Macronutrient intakes vary across people and economic status, leading to a disparity in diet-related metabolic diseases. This study aimed to provide insight into this by: (1) identifying dietary patterns in adults using reduced rank regression (RRR), with macronutrients as response variables, and (2) investigating the associations between economic status and macronutrient based dietary patterns, and between dietary patterns with central obesity (waist circumference) and systemic inflammation (C-reactive protein [CRP]). 41,849 US participants from the National Health and Nutrition Examination Survey (NHANES), 1999-2018 were included. The percentages of energy from protein, carbohydrates, saturated fats, and unsaturated fats were used as response variables in RRR. Multivariable generalized linear models with Gaussian distribution were employed to investigate the associations. Four dietary patterns were identified. Economic status was positively associated with both the high fat, low carbohydrate [β_HighVsLow = 0.22; 95% CI: 0.16, 0.28] and high protein patterns [β_HighVsLow = 0.07; 95% CI: 0.03, 0.11], and negatively associated with both the high saturated fat [β_HighVsLow = -0.06; 95% CI: -0.08, -0.03] and the low alcohol patterns [β_HighVsLow = -0.08; 95% CI; -0.10, -0.06]. The high saturated fat pattern was positively associated with waist circumference [β_Q5VsQ1 = 1.71; 95% CI: 0.97, 2.44] and CRP [β_Q5VsQ1 = 0.37; 95% CI: 0.26, 0.47]. Macronutrient dietary patterns, which varied by economic status and were associated with metabolic health markers, may explain associations between economic status and health.