to which the individual is exposed throughout life. Although European Society of C...
The effect of prednisolone ingestion and acute exercise on lipocalin-2 and its variants in young men: a pilot randomised crossover study.
SCIENTIFIC REPORTS - 06 Feb 2025
Lipocalin-2 (LCN2) has three main variants; polyaminated (hLCN2) and non-polyaminated (C87A and R81E). The polyaminated form is proposed to positively influence energy control, whereas the non-polyaminated forms negatively impact energy control in mice. Glucocorticoids negatively affect glucose regulation and exercise has a positive effect. We hypothesise that glucocorticoids will suppress, whi...
