Publications
Now showing items 1061-1080 of 5027 records
Quality control and removal of technical variation of NMR metabolic biomarker data in ~120,000 UK Biobank participants.
SCIENTIFIC DATA - 31 Jan 2023
Metabolic biomarker data quantified by nuclear magnetic resonance (NMR) spectroscopy in approximately 121,000 UK Biobank participants has recently been released as a community resource, comprising absolute concentrations and ratios of 249 circulating metabolites, lipids, and lipoprotein sub-fractions. Here we identify and characterise additional sources of unwanted technical variation influenci...
Do neighbourhood traffic-related air pollution and socio-economic status moderate the associations of the neighbourhood physical environment with cognitive function? Findings from the AusDiab study.
THE SCIENCE OF THE TOTAL ENVIRONMENT - 01 Feb 2023
Characteristics of the neighbourhood environment, including the built and natural environment, area-level socio-economic status (SES) and air pollution, have been linked to cognitive health. However, most studies have focused on single neighbourhood characteristics and have not considered the extent to which the effects of environmental factors may interact. We examined the associations of meas...
COVID-19-Associated Myocardial Injury: Solving a Mystery Inside an Enigma.
JACC. BASIC TO TRANSLATIONAL SCIENCE - 01 Feb 2023
Pyridoxamine prevents increased atherosclerosis by intermittent methylglyoxal spikes in the aortic arches of ApoE mice.-/-
BIOMEDICINE & PHARMACOTHERAPY = BIOMEDECINE & PHARMACOTHERAPIE - 01 Feb 2023
Methylglyoxal (MGO) is a reactive glucose metabolite linked to diabetic cardiovascular disease (CVD). MGO levels surge during intermittent hyperglycemia. We hypothesize that these MGO spikes contribute to atherosclerosis, and that pyridoxamine as a MGO quencher prevents this injury. To study this, we intravenously injected normoglycemic 8-week old male C57Bl6 ApoE mice with normal saline (NS, n...
Lipids regulated by exercise and phosphoinositide 3-kinase: potential role as biomarkers and therapeutic targets for cardiovascular disease
CURRENT OPINION IN PHYSIOLOGY - 20 Jan 2023
Lipids are organic biomolecules that provide structural support to cells, but are also important for energy storage and signaling. Lipid profiling has emerged as a new technology with the potential of identifying new biomarkers and therapeutic targets. The lipid composition of cardiomyocyte membranes is altered during the process of cardiac remodeling, including exercise-induced heart enlargeme...
cropCSM: designing safe and potent herbicides with graph-based signatures.
BRIEFINGS IN BIOINFORMATICS - 10 Mar 2022
Herbicides have revolutionised weed management, increased crop yields and improved profitability allowing for an increase in worldwide food security. Their widespread use, however, has also led to a rise in resistance and concerns about their environmental impact. Despite the need for potent and safe herbicidal molecules, no herbicide with a new mode of action has reached the market in 30 years...
Depression and genetic susceptibility to cardiometabolic diseases
NATURE CARDIOVASCULAR RESEARCH - 01 Feb 2022
High frequency of depressed mood increases the risk of future cardiometabolic disease above that due to lifestyle factors and genetic susceptibility alone, raising new questions about risk management in individuals susceptible to depression
Substantial Fat Loss in Physique Competitors Is Characterized by Increased Levels of Bile Acids, Very-Long Chain Fatty Acids, and Oxylipins.
METABOLITES - 30 Sep 2022
Weight loss and increased physical activity may promote beneficial modulation of the metabolome, but limited evidence exists about how very low-level weight loss affects the metabolome in previously non-obese active individuals. Following a weight loss period (21.1 ± 3.1 weeks) leading to substantial fat mass loss of 52% (−7.9 ± 1.5 kg) and low body fat (12.7 ± 4.1%), the liquid chromatography-...
Estrogen receptor alpha deficiency in cardiomyocytes reprograms the heart-derived extracellular vesicle proteome and induces obesity in female mice
NATURE CARDIOVASCULAR RESEARCH - 09 Mar 2023
Dysregulation of estrogen receptor alpha (ERα) has been linked with increased metabolic and cardiovascular disease risk. Here, we generate and characterize cardiomyocyte-specific ERα knockout (ERαHKO) mice to assess the role of ERα in the heart. The most striking phenotype was obesity in female ERαHKO but not male ERαHKO mice. Female ERαHKO mice showed cardiac dysfunction, mild glucose and insu...
A Review of Low-Density Lipoprotein-Lowering Diets in the Age of Anti-Sense Technology.
NUTRIENTS - 01 Mar 2023
This narrative review discusses an important issue, the primary role of diet in reducing low-density lipoprotein cholesterol (LDLc) concentrations in polygenic hypercholesterolemia. Two effective drugs, statins, and ezetimibe, that lower LDLc > 20% are relatively inexpensive and potential competitors to strict dieting. Biochemical and genomic studies have shown that proprotein convertase subtil...
Prediction of cardiovascular death and non-fatal cardiovascular events by the Kidney age-Chronological age Difference (KCD) score in men and women of different ages in a community-based cohort.
