Baker Institute open access repository
This open-access repository is a publically accessible, digital repository of the Baker Heart and Diabetes Institute's research outputs. Its purpose is to make our research findings available to the widest possible audience.
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Publications
Now showing items 1-20 of 4509 records
Activated Platelet-Targeted IR780 Immunoliposomes for Photothermal Thrombolysis
ADVANCED FUNCTIONAL MATERIALS - 20 Jan 2023
Acute thrombosis is a leading cause of mortality and morbidity worldwide. Pharmacological thrombolysis relies on plasminogen activators (PAs), which are associated with major side effects including potentially fatal bleeding. Alternative therapeutic options that do not rely on PAs are urgently required. Here, the efficacy of targeted photothermal therapy is evaluated for thrombolysis using lip...
Circulating ether lipids in prostate cancer.
JOURNAL OF CLINICAL ONCOLOGY : OFFICIAL JOURNAL OF THE AMERICAN SOCIETY OF CLINICAL ONCOLOGY - 31 May 2023
Abstract
e17009
Background: Decreased circulating levels of ether lipids (glycerophospholipids with an ether-linked fatty alcohol, e.g. plasmalogens) have been observed in obesity, diabetes and cardiovascular disease. In vitro and in vivo studies suggest that ether lipids are anti-inflammatory and protective against obesity. A recent landmark study revealed that ether lipids can kill cancer cel...
Establishing the Optimum use of High-Intensity Interval Training in Heart Failure: Current Status and Future Directions
CURRENT OPINION IN PHYSIOLOGY - 04 May 2023
High-intensity interval training (HIIT) is increasingly employed in a variety of clinical settings due to the growing evidence of increased efficacy compared with moderate-intensity exercise for a range of health and physical function and exercise outcomes. In this brief review, we highlight the recent findings from randomized trials, discuss the evidence and rationale for the greater physiolog...
Respiratory gas kinetics in patients with congestive heart failure during recovery from peak exercise.
CLINICS (SAO PAULO, BRAZIL) - 01 Jan 2023
Cardiopulmonary Exercise Testing (CPX) is essential for the assessment of exercise capacity for patients with Chronic Heart Failure (CHF). Respiratory gas and hemodynamic parameters such as Ventilatory Efficiency (VE/VCO<sub>2</sub> slope), peak oxygen uptake (peak VO<sub>2</sub>), and heart rate recovery are established diagnostic and prognostic markers for clinical populations. Previous studi...
The Importance of Human Milk Fatty Acids in Infant Growth and Development
PROCEEDINGS - 20 Feb 2023
Fatty acids are the building blocks of the entire human milk lipidome; yet, despite years of research, there is little understanding of their importance in early life health and disease. This may be partly due to the way in measurements have been made of fatty acids in the past. Monthly longitudinal human milk samples were collected from eighteen Western Australian mother–infant dyads, during s...
Diminishing benefits of urban living for children and adolescents' growth and development.
NATURE - 01 Mar 2023
Optimal growth and development in childhood and adolescence is crucial for lifelong health and well-being<sup>1-6</sup>. Here we used data from 2,325 population-based studies, with measurements of height and weight from 71 million participants, to report the height and body-mass index (BMI) of children and adolescents aged 5-19 years on the basis of rural and urban place of residence in 200 cou...
Prolonged Honeymoon Period in a Thai Patient with Adult-Onset Type 1 Diabetes Mellitus.
CASE REPORTS IN ENDOCRINOLOGY - 01 Jan 2021
To describe a usual case of adult-onset T1DM with prolonged honeymoon period for more than 5 years. Repeated mixed meal stimulation tests for a period of 6-12 months together with monitoring pancreatic autoantibodies and laboratory data were followed following the onset of diagnosis. We report a 24-year-old Thai patient with T1DM with sustained remission without antidiabetic medication for more...
Within-visit SBP variability from childhood to adulthood and markers of cardiovascular end-organ damage in mid-life.
JOURNAL OF HYPERTENSION - 01 Sep 2021
Within-visit SBP variability is associated with age and SBP, but its long-term clinical significance is unknown. We examined the association between child, adult, and life-time within-visit SBP variability with markers of end-organ damage using data from a 31-year longitudinal study. Within-visit SBP variability was calculated as the standard deviation of three sitting SBP readings among up to ...
Within-visit and between-visit intra-individual blood pressure variability in an unselected adult population from rural China.
JOURNAL OF HYPERTENSION - 01 Jul 2021
To assess the association between the variability of blood pressure (BP) readings within an initial clinic visit, the variability within subsequent visits and the variability between visits over 1 week in a general population. This study included 1401 adult residents, who were not taking antihypertensive drugs, having BP measurements at three visits over 1 week. The difference between maximal a...
How to check whether a blood pressure monitor has been properly validated for accuracy.
