Publications
Now showing items 81-100 of 4503 records
Clinician Perspectives on Cannulation for Extracorporeal Cardiopulmonary Resuscitation: A Mixed Methods Analysis.
ASAIO JOURNAL (AMERICAN SOCIETY FOR ARTIFICIAL INTERNAL ORGANS : 1992) - 01 Mar 2023
Out-of-hospital cardiac arrest is a leading cause of mortality with survival rates of less than 10%. In selected patients, survival may be improved via timely application of extracorporeal cardiopulmonary resuscitation (ECPR). However, ECPR is a complex and resource intensive intervention with a high risk of complications that impair widespread clinical adoption. This study employed a mixed app...
An Engineered Nanosugar Enables Rapid and Sustained Glucose-Responsive Insulin Delivery in Diabetic Mice.
12 Mar 2023
Glucose-responsive insulin-delivery platforms that are sensitive to dynamic glucose concentration fluctuations and provide both rapid and prolonged insulin release have great potential to control hyperglycemia and avoid hypoglycemia diabetes. Here, biodegradable and charge-switchable phytoglycogen nanoparticles capable of glucose-stimulated insulin release are engineered. The nanoparticles are ...
Blood pressure variability: methodological aspects, clinical relevance and practical indications for management - a European Society of Hypertension position paper ∗.
JOURNAL OF HYPERTENSION - 01 Apr 2023
Blood pressure is not a static parameter, but rather undergoes continuous fluctuations over time, as a result of the interaction between environmental and behavioural factors on one side and intrinsic cardiovascular regulatory mechanisms on the other side. Increased blood pressure variability (BPV) may indicate an impaired cardiovascular regulation and may represent a cardiovascular risk factor...
Device therapy with interatrial shunt devices for heart failure with preserved ejection fraction.
HEART FAILURE REVIEWS - 01 Mar 2023
Heart failure with preserved ejection fraction is responsible for half of all heart failure and confers substantial morbidity and mortality, and yet to date, there have been no effective pharmacologic interventions. Although the pathophysiology is complex, the primary aetiology of exercise intolerance is due to an elevated left atrial pressure, particularly with exercise. In this context, devic...
Corrigendum to 'Temporal Change in the Remaining Life Expectancy in People Who Underwent Percutaneous Coronary Intervention' The American Journal of Cardiology Volume 187, 15 January 2023, Pages 154-161.
THE AMERICAN JOURNAL OF CARDIOLOGY - 01 Mar 2023
Diagnostic evaluation of unexplained ventricular tachyarrhythmias in younger adults.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 17 Feb 2023
The diagnostic work-up for cardiac arrest from ventricular tachyarrhythmias occurring in younger adults and structurally normal hearts is variable and often incomplete.We reviewed records for all recipients of a secondary prevention implantable cardiac defibrillator (ICD) younger than 60 years at a single quaternary referral hospital from 2010 to 2021. Patients with unexplained ventricular arrh...
Association of socioeconomic Status in the incidence, Quality-of-care metrics and outcomes for patients with cardiogenic shock in a pre-hospital setting.
EUROPEAN HEART JOURNAL. QUALITY OF CARE & CLINICAL OUTCOMES - 17 Feb 2023
The relationship between lower socioeconomic status(SES) and poor cardiovascular outcomes is well-described, however there exists a paucity of data exploring this association in cardiogenic shock(CS). This study aimed to investigate whether any disparities exist between SES and the incidence, quality-of-care or outcomes of CS patients attended by emergency medical services(EMS).This population-...
Echocardiographic detection of heart valve disease in a community cohort of asymptomatic Australians > 65 years with cardiovascular risk factors.
INTERNATIONAL JOURNAL OF CARDIOLOGY - 15 Feb 2023
Valvular heart disease is becoming an increasingly prevalent with population ageing. We sought to define the current prevalence of valvular heart disease in Australia.The TasELF and VicELF studies prospectively recruited 962 asymptomatic participants ≥65 years, with at least one cardiovascular risk factor, from the Tasmanian and Victorian communities. People were excluded if they had a previous...
Detailed organisation of the human midbrain periaqueductal grey revealed using ultra-high field magnetic resonance imaging.
NEUROIMAGE - 01 Feb 2023
The midbrain periaqueductal grey (PAG) is a critical region for the mediation of pain-related behavioural responses. Neuronal tract tracing techniques in experimental animal studies have demonstrated that the lateral column of the PAG (lPAG) displays a crude somatotopy, which is thought to be critical for the selection of contextually appropriate behavioural responses, without the need for high...
Multispectroscopic, virtual and insights into the photoaging defense mediated by the natural food colorant bixin.in vivo
03 Jan 2023
An upsurge in early onset of photoaging due to repeated skin exposure to environmental stressors such as UV radiation is a challenge for pharmaceutical and cosmeceutical divisions. Current reports indicate severe side effects because of chemical or synthetic inhibitors of matrix metalloproteases (MMPs) in anti-skin aging cosmeceuticals. We evaluated the adequacy of bixin, a well-known FDA certi...
