Publications
Now showing items 101-120 of 5153 records
Whole blood transcriptional profiles and the pathogenesis of tuberculous meningitis.
ELIFE - 30 Oct 2024
Mortality and morbidity from tuberculous meningitis (TBM) are common, primarily due to inflammatory response to <i>Mycobacterium tuberculosis</i> infection, yet the underlying mechanisms remain poorly understood. We aimed to uncover genes and pathways associated with TBM pathogenesis and mortality, and determine the best predictors of death, utilizing whole-blood RNA sequencing from 281 Vietnam...
A single risk assessment for the most common diseases of ageing, developed and validated on 10 cohort studies.
BMC MEDICINE - 31 Oct 2024
We aimed to develop risk tools for dementia, stroke, myocardial infarction (MI), and diabetes, for adults aged ≥ 65 years using shared risk factors. Data were obtained from 10 population-based cohorts (N = 41,755) with median follow-up time (years) for dementia, stroke, MI, and diabetes of 6.2, 7.0, 6.8, and 7.4, respectively. Disease-free participants at baseline were included, and 22 risk fac...
Persistent Atrial Fibrillation Phenotypes and Ablation Outcomes: Persistent From Outset vs Progression From Paroxysmal AF.
JACC. CLINICAL ELECTROPHYSIOLOGY - 27 Sep 2024
Many patients with persistent atrial fibrillation (PsAF) have progressed from an initial paroxysmal phenotype; however, there are patients in whom atrial fibrillation (AF) is persistent at diagnosis. Relatively little is known about this subgroup, but prior observational studies have suggested these patients have worse outcomes with ablation. This study sought to: 1) assess demographic and elec...
British Cardiovascular Society survey of the provision and structure of cardiology multidisciplinary meetings in England.
CLINICAL MEDICINE (LONDON, ENGLAND) - 12 Sep 2024
Multidisciplinary meetings (MDMs) are central to clinical decision-making in many areas of cardiology. This study assessed current provision and structure of cardiology MDMs in England in comparison with national guidelines. British Cardiovascular Society (BCS) members were surveyed regarding frequency, core attendees, and organisational aspects of cardiology MDMs for myocardial revascularisati...
Replacing sedentary time with sleep and physical activity: associations with physical function and wellbeing in Type 2 diabetes.
DIABETES RESEARCH AND CLINICAL PRACTICE - 05 Oct 2024
To examine the associations of substituting sedentary behaviour (SB) for sleep, light physical activity (LPA) or moderate-to-vigorous physical activity (MVPA) with physical function and wellbeing. Cross-sectional data from 808 adults with Type 2 Diabetes Mellitus, (T2DM) were included. 24-hour behaviours were ascertained through accelerometery. Isotemporal substitution was used to estimate the ...
Prognostic Impact of Diagnosis-to-Ablation Time on Outcomes Following Catheter Ablation in Persistent Atrial Fibrillation and Left Ventricular Systolic Dysfunction.
HEART RHYTHM - 27 Sep 2024
The optimal timing of catheter ablation in individuals with atrial fibrillation (AF) and left ventricular systolic dysfunction (LVSD) remains uncertain. We examined whether AF diagnosis to ablation time (DAT) influences outcomes following catheter ablation(CA) in patients with persistent AF (PsAF) and LVSD from the CAMERA MRI and CAPLA randomized studies. We evaluated clinical outcomes accordin...
2024 HRS expert consensus statement on arrhythmias in the athlete: Evaluation, treatment, and return to play.
HEART RHYTHM - 01 Oct 2024
Youth and adult participation in sports continues to increase, and athletes may be diagnosed with potentially arrhythmogenic cardiac conditions. This international multidisciplinary document is intended to guide electrophysiologists, sports cardiologists, and associated health care team members in the diagnosis, treatment, and management of arrhythmic conditions in the athlete with the goal of ...
Constipation is associated with an increased risk of major adverse cardiac events in a UK population.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Oct 2024
Traditional cardiovascular risk factors, including hypertension, only explain part of major adverse cardiac events (MACEs). Understanding what other risk factors contribute to MACE is essential for prevention. Constipation shares common risk factors with hypertension and is associated with an increased risk of several cardiovascular diseases. We hypothesized that constipation is an underappreci...
Leveraging metabolism for better outcomes in heart failure.
CARDIOVASCULAR RESEARCH - 01 Oct 2024
Whilst metabolic inflexibility and substrate constraint have been observed in heart failure for many years, their exact causal role remains controversial. In parallel, many of our fundamental assumptions about cardiac fuel use are now being challenged like never before. For example, the emergence of sodium glucose cotransporter 2 inhibitor (SGLT2i) therapy as one of the four "pillars" of heart ...
