Publications
Now showing items 101-120 of 5325 records
A paradigm shift in cardiovascular research - new method isolates intestinal interstitial fluid to understand gut microbiome and host cross talk.
CARDIOVASCULAR RESEARCH - 27 Mar 2025
Long-term mortality outcome of a primary care-based mobile health intervention for stroke management: Six-year follow-up of a cluster-randomized controlled trial.
PLOS MEDICINE - 01 Mar 2025
Despite growing evidence of primary care-based interventions for chronic disease management in resource-limited settings, long-term post-trial effects remain inconclusive. We investigated the association of a 12-month system-integrated technology-enabled model of care (SINEMA) intervention with mortality outcomes among patients experiencing stroke at 6-year post-trial. This study (clinicltiral....
Baseline and 10-year change in the number of ideal cardiovascular health metrics and sudden cardiac death in the community.
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 28 Mar 2025
Adherence to an ideal cardiovascular health (CVH) might contribute to lower the burden of sudden cardiac death (SCD) in the community. We aimed to examine the association between the number of ideal CVH metrics at baseline and of its change over 10 years with the risk of SCD. The Copenhagen City Heart Study is a community-based prospective cohort study. The number of ideal CVH metrics (range 0-...
Beyond platelet activation: dysregulated lipid metabolism in defining risk and pathophysiology of VITT.
RESEARCH AND PRACTICE IN THROMBOSIS AND HAEMOSTASIS - 01 Jan 2025
VITT has emerged as a rare but serious adverse event linked primarily to adenoviral vector COVID-19 vaccinations, such as ChAdOx1-S (Oxford/AstraZeneca) vaccination. The syndrome is characterized by thrombosis with thrombocytopenia, elevated D-dimer, and pathologic platelet factor 4 antibodies within 42 days of vaccination. Despite dysregulated lipid metabolism underpinning many thrombotic cond...
Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle.
NATURE COMMUNICATIONS - 08 Mar 2025
During mitochondrial damage, information is relayed between the mitochondria and nucleus to coordinate precise responses to preserve cellular health. One such pathway is the mitochondrial integrated stress response (mtISR), which is known to be activated by mitochondrial DNA (mtDNA) damage. However, the causal molecular signals responsible for activation of the mtISR remain mostly unknown. A ge...
Burden of disease scenarios by state in the USA, 2022-50: a forecasting analysis for the Global Burden of Disease Study 2021.
LANCET (LONDON, ENGLAND) - 07 Dec 2024
The capacity to anticipate future health issues is important for both policy makers and practitioners in the USA, as such insights can facilitate effective planning, investment, and implementation strategies. Forecasting trends in disease and injury burden is not only crucial for policy makers but also garners substantial interest from the general populace and leads to a better-informed public....
Special Issue: "New Trends in Diabetes, Hypertension, and Cardiovascular Diseases-2nd Edition".
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 07 Jan 2025
Cardiovascular diseases (CVDs) encompass a range of conditions affecting both the heart (e.g., coronary heart disease and heart failure [1]) and blood vessels (e.g., cerebrovascular disease [2] and peripheral artery disease [3]) [...].
The Youth Fitness International Test (YFIT) battery for monitoring and surveillance among children and adolescents: A modified Delphi consensus project with 169 experts from 50 countries and territories.
JOURNAL OF SPORT AND HEALTH SCIENCE - 20 Nov 2024
Physical fitness in childhood and adolescence is associated with a variety of health outcomes and is a powerful marker of current and future health. However, inconsistencies in tests and protocols limit international monitoring and surveillance. The objective of the study was to seek international consensus on a proposed, evidence-informed, Youth Fitness International Test (YFIT) battery and pr...
An In Silico Investigation of the Pathogenic G151R G Protein-Gated Inwardly Rectifying K<sup>+</sup> Channel 4 Variant to Identify Small Molecule Modulators.
BIOLOGY - 29 Nov 2024
Primary aldosteronism is characterised by the excessive production of aldosterone, which is a key regulator of salt metabolism, and is the most common cause of secondary hypertension. Studies have investigated the association between primary aldosteronism and genetic alterations, with pathogenic mutations being identified. This includes a glycine-to-arginine substitution at position 151 (G151R)...
Improving the Sustainability of Public Health Interventions: The INNOVATE Model
GLOBAL IMPLEMENTATION RESEARCH AND APPLICATIONS - 07 Feb 2025
Introduction
Improving the sustainability of public health interventions is a priority for policymakers and program implementers. However, existing theories, models, and frameworks focus on describing constructs, processes, and measures of sustainability. Models to guide the improvement of sustainability of public health interventions are currently lacking.
