Publications
Now showing items 1001-1020 of 5325 records
A pilot genome-wide association study meta-analysis of gastroparesis.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL - 08 Sep 2023
Gastroparesis (GP) is characterized by delayed gastric emptying in the absence of mechanical obstruction.Genetic predisposition may play a role; however, investigation at the genome-wide level has not been performed.We carried out a genome-wide association study (GWAS) meta-analysis on (i) 478 GP patients from the National Institute of Diabetes and Digestive and Kidney Diseases Gastroparesis Cl...
Cardiotoxicity of anti-cancer drugs: cellular mechanisms and clinical implications.
FRONTIERS IN CARDIOVASCULAR MEDICINE - 01 Jan 2023
Cardio-oncology is an emerging field that seeks to enhance quality of life and longevity of cancer survivors. It is pertinent for clinicians to understand the cellular mechanisms of prescribed therapies, as this contributes to robust understanding of complex treatments and off-target effects, improved communication with patients, and guides long term care with the goal to minimise or prevent ca...
Community-developed checklists for publishing images and image analyses.
NATURE METHODS - 14 Sep 2023
Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However, for scientists wishing to publish obtained images and image-analysis results, there are currently no unified guidelines for best practices. Consequently, microscopy images and image data in publications may be...
Therapeutic blockade of ER stress and inflammation prevents NASH and progression to HCC.
SCIENCE ADVANCES - 15 Sep 2023
The incidence of hepatocellular carcinoma (HCC) is rapidly rising largely because of increased obesity leading to nonalcoholic steatohepatitis (NASH), a known HCC risk factor. There are no approved treatments to treat NASH. Here, we first used single-nucleus RNA sequencing to characterize a mouse model that mimics human NASH-driven HCC, the mouse fed a high-fat diet. Activation of endoplasmic ...
Aldosterone and renin concentrations and blood pressure in young Indigenous and non-Indigenous adults in the Northern Territory: a cross-sectional study.
THE MEDICAL JOURNAL OF AUSTRALIA - 18 Sep 2023
To evaluate aldosterone and renin levels and aldosterone-to-renin ratios (ARRs) in young Indigenous and non-Indigenous adults in the Northern Territory, and their association with blood pressure levels.Cross-sectional study; single time point sub-study of two prospective birth cohort studies.Participants in the Aboriginal Birth Cohort (ABC) - born to Indigenous mothers at the Royal Darwin Hospi...
Prevalence of atrial septal defects and patent foramen ovale in a cohort of sudden cardiac death patients undergoing autopsy.
JOURNAL OF CARDIOLOGY - 19 Sep 2023
Patent foramen ovale (PFO) and atrial septal defects (ASD) have been described in up to 30 % of subjects in autopsy series but contemporary data are scarce. It is important to confirm the prevalence of ASD/PFO in the general population given the potential associated stroke risk and the increasing availability of intervention via PFO closure.A state-wide prospective out-of-hospital cardiac arres...
Statins to prevent early cardiac dysfunction in cancer patients at increased cardiotoxicity risk receiving anthracyclines.
EUROPEAN HEART JOURNAL. CARDIOVASCULAR PHARMACOTHERAPY - 20 Sep 2023
Anthracyclines can cause cancer therapy-related cardiac dysfunction (CTRCD). We aimed to assess whether statins prevent decline in left ventricular ejection fraction (LVEF) in anthracycline-treated patients at increased risk for CTRCD.In this multicenter double-blinded, placebo-controlled trial, patients with cancer at increased risk of anthracycline-related CTRCD (per ASCO guidelines) were ran...
Association between urban-rural location and prevalence of type 2 diabetes and impaired fasting glucose in West Africa: a cross-sectional population-based epidemiological study.
BMJ OPEN - 21 Sep 2023
We investigated the association between urban/rural location and both type 2 diabetes mellitus (T2DM) and pre-diabetes among populations of five West African countries.Cross-sectional studies, using the WHO Stepwise (STEPs) survey data.National representative data of both urban and rural areas from Benin, Burkina Faso, Ghana, Liberia and Mali.Adults comprising 15 468 participants (6774 men and ...
Associations between postrace atrial fibrillation and measures of performance, racing history and airway disease in horses.
JOURNAL OF VETERINARY INTERNAL MEDICINE - 23 Sep 2023
Atrial fibrillation (AF) is the most common performance limiting arrhythmia in racehorses. High dose exercise and airway disease promote AF in humans. Few studies have investigated epidemiological factors associated with AF in horses.Explore variables relating to performance, exercise volume and postrace endoscopic findings in horses with AF.A total of 164 horses with poor race performance and ...
Reasons for hospitalisation among Australians with type 1 or type 2 diabetes and COVID-19.