BMJ OPEN - 07 Mar 2023
We examined the utility of the Kidney age-Chronological age Difference (KCD) score, an age-adapted measure of kidney function, to identify increased cardiovascular (CV) death or non-fatal CV event risk in participants of the Australian Diabetes, Obesity, and Lifestyle Study (AusDiab), a community-based cohort aged 23-95 years.Cohort study.Community.11205 randomly selected participants from urba...
Screening for Coronary Artery Disease in Cancer Survivors: State-of-the-Art Review.JACC: CardioOncology
JACC. CARDIOONCOLOGY - 01 Feb 2023
Coronary artery disease (CAD) is an important contributor to the cardiovascular burden in cancer survivors. This review identifies features that could help guide decisions about the benefit of screening to assess the risk or presence of subclinical CAD. Screening may be appropriate in selected survivors based on risk factors and inflammatory burden. In cancer survivors who have undergone geneti...
Transform-Us! cluster RCT: 18-month and 30-month effects on children's physical activity, sedentary time and cardiometabolic risk markers.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Mar 2023
To test the efficacy of the school- and home-based intervention on children's physical activity (PA), sedentary behaviour (SB) and cardiometabolic risk factor profiles.Transform-Us!A 30-month 2×2 factorial design cluster randomised controlled trial delivered in 20 primary schools (148 Year 3 classes) in Melbourne, Australia (2010-2012), that used pedagogical and environmental strategies to red...
Dose-response association between maternal smoking during pregnancy and the risk of infant death: a nationwide, population-based, retrospective cohort study.
ECLINICALMEDICINE - 01 Mar 2023
Association of timing and intensity of maternal smoking during pregnancy with all-cause and cause-specific infant death remains inconclusive. We aimed to examine the dose-response association of maternal smoking during each of the three trimesters of pregnancy with all-cause and cause-specific infant death.In this nationwide, population-based, retrospective cohort study, data were extracted fro...
Glucometabolic Perturbations in Type 2 Diabetes Mellitus and Coronavirus Disease 2019: Causes, Consequences, and How to Counter Them Using Novel Antidiabetic Drugs - The CAPISCO International Expert Panel.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES : OFFICIAL JOURNAL, GERMAN SOCIETY OF ENDOCRINOLOGY [AND] GERMAN DIABETES ASSOCIATION - 08 Mar 2023
The growing amount of evidence suggests the existence of a bidirectional relation between coronavirus disease 2019 (COVID-19) and type 2 diabetes mellitus (T2DM), as these two conditions exacerbate each other, causing a significant healthcare and socioeconomic burden. The alterations in innate and adaptive cellular immunity, adipose tissue, alveolar and endothelial dysfunction, hypercoagulation...
Atrial Fibrillation Ablation for Heart Failure With Preserved Ejection Fraction: A Randomized Controlled Trial.
JACC. HEART FAILURE - 28 Feb 2023
Patients with heart failure with preserved ejection fraction (HFpEF) frequently develop atrial fibrillation (AF). There are no randomized trials examining the effects of AF ablation on HFpEF outcomes.The aim of this study is to compare the effects of AF ablation vs usual medical therapy on markers of HFpEF severity, including exercise hemodynamics, natriuretic peptide levels, and patient sympto...
PI3K(p110α) as a determinant and gene therapy for atrial enlargement in atrial fibrillation.
01 Mar 2023
Atrial fibrillation (AF) is an irregular heart rhythm, characterised by chaotic atrial activation, which is promoted by remodelling. Once initiated, AF can also propagate the progression of itself in the so-called ''AF begets AF''. Several lines of investigation have shown that signalling molecules, including reactive oxygen species, angiotensin II, and phosphoinositide 3-kinases (PI3Ks), in pr...
Cardiovascular mortality post burn injury.
THE JOURNAL OF TRAUMA AND ACUTE CARE SURGERY - 01 Mar 2023
Burn injury is responsible for both acute and ongoing inflammation, resulting in systematic changes impacting the cardiovascular, hepatobiliary, endocrine, and metabolic systems, but there is minimal investigation into long-term clinical outcomes. This study aimed to investigate mortality due to cardiovascular related long-term postburn injury.This was a retrospective cohort study linking a bur...
The role of combined modifiable lifestyle behaviors in the longitudinal association between stressful life events and allostatic load in Australian adults.
PSYCHONEUROENDOCRINOLOGY - 01 Mar 2023
Allostatic load is a model that is used to quantify the physiological damage from exposure to stressors. Stressful life events are chronic stressors that can lead to an elevated allostatic load through the physiological and behavioral stress responses. However, there is limited empirical studies that has tested the proposed behavioural pathway. Our study addresses this gap by examining the medi...
Effectiveness, reach, uptake, and feasibility of digital health interventions for adults with hypertension: a systematic review and meta-analysis of randomised controlled trials.
THE LANCET. DIGITAL HEALTH - 01 Mar 2023
Digital health interventions are effective for hypertension self-management, but a comparison of the effectiveness and implementation of the different modes of interventions is not currently available. This study aimed to compare the effectiveness of SMS, smartphone application, and website interventions on improving blood pressure in adults with hypertension, and to report on their reach, upta...