Objective
To develop an evidence-bas...
An optimized plasmalogen modulating dietary supplement provides greater protection in a male than female mouse model of dilated cardiomyopathy.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY PLUS - 01 Mar 2025
We previously reported that plasmalogens, a class of phospholipids, were decreased in a setting of dilated cardiomyopathy (DCM). Plasmalogen levels can be modulated via a dietary supplement called alkylglycerols (AG) which has demonstrated benefits in some disease settings. However, its therapeutic potential in DCM remained unknown. To determine whether an optimized AG supplement could restore ...
Reduced PI3K(p110α) induces atrial myopathy, and PI3K-related lipids are dysregulated in athletes with atrial fibrillation.
JOURNAL OF SPORT AND HEALTH SCIENCE - 16 Jan 2025
Elucidating mechanisms underlying atrial myopathy, which predisposes individuals to atrial fibrillation (AF), will be critical for preventing/treating AF. In a serendipitous discovery, we identified atrial enlargement, fibrosis, and thrombi in mice with reduced phosphoinositide 3-kinase (PI3K) in cardiomyocytes. PI3K(p110α) is elevated in the heart with exercise and is critical for exercise-ind...
Targeting EZH1/2: tackling epigenetic resistance advances cancer therapy.
MEDCOMM - 01 Jan 2025
In a recent paper published in Nature, the mechanisms of action and resistance in histone lysine methylation-targeted treatment of adult T-cell leukemia/lymphoma (ATL) were characterised.1 The study showed tumor regression begins as early as the first week of valemetostat treatment with patients enrolled in Phase I and II trials achieving complete remission. This is mediated by reducing histone...
Impaired Cardiorespiratory Fitness in Cancer Survivors: Time to Come Together to Solve a Complex Problem.
JACC. CARDIOONCOLOGY - 01 Feb 2025
Posterior Wall Box Isolation in Atrial Fibrillation Catheter Ablation: Does Time Change the Outcome?
JACC. ASIA - 01 Feb 2025
Branched silver-iron oxide nanoparticles enabling highly effective targeted and localised drug-free thrombolysis.
BIOMATERIALS SCIENCE - 17 Feb 2025
Ultrasound has been widely used as an external stimulus to trigger drug release from nanomaterials in thrombosis treatment. Here, we introduce a novel strategy leveraging nanomaterials not for drug delivery, but for enhancing US-induced thrombolysis. This innovative strategy is particularly significant, as thrombolytic drugs inherently pose a risk of systemic bleeding. We combined branched silv...
Acetylcholine-loaded nanoparticles protect against doxorubicin-induced toxicity in<i>in vitro</i>cardiac spheroids.
BIOFABRICATION - 18 Feb 2025
Doxorubicin (DOX) is widely used in chemotherapy, yet it significantly contributes to heart failure-associated death. Acetylcholine (ACh) is cardioprotective by enhancing heart rate variability and reducing mitochondrial dysfunction and inflammation. Nonetheless, the protective role of ACh in countering DOX-induced cardiotoxicity (DIC) remains underexplored as current approaches to increasing A...
Age at type 1 diabetes onset does not influence attained brain volume.
BMC ENDOCRINE DISORDERS - 18 Feb 2025
Type 1 diabetes is suspected to hamper brain growth, implying that people with earlier diabetes onset would, on average, achieve lower maximal brain volume. We set out to test this hypothesis. Examining brain MRI scans of middle-aged people with type 1 diabetes, we related age at diabetes onset to intracranial volume in 180 participants, as well as to cerebral gray and white matter volumes in a...
Sex-Specific Association of Myocardial Fibrosis With Mortality in Patients With Aortic Stenosis.
JAMA CARDIOLOGY - 19 Feb 2025
Myocardial fibrosis in aortic stenosis (AS) may exhibit sex differences. However, its prognostic significance in women with AS remains unclear. To investigate sex differences in myocardial fibrosis assessed by cardiovascular magnetic resonance (CMR) and evaluate its prognostic value in women and men with AS. Patients with severe AS who underwent CMR before aortic valve replacement (AVR) were pr...
Mechanisms of ligand-mediated modulation of mineralocorticoid receptor signaling.
MOLECULAR AND CELLULAR ENDOCRINOLOGY - 19 Feb 2025
The mineralocorticoid receptor plays a central role in homeostasis, mediating the regulation by aldosterone of epithelial sodium transport. In addition, it regulates a range of responses in other tissues where it is likely responding to both mineralocorticoids and glucocorticoids. Structural, functional and evolutionary studies have provided insights into the mechanisms of receptor activation b...