CANADIAN JOURNAL OF DIABETES - 23 Sep 2023
To determine the reasons for hospitalisation in those with diabetes who contract COVID-19.We analysed all COVID-19 cases reported to the Victorian Department of Health and linked hospitalisation data. We determined reasons for acute (0-30 days) and post-acute (31-365 days) hospitalisation among those with type 1 or type 2 diabetes and COVID-19, compared to those with COVID-19 and no diabetes, a...
Sudden cardiac death, arrhythmias and abnormal electrocardiography in systemic sclerosis: A systematic review and meta-analysis.
01 Oct 2023
To calculate the frequency of sudden cardiac death(SCD), arrhythmia and conduction defects in SSc.MEDLINE/EMBASE were searched to January 2023. English-language studies reporting the incidence/frequency of SCD, arrhythmia and electrocardiography(ECG) abnormalities in SSc were included. Odds ratios(OR), estimations of annual incidence or pooled frequencies were calculated.Seventy-nine studies(n ...
Incorporating a polygenic risk score-triaged coronary calcium score into cardiovascular disease examinations to identify subclinical coronary artery disease (ESCALATE): Protocol for a prospective, nonrandomized implementation trial.
AMERICAN HEART JOURNAL - 01 Oct 2023
Identifying and targeting established modifiable risk factors has been a successful strategy for reducing the burden of coronary artery disease (CAD) at the population-level. However, up to 1-in-4 patients who present with ST elevation myocardial infarction do so in the absence of such risk factors. Polygenic risk scores (PRS) have demonstrated an ability to improve risk prediction models indep...
Exercise-induced myocardial T1 increase and right ventricular dysfunction in recreational cyclists: a CMR study.
01 Oct 2023
Although cardiac troponin I (cTnI) increase following strenuous exercise has been observed, the development of exercise-induced myocardial edema remains unclear. Cardiac magnetic resonance (CMR) native T1/T2 mapping is sensitive to the pathological increase of myocardial water content. Therefore, we evaluated exercise-induced acute myocardial changes in recreational cyclists by incorporating bi...
Correction to: The T1D Index: Implications of Initial Results, Data Limitations, and Future Development.
CURRENT DIABETES REPORTS - 01 Oct 2023
Current insights and emerging trends in early-onset type 2 diabetes.
THE LANCET. DIABETES & ENDOCRINOLOGY - 01 Oct 2023
Type 2 diabetes diagnosed in childhood or early adulthood is termed early-onset type 2 diabetes. Cases of early-onset type 2 diabetes are increasing rapidly globally, alongside rising obesity. Compared with a diagnosis later in life, an earlier-onset diagnosis carries an unexplained excess risk of microvascular complications, adverse cardiovascular outcomes, and earlier death. Women with early-...
Applying the WHO global targets for diabetes mellitus.
NATURE REVIEWS. ENDOCRINOLOGY - 01 Apr 2023
An atlas of genetic scores to predict multi-omic traits.
NATURE - 01 Apr 2023
The use of omic modalities to dissect the molecular underpinnings of common diseases and traits is becoming increasingly common. But multi-omic traits can be genetically predicted, which enables highly cost-effective and powerful analyses for studies that do not have multi-omics. Here we examine a large cohort (the INTERVAL study; n = 50,000 participants) with extensive multi-omic data for plas...
Interactions between the lipidome and genetic and environmental factors in autism.
NATURE MEDICINE - 01 Apr 2023
Autism omics research has historically been reductionist and diagnosis centric, with little attention paid to common co-occurring conditions (for example, sleep and feeding disorders) and the complex interplay between molecular profiles and neurodevelopment, genetics, environmental factors and health. Here we explored the plasma lipidome (783 lipid species) in 765 children (485 diagnosed with a...
Neutrophils in cardiovascular disease: warmongers, peacemakers, or both?
CARDIOVASCULAR RESEARCH - 20 Sep 2022
Neutrophils, the most abundant of all leucocytes and the first cells to arrive at the sites of sterile inflammation/injury act as a double-edged sword. On one hand, they inflict a significant collateral damage to the tissues and on the other hand, they help facilitate wound healing by a number of mechanisms. Recent studies have drastically changed the perception of neutrophils from being simple...
Heart Failure With Preserved Ejection Fraction as an Exercise Deficiency Syndrome: JACC Focus Seminar 2/4.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 20 Sep 2022
Across differing spectrums of cardiac function and cardiac pathologies, there are strong associations between measures of cardiorespiratory fitness and burden of symptoms, quality of life, and prognosis. In this part 2 of a 4-part series, we contend that there is a strong association among physical activity, cardiorespiratory fitness, and cardiac function. We argue that a chronic lack of exerci...
