Publications
Now showing items 1041-1060 of 5027 records
Differences in Accelerometer-Measured Physical Activity and Sedentary Behavior Between Middle-Aged Men and Women in Japan: A Compositional Data Analysis.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 01 Jul 2022
Differences in accelerometer-measured sedentary behavior and different physical activity (PA) intensities between men and women have been poorly described. The authors examined gender differences in time-use activity composition and total volume of PA.A cross-sectional mail survey was conducted from 2013 to 2015 with a randomized sample of 6000 middle-aged (40-64 y) community-dwelling Japanese ...
The Role of Human Milk Lipids and Lipid Metabolites in Protecting the Infant against Non-Communicable Disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 06 Jul 2022
Non-communicable diseases continue to increase globally and have their origins early in life. Early life obesity tracks from childhood to adulthood, is associated with obesity, inflammation, and metabolic dysfunction, and predicts non-communicable disease risk in later life. There is mounting evidence that these factors are more prevalent in infants who are formula-fed compared to those who are...
Endothelial reactive oxygen-forming NADPH oxidase 5 is a possible player in diabetic aortic aneurysm but not atherosclerosis.
SCIENTIFIC REPORTS - 07 Jul 2022
Atherosclerosis and its complications are major causes of cardiovascular morbidity and death. Apart from risk factors such as hypercholesterolemia and inflammation, the causal molecular mechanisms are unknown. One proposed causal mechanism involves elevated levels of reactive oxygen species (ROS). Indeed, early expression of the ROS forming NADPH oxidase type 5 (Nox5) in vascular endothelial ce...
Intervention effects on children's movement behaviour accumulation as a result of the Transform-Us! school- and home-based cluster randomised controlled trial.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 07 Jul 2022
It is unknown if and how children's movement behaviour accumulation patterns change as a result of physical activity and/or sedentary behaviour interventions. It is important to establish the effectiveness of interventions targeting changes in such accumulation patterns. This study aimed to investigate the effect of the Transform-Us! school- and home-based intervention program on children's mov...
Trained Immunity and HIV Infection.
FRONTIERS IN IMMUNOLOGY - 01 Jan 2022
Findings that certain infections induce immunity not only against the causing agent, but also against an unrelated pathogen have intrigued investigators for many years. Recently, underlying mechanisms of this phenomenon have started to come to light. It was found that the key cells responsible for heterologous protection are innate immune cells such as natural killer cells (NKs), dendritic cell...
Effectiveness of Sodium-Glucose Cotransporter-2 Inhibitors vs. Dipeptidyl Peptidase-4 Inhibitors in Frail People With Diabetes Who Were Recently Hospitalized.
FRONTIERS IN PHARMACOLOGY - 01 Jan 2022
Sodium-glucose cotransporter-2 inhibitors (SGLT-2Is) reduce heart failure (HF) hospitalizations and major adverse cardiovascular events (MACE) in general type 2 diabetes populations. The objective of this study was to determine whether SGLT-2Is vs. dipeptidyl peptidase-4 inhibitors (DPP-4Is) are associated with reductions in MACE, HF hospitalizations and mortality in frail people with type 2 di...
Exploring Systemic Inflammation in the Relationships Between Poor Sleep Health or Shift-Work and Blood Pressure Across BMI, Sex and Age Groups
JOURNAL OF THE ENDOCRINE SOCIETY - 01 Nov 2022
Circadian challenges such as social and travel jetlag, poor sleep health or undertaking shift-work is becoming increasingly linked to incidences of cardiovascular disease, metabolic syndrome and hypertension due to the impact of circadian disruption. Currently, studies that address how such challenges can become specific risk factors for the development of hypertension show inconsistent finding...
CD14 inhibition mitigates left ventricular damage and dysfunction following myocardial infarction
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY - 31 Dec 2022
CD14 mediates immunological responses to damage-associated message patterns (DAMPs) released from damaged cells during acute myocardial infarction. The cardiac impact of CD14 inhibition following myocardial ischemia-reperfusion (MIR) remains undefined. This investigation rigorously assessed both early MIR-associated injury and subsequent cardiac damage and dysfunction following selective antibo...
Noninvasive Identification of Carditis in Acute Rheumatic Fever.
JACC. CARDIOVASCULAR IMAGING - 01 Apr 2022
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MicroRNA-132 may be associated with blood pressure and liver steatosis-preliminary observations in obese individuals.
