Publications
Now showing items 101-120 of 5595 records
Living arrangements and associations with well-being among older adults in China: a national population-based study.
BMC GERIATRICS - 28 Nov 2025
Special Issue "New Trends in Diabetes, Hypertension and Cardiovascular Diseases: 3rd Edition".
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 29 Oct 2025
Cardiovascular disease (CVD) encompasses a broad spectrum of conditions affecting the heart and blood vessels [...].
High Salt Intake and Atherosclerosis Progression-Not Only via Blood Pressure: A Narrative Review.
NUTRIENTS - 03 Nov 2025
Excessive dietary salt intake remains a critical and underestimated global health concern, strongly associated with increased cardiovascular disease risk. While the relationship between salt and arterial hypertension is well established, accumulating evidence highlights additional, blood pressure-independent mechanisms linking high salt intake with the progression of atherosclerosis. Beyond its...
Ceramide as a Biomarker for HFpEF in Women: Menopause, Aging, and Pregnancy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES - 06 Nov 2025
Heart failure with preserved ejection fraction (HFpEF) currently accounts for half of the heart failure (HF) cases world-wide, affecting nearly 32 million people. HFpEF has a skewed prevalence toward females and those older than 65 years old. The pathophysiology of HFpEF is suggestive of a conglomerate of inflammatory, hypertensive, as well as metabolic dysfunction, giving rise to the syndrome....
A Novel Digital Platform to Support Child and Family Mental Health in Australia (Child and Family eHub): Protocol for a Mixed Methods Evaluation.
13 Nov 2025
Child mental health disorders are a significant Australian public health issue with high prevalence rates compounded by inequitably higher rates for those living in families with lower income, lower levels of parental education, and higher levels of unemployment. Prevention and early intervention approaches are critical to address problems early. When caregivers seek information and services to...
Effect of GLP-1 receptor agonists on body composition.
CURRENT OPINION IN ENDOCRINOLOGY, DIABETES, AND OBESITY - 13 Oct 2025
Obesity is present in up to 85% of individuals with type 2 diabetes mellitus (T2DM) and poses a major therapeutic challenge. Glucagon-like peptide-1 receptor agonists (GLP-1RAs), initially developed for T2DM, are now widely used for obesity management and increasingly recognized for their impact on body composition beyond weight reduction. This review summarizes evidence on the effects of GLP-1...
The protective effect of breastfeeding on infant inflammation: a mediation analysis of the plasma lipidome and metabolome.
BMC MEDICINE - 08 Oct 2025
Inflammation has long-term health impacts across the life course. Breastfeeding substantially reduces inflammation risk, but key pathways, including the extent that this is due to protection against early life infection, are poorly understood. We aimed to investigate the relationships between breastfeeding, inflammation, and infection burden, and to determine the extent to which metabolomic and...
Clinical relevance of extracellular vesicles in cancer - therapeutic and diagnostic potential.
NATURE REVIEWS. CLINICAL ONCOLOGY - 08 Oct 2025
Extracellular vesicles (EVs) encompass a multitude of lipid bilayer-delimited particles, of which exosomes are the most widely studied. Bidirectional cell-cell communications via EVs have a pivotal role in the physiology of multicellular organisms. EVs carry biological cargoes (including proteins, RNA, DNA, lipids and metabolites) capable of mediating a range of pleiotropic cellular functions. ...
Joslin Kidney Panel of Circulating Proteins: A Tool for ESKD Risk Discrimination and Individualized Diabetic Kidney Disease Treatment.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY : CJASN - 10 Oct 2025
To facilitate personalized treatment of diabetic kidney disease (DKD), we developed the Joslin Kidney Panel (JKP) of 21 circulating proteins associated with progression to end-stage kidney disease (ESKD). Prognostic models using baseline concentrations of JKP proteins in circulation and clinical markers were then developed to stratify individuals according to ESKD risk and according to response...
Extracellular vesicle profiling reveals novel autism signatures in patient-derived forebrain organoids.
TRANSLATIONAL PSYCHIATRY - 10 Oct 2025
Autism Spectrum Disorder (ASD) affects 1 percent of the world's population with an increased prevalence of 178 percent since 2000. Although altered synaptic function putatively accounts for many of the abnormalities seen in ASD, the specific molecular mechanisms underlying this disorder remain poorly defined. A growing body of evidence suggests that extracellular vesicles (EVs), specifically ex...
