Publications
Now showing items 101-120 of 5702 records
Association of Pericoronary Adipose Attenuation With Major Adverse Cardiovascular Events and High-Risk Plaque.
JACC. CARDIOVASCULAR IMAGING - 10 Jul 2025
The characterization of pericoronary adipose tissue (PCAT) attenuation may provide adjunctive prognostic information to coronary evaluation at coronary computed tomography angiography. However, heterogeneity in measurement methodologies has led to uncertainties regarding its clinical applicability. This systematic review and meta-analysis explores the impact of measurement methodology on the as...
Defining Success in Atrial Fibrillation Ablation Trials: A Response on Antiarrhythmic Drug Use and Diagnosis-to-Ablation Timing.
HEART RHYTHM - 27 Jun 2025
No evidence from euglycaemic-hyperinsulinaemic clamp studies for greater insulin sensitivity in adults with type 1 diabetes using insulin pump versus multiple daily insulin injections-Post hoc meta-analysis.
DIABETES, OBESITY & METABOLISM - 01 Jul 2025
Supine Blood Pressure and Cardiovascular Risk.
JAMA CARDIOLOGY - 02 Jul 2025
Regional structural differences in the brain related to high blood pressure.
JOURNAL OF HYPERTENSION - 23 Jun 2025
Hypertension is characterized by elevations in sympathetic nerve activity that are consistently observed regardless of severity and treatment status. Structural changes in the brain occur with hypertension, including grey matter changes, which are associated with elevated blood pressure (BP). However, whether or not these changes are associated with increased sympathetic nerve activity in hyper...
pH-sensor GPR68 plays a role in how dietary fibre lowers blood pressure in a preclinical model of hypertension.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 23 Jun 2025
Dietary fibre lowers blood pressure (BP) via short-chain fatty acids, acidic metabolites released from fibre fermentation by bacteria in the large intestine. This acidic microenvironment may activate the pH-sensing receptor GPR68, primarily expressed in immune cells. Here, we aimed to investigate whether GPR68 confers the BP-lowering effects of a high-fibre diet in hypertension by regulating in...
Atrial fibrillation in former world-class rowers: role of environmental and genetic factors.
EUROPEAN HEART JOURNAL - 25 Jun 2025
Endurance sport has been associated with an increased risk of atrial fibrillation (AF). The aim of this study was to assess the extent to which this is due to exercise burden or genetic predisposition. Former rowers aged 45-80 years who competed at international championships were compared with a control group extracted from the UK Biobank, matched (1:100) for age and sex. Evaluation included 1...
Expanding the Search for Primary Aldosteronism in Clinical Settings.
HYPERTENSION (DALLAS, TEX. : 1979) - 14 Aug 2025
Increased plasma levels of erythropoietin after renal denervation in patients with resistant hypertension.
HYPERTENSION RESEARCH : OFFICIAL JOURNAL OF THE JAPANESE SOCIETY OF HYPERTENSION - 14 Aug 2025
Erythropoietin (Epo) plays a crucial role in the formation and maturation of erythrocytes and is produced primarily by peritubular cells in the renal cortex. Previous studies suggest that renal sympathetic nerve activity (RSNA) may influence Epo regulation. Catheter-based renal denervation (RDN) has been shown to reduce renal noradrenaline spillover and blood pressure in patients with resistant...
Galectin-3 gene deletion alters lipid profile in healthy and cardiomyopathy mouse hearts.
BIOCHIMICA ET BIOPHYSICA ACTA. MOLECULAR AND CELL BIOLOGY OF LIPIDS - 04 Aug 2025
Galectin-3 (Gal3) is known to interact with glycans of proteins and lipids. In cardiovascular disease, the elevated expression of Gal3 mediates inflammation, hypertrophy and fibrosis. We explored the effect of Gal3 on the cardiac lipid profile in healthy mice or in mice with dilated cardiomyopathy (DCM). Using lipidomics and gene-targeted mouse models, we studied the influence of Gal3 gene dele...
Development of a novel therapy for systolic heart failure.
EMBO MOLECULAR MEDICINE - 04 Aug 2025
Heart failure presents a critical health challenge with a 5-year mortality rate of up to 50%. Conventional treatments often lead to bradycardia or hypotension due to their impact on patient hemodynamics. To address this issue, we utilized high-throughput drug screening combined with structure-activity relationship-based medicinal chemistry to develop a novel drug-like compound that effectively ...
Triage tools to inform the prioritisation of physical health services following a diagnosis of cancer: a scoping review.