JOURNAL OF HUMAN HYPERTENSION - 01 Oct 2022
Recent findings in experimental models have shown that the microRNA miR-132 (mir-132) is an important regulator of liver homeostasis and lipid metabolism. We aimed to assess miR-132 expression in liver and fat tissues of obese individuals and examine its association with blood pressure (BP) and hepatic steatosis. We examined obese individuals undergoing bariatric surgery for weight loss (n = 19...
Type-2 Diabetes and the Clinical Importance of Exaggerated Exercise Blood Pressure.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Oct 2022
Exaggerated exercise blood pressure (EEBP) during clinical exercise testing is associated with poor blood pressure (BP) control and cardiovascular disease (CVD). Type-2 diabetes (T2DM) is thought to be associated with increased prevalence of EEBP, but this has never been definitively determined and was the aim of this study.Clinical exercise test records were analyzed from 13 268 people (aged 5...
An Aspirin a Day….
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Oct 2022
Removing unwanted variation from large-scale RNA sequencing data with PRPS.
NATURE BIOTECHNOLOGY - 01 Jan 2023
Accurate identification and effective removal of unwanted variation is essential to derive meaningful biological results from RNA sequencing (RNA-seq) data, especially when the data come from large and complex studies. Using RNA-seq data from The Cancer Genome Atlas (TCGA), we examined several sources of unwanted variation and demonstrate here how these can significantly compromise various down...
Tissue-Mimicking Materials for Ultrasound-Guided Needle Intervention Phantoms: A Comprehensive Review.
ULTRASOUND IN MEDICINE & BIOLOGY - 01 Jan 2023
Ultrasound-guided needle interventions are common procedures in medicine, and tissue-mimicking phantoms are widely used for simulation training to bridge the gap between theory and clinical practice in a controlled environment. This review assesses tissue-mimicking materials from 24 studies as candidates for a high-fidelity ultrasound phantom, including methods for evaluating relevant acoustic ...
Treatment of haematuria with factor concentrate in people with haemophilia is associated with low rates of complications.
HAEMOPHILIA : THE OFFICIAL JOURNAL OF THE WORLD FEDERATION OF HEMOPHILIA - 01 Jan 2023
"The Times They Are A-Changin'" at Diabetes Care.
DIABETES CARE - 01 Jan 2023
Hippo pathway activation mediates chemotherapy-induced anti-cancer effect and cardiomyopathy through causing mitochondrial damage and dysfunction.
THERANOSTICS - 01 Jan 2023
Chemotherapy is a common clinical strategy for cancer treatment. However, the accompanied cardiomyopathy renders cancer patients under risk of another life-threatening condition. Whereas Hippo pathway is known to play key roles in both cancerogenesis and heart disease, it remains unclear whether Hippo pathway activation mediates chemotherapy-induced cardiomyopathy. In human breast cancer cells...
Improving the rate of inferior vena cava filter retrieval through multidisciplinary engagement.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS - 01 Jan 2023
The placement of retrievable inferior vena cava (IVC) filters occurs commonly, but retrieval rates remain low. Consequently, there is an unmet clinical need to ensure appropriate follow-up and retrieval of these devices.To determine the association between an IVC filter surveillance team with filter retrievals or a documented filter plan, time to retrieval, and incidence of filter complications...
CSM-Toxin: A Web-Server for Predicting Protein Toxicity.
PHARMACEUTICS - 28 Jan 2023
Biologics are one of the most rapidly expanding classes of therapeutics, but can be associated with a range of toxic properties. In small-molecule drug development, early identification of potential toxicity led to a significant reduction in clinical trial failures, however we currently lack robust qualitative rules or predictive tools for peptide- and protein-based biologics. To address this, ...
Age as a predictor of clinical outcomes and determinant of therapeutic measures for emergency medical services treated cardiogenic shock.
JOURNAL OF GERIATRIC CARDIOLOGY : JGC - 28 Jan 2023
The impact of age on outcomes in cardiogenic shock (CS) is poorly described in the pre-hospital setting. We assessed the impact of age on outcomes of patients treated by emergency medical services (EMS).This population-based cohort study included consecutive adult patients with CS transported to hospital by EMS. Successfully linked patients were stratified into tertiles by age (18-63, 64-77, an...