Complications of catheter ablation for atrial fibrillation: important differences in patients with systolic heart failure.
HEART RHYTHM - 16 Sep 2024
Continuous ketone monitoring: Exciting implications for clinical practice.
DIABETES, OBESITY & METABOLISM - 24 Sep 2024
Diabetic ketoacidosis (DKA) is a life-threatening complication usually affecting people with type 1 diabetes (T1D) and, less commonly, people with type 2 diabetes. Early identification of ketosis is a cornerstone in DKA prevention and management. Current methods for ketone measurement by people with diabetes include capillary blood or urine testing. These approaches have limitations, including ...
Firing properties of single axons with cardiac rhythmicity in the human cervical vagus nerve.
THE JOURNAL OF PHYSIOLOGY - 25 Sep 2024
Microneurographic recordings of the human cervical vagus nerve have revealed the presence of multi-unit neural activity with measurable cardiac rhythmicity. This suggests that the physiology of vagal neurones with cardiovascular regulatory function can be studied using this method. Here, the activity of cardiac rhythmic single units was discriminated from human cervical vagus nerve recordings u...
Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice.
JOURNAL OF SPORT AND HEALTH SCIENCE - 26 Sep 2024
Regular exercise can reduce incidence and progression of breast cancer, but the mechanisms for such effects are not fully understood. We used a variety of rodent and human experimental model systems to determine whether exercise training can reduce tumor burden in breast cancer and to identify mechanism associated with any exercise training effects on tumor burden. We show that voluntary wheel ...
Cost-effectiveness of a novel AI technology to quantify coronary inflammation and cardiovascular risk in patients undergoing routine Coronary Computed Tomography Angiography.
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES - 28 Sep 2024
Coronary Computed Tomography Angiography (CCTA) is a first line investigation for chest pain in patients with suspected obstructive coronary artery disease (CAD). However, many acute cardiac events occur in the absence of obstructive CAD. We assessed the lifetime cost-effectiveness of integrating a novel artificial intelligence-enhanced image analysis algorithm (AI-Risk) that stratifies the ris...
Cardiac Function and Functional Capacity in Patients with Long COVID: a Comparison to Propensity-Matched Community Controls.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY : OFFICIAL PUBLICATION OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY - 17 Sep 2024
Cardiac impairment has been associated with acute COVID-19 since the earliest reports of the pandemic. However, its role in post-acute sequelae of COVID-19 (PASC, or "long COVID") is undefined, and many existing observations about cardiovascular involvement in PASC are uncontrolled. To compare the prevalence of cardiac dysfunction in patients with Long COVID, and non-infected controls from the ...
The quest for the holy grail in antithrombotic therapy: revitalized hope for platelet GPVI as a safe and effective antithrombotic target.
EUROPEAN HEART JOURNAL - 20 Sep 2024
The islet tissue plasminogen activator/plasmin system is upregulated with human islet amyloid polypeptide aggregation and protects beta cells from aggregation-induced toxicity.
DIABETOLOGIA - 09 Sep 2024
Apart from its fibrinolytic activity, the tissue plasminogen activator (tPA)/plasmin system has been reported to cleave the peptide amyloid beta, attenuating brain amyloid deposition in Alzheimer's disease. As aggregation of human islet amyloid polypeptide (hIAPP) is toxic to beta cells, we sought to determine whether activation of the fibrinolytic system can also reduce islet amyloid depositio...
The association of glycaemic risk factors and diabetes duration with risk of heart failure in people with type 2 diabetes: A systematic review and meta-analysis.
DIABETES, OBESITY & METABOLISM - 13 Sep 2024
To conduct a systematic review in order to better understand the association of glycaemic risk factors and diabetes duration with risk of heart failure (HF) in individuals with type 2 diabetes (T2D). We identified longitudinal studies investigating the association of glycaemic factors (glycated haemoglobin [HbA1c], HbA1c variability, and hypoglycaemia) and diabetes duration with HF in individua...
Recent trends and disparities in 24-hour movement behaviors among US youth with mental, behavioral and neurodevelopmental conditions.
JOURNAL OF AFFECTIVE DISORDERS - 01 Sep 2024
Meeting 24-h movement behaviors (24-HMB: physical activity [PA], screen time [ST], and sleep [SL]) recommendations may be associated with positive health outcomes among youth with specific mental, behavioral, and neurodevelopmental (MBD) conditions. However, temporal trends and disparities in meeting 24-HMB guidelines in these higher-risk groups have not been investigated, hampering the develop...
Resolution of symptoms of binge eating disorder associated with semaglutide treatment for obesity and type 1 diabetes.
INTERNAL MEDICINE JOURNAL - 01 Sep 2024
