Publications
Now showing items 1021-1040 of 5027 records
Vascular Aging and Vascular Disease Have Much in Common!
ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY - 01 Aug 2022
Long non-coding RNA Tug1 modulates mitochondrial and myogenic responses to exercise in skeletal muscle.
BMC BIOLOGY - 18 Jul 2022
Mitochondria have an essential role in regulating metabolism and integrate environmental and physiological signals to affect processes such as cellular bioenergetics and response to stress. In the metabolically active skeletal muscle, mitochondrial biogenesis is one important component contributing to a broad set of mitochondrial adaptations occurring in response to signals, which converge on t...
Human Milk Lipids and Small Metabolites: Maternal and Microbial Origins.
METABOLITES - 13 Mar 2023
Although there has been limited application in the field to date, human milk omics research continues to gain traction. Human milk lipidomics and metabolomics research is particularly important, given the significance of milk lipids and metabolites for infant health. For researchers conducting compositional milk analyses, it is important to consider the origins of these compounds. The current r...
Potential of plant secondary metabolite-based polymers to enhance wound healing.
ACTA BIOMATERIALIA - 15 Jul 2022
There is a global epidemic of non-healing wounds. Chronic inflammation, overexpression of pro-inflammatory cytokines, oxidative stress and bacterial infection are implicated in delayed wound healing. Natural extracts are a rich source of bioactive molecules called plant secondary metabolites (PSMs) that include terpenes and phenols. These molecules may facilitate wound healing through their ant...
Structural landscapes of PPI interfaces.
BRIEFINGS IN BIOINFORMATICS - 18 Jul 2022
Proteins are capable of highly specific interactions and are responsible for a wide range of functions, making them attractive in the pursuit of new therapeutic options. Previous studies focusing on overall geometry of protein-protein interfaces, however, concluded that PPI interfaces were generally flat. More recently, this idea has been challenged by their structural and thermodynamic charact...
Evaluating hierarchical machine learning approaches to classify biological databases.
BRIEFINGS IN BIOINFORMATICS - 18 Jul 2022
The rate of biological data generation has increased dramatically in recent years, which has driven the importance of databases as a resource to guide innovation and the generation of biological insights. Given the complexity and scale of these databases, automatic data classification is often required. Biological data sets are often hierarchical in nature, with varying degrees of complexity, i...
A solution NMR view of lipidic cubic phases: Structure, dynamics, and beyond
BIOCHIMICA ET BIOPHYSICA ACTA. ADVANCES - 01 Jan 2022
Nuclear magnetic resonance (NMR) spectroscopy is well-established nowadays for the elucidation of the 3D structures of proteins and protein complexes, the evaluation of biomolecular dynamics with atomistic resolution across a range of time scales, the screening of drug candidates with site specificity, and for the quantitation of molecular translational diffusion. Lyotropic lipidic cubic phases...
Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia.
CELL STEM CELL - 01 Aug 2019
Tumors are composed of phenotypically heterogeneous cancer cells that often resemble various differentiation states of their lineage of origin. Within this hierarchy, it is thought that an immature subpopulation of tumor-propagating cancer stem cells (CSCs) differentiates into non-tumorigenic progeny, providing a rationale for therapeutic strategies that specifically eradicate CSCs or induce th...
Defining cardiac fibrosis complexity and regulation towards therapeutic development
CLINICAL AND TRANSLATIONAL DISCOVERY - 01 Jan 2023
Abstract Cardiac fibrosis is insidious, accelerating cardiovascular diseases, heart failure, and death. With a notable lack of effective therapies, advances in both understanding and targeted treatment of fibrosis are urgently needed. Remodelling of the extracellular matrix alters the biomechanical and biochemical cardiac structure and function, disrupting cell-matrix interactions and exacerbat...
Device-measured physical activity, adiposity and mortality: a harmonised meta-analysis of eight prospective cohort studies.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Jul 2022
The joint associations of total and intensity-specific physical activity with obesity in relation to all-cause mortality risk are unclear.We included 34 492 adults (72% women, median age 62.1 years, 2034 deaths during follow-up) in a harmonised meta-analysis of eight population-based prospective cohort studies with mean follow-up ranging from 6.0 to 14.5 years. Standard body mass index categori...
A Comprehensive Approach to Managing Methamphetamine-Associated Cardiomyopathy.
