Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual Participant Data Meta-analysis of Randomized Controlled Trials.
Thirunavukkarasu Sathish; Kamlesh Khunti; K M Venkat Narayan; Viswanathan Mohan; Melanie J Davies; Thomas Yates; Brian Oldenburg; Kavumpurathu R Thankappan; Robyn J Tapp; Ram Bajpai; Ranjit Mohan Anjana; Mary B Weber; Mohammed K Ali; Jonathan E Shaw
Abstract
To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype.We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach.Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01).Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.
Journal | DIABETES CARE |
ISSN | 1935-5548 |
Published | 01 Nov 2023 |
Volume | 46 |
Issue | 11 |
Pages | 1903 1907 1903-1907 |
DOI | 10.2337/dc23-0696 |
Type | Journal Article | Meta-Analysis | Research Support, Non-U.S. Gov't | Research Support, U.S. Gov't, P.H.S. | Research Support, N.I.H., Extramural |
Sponsorship |