Publications
Now showing items 1081-1100 of 5027 records
Telehealth Rapid Access Chest Pain Clinic: Initial Experience During COVID-19 Pandemic.
TELEMEDICINE JOURNAL AND E-HEALTH : THE OFFICIAL JOURNAL OF THE AMERICAN TELEMEDICINE ASSOCIATION - 02 Mar 2023
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Dynamic Vortex Generation, Pulsed Injection, and Rapid Mixing of Blood Samples in Microfluidics Using the Tube Oscillation Mechanism.
ANALYTICAL CHEMISTRY - 07 Feb 2023
Here, we describe the generation of dynamic vortices in micro-scale cavities at low flow rates. The system utilizes a computer-controlled audio speaker to axially oscillate the inlet tube of the microfluidic system at desired frequencies and amplitudes. The oscillation of the tube induces transiently high flow rates in the system, which facilitates the generation of dynamic vortices inside the ...
High Human T-Cell Leukemia Virus Type 1c Proviral Loads Are Associated With Diabetes and Chronic Kidney Disease: Results of a Cross-Sectional Community Survey in Central Australia.
CLINICAL INFECTIOUS DISEASES : AN OFFICIAL PUBLICATION OF THE INFECTIOUS DISEASES SOCIETY OF AMERICA - 08 Feb 2023
A link between chronic inflammation and several noncommunicable diseases (NCDs) has been established. Although chronic infection with the human T-cell leukemia virus type 1 (HTLV-1) is the recognized cause of several inflammatory diseases and these are associated with a high number of HTLV-1-infected cells in peripheral blood (proviral load [PVL]), possible interactions between PVL and NCDs hav...
Putting non-communicable disease data to work in Vietnam: an investigation of community health surveillance capacity.
BMC PUBLIC HEALTH - 14 Feb 2023
Despite the public health system's critical role in non-communicable disease (NCD) surveillance in Vietnam, limited evidence exists on the implementation of NCD surveillance activities within these systems and the need for capacity building across different system levels to meet expected NCD surveillance goals. This study aimed to evaluate the status of and describe factors affecting the implem...
Rationale and design of the Aldose Reductase Inhibition for Stabilization of Exercise Capacity in Heart Failure Trial (ARISE-HF) in patients with high-risk diabetic cardiomyopathy.
AMERICAN HEART JOURNAL - 01 Feb 2023
Diabetic cardiomyopathy (DbCM) is a specific form of heart muscle disease that may result in substantial morbidity and mortality in individuals with type 2 diabetes mellitus (T2DM). Hyperactivation of the polyol pathway is one of the primary mechanisms in the pathogenesis of diabetic complications, including development of DbCM. There is an unmet need for therapies targeting the underlying meta...
Hybrid Closed Loop Using a Do-It-Yourself Artificial Pancreas System in Adults With Type 1 Diabetes.
JOURNAL OF DIABETES SCIENCE AND TECHNOLOGY - 14 Feb 2023
There is increasing use of open-source artificial pancreas systems (APS) in the management of Type 1 diabetes. Our aim was to assess the safety and efficacy of the automated insulin delivery system AndroidAPS (AAPS), compared with stand-alone pump therapy in people with type 1 diabetes. The primary outcome was the difference in the percentage of time in range (TIR, 70-180 mg/dL). Secondary aims...
Top 10 International Priorities for Physical Fitness Research and Surveillance Among Children and Adolescents: A Twin-Panel Delphi Study.
SPORTS MEDICINE (AUCKLAND, N.Z.) - 01 Feb 2023
The measurement of physical fitness has a history that dates back nearly 200 years. Recently, there has been an increase in international research and surveillance on physical fitness creating a need for setting international priorities that could help guide future efforts.This study aimed to produce a list of the top 10 international priorities for research and surveillance on physical fitness...
Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH.
ISCIENCE - 20 Jan 2023
Sucrose, the primary circulating sugar in plants, contains equal amounts of fructose and glucose. The latter is the predominant circulating sugar in animals and thus the primary fuel source for various tissue and cell types in the body. Chronic excessive energy intake has, however, emerged as a major driver of obesity and associated pathologies including nonalcoholic fatty liver diseases (NAFLD...
embryoTox: Using Graph-Based Signatures to Predict the Teratogenicity of Small Molecules.
JOURNAL OF CHEMICAL INFORMATION AND MODELING - 23 Jan 2023
Teratogenic drugs can lead to extreme fetal malformation and consequently critically influence the fetus's health, yet the teratogenic risks associated with most approved drugs are unknown. Here, we propose a novel predictive tool, embryoTox, which utilizes a graph-based signature representation of the chemical structure of a small molecule to predict and classify molecules likely to be safe du...
LidocAine Versus Opioids In MyocarDial infarction: the AVOID-2 randomized controlled trial.