JOURNAL OF CLINICAL HYPERTENSION (GREENWICH, CONN.) - 01 Dec 2020
Hypertension guidelines recommend that blood pressure (BP) should be measured using a monitor that has passed validation testing for accuracy. BP monitors that have not undergone rigorous validation testing can still be cleared by regulatory authorities for marketing and sale. This is the situation for most BP monitors worldwide. Thus, consumers (patients, health professionals, procurement offi...
Impact of Catheter Ablation on Cognitive Function in Atrial Fibrillation: A Randomized Control Trial.
JACC. CLINICAL ELECTROPHYSIOLOGY - 10 Apr 2023
Early postoperative cognitive dysfunction (POCD) has been reported following atrial fibrillation (AF) ablation. However, whether POCD is persistent long-term is unknown.The purpose of this study was to determine if AF catheter ablation is associated with persistent cognitive dysfunction at 12-month follow-up.This is a prospective study of 100 patients with symptomatic AF who failed at least 1 a...
Assessment of pericoronary adipose tissue attenuation.
EUROPEAN HEART JOURNAL CARDIOVASCULAR IMAGING - 21 Mar 2023
Impact of Early Versus Delayed Atrial Fibrillation Catheter Ablation on Atrial Arrhythmia Recurrences.
EUROPEAN HEART JOURNAL - 16 Apr 2023
Catheter ablation is an effective strategy in atrial fibrillation (AF). However, its timing in the course of management remains unclear. The aim of this study was to determine if an early versus delayed AF ablation strategy is associated with differences in arrhythmia outcomes during 12-month follow-up.One hundred patients with symptomatic AF referred to a tertiary centre for management were ra...
Projecting the incidence and costs of major cardiovascular and kidney complications of type 2 diabetes with widespread SGLT2i and GLP-1 RA use: a cost-effectiveness analysis.
DIABETOLOGIA - 01 Apr 2023
Whether sodium-glucose co-transporter 2 inhibitors (SGLT2is) or glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are cost-effective based solely on their cardiovascular and kidney benefits is unknown. We projected the health and economic outcomes due to myocardial infarction (MI), stroke, heart failure (HF) and end-stage kidney disease (ESKD) among people with type 2 diabetes, with and wit...
A systematic review of global autopsy rates in all-cause mortality and young sudden death.
HEART RHYTHM - 01 Apr 2023
Autopsy is the gold standard method for determining cause of death. Young sudden death (SD) is a prototype condition in which autopsy is universally recommended. The aim of this review was to quantify real-world global rates of autopsy in either all-cause death or young SD. A systematic review was conducted. Rates of autopsy in all-cause death and in young SD were determined in each country usi...
Inotropic therapy in patients with advanced heart failure. A clinical consensus statement from the Heart Failure Association of the European Society of Cardiology.
EUROPEAN JOURNAL OF HEART FAILURE - 01 Apr 2023
This clinical consensus statement reviews the use of inotropic support in patients with advanced heart failure. The current guidelines only support use of inotropes in the setting of acute decompensated heart failure with evidence of organ malperfusion or shock. However, inotropic support may be reasonable in other patients with advanced heart failure without acute severe decompensation. The cl...
Mitochondrial damage in a Takotsubo syndrome-like mouse model mediated by activation of β-adrenoceptor-Hippo signaling pathway.
AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY - 01 Apr 2023
Takotsubo syndrome (TTS) is characterized by short-term contractile dysfunction with its mechanism undefined. We showed that activation of cardiac Hippo pathway mediates mitochondrial dysfunction and that stimulation of β-adrenoceptors (βAR) activates Hippo pathway. Here, we investigated the role of βAR-Hippo signaling in mediating mitochondrial dysfunction in isoproterenol (Iso)-induced TTS-li...
Declining Recognition of Chest Pain as a Cardiac Symptom Should Act as a Shot in The Arm.
HEART, LUNG & CIRCULATION - 01 Apr 2023
Inhibition of pancreatic EZH2 restores progenitor insulin in T1D donor.
SIGNAL TRANSDUCTION AND TARGETED THERAPY - 22 Jul 2022
Type 1 diabetes (T1D) is an autoimmune disease that selectively destroys insulin-producing β-cells in the pancreas. An unmet need in diabetes management, current therapy is focussed on transplantation. While the reprogramming of progenitor cells into functional insulin-producing β-cells has also been proposed this remains controversial and poorly understood. The challenge is determining why def...
Intestinal microbiota regulates diabetes and cancer progression by IL-1β and NOX4 dependent signaling cascades.
CELLULAR AND MOLECULAR LIFE SCIENCES : CMLS - 01 Sep 2022
Diabetes changes the host microbiota, a condition known as dysbiosis. Dysbiosis is an important factor for the pathogenesis of diabetes and colorectal cancer (CRC). We aimed at identifying the microbial signature associated with diabetes and CRC; and identifying the signaling mechanism altered by dysbiosis and leading to CRC progression in diabetes. MKR mice that can spontaneously develop type ...
