Publications
Now showing items 1041-1060 of 5325 records
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity.
01 Mar 2023
Recently, common genetic risk factors for intracranial aneurysm (IA) and aneurysmal subarachnoid hemorrhage (ASAH) were found to explain a large amount of disease heritability and therefore have potential to be used for genetic risk prediction. We constructed a genetic risk score to (1) predict ASAH incidence and IA presence (combined set of unruptured IA and ASAH) and (2) assess its associatio...
The gut microbiome and hypertension.
NATURE REVIEWS. NEPHROLOGY - 01 Mar 2023
A large body of evidence has emerged in the past decade supporting a role for the gut microbiome in the regulation of blood pressure. The field has moved from association to causation in the last 5 years, with studies that have used germ-free animals, antibiotic treatments and direct supplementation with microbial metabolites. The gut microbiome can regulate blood pressure through several mecha...
Plasma AGE and Oxidation Products, Renal Function, and Preeclampsia in Pregnant Women with Type 1 Diabetes: A Prospective Observational Study.
JOURNAL OF DIABETES RESEARCH - 01 Jan 2023
We aimed to determine whether plasma advanced glycation end products or oxidation products (AGE/oxidation-P) predict altered renal function and/or preeclampsia (PE) in pregnant women with type 1 diabetes.Prospectively, using a nested case-control design, we studied 47 pregnant women with type 1 diabetes, of whom 23 developed PE and 24 did not. Nineteen nondiabetic, normotensive pregnant women p...
Cell-type-specific regulation of APOE and CLU levels in human neurons by the Alzheimer's disease risk gene SORL1.
CELL REPORTS - 18 Aug 2023
SORL1 is implicated in the pathogenesis of Alzheimer's disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were differentiated to neuron, astrocyte, microglial, and endothelial cell fates. Loss of SORL1 leads to alterations in both overlapping and distinct pathways across cell types, with the greatest ef...
Review and comparison of retinal vessel calibre and geometry software and their application to diabetes, cardiovascular disease, and dementia.
GRAEFE'S ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY = ALBRECHT VON GRAEFES ARCHIV FUR KLINISCHE UND EXPERIMENTELLE OPHTHALMOLOGIE - 01 Aug 2023
Developments in retinal imaging technologies have enabled the quantitative evaluation of the retinal vasculature. Changes in retinal calibre and/or geometry have been reported in systemic vascular diseases, including diabetes mellitus (DM), cardiovascular disease (CVD), and more recently in neurodegenerative diseases, such as dementia. Several retinal vessel analysis softwares exist, some being...
State of Shock: Contemporary Vasopressor and Inotrope Use in Cardiogenic Shock.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 01 Aug 2023
Cardiogenic shock is characterized by tissue hypoxia caused by circulatory failure arising from inadequate cardiac output. In addition to treating the pathologic process causing impaired cardiac function, prompt hemodynamic support is essential to reduce the risk of developing multiorgan dysfunction and to preserve cellular metabolism. Pharmacologic therapy with the use of vasopressors and inot...
Continuous subcutaneous insulin infusion: a local perspective.
HONG KONG MEDICAL JOURNAL = XIANGGANG YI XUE ZA ZHI - 01 Aug 2023
Cost effectiveness review of text messaging, smartphone application, and website interventions targeting T2DM or hypertension.
NPJ DIGITAL MEDICINE - 18 Aug 2023
Digital health interventions have been shown to be clinically-effective for type 2 diabetes mellitus (T2DM) and hypertension prevention and treatment. This study synthesizes and compares the cost-effectiveness of text-messaging, smartphone application, and websites by searching CINAHL, Cochrane Central, Embase, Medline and PsycInfo for full economic or cost-minimisation studies of digital healt...
Vascular ageing: moving from bench towards bedside.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY - 21 Aug 2023
Prevention of cardiovascular disease (CVD) remains one of the largest public health challenges of our time. Identifying individuals at increased cardiovascular risk at an asymptomatic, sub-clinical stage is of paramount importance for minimizing disease progression as well as the substantial health and economic burden associated with overt CVD. Vascular ageing (VA) involves the deterioration in...
Defibrillator access across Australia: the first step in avoiding a chain of fatality.
THE MEDICAL JOURNAL OF AUSTRALIA - 21 Aug 2023
Third Places for Older Adults' Social Engagement: A Scoping Review and Research Agenda.
THE GERONTOLOGIST - 24 Aug 2023
Neighborhood places that facilitate older residents to meet and interact (third places) receive an increasing research interest as studies have consistently shown the benefits of social engagement for older adults' health. This scoping review synthesized the findings of studies examining the role of third places in older adults' social engagement.Searching 5 databases (CINAHL, Medline, PsycInfo...
