Publications
Now showing items 101-120 of 4875 records
Integrated image-based deep learning and language models for primary diabetes care.
NATURE MEDICINE - 19 Jul 2024
Primary diabetes care and diabetic retinopathy (DR) screening persist as major public health challenges due to a shortage of trained primary care physicians (PCPs), particularly in low-resource settings. Here, to bridge the gaps, we developed an integrated image-language system (DeepDR-LLM), combining a large language model (LLM module) and image-based deep learning (DeepDR-Transformer), to pro...
piscesCSM: prediction of anticancer synergistic drug combinations.
JOURNAL OF CHEMINFORMATICS - 19 Jul 2024
While drug combination therapies are of great importance, particularly in cancer treatment, identifying novel synergistic drug combinations has been a challenging venture. Computational methods have emerged in this context as a promising tool for prioritizing drug combinations for further evaluation, though they have presented limited performance, utility, and interpretability. Here, we propose...
Aptasensors and Advancement in Molecular Recognition Technology
ADVANCED MATERIALS TECHNOLOGIES - 02 Jul 2024
Synthetic oligonucleic acids known as aptamers exhibit remarkable selectivity and affinity for target recognition and binding. Selected via an iterative process known as “selective evolution of ligands by exponential enrichment” (SELEX), aptamers fold into defined 3D conformations to interact with their targets. The incorporation of aptamers as recognition elements has driven notable progress i...
PVC Triggers in Early Repolarization Syndrome: A New Wave of Knowledge.
JACC. CLINICAL ELECTROPHYSIOLOGY - 01 Jan 2024
Predictors of pacemaker requirement in patients receiving implantable loop recorders for unexplained syncope: A systematic review and meta-analysis.
HEART RHYTHM - 18 Mar 2024
Implantable loop recorders (ILRs) are increasingly used to evaluate patients with unexplained syncope. Identification of all predictors of bradycardic syncope and consequent permanent pacemaker (PPM) insertion is of substantial clinical interest as patients in the highest risk category may benefit from upfront pacemaker insertion. We performed a systematic review and meta-analysis to identify r...
C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation.
JOURNAL OF ADVANCED RESEARCH - 09 Jul 2024
Despite recent substantial progress in vascularized composite allotransplantation (VCA), such as face transplantations, short- and long-term allograft survival is severely limited by allograft rejection. The acute-phase response, directly after allogeneic transplantation, represents an immune-inflammatory reaction to ischemia/reperfusion and acts as an early initiator of graft rejection. Acute-...
Mechanical dyssynchrony as a selection criterion for cardiac resynchronization therapy: Design of the AMEND-CRT trial.
ESC HEART FAILURE - 10 Jul 2024
One third of patients do not improve after cardiac resynchronization therapy (CRT). Septal flash (SF) and apical rocking (ApRock) are deformation patterns observed on echocardiography in most patients eligible for CRT. These markers of mechanical dyssynchrony have been associated to improved outcome after CRT in observational studies and may be useful to better select patients. The aim of this ...
The effect of ambient temperatures on hospital admissions for kidney diseases in Central Australia.
ENVIRONMENTAL RESEARCH - 29 Jun 2024
This study aimed to quantify risk of hospitalisations for kidney diseases related to ambient temperature in Central Australia, Northern Territory (NT). Daily hospitalisation data were extracted for Alice Springs Hospital, Central Australia, 2010-2021. The association between daily mean temperature and daily hospital admissions for total kidney and specific kidney conditions was assessed using a...
How to build an actionable narrative for Cardio-Oncology.
TRENDS IN CARDIOVASCULAR MEDICINE - 29 Jun 2024
Harnessing human microbiomes for disease prediction.
TRENDS IN MICROBIOLOGY - 01 Jul 2024
The human microbiome has been increasingly recognized as having potential use for disease prediction. Predicting the risk, progression, and severity of diseases holds promise to transform clinical practice, empower patient decisions, and reduce the burden of various common diseases, as has been demonstrated for cardiovascular disease or breast cancer. Combining multiple modifiable and non-modif...
The impact of frailty on initiation, continuation and discontinuation of secondary prevention medications following myocardial infarction.