Paternal SARS-CoV-2 infection impacts sperm small noncoding RNAs and increases anxiety in offspring in a sex-dependent manner.
NATURE COMMUNICATIONS - 11 Oct 2025
Given that the SARS-CoV-2 virus, and the COVID-19 pandemic, constitutes a major environmental challenge faced by billions of people worldwide, we investigated whether paternal pre-conceptual SARS-CoV-2 infection has impacts on sperm RNA content, and intergenerational (F1) and transgenerational (F2) effects on offspring phenotypes. Using an established mouse-adapted SARS-CoV-2 (P21) preclinical ...
When Microbes Meet Androgens: A Sex-Specific Path to Hypertension.
HYPERTENSION (DALLAS, TEX. : 1979) - 01 Nov 2025
The Around the Clock Terminology Consortium: A Global Consensus on Terminology to Discuss the 24-Hour Cycle of Physical Activity, Sedentary Behavior, and Sleep.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 11 Oct 2025
The Development of Can Walk Can Run: A Walking and Running Program for People Living With and Beyond Cancer.
JOURNAL OF PHYSICAL ACTIVITY & HEALTH - 11 Oct 2025
Finding new ways to support physical activity participation after cancer is an important challenge. This research aimed to develop a walking and running program that could support people living with and beyond cancer to participate in fun run-style events. Mixed methods research that followed guidance for developing complex interventions was conducted in 2 phases. Phase 1 included a review of p...
Diabetes mellitus and work participation.
NATURE REVIEWS. ENDOCRINOLOGY - 20 Oct 2025
Work participation is beneficial for health. Diabetes mellitus is highly prevalent among adults, and although it poses a substantial healthcare cost burden, the true burden might be greater than is currently appreciated through effects on work participation. This Review summarizes the evidence regarding the effect of diabetes mellitus on paid employment. Several studies report increased risks o...
Exome and Genome Sequencing Reveals Novel Variants for Severe Diabetic Retinopathy in Type 1 Diabetes.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE - 01 Oct 2025
Diabetic retinopathy affects a substantial proportion of individuals with diabetes and, if not treated, may lead to acquired visual impairment or even blindness. An improved comprehension of the genetics of diabetic retinopathy (DR) is crucial in understanding the disease mechanisms. We aimed to identify rare and low-frequency variants predisposing to severe DR (SDR) in type 1 diabetes. Whole e...
Incidence of Type 2 Diabetes With Verapamil Compared With Other Calcium Channel Blockers.
DIABETES CARE - 30 Oct 2025
Evidence that the calcium channel blocker (CCB) verapamil slows type 1 diabetes progression suggests possible preventive benefits among people at risk of developing type 2 diabetes. We compared type 2 diabetes incidence between users of verapamil versus other CCBs in a population-based cohort. From a random sample of Australians in national subsidized health care databases, we identified 90,026...
Association of the Age at Type 2 Diabetes Onset With Diabetes Progression.
DIABETES CARE - 07 Nov 2025
To examine whether age at type 2 diabetes onset affects disease progression, assessed by changes in glycemic control and clinical biomarkers during follow-up. Participants in the Kerala Diabetes Prevention Program (K-DPP) and U.S. Diabetes Prevention Program (US-DPP) who developed type 2 diabetes during the trial were analyzed. Data on fasting plasma glucose (FPG), hemoglobin A1c (HbA1c), trigl...
DNA Methylation Biomarkers Predict Offspring Metabolic Risk From Mothers With Hyperglycemia in Pregnancy.
DIABETES - 01 Sep 2025
Maternal hyperglycemia is linked to 19 cord blood DNA methylation biomarkers that predict offspring metabolic dysfunction. These methylation changes, associated with maternal glycemic status, improved the prediction of β-cell dysfunction at 7, 11, and 18 years of age compared with clinical factors alone. Validation in human β-cells and pancreatic ductal epithelial cells confirmed that hyperglyc...
MitoQ Protects Against Oxidative Stress-Induced Mitochondrial Dysregulation in Human Cardiomyocytes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY PLUS - 01 Sep 2025
The overproduction of reactive oxygen species (ROS) and mitochondrial dysregulation are regarded as key mechanisms in the progression of cardiac remodelling in cardiometabolic diseases including heart failure. Conventional treatments are often ineffective as they do not specifically target the underlying pathological mechanisms. Mitoquinone mesylate (MitoQ), a mitochondrial-targeted antioxidant...