Characterization of K562 cells: uncovering novel chromosomes, assessing transferrin receptor expression, and probing pharmacological therapies.
CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - 14 Aug 2023
Human erythroleukemic K562 cells represent the prototypical cell culture model of chronic myeloid leukemia (CML). The cells are pseudo-triploid and positive for the Philadelphia chromosome. Therefore, K562 cells have been widely used for investigating the BCR/ABL1 oncogene and the tyrosine kinase inhibitor, imatinib-mesylate. Further, K562 cells overexpress transferrin receptors (TfR) and have ...
Asymptomatic people with well-controlled HIV do not have abnormal left ventricular global longitudinal strain.
FRONTIERS IN CARDIOVASCULAR MEDICINE - 01 Jan 2023
Previous studies have reported impairment in systolic and diastolic function in people with HIV (PWHIV). Our aim was to determine if echocardiographically measured left ventricular (LV) global longitudinal strain (GLS) is abnormal in asymptomatic PWHIV.A cross-sectional study of PWHIV ( = 98, 89% male, median age 53 years) and HIV-negative people ( = 50, median age 53 years) without known cardi...
Small extracellular vesicles promote invadopodia activity in glioblastoma cells in a therapy-dependent manner.
CELLULAR ONCOLOGY (DORDRECHT) - 01 Aug 2023
The therapeutic efficacy of radiotherapy/temozolomide treatment for glioblastoma (GBM) is limited by the augmented invasiveness mediated by invadopodia activity of surviving GBM cells. As yet, however the underlying mechanisms remain poorly understood. Due to their ability to transport oncogenic material between cells, small extracellular vesicles (sEVs) have emerged as key mediators of tumour ...
Dietary patterns from youth to adulthood and cognitive function in midlife: The cardiovascular risk in Young Finns Study.
NUTRITION (BURBANK, LOS ANGELES COUNTY, CALIF.) - 01 Aug 2023
Diet plays an important role in cognitive health, but the long-term association of diet early in life with cognitive function in adulthood has not, to our knowledge, been rigorously studied. The aim of this study was to examine the association of youth, adulthood, and long-term dietary patterns from youth to adulthood with cognitive function in midlife.This was a population-based cohort study t...
Dulaglutide and Kidney Function-Related Outcomes in Type 2 Diabetes: A REWIND Post Hoc Analysis.
DIABETES CARE - 01 Aug 2023
Dulaglutide (DU) 1.5 mg was associated with improved composite renal outcomes that included new-onset macroalbuminuria in people with type 2 diabetes with previous cardiovascular disease or cardiovascular risk factors in the REWIND (Researching cardiovascular Events with a Weekly INcretin in Diabetes) trial. This exploratory post hoc analysis evaluated kidney function-related outcomes, excludin...
Using Polygenic Risk Scores for Prioritizing Individuals at Greatest Need of a Cardiovascular Disease Risk Assessment.
JOURNAL OF THE AMERICAN HEART ASSOCIATION - 01 Aug 2023
Background The aim of this study was to provide quantitative evidence of the use of polygenic risk scores for systematically identifying individuals for invitation for full formal cardiovascular disease (CVD) risk assessment. Methods and Results A total of 108 685 participants aged 40 to 69 years, with measured biomarkers, linked primary care records, and genetic data in UK Biobank were used fo...
Gene-regulation modules in nonalcoholic fatty liver disease revealed by single-nucleus ATAC-seq.
LIFE SCIENCE ALLIANCE - 01 Oct 2023
We investigated the progression of nonalcoholic fatty liver disease from fatty liver to steatohepatitis using single-nucleus and bulk ATAC-seq on the livers of rats fed a high-fat diet (HFD). Rats fed HFD for 4 wk developed fatty liver, and those fed HFD for 8 wk further progressed to steatohepatitis. We observed an increase in the proportion of inflammatory macrophages, consistent with the pat...
ECMO PAL: using deep neural networks for survival prediction in venoarterial extracorporeal membrane oxygenation.
INTENSIVE CARE MEDICINE - 07 Aug 2023
Venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a complex and high-risk life support modality used in severe cardiorespiratory failure. ECMO survival scores are used clinically for patient prognostication and outcomes risk adjustment. This study aims to create the first artificial intelligence (AI)-driven ECMO survival score to predict in-hospital mortality based on a large intern...
Direct inference and control of genetic population structure from RNA sequencing data.
COMMUNICATIONS BIOLOGY - 02 Aug 2023
RNAseq data can be used to infer genetic variants, yet its use for estimating genetic population structure remains underexplored. Here, we construct a freely available computational tool (RGStraP) to estimate RNAseq-based genetic principal components (RG-PCs) and assess whether RG-PCs can be used to control for population structure in gene expression analyses. Using whole blood samples from und...