ARCHIVES OF GERONTOLOGY AND GERIATRICS - 01 Jul 2024
To evaluate the association between frailty and initiating, continuing, or discontinuing secondary prevention medications following myocardial infarction (MI). We conducted a cohort study using linked health data, including all adults aged ≥65 years who discharged from hospital following MI from January 2013 to April 2018 in Victoria, Australia (N = 29,771). The Hospital Frailty Risk Score (HFR...
Urine Albumin-Creatinine Ratio Variability in People With Type 2 Diabetes: Clinical and Research Implications.
AMERICAN JOURNAL OF KIDNEY DISEASES : THE OFFICIAL JOURNAL OF THE NATIONAL KIDNEY FOUNDATION - 01 Jul 2024
Evidence has demonstrated that albuminuria is a key diagnostic and prognostic marker of diabetic chronic kidney disease, but the impact of its day-to-day variability has not been adequately considered. This study quantified within-individual variability of albuminuria in people with type 2 diabetes to inform clinical albuminuria monitoring. Descriptive cross-sectional analysis. People with type...
Cardiovascular disease hospitalizations among women who undergo fertility treatment.
01 Jul 2024
Are women who receive fertility treatment at increased risk of cardiovascular disease (CVD) hospitalization compared with women who do not? A retrospective cohort study of all women registered for fertility treatment at Monash IVF between 1998 and 2014. This cohort was linked to the Victorian Admitted Episodes Dataset, which contains records of all hospital admissions in the Australian state of...
Prevalence and Characteristics of Low-renin Hypertension in a Primary Care Population.
JOURNAL OF THE ENDOCRINE SOCIETY - 01 Jul 2024
Low-renin hypertension is an underrecognized subtype of hypertension with specific treatment options. This study aims to identify the prevalence in primary care and to compare patient characteristics to those with normal-renin hypertension and primary aldosteronism (PA). In a cohort study, patients with treatment-naïve hypertension were screened for PA with plasma aldosterone and direct renin c...
Cardiovascular Risk Factors in Childhood and Adulthood and Cardiovascular Disease in Middle Age.
JAMA NETWORK OPEN - 03 Jun 2024
Recent evidence suggests that childhood levels of serum lipids, blood pressure, body mass index (BMI), and smoking contribute to adult risk of cardiovascular disease (CVD). Evidence is lacking on whether this is independent of adult risk levels. To quantify direct and indirect effects of childhood risk factors on adult CVD via adulthood risk factors using mediation analysis, and to quantify the...
The shifting roles of community health workers in the prevention and management of Noncommunicable disease during COVID-19 Pandemic: A scoping review.
HEALTH POLICY AND PLANNING - 24 Jun 2024
Community Health Workers (CHWs) play a crucial role in the prevention and management of noncommunicable diseases (NCDs). The COVID-19 pandemic triggered the implementation of crisis-driven responses that involved shifts in the roles of CHWs in terms of delivering services for people with NCDs. Strategically aligning these shifts with health systems is crucial to improve NCD service delivery. Th...
Novel use of surface isochronal dispersion mapping to identify source depth for focal ventricular ectopic catheter ablation.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY : AN INTERNATIONAL JOURNAL OF ARRHYTHMIAS AND PACING - 24 Jun 2024
Correction to: Temporal features of sitting, standing and stepping changes in a cluster-randomised controlled trial of a workplace sitting-reduction intervention.
THE INTERNATIONAL JOURNAL OF BEHAVIORAL NUTRITION AND PHYSICAL ACTIVITY - 24 Jun 2024
Excess Risk of Injury in Individuals With Type 1 or Type 2 Diabetes Compared With the General Population.
DIABETES CARE - 25 Jun 2024
To estimate the relative risk (RR) and excess hospitalization rate for injury in individuals with diabetes compared with the general population. Data were obtained from the Australian National Diabetes Services Scheme, hospitalization data sets, the Australian Pharmaceutical Benefits Scheme, the National Death Index, and the census spanning from 2011 to 2017. Hospitalizations for injury were co...
Pulsed-field ablation: a revolution in atrial fibrillation therapy.
NATURE REVIEWS. CARDIOLOGY - 25 Jun 2024