01 Jul 2022
Methamphetamines are illicit drugs of the amphetamine-type stimulant class that have been increasing in popularity, availability, and purity in recent decades. As a result, rates of methamphetamine-associated cardiomyopathy (MAC) are rising globally. MAC is associated with high rates of sudden cardiac arrest, late presentation, and poor outcomes. This review discusses the medical management of ...
Transitional changes in the structure of C-reactive protein create highly pro-inflammatory molecules: Therapeutic implications for cardiovascular diseases.
PHARMACOLOGY & THERAPEUTICS - 01 Jul 2022
C-reactive protein (CRP) is the prototypic acute-phase reactant that has long been recognized almost exclusively as a marker of inflammation and predictor of cardiovascular risk. However, accumulating evidence indicates that CRP is also a direct pathogenic pro-inflammatory mediator in atherosclerosis and cardiovascular diseases. The 'CRP system' consists of at least two protein conformations wi...
Tackling an unmet need in sports cardiology: understanding exercise-induced cardiac remodelling and its clinical consequences.
BRITISH JOURNAL OF SPORTS MEDICINE - 01 Jul 2022
Treatment gaps, 1-year readmission and mortality following myocardial infarction by diabetes status, sex and socioeconomic disadvantage.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH - 01 Jul 2022
We evaluated variation in treatment for, and outcomes following, myocardial infarction (MI) by diabetes status, sex and socioeconomic disadvantage.We included all people aged ≥30 years who were discharged alive from hospital following MI between 1 July 2012 and 30 June 2017 in Victoria, Australia (n=43 272). We assessed receipt of inpatient procedures and discharge dispensing of cardioprotectiv...
Defective AMPK regulation of cholesterol metabolism accelerates atherosclerosis by promoting HSPC mobilization and myelopoiesis.
MOLECULAR METABOLISM - 01 Jul 2022
Dysregulation of cholesterol metabolism in the liver and hematopoietic stem and progenitor cells (HSPCs) promotes atherosclerosis development. Previously, it has been shown that HMG-CoA-Reductase (HMGCR), the rate-limiting enzyme in the mevalonate pathway, can be phosphorylated and inactivated by the metabolic stress sensor AMP-activated protein kinase (AMPK). However, the physiological signifi...
Global Impact of Different Blood Pressure Thresholds in 4 021 690 Participants of the May Measurement Month Initiative.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Jul 2022
Influential guidelines currently define hypertension at different thresholds of blood pressure (BP). The global May Measurement Month initiative provides a unique opportunity to estimate the potential consequences of universal lowering of BP thresholds on the prevalence of hypertension based on a large, real-world, patient-level data set.The average of the second and third of 3 attended BP read...
Impact of device length on electrogram sensing in miniaturized insertable cardiac monitors.
JOURNAL OF ELECTROCARDIOLOGY - 01 Jan 2022
Little data exists on electrogram sensing in current generation of miniaturized insertable cardiac monitors (ICMs).To compare the sensing capability of ICM with different vector length: Medtronic Reveal LINQ (~40 mm) vs. Biotronik Biomonitor III (BM-III, ~70 mm).De-identified remote monitoring transmissions from n = 40 patients with BM-III were compared with n = 80 gender and body mass index (B...
Return to exercise post-COVID-19 infection: A pragmatic approach in mid-2022.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT - 01 Jul 2022
Glucagon-like peptide-1 receptor agonist (GLP1-RA) therapy in type 2 diabetes.
AUSTRALIAN JOURNAL OF GENERAL PRACTICE - 01 Jul 2022
Type 2 diabetes (T2D) is a national health priority. Its rising prevalence is accompanied by a high burden of diabetes-related complications, many of which are preventable. Numerous glucose-lowering medications have been developed in recent years with growing evidence relating to their efficacy and safety. These advances have increased the complexity of prescribing decisions in T2D.This review ...
Challenges and opportunities for prevention and removal of unwanted variation in lipidomic studies.
PROGRESS IN LIPID RESEARCH - 01 Jul 2022
Large 'omics studies are of particular interest to population and clinical research as they allow elucidation of biological pathways that are often out of reach of other methodologies. Typically, these information rich datasets are produced from multiple coordinated profiling studies that may include lipidomics, metabolomics, proteomics or other strategies to generate high dimensional data. In ...