SUPPORTIVE CARE IN CANCER : OFFICIAL JOURNAL OF THE MULTINATIONAL ASSOCIATION OF SUPPORTIVE CARE IN CANCER - 06 Aug 2025
Many people face multiple cancer- and treatment-related sequalae. Triage and referral to physical health services can manage such consequences, but a comprehensive understanding of available triage tools is lacking. This review (i) identifies tools used to triage to physical health services, (ii) maps tool characteristics and application outcomes and (iii) summarises existing gaps. A systematic...
The association between circulating SIGLEC6 and preeclampsia: observational studies of seven cohorts.
EBIOMEDICINE - 29 Jul 2025
Preeclampsia is a serious complication of pregnancy. We did an observational study using seven tissue bank/cohorts to examine the association between circulating SIGLEC6 and preeclampsia. We included samples from participants with preterm disease (delivering <34 weeks gestation in Australia), examined whether levels altered with clinical disease severity (samples collected in South Africa) and ...
Recurrent Ventricular Fibrillation Due to Coronary Vasospasm Without Preceding ST-Segment Elevation or Chest Pain.
JACC. CASE REPORTS - 30 Jul 2025
Coronary vasospasm (CV) is a rare cause of malignant ventricular arrhythmia and cardiac arrest. It typically presents with chest pain and marked ST-segment elevation. We present the case of a 61-year-old man with recurrent malignant ventricular arrhythmia and implantable defibrillator shocks without preceding chest pain. The diagnosis of CV remained elusive for 3 months despite extensive invest...
Daily steps and health outcomes in adults: a systematic review and dose-response meta-analysis.
THE LANCET. PUBLIC HEALTH - 01 Aug 2025
Despite the rapid increase in evidence from the past decade on daily steps and health-related outcomes, existing systematic reviews primarily focused on few outcomes, such as all-cause mortality. This study synthesised the prospective dose-response relationship between daily steps and health outcomes including all-cause mortality, cardiovascular disease, cancer, type 2 diabetes, cognitive outco...
Targeting renal nerves for arterial hypertension - The path to renal denervation.
AUTONOMIC NEUROSCIENCE : BASIC & CLINICAL - 19 Jun 2025
Renal nerves are critical in regulation of blood pressure and renal function. The concept of renal denervation is based on solid pathophysiologic principles and both experimental and human data. Renal denervation has consistently shown to reduce blood pressure in patients with resistant hypertension and complex to manage blood pressure. This occurs both in the clinical trial environment and in ...
Associations between health literacy, well-being and general health in adults with type 2 diabetes, considering culturally and linguistically diverse background: Results from the first diabetes MILES Australia study.
DIABETIC MEDICINE : A JOURNAL OF THE BRITISH DIABETIC ASSOCIATION - 17 Jun 2025
To examine the relationships between health literacy, well-being and general health among adults with type 2 diabetes (T2DM) in Australia, overall and separately for those reporting culturally and linguistically diverse (CALD) backgrounds. Data were analyzed from 1962 adults with T2DM (aged 59 ± 9 years; 51% men) from the Diabetes MILES-1 survey. Participants completed the Health Literacy Manag...
Bidirectional relationships between television viewing and loneliness in middle-aged and older men and women.
JOURNAL OF AFFECTIVE DISORDERS - 19 Jun 2025
There is growing evidence that both sedentary behaviour and loneliness have adverse health consequences; however, the potential relationships between sedentary behaviour and loneliness are unclear. Accordingly, we examined the relationship and the directionality of prospective relationships between television (TV) viewing time (a ubiquitous leisure-time sedentary behaviour) and loneliness in mi...
Online tool for cross-sectional and longitudinal comparison of socio-economic status indices based on postcodes in Australia.
INTERNAL MEDICINE JOURNAL - 20 Jun 2025
Socio-economic status (SES) is strongly associated with health outcomes, yet it remains relatively difficult to measure, particularly for longitudinal comparisons. We have developed an interactive online tool (available at bit.ly/SEIFA-POA) that facilitates SES assessment based on postcodes (POA). By utilising percentiles of socio-economic indices for areas (SEIFA) derived from postcode-based r...
Microelectrode recordings from the human cervical vagus nerve during maximal breath-holds.
EXPERIMENTAL PHYSIOLOGY - 11 Jun 2025
Voluntary breath-holds can be sustained for a long time following training, but ultimately, regardless of duration, the asphyxic break-point is reached and the apnoea terminated. The physiological changes occurring during the apnoea include a marked increase in sympathetically-mediated vasoconstriction in non-essential organs, such as skeletal muscle, spleen and kidney, while the brain is prote...