Managing peri-mitral flutter.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY - 04 Jan 2023
The exponential rise in the incidence of peri-mitral flutter has paralleled the increasing use of more extensive atrial substrate ablation for atrial fibrillation (AF). Given the relative paucity of randomized evidence to support its role in AF management, mitral isthmus ablation should largely be reserved for patients with peri-mitral flutter. Catheter ablation for peri-mitral flutter is chall...
Back to the future: Can retrospective analyses fill in the gaps left by prospective data?
INTERNATIONAL JOURNAL OF CARDIOLOGY - 15 Jan 2023
Linking Physical Activity to Breast Cancer Risk via the Insulin/Insulin-like Growth Factor Signaling System, Part 2: The Effect of Insulin/Insulin-like Growth Factor Signaling on Breast Cancer Risk.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 05 Dec 2022
Perturbation of the insulin/insulin-like growth factor (IGF) signaling system is often cited as a mechanism driving breast cancer risk. A systematic review identified prospective cohort studies and Mendelian randomization studies that examined the effects of insulin/IGF signaling (IGF, their binding proteins (IGFBP), and markers of insulin resistance] on breast cancer risk. Meta-analyses genera...
Linking Physical Activity to Breast Cancer Risk via Insulin/Insulin-Like Growth Factor Signaling System, Part 1: The Effect of Physical Activity on the Insulin/Insulin-Like Growth Factor Signaling System.
CANCER EPIDEMIOLOGY, BIOMARKERS & PREVENTION : A PUBLICATION OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, COSPONSORED BY THE AMERICAN SOCIETY OF PREVENTIVE ONCOLOGY - 05 Dec 2022
Physical activity may reduce the risk of developing breast cancer via its effect on the insulin/insulin-like growth factor (IGF) signaling system. A systematic review searched for randomized controlled trials (RCT), Mendelian randomization and prospective cohort studies that examined the effects of physical activity on insulin/IGF signaling [IGFs, their binding proteins (IGFBP), and markers of ...
Translating atherosclerosis research from bench to bedside: navigating the barriers for effective preclinical drug discovery.
CLINICAL SCIENCE (LONDON, ENGLAND : 1979) - 09 Dec 2022
Cardiovascular disease (CVD) remains the leading cause of death worldwide. An ongoing challenge remains the development of novel pharmacotherapies to treat CVD, particularly atherosclerosis. Effective mechanism-informed development and translation of new drugs requires a deep understanding of the known and currently unknown biological mechanisms underpinning atherosclerosis, accompanied by opti...
Reasons for hospitalisation in Australians with type 2 diabetes compared to the general population, 2010-2017.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Dec 2022
We sought to quantify the burden and diversity of reasons for hospital admission amongst Australians with type 2 diabetes compared to the general population.We linked Australians aged 15 and above with type 2 diabetes on the National Diabetes Services Scheme (n = 456,265) to hospital admission data to determine hospitalisation risks at ICD-10 three-digit diagnosis level for 2010-2017. We perfor...
Trends in diabetes-related foot disease hospitalizations and amputations in Australia, 2010 to 2019.
DIABETES RESEARCH AND CLINICAL PRACTICE - 01 Dec 2022
To determine trends in the incidence of hospitalizations and amputations for diabetes-related foot disease (DFD) in Australia.We included 70,766 people with type 1, and 1,087,706 with type 2 diabetes from the Australian diabetes registry from 2010 to 2019, linked to hospital admissions databases. Trends in age-adjusted incidence were summarized as annual percent changes (APC).In people with typ...
The flatlining of cardiac arrest survival: can we revive the upward trend?
EUROPEAN HEART JOURNAL - 07 Dec 2022
Causes, circumstances, and potential preventability of cardiac arrest in the young: insights from a state-wide clinical and forensic registry.
EUROPACE : EUROPEAN PACING, ARRHYTHMIAS, AND CARDIAC ELECTROPHYSIOLOGY : JOURNAL OF THE WORKING GROUPS ON CARDIAC PACING, ARRHYTHMIAS, AND CARDIAC CELLULAR ELECTROPHYSIOLOGY OF THE EUROPEAN SOCIETY OF CARDIOLOGY - 09 Dec 2022
The causes, circumstances, and preventability of young sudden cardiac arrest remain uncertain.A prospective state-wide multi-source registry identified all out-of-hospital cardiac arrests (OHCAs) in 1-50 year olds in Victoria, Australia, from 2019 to 2021. Cases were adjudicated using hospital and forensic records, clinic assessments and interviews of survivors and family members. For confirmed...
Assessment of Myocardial Texture: The Next Frontier in Echocardiographic Quantification.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY - 06 Dec 2022