EUROPEAN HEART JOURNAL. ACUTE CARDIOVASCULAR CARE - 27 Jan 2023
Opioid analgesia has been shown to interfere with the bioavailability of oral P2Y12 inhibitors prompting the search for safe and effective non-opioid analgesics to treat ischaemic chest pain.The lidocAine Versus Opioids In MyocarDial infarction trial was a prospective, Phase II, prehospital, open-label, non-inferiority, randomized controlled trial enrolling patients with suspected STEACS with m...
Impact of prehospital opioid dose on angiographic and clinical outcomes in acute coronary syndromes.
01 Feb 2023
An adverse interaction whereby opioids impair and delay the gastrointestinal absorption of oral P2Y inhibitors has been established, however the clinical significance of this in acute coronary syndrome (ACS) is uncertain. We sought to characterise the relationship between prehospital opioid dose and clinical outcomes in patients with ACS.12Patients given opioid treatment by emergency medical se...
Disease specific determinants of cardiopulmonary fitness in systemic sclerosis.
01 Feb 2023
We aimed to quantify the burden of exercise intolerance in systemic sclerosis (SSc) and explore the disease features that contribute to impaired exercise capacity (measured as peak oxygen uptake, peak VO) to provide novel mechanistic insights into the causes of physical disability in SSc.2Thirty-three SSc patients with no history of cardiac disease and no active myositis underwent cardiac and s...
Studying the Synergistic Effect of Substrate Stiffness and Cyclic Stretch Level on Endothelial Cells Using an Elastomeric Cell Culture Chamber.
ACS APPLIED MATERIALS & INTERFACES - 01 Feb 2023
Endothelial cells lining blood vessels are continuously exposed to biophysical cues that regulate their function in health and disease. As we age, blood vessels lose their elasticity and become stiffer. Vessel stiffness alters the mechanical forces that endothelial cells experience. Despite ample evidence on the contribution of endothelial cells to vessel stiffness, less is known about how vess...
COVID-19 thromboembolism is reduced in ambulatory, but not hospitalized patients, following COVID-19 vaccination Short title: COVID-19 thromboembolism.
HAEMATOLOGICA - 26 Jan 2023
Not available.
Regulation of mineralocorticoid receptor activation by circadian protein TIMELESS.
01 Jan 2023
The mineralocorticoid receptor (MR) is a ligand-activated transcription factor that regulates cardiorenal physiology and disease. Ligand-dependent MR transactivation involves a conformational change in the MR and recruitment of coregulatory proteins to form a unique DNA-binding complex at the hormone response element in target gene promoters. Differences in the recruitment of coregulatory prote...
Immune Checkpoint Inhibitor Myocarditis and Cellular Rejection in Orthotopic Heart Transplant Recipients.
JACC. CARDIOONCOLOGY - 01 Dec 2022
Dose-response association of leisure time physical activity with mortality in adults with major chronic diseases.
FRONTIERS IN NUTRITION - 01 Jan 2022
We aimed to evaluate the association between leisure-time physical activity (PA) and mortality risk in adults with major chronic diseases. A total of 170,579 adults with major chronic diseases aged 30-84 years from the U.S. National Health Interview Surveys (1997-2014) with linkage to the National Death Index (NDI) through December 31, 2015 were included in this study. During a median follow-up...
A novel phosphocholine-mimetic inhibits a pro-inflammatory conformational change in C-reactive protein.
EMBO MOLECULAR MEDICINE - 11 Jan 2023
C-reactive protein (CRP) is an early-stage acute phase protein and highly upregulated in response to inflammatory reactions. We recently identified a novel mechanism that leads to a conformational change from the native, functionally relatively inert, pentameric CRP (pCRP) structure to a pentameric CRP intermediate (pCRP*) and ultimately to the monomeric CRP (mCRP) form, both exhibiting highly ...
No fear: Willingness of smartphone activated first responders to assist with cardiac arrest during the COVID-19 pandemic.
RESUSCITATION PLUS - 01 Mar 2023
To understand the fear and willingness to respond of smartphone activated first responders during the COVID-19 pandemic.We invited smartphone activated first responders registered with the GoodSAM application in Victoria, Australia to take part in an online survey in November 2020. We assessed willingness to respond to an alert and provide CPR during the pandemic and administered the Fear of CO...
Ammonium chloride administration prevents training-induced improvements in mitochondrial respiratory function in the soleus muscle of male rats.
AMERICAN JOURNAL OF PHYSIOLOGY. CELL PHYSIOLOGY - 28 Nov 2022
Exercise training can increase both mitochondrial content and mitochondrial respiration. Despite its popularity, high-intensity exercise can be accompanied by mild acidosis (also present in certain pathological states), which may limit exercise-induced adaptations to skeletal muscle mitochondria. The aim of this study was to determine if administration of ammonium chloride (0.05 g/kg) to Wistar...
