Evolution and transmission of antibiotic resistance is driven by Beijing lineage in Vietnam.Mycobacterium tuberculosis

Matthew Silcocks; Xuling Chang; Nguyen Thuy Thuong Thuong; Youwen Qin; Dang Thi Minh Ha; Phan Vuong Khac Thai; Srinivasan Vijay; Do Dang Anh Thu; Vu Thi Ngoc Ha; Hoang Ngoc Nhung; Nguyen Huu Lan; Nguyen Thi Quynh Nhu; David Edwards; Artika Nath; Kym Pham; Nguyen Duc Bang; Tran Thi Hong Chau; Guy Thwaites; A Dorothee Heemskerk; Chiea Chuen Khor; Yik Ying Teo; Michael Inouye; Rick Twee-Hee Ong; Maxine Caws; Kathryn E Holt; Sarah J Dunstan
Drug-resistant tuberculosis (TB) infection is a growing and potent concern, and combating it will be necessary to achieve the WHO's goal of a 95% reduction in TB deaths by 2035. While prior studies have explored the evolution and spread of drug resistance, we still lack a clear understanding of the fitness costs (if any) imposed by resistance-conferring mutations and the role that genetic lineage plays in determining the likelihood of resistance evolution. This study offers insight into these questions by assessing the dynamics of resistance evolution in a high-burden Southeast Asian setting with a diverse lineage composition. It demonstrates that there are clear lineage-specific differences in the dynamics of resistance acquisition and transmission and shows that different lineages evolve resistance via characteristic mutational pathways.Mtb
ISSN 2165-0497
Published 12 Dec 2023
Volume 11
Issue 6
Pages e0256223 e0256223
DOI 10.1128/spectrum.02562-23
Type Journal Article